Quantifying proximal and distal sources of NO in asthma using a multicompartment model

Journal of Applied Physiology

Volumn 108, Issue 4, 2010, Pages 821-829

  Shelley, David A ^a   Puckett, James L ^a   George, Steven C ^a  

^a University of California at Irvine   (United States)

Author keywords

Heterogeneity; Nitric oxide; Phase III slope; Sensitivity

Indexed keywords

NITRIC OXIDE;

ADOLESCENT; ARTICLE; ASTHMA; AUDIOVISUAL EQUIPMENT; BIOLOGICAL MODEL; BREATH ANALYSIS; BREATHING MECHANICS; BRONCHOSPASM; CHILD; DIFFUSION; FEMALE; HUMAN; LUNG; LUNG GAS EXCHANGE; LUNG VENTILATION; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADOLESCENT; ASTHMA; BREATH TESTS; BRONCHOCONSTRICTION; CHILD; DIFFUSION; FEMALE; HUMANS; LUNG; MALE; MODELS, ANATOMIC; MODELS, BIOLOGICAL; NITRIC OXIDE; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; RESPIRATORY MECHANICS;

EID: 77950560393     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00795.2009     Document Type: Article

References (49)

1. American Thoracic Society/European Respiratory Society. Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med 171: 912-930, 2005.
2. American Thoracic Society. Lung function testing: selection of reference values, and interpretative strategies. Am Rev Respir Dis 144: 1202-1218, 1991.
3. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 6: 1368-1370, 1993. (Pubitemid 23329557)
4. Aris R. Elementary Chemical Reactor Analysis. Boston: Butterworths, 1989, p. xii, 352.
5. Bates JH, Rossi A, Milic-Emili J. Analysis of the behavior of the respiratory system with constant inspiratory flow. J Appl Physiol 58: 1840-1848, 1985.
6. Beck JV, Arnold KJ. Parameter Estimation in Engineering and Science. New York: Wiley, 1977, p. xix, 501.
7. Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, Silkoff PE, Bisgaard H. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 115: 1130-1136, 2005. (Pubitemid 40824579)
8. Bui TD, Dabdub D, George SC. Modeling bronchial circulation with application to soluble gas exchange: description and sensitivity analysis. J Appl Physiol 84: 2070-2088, 1998. (Pubitemid 28255970)
9. Condorelli P, George SC. In vivo control of soluble guanylate cyclase activation by nitric oxide: a kinetic analysis. Biophys J 80: 2110-2119, 2001. (Pubitemid 32401977)
10. Condorelli P, Shin HW, Aledia AS, Silkoff PE, George SC. A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model. J Appl Physiol 102: 417-425, 2007. (Pubitemid 46089793)
11. Condorelli P, Shin HW, George SC. Characterizing airway and alveolar nitric oxide exchange during tidal breathing using a three-compartment model. J Appl Physiol 96: 1832-1842, 2004.
12. Geigel EJ, Hyde RW, Perillo IB, Torres A, Perkins PT, Pietropaoli AP, Frasier LM, Frampton MW, Utell MJ. Rate of nitric oxide production by lower alveolar airways of human lungs. J Appl Physiol 86: 211-221, 1999. (Pubitemid 29046960)
13. Gelb AF, Taylor CF, Nussbaum E, Gutierrez C, Schein A, Shinar CM, Schein MJ, Epstein JD, Zamel N. Alveolar and airway sites of nitric oxide inflammation in treated asthma. Am J Respir Crit Care Med 170: 737-741, 2004. (Pubitemid 39298987)
14. Harris RS, Winkler T, Tgavalekos N, Musch G, Melo MF, Schroeder T, Chang Y, Venegas JG. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med 174: 245-253, 2006. (Pubitemid 44156602)
15. Kerckx Y, Michils A, Van Muylem A. Airway contribution to alveolar nitric oxide in healthy subjects and stable asthma patients. J Appl, Physiol 104: 918-924, 2008. (Pubitemid 351507926)
16. Kerr AA. Dead space ventilation in normal children and children with obstructive airways disease. Thorax 31: 63-69, 1976.
17. Kharitonov SA, Yates DH, Chung KF, Barnes PJ. Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur Respir J 9: 196-201, 1996. (Pubitemid 26068611)
18. Lehtimaki L, Kankaanranta H, Saarelainen S, Turjanmaa V, Moilanen E. Increased alveolar nitric oxide concentration in asthmatic patients with nocturnal symptoms. Eur Respir J 20: 841-845, 2002. (Pubitemid 35175118)
19. Lehtimaki L, Kankaanranta H, Saarelainen S, Turjanmaa V, Moilanen E. Peripheral inflammation in patients with asthmatic symptoms but normal lung function. J Asthma 42: 605-609, 2005. (Pubitemid 41765314)
20. Liu AH, Zeiger R, Sorkness C, Mahr T, Ostrom N, Burgess S, Rosenzweig JC, Manjunath R. Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol 119: 817-825, 2007. (Pubitemid 46527825)
21. Mattes J, Storm van's Gravesande K, Reining U, Alving K, Ihorst G, Henschen M, Kuehr J. NO in exhaled air is con-elated with markers of eosinophilic airway inflammation in corticosteroid-dependent childhood asthma. Eur Respir J 13: 1391-1395, 1999.
22. McKay MD, Beckman RJ, Conover WJ. A comparison of three methods for selecting values of input variables in the analysis of output from, a computer code. Technometrics 2.1: 239-245, 1979.
23. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB. Development of the Asthma Control Test: a survey for assessing asthma control. J Allergy Clin Immunol 113: 59-65, 2004. (Pubitemid 38096162)
24. Paiva M. Two new pulmonary functional indexes suggested by a simple mathematical model. Respiration 32: 389-403, 1975.
25. 2 plateau. Respir Physiol 44: 325-337, 1981.
26. Paiva M, van Muylem A, Engel LA. Slope of phase III in multibreath nitrogen washout and washin. Bull Eur Physiopath Respir 18: 273-280, 1982. (Pubitemid 12143522)
27. Paraskakis E, Brindicci C, Fleming L, Krol R, Kharitonov SA, Wilson NM, Barnes PJ, Bush A. Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma. Am J Respir Crit Care Med 174: 260-267, 2006. (Pubitemid 44156604)
28. Perillo IB, Hyde RW, Olszowka AJ, Pietropaoli AP, Frasier LM, Torres A, Perkins PT, Forster RE 2nd, Utell MJ, Frampton MW. Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans. J Appl Physiol 91: 1931-1940, 2001.
29. Pietropaoli AP, Perillo IB, Torres A, Perkins PT, Frasier LM, Utell MJ, Frampton MW, Hyde RW. Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans. J Appl Physiol 87: 1532-1542, 1999. (Pubitemid 29483144)
30. Puckett JL, Taylor RWE, Galant SP, George SC. Impact of analysis interval on the multiple flow technique to partition exhaled nitric oxide. Pediatr Pulmonal 45: 182-191, 2010.
31. 2 and inert gas washout. J Appl Physiol 64: 1022-1029, 1988.
32. Shin HW, Condorelli P, George SC. Examining axial diffusion of nitric oxide in the lungs using heliox and breath hold. J Appl Physiol 100: 623-630, 2006. (Pubitemid 43671617)
33. Shin HW, Condorelli P, George SC. A new and more accurate technique to characterize airway nitric oxide using different breath-hold times. J Appl Physiol. 98: 1869-1877, 2005.
34. Shin HW, George SC. Impact of axial diffusion on nitric oxide exchange in the lungs. J Appl Physiol 93: 2070-2080, 2002.
35. Shin HW, Rose-Gottron CM, Cooper DM, Hill M, George SC. Impact of high-intensity exercise on nitric oxide exchange in healthy adults. Med Sci Sports Exerc 35: 995-1003, 2003. (Pubitemid 36706288)
36. Shin HW, Rose-Gottron CM, Cooper DM, Newcomb RL, George SC. Airway diffusing capacity of nitric oxide and steroid therapy in asthma. J Appl Physiol. 96: 65-75, 2004. (Pubitemid 38031983)
37. Shin HW, Rose-Gottron CM, Perez F, Cooper DM, Wilson AF, George SC. Flow-independent nitric oxide exchange parameters in healthy adults. J Appl Physiol 91: 2173-2181, 2001. (Pubitemid 33015071)
38. Shin HW, Rose-Gottron CM, Sufi RS, Perez F, Cooper DM, Wilson AF, George SC. Flow-independent nitric oxide exchange parameters in cystic fibrosis. Am J Respir Crit Care Med 165: 349-357, 2002. (Pubitemid 34118508)
39. Shin HW, Schwindt CD, Aledia AS, Rose-Gottron CM, Larson JK, Newcomb RL, Cooper DM, George SC. Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. Am J Physiol Regul Integr Comp Physiol 291: R1741-R1748, 2006.
40. Shin HY, George SC. Microscopic modeling of NO and S -nitrosoglutathione kinetics and transport in human airways. J Appl Physiol 90: 777-788, 2001.
41. Suresh V, Shelley DA, Shin HW, George SC. Effect of heterogeneous ventilation and nitric oxide production on exhaled nitric oxide profiles. J Appl Physiol 104: 1743-1752, 2008.
42. Suri R, Paraskakis E, Bush A. Alveolar, but not bronchial nitric oxide production is elevated in cystic fibrosis. Pediatr Pulmonol 42: 1215-1221, 2007. (Pubitemid 350231874)
43. Tsoukias NM, George SC. A two-compartment model of pulmonary nitric oxide exchange dynamics. J Appl, Physiol 85: 653-666, 1998. (Pubitemid 28365835)
44. Tsoukias NM, Shin HW, Wilson AF, George SC. A single-breath technique with variable flow rate to characterize nitric oxide exchange dynamics in the lungs. J Appl Physiol 91: 477-487, 2001.
45. Venegas JG, Schroeder T, Harris S, Winkler RT, Melo MF. The distribution of ventilation during bronchoconstriction is patchy and bimodal: a PET imaging study. Respir Physiol Neurobiol 148: 57-64, 2005. (Pubitemid 41132750)
46. Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfleld D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature 434: 777-782, 2005. (Pubitemid 44739522)
47. Verbanck S, Kerckx Y, Schuermans D, de Bisschop C, Guenard H, Naeije R, Vincken W, Van Muylem A. The effect of posture-induced changes in peripheral nitric oxide uptake on exhaled nitric oxide. J Appl Physiol 106: 1494-1498, 2009.
48. Verbanck S, Kerckx Y, Schuermans D, Vincken W, Paiva M, Van Muylem A. Effect of airways constriction on exhaled nitric oxide. J Appl Physiol 104: 925-930, 2008. (Pubitemid 351507927)
49. Weibel ER. Morphometry of the Human Lung. Berlin: Springer, 1963, p. xi, 151.