[68Ga]NS3-RGD and [68Ga] Oxo-DO3A-RGD for imaging αvβ3 integrin expression: Synthesis, evaluation, and comparison

Nuclear Medicine and Biology

Volumn 40, Issue 1, 2013, Pages 65-72

  Knetsch, Peter A ^a   Petrik, Milos ^a,b   Rangger, Christine ^a   Seidel, Gesine ^c   Pietzsch, Hans Jürgen ^c   Virgolini, Irene ^a   Decristoforo, Clemens ^a   Haubner, Roland ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

Author keywords

v 3; 68Ga; Angiogenesis; Molecular imaging; RGD

Indexed keywords

GALLIUM 1 OXA 4,7,10 TRIAZACYCLODODECANE 5 (4 ISOTHIOCYANATOBENZYL) 4,7,10 TRIACTEIC ACID ARGINYLGLYCYLASPARTIC ACID GA 68; GALLIUM 1,4,7 TRIAZACYCLONONANE 1,4 BIS(ACETIC ACID) 7 (2 GLUTARIC ACID) ARGINYLGLYCYLASPARTIC ACID GA 68; GALLIUM MONTIRELIN ARGINYLGLYCYLASPARTIC ACID GA 68; GALLIUM TETRAXETAN GA 68; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR; 68GA NS3 RGD; 68GA OXO DO3A RGD; 68GA-NS3-RGD; 68GA-OXO-DO3A-RGD; ARGINYL-GLYCYL-ASPARTIC ACID; ARGINYLGLYCYLASPARTIC ACID; CHELATING AGENT; COORDINATION COMPOUND; CYCLOPEPTIDE; DIAGNOSTIC AGENT; GALLIUM; OLIGOPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONJUGATION; CONTROLLED STUDY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MELANOMA; MOUSE; NANOANALYSIS; NANOCHEMISTRY; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIOACTIVITY; RADIOCHEMISTRY; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; METABOLISM; METHODOLOGY; POSITRON EMISSION TOMOGRAPHY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHELATING AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; COORDINATION COMPLEXES; GALLIUM RADIOISOTOPES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHAVBETA3; ISOTOPE LABELING; MICE; OLIGOPEPTIDES; PEPTIDES, CYCLIC; POSITRON-EMISSION TOMOGRAPHY;

EID: 84871925502     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2012.09.006     Document Type: Article

References (31)

1. Weis S.M., Cheresh D.A. αv integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med 2011, 1:a006478.
2. Shojaei F. Anti-angiogenesis therapy in cancer: current challenges and future perspectives. Cancer Lett 2012, 320:130-137.
3. Heidenreich R., Röcken M., Ghoreschi K. Angiogenesis drives psoriasis pathogenesis. Int J Exp Pathol 2009, 90:232-248.
4. Sadeghi M.M., Glover D.K., Lanza G.M., Fayad Z.A., Johnson L.L. Imaging atherosclerosis and vulnerable plaque. J Nucl Med 2010, 51(Suppl.):S51-S65.
5. 3-receptor blockade reduces macrophage infiltration and restenosis after balloon angioplasty in the atherosclerotic rabbit. Circulation 2001, 103:1906-1911.
6. 3 antagonist [see comments]. J Clin Invest 1999, 103:47-54.
7. Haubner R., Decristoforo C. Radiolabelled RGD peptides and peptidomimetics for tumour targeting. Front Biosci 2009, 14:872-886.
8. 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res 2001, 61:1781-1785.
9. 3 expression on the neovasculature in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 2007, 13:6610-6616.
10. 18F-FDG. J Nucl Med 2008, 49:22-29.
11. 18F-Galacto-RGD PET. J Nucl Med 2008, 49:255-259.
12. Gaertner F.C., Kessler H., Wester H.J., Schwaiger M., Beer A.J. Radiolabelled RGD peptides for imaging and therapy. Eur J Nucl Med 2012, 39(Suppl 1):S126-S138.
13. 3 integrin expression. Eur J Nucl Med Mol Imaging 2008, 35:1507-1515.
14. 111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjug Chem 2002, 13:530-541.
15. 188Re analogues. Bioconjug Chem 2004, 15:856-863.
16. 68Ga]NODAGA-RGD for imaging αvβ3 integrin expression. Eur J Nucl Med Mol Imaging 2011, 38:1303-1312.
17. 68Ga. Eur J Nucl Med Mol Imaging 2005, 32:478-485.
18. 18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates. Bioconjug Chem 2004, 15:61-69.
19. 99mTc]cRGD peptides labeled using different novel Tc-cores. Q J Nucl Med Mol Imaging 2007, 51:33-41.
20. Sun Y., Anderson C.J., Pajeau T.S., Reichert D.E., Hancock R.D., Motekaitis R.J., et al. Indium (III) and gallium (III) complexes of bis(aminoethanethiol) ligands with different denticities: stabilities, molecular modeling, and in vivo behavior. J Med Chem 1996, 39:458-470.
21. 68Ga-labelled mono-, di- and tetrameric RGD peptides. Eur J Nucl Med Mol Imaging 2011, 38:128-137.
22. Govindaswamy N., Quarless D.A., Koch S.A. New amine trithiolate tripod ligand and its iron(II) and iron (III) complexes. J Am Chem Soc 1995, 117:8468-8469.
23. Motekaitis R.J., Martell A.E., Koch S.A., Hwang J.W., Duncan A.Q., Welch M.J. The gallium(III) and indium(III) complexes of Tris(2-mercaptobenzyl)amine and Tris(2-hydroxybenzyl)amine. Inorg Chem 1998, 37:5902-5911.
24. Cutler C.S., Giron M.C., Reichert D.E., Snyder A.Z., Herrero P., Anderson C.J., et al. Evaluation of gallium-68 tris(2-mercaptobenzyl)amine: a complex with brain and myocardial uptake. Nucl Med Biol 1999, 26:305-316.
25. Luyt L.G., Katzenellenbogen J.A. A trithiolate tripodal bifunctional ligand for the radiolabeling of peptides with gallium(III). Bioconjug Chem 2002, 13:1140-1145.
26. 99mTcIII '4+1' mixed-ligand complexes conjugated to bombesin. J Inorg Biochem 2011, 105:1383-1390.
27. 68Ga complexes with tetradentate/monodentate NS3/N ('4+1') coordination: relation of structure with in vitro stability. Technetium, rhenium and other metals in chemistry and nuclear medicine 2006, 227-228. SGEditoriali, Padova. U. Mazzi (Ed.).
28. Delgado R., Quintino S., Teixeira M., Zhang A. Metal complexes of a 12-membered tetraaza macrocycle containing pyridine and N-carboxymethyl groups. J Chem Soc Dalton Trans 1997, 55-64.
29. Fani M., Maecke H.R. Radiopharmaceutical development of radiolabelled peptides. Eur J Nucl Med Mol Imaging 2012, 39(Suppl 1):S11-S30.
30. Ferreira C.L., Lamsa E., Woods M., Duan Y., Fernando P., Bensimon C., et al. Evaluation of bifunctional chelates for the development of gallium-based radiopharmaceuticals. Bioconjug Chem 2010, 21:531-536.
31. Ferreira C.L., Yapp D.T., Crisp S., Sutherland B.W., Ng S.W., Gleave M., et al. Comparison of bifunctional chelates for 64Cu antibody imaging. Eur J Nucl Med Mol Imaging 2010, 37:2117-2126.