Treatment of Full-Thickness Chondral Defects with Hyalograft C in the Knee: A Prospective Clinical Case Series with 2 to 7 Years' Follow-up

American Journal of Sports Medicine

Volumn 37, Issue 1_suppl, 2009, Pages 81S-87S

  Nehrer, Stefan ^a,b   Dorotka, Ronald ^b,c   Domayer, Stephan ^b   Stelzeneder, David ^b   Kotz, Rainer ^b  

^a DANUBE UNIVERSITY KREMS   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Orthopaedic City Center Vienna   (Austria)

Author keywords

autologous chondrocyte implantation (ACI); cartilage repair; matrix assisted; scaffold

Indexed keywords

HYALURONIC ACID; TISSUE SCAFFOLD;

ADULT; ARTICLE; ARTICULAR CARTILAGE; AUSTRIA; AUTOTRANSPLANTATION; CARTILAGE CELL; FEMALE; FOLLOW UP; HUMAN; INJURY; KNEE; KNEE INJURY; MALE; METHODOLOGY; ORTHOPEDIC SURGERY; OUTCOME ASSESSMENT; PROSPECTIVE STUDY; TRANSPLANTATION;

ADULT; AUSTRIA; CARTILAGE, ARTICULAR; CHONDROCYTES; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYALURONIC ACID; KNEE INJURIES; KNEE JOINT; MALE; ORTHOPEDIC PROCEDURES; OUTCOME ASSESSMENT (HEALTH CARE); PROSPECTIVE STUDIES; TISSUE SCAFFOLDS; TRANSPLANTATION, AUTOLOGOUS; YOUNG ADULT;

EID: 77949905450     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546509350704     Document Type: Article

References (41)

1. Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI)-5-year follow-up. Knee. 2006;13(3):194-202.
2. Benedetti L, Cortivo R, Berti T, et al. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats. Biomaterials. 1993;14(15):1154-1160.
3. Briggs KK, Kocher MS, Rodkey WG, Steadman JR. Reliability, validity, and responsiveness of the Lysholm knee score and Tegner activity scale for patients with meniscal injury of the knee. J Bone Joint Surg Am. 2006;88(4):698-705.
4. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994;331(14):889-895.
5. Buckwalter JA, Mankin HJ. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect. 1998;47:487-504.
6. Campoccia D, Doherty P, RadiceM, Brun P, AbatangeloG, WilliamsDF. Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials. 1998;19(23):2101-2127.
7. Chu CR, Coutts RD, Yoshioka M, Harwood FL, Monosov AZ, Amiel D. Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): A tissue-engineering study. J Biomed Mater Res. 1995;29(9):1147-1154.
8. Domayer SE, Welsch GH, Dorotka R, et al. MRI monitoring of cartilage repair in the knee: A review. Semin Musculoskelet Radiol. 2008;12(4):302-317.
9. Dorotka R, Bindreiter U, Macfelda K, Windberger U, Nehrer S. Marrow stimulation and chondrocyte transplantation using a collagen matrix for cartilage repair. Osteoarthritis Cartilage. 2005;13(8):655-664.
10. Dorotka R, Windberger U, Macfelda K, Bindreiter U, Toma C, Nehrer S. Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix. Biomaterials. 2005;26(17): 3617-3629.
11. Girotto D, Urbani S, Brun P, Renier D, Barbucci R, Abatangelo G. Tissue-specific gene expression in chondrocytes grown on threedimensional hyaluronic acid scaffolds. Biomaterials. 2003;24(19): 3265-3275.
12. Gobbi A, Kon E, Berruto M, Francisco R, Filardo G, Marcacci M. Patellofemoral full-thickness chondral defects treated with Hyalograft-C: A clinical, arthroscopic, and histologic review. Am J Sports Med. 2006;34(11):1763-1773.
13. Grigolo B, Lisignoli G, Piacentini A, et al. Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAff 11): molecular, immunohistochemical and ultrastructural analysis. Biomaterials. 2002;23(4):1187-1195.
14. Grigolo B, Roseti L, Fiorini M, et al. Transplantation of chondrocytes seeded on a hyaluronan derivative (hyaff-11) into cartilage defects in rabbits. Biomaterials. 2001;22(17):2417-2424.
15. Hefti F, Muller W, Jakob RP, Staubli HU. Evaluation of knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc. 1993;1(3-4):226-234.
16. Henderson I, Lavigne P, Valenzuela H, Oakes B. Autologous chondrocyte implantation: superior biologic properties of hyaline cartilage repairs. Clin Orthop Relat Res. 2007;455:253-261.
17. Higgins LD, Taylor MK, Park D, et al. Reliability and validity of the International Knee Documentation Committee (IKDC) Subjective Knee Form. Joint Bone Spine. 2007;74(6):594-599.
18. Hunziker EB. Articular cartilage repair: basic science and clinical progress: A review of the current status and prospects. Osteoarthritis Cartilage. 2002;10(6):432-463.
19. Jones DG, Peterson L. Autologous chondrocyte implantation. J Bone Joint Surg Am. 2006;88(11):2502-2520.
20. Knutsen G, Drogset JO, Engebretsen L, et al. A randomized trial comparing autologous chondrocyte implantation with microfracture: findings at five years. J Bone Joint Surg Am. 2007;89(10):2105-2112.
21. Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee: A randomized trial. J Bone Joint Surg Am. 2004;86(3):455-464.
22. Kocher MS, Steadman JR, Briggs KK, Sterett WI, Hawkins RJ. Reliability, validity, and responsiveness of the Lysholm knee scale for various chondral disorders of the knee. J Bone Joint Surg Am. 2004;86(6):1139-1145.
23. Kon E, Gobbi A, Filardo G, Delcogliano M, Zaffagnini S, Marcacci M. Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years. Am J Sports Med. 2009;37(1):33-41.
24. Kreuz PC, Steinwachs MR, Erggelet C, et al. Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthritis Cartilage. 2006;14(11):1119-1125.
25. Lysholm J, Gillquist J. Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale. Am J Sports Med. 1982;10(3):150-154.
26. Manfredini M, Zerbinati F, Gildone A, Faccini R. Autologous chondrocyte implantation: A comparison between an open periostealcovered and an arthroscopic matrix-guided technique. Acta Orthop Belg. 2007;73(2):207-218.
27. Marcacci M, Berruto M, Brocchetta D, et al. Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res. 2005;435:96-105.
28. Marcacci M, Zaffagnini S, Kon E, Visani A, Iacono F, Loreti I. Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc. 2002;10(3):154-159.
29. Micheli LJ, Browne JE, Erggelet C, et al. Autologous chondrocyte implantation of the knee: multicenter experience and minimum 3-year follow-up. Clin J Sport Med. 2001;11(4):223-228.
30. Minas T, Gomoll AH, Rosenberger R, Royce RO, Bryant T. Increased failure rate of autologous chondrocyte implantation after previous treatment with marrow stimulation techniques. Am J Sports Med. 2009;37(5):902-908.
31. Nehrer S, Breinan HA, Ramappa A, et al. Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model. Biomaterials. 1998;19(24):2313-2328.
32. Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R. Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol. 2006;57(1):3-8.
33. Nehrer S, Minas T. Treatment of articular cartilage defects. Invest Radiol. 2000;35(10):639-646.
34. Nehrer S, Spector M, Minas T. Histologic analysis of tissue after failed cartilage repair procedures. Clin Orthop Relat Res. 1999;365: 149-162.
35. Pavesio A, Abatangelo G, Borrione A, et al. Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. Novartis Found Symp. 2003;249:203-217; discussion 229-233, 234-208, 239-241.
36. Pinker K, Szomolanyi P, Welsch GC, et al. Longitudinal evaluation of cartilage composition of matrix-associated autologous chondrocyte transplants with 3-T delayed gadolinium-enhanced MRI of cartilage. AJR Am J Roentgenol. 2008;191(5):1391-1396.
37. Roos E. Rigorous statistical reliability, validity, and responsiveness testing of the Cincinnati Knee Rating System in 350 subjects with uninjured, injured, or anterior cruciate ligament-reconstructed knee. Am J Sports Med. 2000;28(3):436-438.
38. Steinwachs M, Kreuz PC. Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: A prospective study with a 3-year follow-up. Arthroscopy. 2007; 23(4):381-387.
39. Trattnig S, Mamisch TC, Pinker K, et al. Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 Tesla. Eur Radiol. 2008;18(6):1251-1259.
40. Trattnig S, Marlovits S, Gebetsroither S, et al. Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3. 0T: preliminary results. J Magn Reson Imaging. 2007;26(4):974-982.
41. Welsch GH, Mamisch TC, Domayer S, Dorotka R, Kutsch-Lissberg F, Marlovits S, White L, Trattnig S. Cartilage T2 assessment at 3 Tesla: in vivo differentiation of normal hyaline cartilage and reparative tissue in patients after two different cartilage repair procedures-initial experiences. Radiology. 2008;247:154-161.