Detection of Aspergillus fumigatus pulmonary fungal infections in mice with 99mTc-labeled MORF oligomers targeting ribosomal RNA

Nuclear Medicine and Biology

Volumn 40, Issue 1, 2013, Pages 89-96

  Wang, Yuzhen ^a   Chen, Ling ^a   Liu, Xinrong ^a   Cheng, Dengfeng ^b   Liu, Guozheng ^a   Liu, Yuxia ^a   Dou, Shuping ^a   Hnatowich, Donald J ^a   Rusckowski, Mary ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b FUDAN UNIVERSITY   (China)

Author keywords

A. fumigatus; Invasive aspergillosis; Phosphorodiamidate morpholino (MORF); RRNA targeted probe; SPECT

Indexed keywords

MORPHOLINO OLIGONUCLEOTIDE; OLIGOMER; RNA 28S; TECHNETIUM 99M;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CONIDIUM; CONTROLLED STUDY; DOT HYBRIDIZATION; DRUG ACCUMULATION; DRUG DISTRIBUTION; FLUORESCENCE IN SITU HYBRIDIZATION; FUNGAL DETECTION; ISOTOPE LABELING; LUNG ASPERGILLOSIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE PROBE; RADIOISOTOPE DISTRIBUTION; SEQUENCE ANALYSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION;

ANIMALS; ASPERGILLUS FUMIGATUS; BASE SEQUENCE; LUNG; LUNG DISEASES, FUNGAL; MALE; MICE; MICE, INBRED BALB C; MORPHOLINOS; OLIGONUCLEOTIDE PROBES; ORGANOTECHNETIUM COMPOUNDS; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; RNA, FUNGAL; RNA, RIBOSOMAL, 28S; SPECIES SPECIFICITY; SPORES, FUNGAL;

EID: 84871923645     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2012.10.001     Document Type: Article

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