A significant proportion of exhaled nitric oxide arises in large airways in normal subjects

Respiration Physiology

Volumn 113, Issue 1, 1998, Pages 33-38

  Silkoff, P E ^a   McClean, P A ^b   Caramori, M ^b   Slutsky, A S ^b   Zamel, N ^b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Mammals, humans; Mediators, NO; Upper airways, NO

Indexed keywords

NITRIC OXIDE;

ADULT; ARTICLE; CONTROLLED STUDY; EXHALATION; EXPIRED AIR; HUMAN; HUMAN EXPERIMENT; MEASUREMENT; NORMAL HUMAN; OROPHARYNX; PRIORITY JOURNAL; UPPER RESPIRATORY TRACT; VOLUNTEER;

ADULT; BRONCHI; HUMANS; LUNG; MIDDLE AGED; NITRIC OXIDE; OROPHARYNX; PEAK EXPIRATORY FLOW RATE; REFERENCE VALUES; RESPIRATION; TRACHEA;

EID: 0032123463     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(98)00033-4     Document Type: Article

References (19)

1. Alving K., Weitzberg E., Lundberg J.M. Increased amount of nitric oxide in exhaled air of asthmatics. Eur. Respir. J. 6:1993;1368-1370.
2. Belvisi M.G., Stretton C.D., Yacoub M., Barnes P.J. Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur. J. Pharmacol. 210:1992;221-222.
3. Deliconstantinos G., Villiotou V., Stavrides J.C. Scavenging effects of hemoglobin and related heme containing compounds on nitric oxide, reactive oxidants and carcinogenic volatile nitrosocompounds of cigarette smoke. A new method for protection against the dangerous cigarette constituents. Anticancer. Res. 14:1994;2717-2726.
4. Hyde R.W., Geigel E.J., Olszowka A.J., Krasney J.A., Forster R.E., Utell M.J., Frampton M.W. Determination of production of nitric oxide by lower airways of humans - theory. J. Appl. Physiol. 82:1997;1290-1296.
5. Kharitonov S.A., Wells A.U., O'Connor B.J., Cole P.J., Hansell D.M., Logan-Sinclair R.B., Barnes P.J. Elevated levels of exhaled nitric oxide in bronchiectasis. Am. J. Respir. Crit. Care Med. 151:1995;1889-1893.
6. Kharitonov S.A., Yates D., Barnes P.J. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur. Respir. J. 8:1995;295-297.
7. Kharitonov S.A., Chung K.F., Evans D., O'Connor B.J., Barnes P.J. Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am. J. Respir. Crit. Care Med. 153:1996;1773-1780.
8. Kharitonov S.A., Yates D.H., Chung K.F., Barnes P.J. Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients. Eur. Respir. J. 9:1996;196-201.
9. Kimberly B., Nejadnik B., Giraud G.D., Holden W.E. Nasal contribution to exhaled nitric oxide at rest and during breathholding in humans. Am. J. Respir. Crit. Care Med. 153:1996;829-836.
10. Kobzik L., Bredt D.S., Lowenstein C.J., Drazen J., Gaston B., Sugarbaker D., Stamler J.S. Nitric oxide synthase in human and rat lung: Immunocytochemical and histochemical localization. Am. J. Respir. Cell Mol. Biol. 9:1993;371-377.
11. Lundberg J.O., Rinder J., Weitzberg E., Lundberg J.M., Alving K. Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol. Scand. 152:1994;431-432.
12. Lundberg J.O., Weitzberg E., Nordvall S.L., Kuylenstierna R., Lundberg J.M., Alving K. Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome. Eur. Respir. J. 7:1994;1501-1504.
13. Massaro A.F., Gaston B., Kita D., Fanta C., Stamler J.S., Drazen J.M. Expired nitric oxide levels during treatment of acute asthma. Am. J. Respir. Crit. Care Med. 152:1995;800-803.
14. Massaro A.F., Mehta S., Lilly C.M., Kobzik L., Reilly J.J., Drazen J.M. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am. J. Respir. Crit. Care Med. 153:1996;1510-1514.
15. Miller R.D. Anesthesia. 4th:1994;1412-1413 Churchill Livingstone, New York.
16. Nakamura K., Terasako K., Toda H., Miyawaki M., Nishiwada Y., Hatano Y., Mori K. Mechanisms of inhibition of endothelium-dependent relaxation by halothane, isoflurane and servoflurane. Can. J. Anesth. 41:1998;340-346.
17. Schedin U., Frostell C., Persson M.G., Jakobsson J., Andersson G., Gustafsson L.E. Contribution from upper and lower airways to exhaled endogenous nitric oxide in humans. Acta Anesth. Scand. 39:1995;327-332.
18. Silkoff P.E., McClean P.A., Slutsky A.S., Furlott H.G., Hoffstein E., Wakita S., Chapman K.R., Szalai J.P., Zamel N. Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am. J. Respir. Crit. Care Med. 155:1997;260-267.
19. Zapol W.M., Rimar S., Gillis N., Marletta M., Bosken C.H. NHLBI Workshop summary: Nitric oxide and the lung. Am. J. Respir. Crit. Care Med. 149:1994;1375-1380.