Evaluation of bifunctional chelates for the development of gallium-based radiopharmaceuticals

Bioconjugate Chemistry

Volumn 21, Issue 3, 2010, Pages 531-536

  Ferreira, Cara L ^a   Lamsa, Eric ^a   Woods, Michael ^a   Duan, Yin ^b   Fernando, Pasan ^b   Bensimon, Corinne ^b   Kordos, Myra ^b   Guenther, Katharina ^a   Jurek, Paul ^c   Kiefer, Garry E ^c  

^a MDS Inc   (Canada)

^b UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^c Macrocyclics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 OXA 4,7,10 TRIAZACYCLODODECANE 4,7,10 TRIACETIC ACID; 1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; 3,6,9,15 TETRAAZABICYCLO[9.3.1]PENTADECA 1(15),11,13 TRIENE 3,6,9 TRIACETIC ACID; CHELATING AGENT; GALLIUM 68; UNCLASSIFIED DRUG; GALLIUM; ORGANOMETALLIC COMPOUND; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; BLOOD; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG CLEARANCE; DRUG STABILITY; ISOTOPE LABELING; KIDNEY; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; RADIOCHEMISTRY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; INBRED MOUSE STRAIN; KINETICS; POSITRON EMISSION TOMOGRAPHY; SYNTHESIS; TISSUE DISTRIBUTION;

MUS;

ANIMALS; CHELATING AGENTS; GALLIUM RADIOISOTOPES; KINETICS; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION;

EID: 77949783089     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc900443a     Document Type: Article

References (22)

1. 67Ga localization in malignant disease. Nucl. Med. Biol. 23, 745-752.
2. Weiner, R. E., and Thakur, M. L. (2003) Chemistry of galllium and indium radiopharmaceuticals, in Handbook of Radiopharmaceuticas Radiochemistry and Applications (Welch, M., and Redvanly, C. S., Eds.), John Wiley and Sons Ltd., West. Sussex, England.
3. Khan, M. U., Khan, S., El-Refaie, S., Win, Z., Rubello, D., and Al-Nahhas, A. (2009) Clinical indication for Gallium-68 positron emission tomography imaging. EJSO 35, 561-567.
4. 68Ga-PET: a powerful, generator-based alternative to cyclotron-based PET radiopharmacueticals. Corar. Med. Mol. Imagine 3, 53-62.
5. 68Galabeled peptides in tumor imaging. J. Nucl. Med. 46, 172S-178S.
6. Fichna, J., and Janecka, A. (2003) Synthesis of target-specific radiolabeled peptides in diagnostic imaging. Bioconiugate Chem. 14, 3-17.
7. 68Ga bioconjugates with high sepcific radioactivity. Bioconiueate Chem. 15, 554-560.
8. 68Ga-Labeling of biotin analogues and their characterization. Bioconiueate Chem. 20, 1146-1151.
9. 3 integran expression. Eur. J. Nucl. Med. Mol. Imaging 35, 1507-1515.
10. 68Ga-radiolabeled bivalent hapten-peptide-chelate conjugates. J. Nucl. Med. 45, 30-39.
11. 68Ga for PET imaging of HER2 expression. J. Nucl. Med. 50, 1492-1499.
12. 68Ga labeled RGD-bombesin heterodimeric peptides for PET imaging of breast cancer. Bioconiugate Chem. 20, 1016-1025.
13. 3, expression. Eur. J. Nucl. Med. Mol. Imaging 35, 1100-1108.
14. Velikyan, I., Maecke, H., and Langstrom, B. (2008) Convenient preparation of Ga-68 based PET-radiopharmaceutieals at. room temperature. Bioconiugate Chem. 19, 569-573.
15. 68Ga-Labeled c(RGDyK.)-Isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid and feasibility studies in mice. J. Nucl. Med. 49, 830-836.
16. Ferreira, C. L., Yapp, D. T., Lamsa, E., Gleave, M., Bensimon, C., Jurek, P., and Kiefer, G. E. (2008) Evaluation, of novel bifunctional chelates for development of Cu-64 based radiopharmaceuticals. Nucl. Med. Biol. 35, 875-882.
17. 68Ga-labeled peptide. Nucl. Med. Biol. 35, 529-536.
18. Shannon, R. D. (1976) Revised effective radii and systematic studies of interatomic distances in halide and chalcogenides. Acta Crystallogr. A32, 751-767.
19. Delgado, R., Quintino, S., Teixeira, M., and Zhang, A. (1996) Metal complexes of a 12-membered tetraaza macrocycle containing pyridine and N-carboxymethyl groups. J. Chem. Soc., Dalton Trans. 55-63.
20. Clarke, E. T., and Martell, A. E. (1991) Stabilities of trivalent metal ion complexes of the tetraacetate derivatives of 12-, 13and 14-membered tetraazamacrocycles. Inorg. Chim. Acta 190, 37-46.
21. Tircso, G., Benyo, E. T., Sun, E. H., Jurek, P., Kiefer, G. E., Sherry, A. D., and Kovacs, Z. (2009) (S)-5-(p-Nitrobenzyl)PCTA, a promising bifunctional ligand with advantageous metal ion complexation kinetics. Bioconjugate Chem. 20, 565-575.
22. Woods, M., Kovacs, Z., Kiraly, R., Brucher, E., Zhanng, S. R., and Sherry, A. D. (2004) Solution dynamics and stability of lanthanide(III) (S)-2-(p-nitrobenzyl) DOTA complexes. Inorg. Chem. 43, 2845-2851.