The absolute structural requirement for a proline in the P3′-position of Bowman-Birk protease inhibitors is surmounted in the minimized SFTI-1 scaffold

Journal of Biological Chemistry

Volumn 281, Issue 33, 2006, Pages 23668-23675

  Daly, Norelle L ^a   Chen, Yi Kuang ^a   Foley, Fiona M ^a   Bansal, Paramjit S ^a   Bharathi, Rekha ^a   Clark, Richard J ^a   Sommerhoff, Christian P ^b   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; PLANTS (BOTANY); SYNTHESIS (CHEMICAL); TUMORS;

BINDING LOOPS; CHEMOPREVENTIVE AGENTS; CYCLIZATION; NANOMOLAR ACTIVITY;

ENZYME INHIBITION;

AMINO ACID; ANTINEOPLASTIC AGENT; ASPARTIC ACID; BOWMAN BIRK INHIBITOR; TRYPSIN INHIBITOR;

ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; CYCLIZATION; DISULFIDE BOND; DRUG ACTIVITY; DRUG BINDING SITE; DRUG MECHANISM; DRUG STRUCTURE; GENE MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; PLANT SEED; PRIORITY JOURNAL;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; APROTININ; CATTLE; CONSERVED SEQUENCE; HELIANTHUS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PLANT PROTEINS; PROLINE; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPSIN INHIBITOR, BOWMAN-BIRK SOYBEAN;

HELIANTHUS;

EID: 33747664336     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M601426200     Document Type: Article

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