Scaffold-based repair for cartilage healing: A systematic review and technical note

Arthroscopy - Journal of Arthroscopic and Related Surgery

Volumn 29, Issue 1, 2013, Pages 174-186

  Filardo, Giuseppe ^a   Kon, Elizaveta ^a   Roffi, Alice ^a   Di Martino, Alessandro ^a   Marcacci, Maurilio ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRIN GLUE; TISSUE SCAFFOLD;

ARTHROPATHY; ARTICULAR CARTILAGE; CARTILAGE; CARTILAGE CELL; CARTILAGE MATRIX; CASE STUDY; CLINICAL PRACTICE; FOLLOW UP; HUMAN; HYALINE CARTILAGE; KIRSCHNER WIRE; MESENCHYMAL STEM CELL; REGENERATION; REVIEW; STEM CELL; SUPINE POSITION; SURGICAL TECHNIQUE; SYSTEMATIC REVIEW; THROMBOCYTE RICH PLASMA;

ABSORBABLE IMPLANTS; ANIMALS; ARTHROSCOPY; BIBLIOMETRICS; BIOCOMPATIBLE MATERIALS; CARTILAGE, ARTICULAR; CHONDROCYTES; COLLAGEN; DURAPATITE; FIBRIN; HUMANS; HYALURONIC ACID; HYDROGELS; IMPLANTS, EXPERIMENTAL; KNEE JOINT; NANOSTRUCTURES; ORTHOPEDIC PROCEDURES; POLYMERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REGENERATION; RETROSPECTIVE STUDIES; TISSUE SCAFFOLDS; WOUND HEALING;

EID: 84871923678     PISSN: 07498063     EISSN: 15263231     Source Type: Journal    
DOI: 10.1016/j.arthro.2012.05.891     Document Type: Review

References (70)

1. J.A. Buckwalter, and H.J. Mankin Articular cartilage: Tissue design and chondrocyte-matrix interactions Instr Course Lect 47 1998 477 486
2. S. Nehrer, M. Spector, and T. Minas Histologic analysis of tissue after failed cartilage repair procedures Clin Orthop Rel Res 365 1999 149 162
3. E. Kon, A. Gobbi, G. Filardo, M. Delcogliano, S. Zaffagnini, and M. Marcacci Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: Prospective nonrandomized study at 5 years Am J Sports Med 37 2009 33 41
4. M. Marcacci, E. Kon, M. Delcogliano, G. Filardo, M. Busacca, and S. Zaffagnini Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: Prospective study results at a minimum 7-year follow-up Am J Sports Med 35 2007 2014 2021
5. A.E. Gross, N. Shasha, and P. Aubin Long-term followup of the use of fresh osteochondral allografts for post-traumatic knee defects Clin Orthop Relat Res 435 2005 79 87
6. M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation N Engl J Med 331 1994 889 895
7. L. Peterson, H.S. Vasiliadis, M. Brittberg, and A. Lindahl Autologous chondrocyte implantation: A long-term follow-up Am J Sports Med 38 2010 1117 1124
8. E. Kon, P. Verdonk, V. Condello, M. Delcogliano, A. Dhollander, and G. Filardo Matrix-assisted autologous chondrocyte transplantation for the repair of cartilage defects of the knee: systematic clinical data review and study quality analysis Am J Sports Med 37 Suppl 1 2009 156S 166S
9. E. Kon, M. Delcogliano, G. Filardo, C. Montaperto, and M. Marcacci Second generation issues in cartilage repair Sports Med Arthrosc 16 2008 221 229
10. B. Grigolo, G. Lisignoli, and A. Piacentini Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAff 11): Molecular, immunohistochemical and ultrastructural analysis Biomaterials 23 2002 1187 1195
11. M. Marcacci, S. Zaffagnini, and E. Kon Arthroscopic autologous chondrocyte transplantation: Technical note Knee Surg Sports Traumatol Arthrosc 10 2002 154 159
12. C. Erggelet, M. Sittinger, and A. Lahm The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint Arthroscopy 19 2003 108 110
13. S. Della Villa, E. Kon, and G. Filardo Does intensive rehabilitation permit early return to sport without compromising the clinical outcome after arthroscopic autologous chondrocyte implantation in highly competitive athletes? Am J Sports Med 38 2010 68 77
14. J. Gille, E. Schuseil, J. Wimmer, J. Gellissen, A.P. Schulz, and P. Behrens Mid-term results of autologous matrix-induced chondrogenesis for treatment of focal cartilage defects in the knee Knee Surg Sports Traumatol Arthrosc 18 2010 1456 1464
15. E. Kon, M. Delcogliano, G. Filardo, M. Busacca, A. Di Martino, and M. Marcacci Novel nano-composite multilayered biomaterial for osteochondral regeneration: A pilot clinical trial Am J Sports Med 39 2011 1180 1190
16. M.R. Carmont, R. Carey-Smith, A. Saithna, M. Dhillon, P. Thompson, and T. Spalding Delayed incorporation of a TruFit plug: Perseverance is recommended Arthroscopy 25 2009 810 814
17. P. Behrens, T. Bitter, and B. Kurz Matrix-associated autologous chondrocyte transplantation/implantation (MATC/MACI): 5-Year follow-up Knee 13 2006 194 202
18. M. Ronga, F.A. Grassi, A. Manelli, and P. Bulgheroni Tissue engineering techniques for the treatment of a complex knee injury Arthroscopy 22 2006 576.e1 576.e3
19. G.M. Salzmann, J. Paul, J.S. Bauer, K. Woertler, M. Sauerschnig, and S. Landwehr T2 assessment and clinical outcome after autologous matrix-assisted chondrocyte and osteochondral autograft transplantation Osteoarthritis Cartilage 17 2009 1576 1582
20. A. Gigante, D. Enea, F. Greco, C. Bait, M. Denti, and H. Schonhuber Distal realignment and patellar autologous chondrocyte implantation: Mid-term results in a selected population Knee Surg Sports Traumatol Arthrosc 17 2009 2 10
21. E. Basad, B. Ishaque, G. Bachmann, H. Stürz, and J. Steinmeyer Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: A 2-year randomised study Knee Surg Sports Traumatol Arthrosc 18 2010 519 527
22. J.R. Ebert, W.B. Robertson, J. Woodhouse, M. Fallon, M.H. Zheng, and T. Ackland Clinical and magnetic resonance imaging-based outcomes to 5 years after matrix-induced autologous chondrocyte implantation to address articular cartilage defects in the knee Am J Sports Med 39 2011 753 763
23. S. Macmull, P.K. Jaiswal, G. Bentley, J.A. Skinner, R.W. Carrington, and T.W. Briggs The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae Int Orthop 2012 Jan 14 [Epub ahead of print] http://dx.doi.org/10.1007/s00264-011-1465-6
24. S. Bauer, R.J. Khan, J.R. Ebert, W.B. Robertson, W. Breidahl, and T.R. Ackland Knee joint preservation with combined neutralising high tibial osteotomy (HTO) and matrix-induced autologous chondrocyte implantation (MACI) in younger patients with medial knee osteoarthritis: A case series with prospective clinical and MRI follow-up over 5 years Knee 2011 Jul 22 [Epub ahead of print] http://dx.doi.org/10.1016/j.knee.2011.06.005
25. A. Ventura, A. Memeo, E. Borgo, C. Terzaghi, C. Legnani, and W. Albisetti Repair of osteochondral lesions in the knee by chondrocyte implantation using the MACI® technique Knee Surg Sports Traumatol Arthrosc 20 2012 121 126
26. M. Marcacci, M. Berruto, and D. Brocchetta Articular cartilage engineering with Hyalograft C: 3-Year clinical results Clin Orthop Relat Res 435 2005 96 105
27. S. Nehrer, S. Domayer, R. Dorotka, K. Schatz, U. Bindreiter, and R. Kotz Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair Eur J Radiol 57 2006 3 8
28. A. Gobbi, E. Kon, M. Berruto, R. Francisco, G. Filardo, and M. Marcacci Patellofemoral full-thickness chondral defects treated with Hyalograft-C: A clinical, arthroscopic, and histologic review Am J Sports Med 34 2006 1763 1773
29. A. Gobbi, E. Kon, M. Berruto, G. Filardo, M. Delcogliano, and L. Boldrini Patellofemoral full-thickness chondral defects treated with second-generation autologous chondrocyte implantation: Results at 5 years' follow-up Am J Sports Med 37 2009 1083 1092
30. M. Marcacci, E. Kon, S. Zaffagnini, G. Filardo, M. Delcogliano, and M.P. Neri Arthroscopic second generation autologous chondrocyte implantation Knee Surg Sports Traumatol Arthrosc 15 2007 610 619
31. S. Nehrer, R. Dorotka, S. Domayer, D. Stelzeneder, and R. Kotz Treatment of full-thickness chondral defects with hyalograft C in the knee: A prospective clinical case series with 2 to 7 years' follow-up Am J Sports Med 37 Suppl 1 2009 81S 87S
32. A. Ferruzzi, R. Buda, C. Faldini, F. Vannini, F. Di Caprio, and D. Luciani Autologous chondrocyte implantation in the knee joint: Open compared with arthroscopic technique. Comparison at a minimum follow-up of five years J Bone Joint Surg Am 90 Suppl 4 2008 90 101
33. E. Kon, A. Di Martino, G. Filardo, C. Tetta, M. Busacca, and F. Iacono Second-generation autologous chondrocyte transplantation: MRI findings and clinical correlations at a minimum 5-year follow-up Eur J Radiol 79 2011 382 388
34. E. Kon, G. Filardo, M. Berruto, F. Benazzo, G. Zanon, and S. Della Villa Articular cartilage treatment in high-level male soccer players: A prospective comparative study of arthroscopic second-generation autologous chondrocyte implantation versus microfracture Am J Sports Med 39 2011 2549 2557
35. H. Clar, A. Pascher, N. Kastner, G. Gruber, T. Robl, and R. Windhager Matrix-assisted autologous chondrocyte implantation into a 14 cm cartilage defect, caused by steroid-induced osteonecrosis Knee 17 2010 255 257
36. E. Kon, G. Filardo, V. Condello, M. Collarile, A. Di Martino, and C. Zorzi Second-generation autologous chondrocyte implantation: Results in patients older than 40 years Am J Sports Med 39 2011 1668 1675
37. G. Filardo, E. Kon, M. Berruto, A. Di Martino, S. Patella, and G.M. Marcheggiani Muccioli Arthroscopic second generation autologous chondrocytes implantation associated with bone grafting for the treatment of knee osteochondritis dissecans: Results at 6 years Knee 2011 Nov 22 [Epub ahead of print] http://dx.doi.org/10.1016/j.knee.2011.08.007
38. G. Filardo, E. Kon, A. Di Martino, S. Patella, G. Altadonna, and F. Balboni Second-generation arthroscopic autologous chondrocyte implantation for the treatment of degenerative cartilage lesions Knee Surg Sports Traumatol Arthrosc 2011 Nov 1 [Epub ahead of print] http://dx.doi.org/10.1007/s00167-011- 1732-5
39. G. Filardo, E. Kon, A. Di Martino, F. Iacono, and M. Marcacci Arthroscopic second-generation autologous chondrocyte implantation: A prospective 7-year follow-up study Am J Sports Med 39 2011 2153 2160
40. C. Ossendorf, C. Kaps, P.C. Kreuz, G.R. Burmester, M. Sittinger, and C. Erggelet Treatment of post-traumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-Year clinical results Arthritis Res Ther 9 2007 R41
41. P.C. Kreuz, S. Muller, C. Ossendorf, C. Kaps, and C. Erggelet Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: Four year clinical results Arthritis Res Ther 11 2009 R33
42. P.C. Kreuz, S. Müller, U. Freymann, C. Erggelet, P. Niemeyer, and C. Kaps Repair of focal cartilage defects with scaffold-assisted autologous chondrocyte grafts: Clinical and biomechanical results 48 months after transplantation Am J Sports Med 39 2011 1697 1705
43. C. Erggelet, P.C. Kreuz, E.H. Mrosek, J.C. Schagemann, A. Lahm, and P.P. Ducommun Autologous chondrocyte implantation versus ACI using 3D-bioresorbable graft for the treatment of large full-thickness cartilage lesions of the knee Arch Orthop Trauma Surg 130 2010 957 964
44. F. Zeifang, D. Oberle, C. Nierhoff, W. Richter, B. Moradi, and H. Schmitt Autologous chondrocyte implantation using the original periosteum-cover technique versus matrix-associated autologous chondrocyte implantation: A randomized clinical trial Am J Sports Med 38 2010 924 933
45. D.C. Crawford, C.M. Heveran, W.D. Cannon Jr., L.F. Foo, and H.G. Potter An autologous cartilage tissue implant NeoCart for treatment of grade III chondral injury to the distal femur: Prospective clinical safety trial at 2 years Am J Sports Med 37 2009 1334 1343
46. A. Panagopoulos, L. van Niekerk, and I. Triantafillopoulos Autologous chondrocyte implantation for knee cartilage injuries: Moderate functional outcome and performance in patients with high-impact activities Orthopedics 35 2012 e6 e14
47. G.H. Welsch, T.C. Mamisch, L. Zak, M. Blanke, A. Olk, and S. Marlovits Evaluation of cartilage repair tissue after matrix-associated autologous chondrocyte transplantation using a hyaluronic-based or a collagen-based scaffold with morphological MOCART scoring and biochemical T2 mapping: Preliminary results Am J Sports Med 38 2010 934 942
48. B. Wondrasch, L. Zak, G.H. Welsch, and S. Marlovits Effect of accelerated weightbearing after matrix-associated autologous chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after 2 years: A prospective, randomized controlled pilot study Am J Sports Med 37 Suppl 1 2009 88S 96S
49. U. Schneider, L. Rackwitz, S. Andereya, S. Siebenlist, F. Fensky, and J. Reichert A prospective multicenter study on the outcome of type I collagen hydrogel-based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee Am J Sports Med 39 2011 2558 2565
50. T.A. Selmi, P. Verdonk, P. Chambat, F. Dubrana, J.F. Potel, and L. Barnouin Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: Outcome at two years J Bone Joint Surg Br 90 2008 597 604
51. N. Adachi, M. Ochi, M. Deie, M. Ishikawa, and Y. Ito Osteonecrosis of the knee treated with a tissue-engineered cartilage and bone implant. A case report J Bone Joint Surg Am 89 2007 2752 2757
52. H. Tohyama, K. Yasuda, A. Minami, T. Majima, N. Iwasaki, and T. Muneta Atelocollagen-associated autologous chondrocyte implantation for the repair of chondral defects of the knee: A prospective multicenter clinical trial in Japan J Orthop Sci 14 2009 579 588
53. N.Y. Choi, B.W. Kim, W.J. Yeo, H.B. Kim, D.S. Suh, and J.S. Kim Gel-type autologous chondrocyte (Chondron) implantation for treatment of articular cartilage defects of the knee BMC Musculoskelet Disord 11 2010 103
54. M.K. Kim, S.W. Choi, S.R. Kim, I.S. Oh, and M.H. Won Autologous chondrocyte implantation in the knee using fibrin Knee Surg Sports Traumatol Arthrosc 18 2010 528 534
55. A. Gobbi, and L. Bathan Biological approaches for cartilage repair J Knee Surg 22 2009 36 44
56. A. Gobbi, G. Karnatzikos, C. Scotti, V. Mahajan, L. Mazzucco, and B. Grigolo One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full-thickness knee cartilage lesions: Results at 2-year follow-up Cartilage 2 2011 286
57. B.J. Cole, J. Farr, C.S. Winalski, T. Hosea, J. Richmond, and B. Mandelbaum Outcomes after a single-stage procedure for cell-based cartilage repair: A prospective clinical safety trial with 2-year follow-up Am J Sports Med 39 2011 1170 1179
58. R. Buda, F. Vannini, M. Cavallo, B. Grigolo, A. Cenacchi, and S. Giannini Osteochondral lesions of the knee: A new one-step repair technique with bone-marrow-derived cells J Bone Joint Surg Am 92 Suppl 2 2010 2 11
59. K.F. Almqvist, A.A. Dhollander, P.C. Verdonk, R. Forsyth, R. Verdonk, and G. Verbruggen Treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes Am J Sports Med 37 2009 1920 1929
60. J. Gille, E. Schuseil, J. Wimmer, J. Gellissen, A.P. Schulz, and P. Behrens Mid-term results of autologous matrix-induced chondrogenesis for treatment of focal cartilage defects in the knee Knee Surg Sports Traumatol Arthrosc 18 2010 1456 1464
61. J.M. Patrascu, U. Freymann, C. Kaps, and D.V. Poenaru Repair of a post-traumatic cartilage defect with a cell-free polymer-based cartilage implant: A follow-up at two years by MRI and histological review J Bone Joint Surg Br 92 2010 1160 1163
62. A. Pascarella, R. Ciatti, F. Pascarella, C. Latte, M.G. Di Salvatore, and L. Liguori Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique Knee Surg Sports Traumatol Arthrosc 18 2010 509 513
63. A.A. Dhollander, F. De Neve, and K.F. Almqvist Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: Technical description and a five pilot patients report Knee Surg Sports Traumatol Arthrosc 19 2011 536 542
64. A. Schiavone Panni, S. Cerciello, and M. Vasso The management of knee cartilage defects with modified AMIC technique: Preliminary results Int J Immunopathol Pharmacol 24 Suppl 2 2011 149 152
65. T. Kusano, R.P. Jakob, E. Gautier, R.A. Magnussen, H. Hoogewoud, and M. Jacobi Treatment of isolated chondral and osteochondral defects in the knee by autologous matrix-induced chondrogenesis (AMIC) Knee Surg Sports Traumatol Arthrosc 2011 Dec 25 [Epub ahead of print] http://dx.doi.org/10.1007/s00167-011- 1840-2
66. M.R. Carmont, R. Carey-Smith, A. Saithna, M. Dhillon, P. Thompson, and T. Spalding Delayed incorporation of a TruFit plug: perseverance is recommended Arthroscopy 25 2009 810 814
67. E. Kon, M. Delcogliano, G. Filardo, M. Fini, G. Giavaresi, and S. Francioli Orderly osteochondral regeneration in a sheep model using a novel nano-composite multilayered biomaterial J Orthop Res 28 2010 116 124
68. E. Kon, M. Delcogliano, G. Filardo, D. Pressato, M. Busacca, and B. Grigolo A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: Technique note and an early stability pilot clinical trial Injury 41 2010 693 701
69. B. Sharma, and J.H. Elisseeff Engineering structurally organized cartilage and bone tissues Ann Biomed Eng 32 2004 148 159
70. D.B. Saris, J. Vanlauwe, and J. Victor Treatment of symptomatic cartilage defects of the knee: Characterized chondrocyte implantation results in better clin-ical outcome at 36 months in a randomized trial compared with microfracture Am J Sports Med 37 2009 10S 19S