Combination of phage display and molecular grafting generates highly specific tumor-targeting miniproteins

Angewandte Chemie - International Edition

Volumn 51, Issue 52, 2012, Pages 13136-13139

  Zoller, Frederic ^a   Markert, Annette ^a   Barthe, Philippe ^b   Zhao, Wenye ^c   Weichert, Wilko ^c   Askoxylakis, Vasileios ^a   Altmann, Annette ^a   Mier, Walter ^c   Haberkorn, Uwe ^c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b CENTRE DE BIOCHIMIE STRUCTURALE   (France)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Diagnostic agents; Drug discovery; Peptides; Protein structure; Radiochemical analysis

Indexed keywords

AFFINITY REAGENTS; DIAGNOSTIC AGENTS; DRUG DESIGN; DRUG DISCOVERY; MINI-PROTEINS; MOLECULAR DIAGNOSTICS; MOLECULAR ENTITIES; MOLECULAR GRAFTING; PHAGE DISPLAY; PROTEIN STRUCTURES; PROTEOLYTIC STABILITY; RADIOCHEMICAL ANALYSIS;

DRUG THERAPY;

PEPTIDES;

FLUORESCENT DYE; MEMBRANE PROTEIN; PEPTIDE; PROTEIN; SIGNAL PEPTIDE; TRYPSIN INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; CONFOCAL MICROSCOPY; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR GENETICS; NEOPLASM; PATHOLOGY; PEPTIDE LIBRARY; PROTEIN BINDING; SURFACE PLASMON RESONANCE; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; FLUORESCENT DYES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; NEOPLASMS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; SURFACE PLASMON RESONANCE; TRYPSIN INHIBITORS;

EID: 84871941556     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201203857     Document Type: Article

References (21)

1. H. K. Binz, P. Amstutz, A. Pluckthun, Nat. Biotechnol. 2005, 23, 1257.
2. D. J. Craik, R. J. Clark, N. L. Daly, Expert Opin. Invest. Drugs 2007, 16, 595.
3. F. Zoller, U. Haberkorn, W. Mier, Molecules 2011, 16, 2467.
4. A. Skerra, Curr. Opin. Biotechnol. 2007, 18, 295.
5. P. A. Nygren, A. Skerra, J. Immunol. Methods 2004, 290, 3.
6. L. Y. Chan, S. Gunasekera, S. T. Henriques, N. F.Worth, S. J. Le, R. J. Clark, J. H. Campbell, D. J. Craik, N. L. Daly, Blood 2011, 118, 6709.
7. G. P. Smith, V. A. Petrenko, Chem. Rev. 1997, 97, 391.
8. A. Marr, A. Markert, A. Altmann, V. Askoxylakis, U. Haberkorn, Methods 2011, 55, 215.
9. A. Heitz, D. Le-Nguyen, L. Chiche, Biochemistry 1999, 38, 10615.
10. F. Zoller, T. Schwaebel, A. Markert, U. Haberkorn, W. Mier, ChemMedChem 2012, 7, 237.
11. C. Souriau, L. Chiche, R. Irving, P. Hudson, Biochemistry 2005, 44, 7143.
12. N. L. Daly, S. Love, P. F. Alewood, D. J. Craik, Biochemistry 1999, 38, 10606.
13. O. Avrutina, H. U. Schmoldt, D. Gabrijelcic-Geiger, D. Le Nguyen, C. P. Sommerhoff, U. Diederichsen, H. Kolmar, Biol. Chem. 2005, 386, 1301.
14. S. Luckett, R. S. Garcia, J. J. Barker, A. V. Konarev, P. R. Shewry, A. R. Clarke, R. L. Brady, J. Mol. Biol. 1999, 290, 525.
15. M. L. Korsinczky, H. J. Schirra, D. J. Craik, Curr. Protein Pept. Sci. 2004, 5, 351.
16. N. L. Daly, Y. K. Chen, F. M. Foley, P. S. Bansal, R. Bharathi, R. J. Clark, C. P. Sommerhoff, D. J. Craik, J. Biol. Chem. 2006, 281, 23668.
17. R. G. Boy, W. Mier, E. M. Nothelfer, A. Altmann, M. Eisenhut, H. Kolmar, M. Tomaszowski, S. Kramer, U. Haberkorn, Mol. Imaging Biol. 2010, 12, 377.
18. J. Ridgway, G. Zhang, Y. Wu, S. Stawicki, W. C. Liang, Y. Chanthery, J. Kowalski, R. J. Watts, C. Callahan, I. Kasman, M. Singh, M. Chien, C. Tan, J. A. Hongo, F. de Sauvage, G. Plowman, M. Yan, Nature 2006, 444, 1083.
19. I. Noguera-Troise, C. Daly, N. J. Papadopoulos, S. Coetzee, P. Boland, N. W. Gale, H. Chieh Lin, G. D. Yancopoulos, G. Thurston, Nature 2006, 444, 1032.
20. N. S. Patel, J. L. Li, D. Generali, R. Poulsom, D. W. Cranston, A. L. Harris, Cancer Res. 2005, 65, 8690.
21. D. J. Hicklin, Nat. Biotechnol. 2007, 25, 300.