Matrix-Assisted Autologous Chondrocyte Transplantation for the Repair of Cartilage Defects of the Knee: Systematic Clinical Data Review and Study Quality Analysis

American Journal of Sports Medicine

Volumn 37, Issue 1_suppl, 2009, Pages 156S-166S

  Kon, Elizaveta ^a   Verdonk, Peter ^b,c   Condello, Vincenzo ^d   Delcogliano, Marco ^a   Dhollander, Aad ^b   Filardo, Giuseppe ^a   Pignotti, Elettra ^a   Marcacci, Maurilio ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Stedelijk Ziekenhuis Roeselare   (Belgium)

^d SACRO CUORE DON CALABRIA HOSPITAL   (Italy)

Author keywords

arthroscopy; cartilage lesion; knee; second generation autologous chondrocyte implantation; systematic review

Indexed keywords

AUTOTRANSPLANTATION; CARTILAGE; CARTILAGE CELL; EXTRACELLULAR MATRIX; HUMAN; KNEE; METHODOLOGY; PATHOLOGY; REVIEW; TISSUE ENGINEERING; TRANSPLANTATION;

CARTILAGE; CHONDROCYTES; EXTRACELLULAR MATRIX; HUMANS; KNEE JOINT; TISSUE ENGINEERING; TRANSPLANTATION, AUTOLOGOUS;

EID: 77949882110     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546509351649     Document Type: Review

References (59)

1. Adachi N, Ochi M, Deie M, Ishikawa M, Ito Y. Osteonecrosis of the knee treated with a tissue-engineered cartilage and bone implant: A case report. J Bone Joint Surg Am. 2007;89:2752-2757.
2. Adachi N, Ochi M, Deie M, Ito Y, Izuta Y. Lateral compartment osteoarthritis of the knee after mensiscectomy treated by the transplantation of tissue-engineered cartilage and osteochondral plug. Arthroscopy. 2006;22(1):107-112.
3. Andereya S, Maus U, Gavenis K, et al. First clinical experiences with a novel 3D-collagen gel (CaRes) for the treatment of focal cartilage defects in the knee. Z Orthop Ihre Grenzgeb. 2006;144(3): 272-280.
4. Andereya S, Maus U, Gavenis K, et al. Treatment of patellofemoral cartilage defects utilizing a 3D collagen gel: two-year clinical results. Z Orthop Unfall. 2007;145(2):139-145.
5. Bachmann G, Basad E, Lommel D, Steinmeyer J. MRI in the follow up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture. Radiologe. 2004;44(8):773-782.
6. Bartlett W, Gooding CR, Carrington RW, Skinner JA, Briggs TW, Bentley G. Autologous chondrocyte implantation at the knee using a bilayer collagen membrane with bone graft: A preliminary report. J Bone Joint Surg Br. 2005;87:330-332.
7. Bartlett W, Skinner JA, Gooding CR, et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee. J Bone Joint Surg Br. 2005;87:640-645.
8. Behrens P, Bitter T, Kurz B, Russlies M. Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI): 5-year follow-up. Knee. 2006;13(3):194-202.
9. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1(8476): 307-310.
10. Browne JE, Anderson AF, Arciero R, et al. Clinical outcome of autologous chondrocyte implantation at 5 years in US subjects. Clin Orthop Relat Res. 2005;436:237-245.
11. Campoccia D, Doherty P, Radice M, Brum P, Abatangelo G, Williams DF. Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials. 1998;19:2101-2127.
12. Caterson EJ, Nesti LJ, Li WJ, et al. Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/alginate amalgam. J Biomed Mater Res. 2001;57(3):394-403.
13. Cherubino P, Grassi FA, Bulgheroni P, Ronga M. Autologous chondrocyte implantation using a bilayer collagen membrane: A preliminary report. J Orthop Surg. 2003;11(1):10-15.
14. Coleman BD, Khan KM, Maffulli N, Cook JL, Wark JD. Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies. Scand J Med Sci Sports. 2000;10(1):2-11.
15. Domayer SE, Nehrer S, Dorotka R, et al. Matrix associated autologous chondrocyte implantation with Hyalograft C in the knee: results at five years. Osteoarthritis Cartilage. 2007;15(suppl C):135-136.
16. Erggelet C, Sittinger M, Lahm A. The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint. Arthroscopy. 2003;19(1):108-110.
17. Farr J. Autologous chondrocyte implantation improves patellofemoral cartilage treatment outcomes. Clin Orthop Relat Res. 2007; 463:187-194.
18. Ferruzzi A, Buda R, Faldini C, et al. Autologous chondrocyte implantation in the knee joint: open compared with arthroscopic technique. Comparison at a minimum follow-up of five years. J Bone Joint Surg Am. 2008;90(suppl 4):90-101.
19. Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res. 1993;27(1): 11-23.
20. Gobbi A, Kon E, Berruto M, Francisco R, Filardo G, Marcacci M. Patellofemoral full-thickness chondral defects treated with Hyalograft-C: A clinical, arthroscopic, and histologic review. Am J Sports Med. 2006;34(11):1763-1773.
21. Grigolo B, Lisignoli G, Piacentini A, et al. Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAff 11): molecular, immunohistochemical and ultrastructural analysis. Biomaterials. 2002;23(4):1187-1195.
22. Hanna SA, Aston WJ, Gikas PD, Briggs TW. Bicondylar osteochondritis dissecans in the knee: A report of two cases. J Bone Joint Surg Br. 2008;90(2):232-235.
23. Hollander AP, Dickinson SC, Sims TJ, et al. Maturation of tissue engineered cartilage implanted in injured and osteoarthritic human knees. Tissue Eng. 2006;12(7):1787-1798.
24. Jakobsen RB, Engebretsen L, Slauterbeck JR. An analysis of the quality of cartilage repair studies. J Bone Joint Surg Am. 2005;87(10): 2232-2239.
25. Kon E, Gobbi A, Filardo G, Delcogliano M, Zaffagnini S, Marcacci M. Arthroscopic second generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years. Am J Sports Med. 2009;37(1):33-41.
26. Manfredini M, Zerbinati F, Gildone A, Faccini R. Autologous chondrocyte implantation: A comparison between an open periostealcovered and an arthroscopic matrix-guided technique. Acta Orthop Belg. 2007;73(2):207-218.
27. Marcacci M, Berruto M, Brocchetta D, et al. Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res. 2005;435:96-105.
28. Marcacci M, Kon E, Grigolo B, et al. The clinician view. Osteoarthritis Cartilage. 2007;15(suppl B):11-13.
29. Marcacci M, Kon E, Zaffagnini S, et al. Arthroscopic second generation autologous chondrocyte implantation. Knee Surg Sports Traumatol Arthrosc. 2007;15(5):610-619.
30. Marcacci M, Kon E, Zaffagnini S, Vascellari A, Neri MP, Iacono F. New cell-based technologies in bone and cartilage tissue engineering. Chir Organi Mov. 2003;88:33-42.
31. Marcacci M, Zaffagnini S, Kon E, Visani A, Iacono F, Loreti I. Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc. 2002;10(3):154-159.
32. Marlovits S, Striessnig G, Kutscha-Lissberg F, et al. Early postoperative adherence of matrix-induced autologous chondrocyte implantation for the treatment of full-thickness cartilage defects of the femoral condyle. Knee Surg Sports Traumatol Arthrosc. 2005;13:451-457.
33. Marlovits S, Zeller P, Zimmermann V, et al. Postoperative adherence of matrix associated autologous chondrocyte transplantation of a three-dimensional collagen gel (CaRes). Osteoarthritis Cartilage. 2007;15(suppl B):105.
34. Maus U, Schneider U, Gravius S, et al. Clinical results after three years use of matrix-associated ACT for the treatment of osteochondral defects of the knee. Z Orthop Unfall. 2008;146(1):31-37.
35. Micheli LJ, Browne JE, Erggelet C, et al. Autologous chondrocyte implantation of the knee: multicenter experience and minimum 3-year follow-up. Clin J Sport Med. 2001;11(4):223-228.
36. Nehrer S, Chiari C, Domayer S, Barkay H, Yayon A. Results of chondrocyte implantation with a fibrin-hyaluronan matrix: A preliminary study. Clin Orthop Relat Res. 2008;466(8):1849-1855.
37. Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R. Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol. 2006;57:3-8.
38. Ochi M, Uchio Y, Kawasaki K, Wakitani S, Iwasa J. Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee. J Bone Joint Surg Br. 2002;84 (4):571-578.
39. Ochs BG, Muller-Hovart C, Rolauffs B, Fritz J, Weise K, Schewe B. Treatment of osteochondritis dissecans of the knee: one-step procedure with bone grafting and matrix-supported autologous chondrocyte transplantation. Z Orthop Unfall. 2007;145(2):146-151.
40. Ossendorf C, Kaps C, Kreuz P, Burmester GR, Sittinger M, Erggelet C. Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autologous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther. 2007;9(2):R41.
41. Pavesio A, Abatangelo G, Borrione A, et al. Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings. Novartis Found Symp. 2003;249:203-217.
42. Peterson L, Brittberg M, Kiviranta I, Akerlund EL, Lindahl A. Autologous chondrocyte transplantation: biomechanics and long-term durability. Am J Sports Med. 2002;30(1):2-12.
43. Podskubka A, PovysilC, Kubes R, Sprindrich J, Sedlacek R. Treatment of deep cartilage defects of the knee with autologous chondrocyte transplantation on a hyaluronic acid ester scaffolds (Hyalograft C). Acta Chir Orthop Traumatol Cech. 2006;73(4):251-263.
44. Richard N. Mac Lennan intrarrater reliability with SPSS 5. 0. Am Stat. 1993;47(4):292-296.
45. Ronga M, Grassi FA, Bulgheroni P. Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee. Arthroscopy. 2004;20(1):79-84.
46. Ronga M, Grassi FA, Manelli A, Bulgheroni P. Tissue engineering techniques for the treatment of a complex knee injury. Arthroscopy. 2006;22(5):576e1-576e3.
47. Selmi TA, Verdonk P, Chambat P, et al. Autologous chondrocyte implantation in a novel alginate-agarose hydrogel: outcome at two years. J Bone Joint Surg Br. 2008;90(5):597-604.
48. Solchaga LA, Dennis JE, Goldberg VM, Caplan AI. Hyaluronic acidbased polymers as cell carriers for tissue-engineered repair of bone and cartilage. J Orthop Res. 1999;17:205-213.
49. Solchaga LA, Yoo JU, Lundberg M, et al. Hyaluronic acid-based polymers in the treatment of osteochondral defects. J Orthop Res. 2000;18:773-780.
50. Tratting S, Ba-Ssalamah A, Pinker K, Plank C, Vecsei V, Marlovits S. Matrix-based autologous chondrocyte implantation for cartilage repair: noninvasive monitoring by high-resolution magnetic resonance imaging. Magn Reson Imaging. 2005;23:779-787.
51. Tratting S, Mamisch TC, Pinker K, et al. Differentiating normal hyaline cartilage from post-surgical repair tissue using fast gradient echo imaging in delayed gadolinium-enhanced MRI (dGEMRIC) at 3 tesla [published online ahead of print February 2008]. Eur Radiol. 2008;2.
52. Tratting S, Mamisch TC, Welsch GH, et al. Quantitative T2 mapping of matrix-associated autologous chondrocyte transplantation at 3 tesla: An in vivo cross-sectional study. Invest Radiol. 2007;42(6):442-448.
53. Tratting S, Pinker K, Krestan C, et al. Matrix-based autologous chondrocyte implantation for cartilage repair with Hyalograft C: two-year follow-up by magnetic resonance imaging. Eur J Radiol. 2006;57:9-15.
54. Valis P, Chaloupka R, Krbec M, Repko M, Adler J, Nydrle M. Treatment of patellar cartilage defects by solid chondral graft: first experience. Acta Chir Orthop Traumatol Cech. 2004;71(6):339-344.
55. Van Susante JL, Buma P, van Osch GJ, et al. Culture of chondrocytes in alginate and collagen carrier gels. Acta Orthop Scand. 1995;66(6):549-556.
56. Visna P, Pasa L, Cizmar I, Hart R, Hoch J. Treatment of deep cartilage defects of the knee using autologous chondrograft transplantation and by abrasive techniques: A randomized controlled study. Acta Chir Belg. 2004;104(6):709-714.
57. Visna P, Pasa L, Hart R, Kocis J, Cizmar I, Adler J. Treatment of deep chondral defects of the knee using autologous chondrocytes cultured on a support: results after one year. Acta Chir Orthop Traumatol Cech. 2003;70(6):356-362.
58. Von der Mark K, Gauss V, Von der mark H, Muller P. Relationship between cell shape and type of collagen synthesized as chondrocytes lose their cartilage phenotype in culture. Nature. 1977;267: 531-532.
59. Zheng MH, Willers C, Wood D. Matrix-induced autologous chondrocytes implantation (MACI): biological and clinical evaluation. In: Zanasi S, Brittberg M, Maracci M, eds. Basic science, clinical repair and reconstruction of articular cartilage defects: Current status and prospects. Brooklandville, MD: Data Trace Publishing Co; 2006: 517-528.