Genetics of ethanol-induced locomotor activation: Detection of QTLs in a C57BL/6J x DBA/2J F2 intercross

Mammalian Genome

Volumn 9, Issue 12, 1998, Pages 956-962

  Hitzemann, Robert ^a   Cipp, Laura ^a   Demarest, Kristin ^a   Mahjubi, Elham ^a   McCaughran Jr , James ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ANIMAL MODEL; ARTICLE; CHROMOSOME 2; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE LOCUS; GENE MAPPING; GENETIC RISK; GENETIC VARIABILITY; INBRED STRAIN; LOCOMOTION; MOUSE; NONHUMAN; PHENOTYPE; QUANTITATIVE TRAIT; STRAIN DIFFERENCE;

ANIMALS; CHROMOSOME MAPPING; CHROMOSOMES; CROSSES, GENETIC; ETHANOL; FEMALE; LOD SCORE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICROSATELLITE REPEATS; MOTOR ACTIVITY; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE;

ANIMALIA; GENETTA; MELO;

EID: 0032438032     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900906     Document Type: Article

References (48)

1. Barton NH, Turelli M (1989) Evolutionary quantitative genetics: how little do we know? Annu Rev Genet 23, 337-370
2. Belknap JK, Metten P, Helms ML, O'Toole LA, Angeli-Gade S, et al. (1993) Quantitative trait loci (QTL) applications to substances of abuse: physical dependence studies with nitrous oxide and ethanol in BXD mice. Behav Genet 23, 213-222
3. Belknap JK, Mitchell SR, O'Toole LA, Helms ML, Crabbe JC (1996) Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains. Behav Genet 26, 149-160
4. Belknap JK, Richards SP, O'Toole LA, Helms ML, Philips TJ (1997) Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice. Behav Genet 27, 27-55
5. Buck KJ (1996) Molecular genetic analysis of the role of GABAergic systems in the behavioral and cellular actions of alcohol. Behav Genet 26, 313-326
6. Buck KJ, Metten P, Belknap JK, Crabbe JC (1997) Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 17, 3946-3955
7. Copeland NG, Jenkins NA, Gilbert DJ, Eppig JT, Maltais LJ, et al. (1993) A genetic linkage map of the mouse: current applications and future prospects. Science 262, 57-66
8. Crabbe JC (1986) Genetic differences in locomotor activation in mice. Pharmacol Biochem Behav 25, 289-292
9. Crabbe JC, Johnson NA, Gray DK, Kosobud A, Young ER (1982) Biphasic effects of ethanol on open field activity: sensitivity and tolerance to C57BL/6N and DBA/2N mice. J Comp Physiol Psychol 96, 440-451
10. Crabbe JC, Kosobud A, Young ER, Janowsky JS (1983) Polygenic and single-gene determination or responses to ethanol in BXD/Ty recombinant inbred mouse strains. Neurobehav Toxicol Teratol 5, 181-187
11. Crabbe JC, Young ER, Deutsch CM, Tam BR, Kosobud A (1987) Mice genetically selected for differences in open-field activity after ethanol. Pharmacol Biochem Behav 27, 577-581
12. Crabbe JC, Belknap JK, Buck KJ (1994) Genetic animal models of alcohol and drug abuse. Science 264, 1715-1723
13. Cunningham CL (1995) Localization of genes influencing ethanol-induced conditioned place preference and locomotor activity in BXD recombinant inbred mice. Psychopharmacology 120, 28-41
14. Darvasi A, Weinreb A, Minke V, Weller JI, Soller M (1993) Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 134, 943-951
15. Darvasi A (1998) Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18, 19-24
16. Deitrich RA, Dunwidde TV, Harris RA, Erwin VG (1989) Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev 41, 489-537
17. Demarest K, Hitzemann B, McCaughran J, Mahjubi E, Hitzemann R (1997) Ethanol, the Fos response and the central nucleus of the amygdala. Soc Neurosci 23, 551.11
18. Demarest K, Cipp L, McCaughran J, Hitzemann R (1998a) QTL analysis of the stimulant and depressant effects of ethanol on locomotor activity in the BXD recombinant inbred series. Soc Neurosci 24, 292.3
19. Demarest K, Hitzemann B, Hitzemann R (1998b) Further evidence that the central nucleus of the amygdala is associated with ethanol-induced activation. Alcohol Clin Exp Res, in press
20. Demarest K, Hitzemann B, Phillips T, Hitzemann R (1998c) Ethanol-induced expression of c-Fos differentiates the FAST and SLOW selected lines of mice. Alcohol Clin Exp Res, in press
21. Dietrich W, Katz H, Lincoln SE, Shin H, Friedman J, et al. (1992) A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131, 423-447
22. Dudek BC, Phillips TJ (1990) Distinctions among sedative, disinhibitory, and ataxic properties of ethanol in inbred and selectively bred mice. Psychopharmacology 101, 93-99
23. Dudek BC, Tritto T (1994) Biometrical genetic analysis of ethanol's psychomotor stimulant effect. Alcohol Clin Exp Res 18, 956-963
24. Dudek BC, Abott ME, Phillips TJ (1984) Stimulant and depressant properties of sedative hypnotics in mice selectively bred for differential sensitivity to ethanol. Psychopharmacology 82, 46-51
25. Dudek BC, Phillips TJ, Hahn ME (1991) Genetic analysis of the biphasic nature of the alcohol dose-response curve. Alcohol Clin Exp Res 15, 262-269
26. Erwin VG, Radcliffe RA, Gehle VM, Jones BC (1997) Common quantitative trait loci for alcohol-related behaviors and central nervous systems neurotensin measures: locomotor activation. J Pharmacol Exp Ther 280, 919-926
27. Fisher RA (1918) The correlation between relatives on the supposition of Mendelian inheritance. Trans Royal Soc Edinburgh 52, 399-433
28. Frankel WN, Johnson EW, Lutz CM (1995) Congenic strains reveal effects of the epilepsy quantitative trait locus, EL2, separate from other El loci. Mamm Genome 6, 839-843
29. Gora-Maslak G, McClearn GE, Crabbe JC, Phillips TJ, Belknap JK, et al. (1991) Use of recombinant inbred strains to identify quantitative trait loci in psychopharmacology. Psychopharmacology 104, 413-424
30. Hitzemann B, Hitzemann R (1997) Genetics, ethanol and the Fos response: a comparison of the C57BL/6J and DBA/2J inbred mouse strains. Alcohol Clin Exp Res 21, 1497-1507
31. Hitzemann R, Hitzemann B, Kanes S, Dains K (1995) Genetics and organization of the basal ganglia. In Int Rev Neurobiol 38, 43-94
32. Kanes S, Hitzemann B, Hitzemann R (1996) Mapping the genes for haloperidol-induced catalepsy. J Pharmacol Exp Ther 277, 1016-1025
33. Lander ES, Botstein E (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199
34. Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265, 2037-2048
35. Lembertas AV, Perusse L, Chagnon YC, Fisler JS, Warden GH, et al. (1997) Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage of body fat and insulin on the human homologous region 20q. J Clin Invest 100, 1240-1247
36. Markel PD, DeFries JC, Johnson TE (1995) Ethanol-induced anaesthesia in inbred strains of long-sleep and short-sleep mice: a genetic analysis of repeated measures using censored data. Behav Genet 25, 67-73
37. Markel PD, Bennett B, Beeson M, Gordon L, Johnson TE (1997) Confirmation of quantitative trait loci for ethanol sensitivity in long-sleep and short-sleep mice. Genome Res 7, 92-99
38. Martin N, Boomsma D, Machin G (1997) A twin-pronged attack on complex traits. Nat Genet 17, 387-392
39. Melo JA, Shendure J, Pociask K, Silver LM (1996) Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nat Genet 13, 147-153
40. Morgan J, Curran T (1991) Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Ann Rev Neurosci 14, 421-451
41. Phillips TJ, Crabbe JC, Metten P, Belknap JK (1994) Localization of genes affecting alcohol drinking in mice. Alcohol Clin Exp Res 18, 931-941
42. Phillips TJ, Huson M, Gwiazdon C, Burkhart-Kasch S, Shen EH (1995) Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice. Alcohol Clin Exp Res 19, 1-10
43. Phillips TJ, Belknap JK, Buck KJ, Cunningham CL (1998) Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. Mamm Genome, in press
44. Rodriguez LA, Plomin R, Blizzard DA, Jones BC, McClearn GE (1995) Alcohol acceptance, preference, and sensitivity in mice. II. Quantitative trait loci mapping analyses using BXD recombinant inbred strains. Alcohol Clin Exp Res 19, 367-373
45. Schuckit MA (1994) A clinical model of genetic influences in alcohol dependence. J Stud Alcohol 55, 5-17
46. Shen EH, Dorow JD, Huson M, Phillips TJ (1996) Correlated responses to selection in FAST and SLOW mice: effects of ethanol on ataxia, temperature, sedation, and withdrawal. Alcohol Clin Exp Res 20, 688-696
47. Simler S, Puglisi-allegra S, Mandel P (1982) Gamma-aminobutyric acid in brain areas of isolated aggressive or non-aggressive inbred strains of mice. Pharmacol Biochem Behav 16, 57-61
48. Soller M, Brody T, Genizi A (1976) On the power of experimental designs for the direction of linkage between marker loci and quantitative loci in crosses between inbred lines. Theor Appl Genet 47, 35-39