Indications, tolerance and complications of a sirolimus and calcineurin inhibitor immunosuppression regimen: Intermediate experience in pediatric heart transplantation recipients

Pediatric Transplantation

Volumn 14, Issue 3, 2010, Pages 402-408

  Matthews, Kathleen ^a   Gossett, Jeffrey ^a,b   Kappelle, Peter Vande ^a   Jellen, Gina ^a   Pahl, Elfriede ^a,b  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Calcineurin inhibitors; Heart transplantation; Sirolimus

Indexed keywords

CALCINEURIN INHIBITOR; CREATININE; CYCLOSPORIN; RAPAMYCIN; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CARDIAC GRAFT REJECTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG INDICATION; DRUG TOLERABILITY; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HEART INFARCTION; HEART TRANSPLANTATION; HEMOGLOBIN DETERMINATION; HUMAN; INFANT; INFECTION; KIDNEY FAILURE; KIDNEY FUNCTION; LIPID COMPOSITION; LOW DRUG DOSE; MALE; MOUTH ULCER; PERSONAL EXPERIENCE; PNEUMONIA; POSTOPERATIVE COMPLICATION; PRESCHOOL CHILD; PROTEINURIA; RETRANSPLANTATION; SCHOOL CHILD; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; DRUG EFFECTS; GRAFT REJECTION; IMMUNOLOGY; KIDNEY; PATHOPHYSIOLOGY; RETROSPECTIVE STUDY;

ADOLESCENT; CALCINEURIN; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CREATININE; FEMALE; GLOMERULAR FILTRATION RATE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; KIDNEY; MALE; RETROSPECTIVE STUDIES; SIROLIMUS; CALCINEURIN INHIBITORS;

EID: 77950676475     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2010.01306.x     Document Type: Article

References (34)

1. John R, Rajasinghe HA, Chen JM, et al. Long-term outcomes after cardiac transplantation: An experience based on different eras of immunosuppressive therapy. Ann Thorac Surg 2001 : 72 : 440 449.
2. Baran DA, Galin ID, Gass AL. Calcineurin inhibitor-associated early renal insufficiency in cardiac transplant recipients: Risk factors and strategies for prevention and treatment. Am J Cardiovasc Drugs 2004 : 4 : 21 29.
3. Bharat W, Manlhiot C, Mccrindle BW, Pollock-Barziv S, Dipchand AI. The profile of renal function over time in a cohort of pediatric heart transplant recipients. Pediatr Transplant 2009 : 13 : 111 118.
4. Lee CK, Christensen LL, Magee JC, Ojo AO, Harmon WE, Bridges ND. Pre-transplant risk factors for chronic renal dysfunction after pediatric heart transplantation: A 10-year national cohort study. J Heart Lung Transplant 2007 : 26 : 458 465.
5. Sehgal SN. Rapamune (RAPA, rapamycin, sirolimus): Mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998 : 31 : 335 340.
6. Bestetti R, Theodoropoulos TA, Burdmann EA, Filho MA, Cordeiro JA, Villafanha D. Switch from calcineurin inhibitors to sirolimus-induced renal recovery in heart transplant recipients in the midterm follow-up. Transplantation 2006 : 81 : 692 696.
7. Hunt J, Lerman M, Magee MJ, Dewey TM, Herbert M, Mack MJ. Improvement of renal dysfunction by conversion from calcineurin inhibitors to sirolimus after heart transplantation. J Heart Lung Transplant 2005 : 24 : 1863 1867.
8. Kushwaha SS, Khalpey Z, Frantz RP, et al. Sirolimus in cardiac transplantation: Use as a primary immunosuppressant in calcineurin inhibitor-induced nephrotoxicity. J Heart Lung Transplant 2005 : 24 : 2129 2136.
9. Ubilla M, Mastrobuoni S, Cordero A, Castano S, Herreros J, Rabago G. Impact on renal function of the use of sirolimus in cardiac transplantation. Transplant Proc 2007 : 39 : 2401 2402.
10. Meiser B, Kaczmarek I, Mueller M, et al. Low-dose tacrolimus/sirolimus and steroid withdrawal in heart recipients is highly efficacious. J Heart Lung Transplant 2007 : 26 : 598 603.
11. Raichlin E, Bae JH, Khalpey Z, et al. Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation. Circulation 2007 : 116 : 2726 2733.
12. Sinha SS, Pham MX, Vagelos RH, et al. Effect of rapamycin therapy on coronary artery physiology early after cardiac transplantation. Am Heart J 2008 : 155 : 889 896.
13. Leet AS, Bergin PJ, Richardson M, Taylor AJ, Esmore D, Kaye DM. Outcomes following de novo CNI-free immunosuppression after heart transplantation: A single-center experience. Am J Transplant 2009 : 9 : 140 148.
14. Balfour IC, Srun SW, Wood EG, Belsha CW, Marshall DL, Ferdman BR. Early renal benefit of rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients. J Heart Lung Transplant 2006 : 25 : 518 522.
15. Chinnock T, Shankel T, Cutler D, Sahney S, Fitts J, Chinnock R. Conversion to sirolimus with calcineurin inhibitor minimization improves renal insufficiency in pediatric heart transplant recipients. Am J Transplant 2008 : 8 (Suppl. 2 570 Ref Type: Generic.
16. Lobach NE, Pollock-Barziv SM, West LJ, Dipchand AI. Sirolimus immunosuppression in pediatric heart transplant recipients: A single-center experience. J Heart Lung Transplant 2005 : 24 : 184 189.
17. Schwartz GJ, Brion LP, Spitzer A. The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 1987 : 34 : 571 590.
18. Pahl E. Statins in the prevention of transplant coronary artery disease: In pediatric heart recipients. Pediatr Transplant 2007 : 11 : 459 460.
19. Seipelt IM, Crawford SE, Rodgers S, et al. Hypercholesterolemia is common after pediatric heart transplantation: Initial experience with pravastatin. J Heart Lung Transplant 2004 : 23 : 317 322.
20. Cheng CH, Chang HR, Chiang CW, Shu KH, Chou MC. Possible mechanism by which rapamycin increases cyclosporine nephrotoxicity. Transplant Proc 2008 : 40 : 2373 2375.
21. Lloberas N, Torras J, Alperovich G, et al. Different renal toxicity profiles in the association of cyclosporine and tacrolimus with sirolimus in rats. Nephrol Dial Transplant 2008 : 23 : 3111 3119.
22. Kuppahally S, Al-Khaldi A, Weisshaar D, et al. Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiac transplant recipients. Am J Transplant 2006 : 6 (5 Pt 1 986 992.
23. Zakliczynski M, Nozynski J, Kocher A, et al. Surgical wound-healing complications in heart transplant recipients treated with rapamycin. Wound Repair Regen 2007 : 15 : 316 321.
24. Langer RM, Kahan BD. Incidence, therapy, and consequences of lymphocele after sirolimus-cyclosporine-prednisone immunosuppression in renal transplant recipients. Transplantation 2002 : 74 : 804 808.
25. Aliabadi AZ, Pohanka E, Seebacher G, et al. Development of proteinuria after switch to sirolimus-based immunosuppression in long-term cardiac transplant patients. Am J Transplant 2008 : 8 : 854 861.
26. Potter BJ, Giannetti N, Edwardes MD, Cecere R, Cantarovich M. Calcineurin inhibitor substitution with sirolimus vs. reduced-dose calcineurin inhibitor plus sirolimus is associated with improved renal dysfunction in heart transplant patients. Clin Transplant 2007 : 21 : 305 308.
27. Mancini D, Pinney S, Burkhoff D, et al. Use of rapamycin slows progression of cardiac transplantation vasculopathy. Circulation 2003 : 108 : 48 53.
28. Sindhi R, Webber S, Venkataramanan R, et al. Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus. Transplantation 2001 : 72 : 851 855.
29. Champion L, Stern M, Israel-Biet D, et al. Brief communication: Sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 2006 : 144 : 505 509.
30. Delgado JF, Torres J, Jose Ruiz-Cano M, et al. Sirolimus-associated interstitial pneumonitis in 3 heart transplant recipients. J Heart Lung Transplant 2006 : 25 : 1171 1174.
31. Hamour IM, Mittal TK, Bell AD, Banner NR. Reversible sirolimus-associated pneumonitis after heart transplantation. J Heart Lung Transplant 2006 : 25 : 241 244.
32. Almasood A, Gustafsson F, Barth D, Delgado D, Kozuszko S, Ross H. Incidence and underlying cause of anemia in cardiac transplant recipients treated with sirolimus. J Heart Lung Transplant 2009 : 28 (2S 238. Ref Type: Generic.
33. Seikaly MG, Browne R, Bajaj G, Arant BS Jr. Limitations to body length/serum creatinine ratio as an estimate of glomerular filtration in children. Pediatr Nephrol 1996 : 10 : 709 711.
34. Filler G, Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol 2003 : 18 : 981 985.