Gene expression profiling of DEHP-treated cardiomyocytes reveals potential causes of phthalate arrhythmogenicity

Toxicology

Volumn 279, Issue 1-3, 2011, Pages 54-64

  Posnack, Nikki Gillum ^a   Lee, Norman H ^a   Brown, Ronald ^b   Sarvazyan, Narine ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

Author keywords

Arrhythmia; Calcium handling; Cardiac myocyte; Connexin 43; Gene expression; Microarray; Phthalate

Indexed keywords

ALPHA TUBULIN; ALPHA1 INTEGRIN; BETA1 INTEGRIN; DI (2 ETHYLHEXYL) PHTHALATE; KINESIN; MESSENGER RNA; PHTHALIC ACID; PLASTICIZER; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARRHYTHMOGENICITY; ARTICLE; CELL ADHESION; ELECTRIC ACTIVITY; EXPOSURE; GENE EXPRESSION; HEART MUSCLE CELL; MICROARRAY ANALYSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TERATOGENICITY; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; ARRHYTHMIAS, CARDIAC; CELL ADHESION; DIETHYLHEXYL PHTHALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; MYOCYTES, CARDIAC; PLASTICIZERS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

RATTUS;

EID: 78650018617     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.09.007     Document Type: Article

References (43)

1. Ahmed S.H., Clark L.L., Pennington W.R., Webb C.S., Bonnema D.D., Leonardi A.H., McClure C.D., Spinale F.G., Zile M.R. Matrix metalloproteinases/tissue inhibitors of metalloproteinases: relationship between changes in proteolytic determinants of matrix composition and structural, functional, and clinical manifestations of hypertensive heart disease. Circulation 2006, 113:2089-2096.
2. Aronson C.E., Serlick E.R., Preti G. Effects of di-2-ethylhexyl phthalate on the isolated perfused rat heart. Toxicol. Appl. Pharmacol. 1978, 44:155-169.
3. Arutunyan A., Webster D.R., Swift L.M., Sarvazyan N. Localized injury in cardiomyocyte network: a new experimental model of ischemia-reperfusion arrhythmias. Am. J. Physiol. Heart Circ. Physiol. 2001, 280:H1905-H1915.
4. Barry Y.A., Labow R.S., Keon W.J., Tocchi M. Atropine inhibition of the cardiodepressive effect of mono(2-ethylhexyl)phthalate on human myocardium. Toxicol. Appl. Pharmacol. 1990, 106:48-52.
5. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. Roy. Stat. Soc. 1995, 57:289-300.
6. Calafat A.M., Needham L.L., Silva M.J., Lambert G. Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit. Pediatrics 2004, 113:e429-e434.
7. 2+ and trigger ventricular arrhythmias in mice. Circ. Res. 2007, 101:617-626.
8. Fabiato A., Fabiato F. Calcium and cardiac excitation-contraction coupling. Annu. Rev. Physiol. 1979, 41:473-484.
9. FDA: Center for Devices and Radiological Health Safety Assessment of Di(2-ethylhexyl)phthalate (DEHP) 2002, Released from PVC Medical Devices.
10. George C.H., Kendall J.M., Evans W.H. Intracellular trafficking pathways in the assembly of connexins into gap junctions. J. Biol. Chem. 1999, 274:8678-8685.
11. Gillum N., Karabekian Z., Swift L.M., Brown R.P., Kay M.W., Sarvazyan N. Clinically relevant concentrations of di (2-ethylhexyl) phthalate (DEHP) uncouple cardiac syncytium. Toxicol. Appl. Pharmacol. 2009, 236:25-38.
12. Gyorke S., Gyorke I., Terentyev D., Viatchenko-Karpinski S., Williams S.C. Modulation of sarcoplasmic reticulum calcium release by calsequestrin in cardiac myocytes. Biol. Res. 2004, 37:603-607.
13. Gyorke S., Terentyev D. Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc. Res. 2008, 77:245-255.
14. Hirokawa N., Noda Y. Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics. Physiol. Rev. 2008, 88:1089-1118.
15. Hu V.W., Nguyen A., Kim K.S., Steinberg M.E., Sarachana T., Scully M.A., Soldin S.J., Luu T., Lee N.H. Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis. PLoS ONE 2009, 4:e5775.
16. Jahnke G.D., Iannucci A.R., Scialli A.R., Shelby M.D. Center for the evaluation of risks to human reproduction-the first five years. Birth Defects Res.: B. Dev. Reprod. Toxicol. 2005, 74:1-8.
17. Jenke D. Extractable substances from plastic materials used in solution contact applications: an updated review. PDA J. Pharm. Sci. Technol. 2006, 60:191-207.
18. Karle V.A., Short B.L., Martin G.R., Bulas D.I., Getson P.R., Luban N.L., O'Brien A.M., Rubin R.J. Extracorporeal membrane oxygenation exposes infants to the plasticizer, di(2-ethylhexyl)phthalate. Crit. Care Med. 1997, 25:696-703.
19. Katra R.P., Oya T., Hoeker G.S., Laurita K.R. Ryanodine receptor dysfunction and triggered activity in the heart. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H2144-H2151.
20. Kavlock R., Boekelheide K., Chapin R., Cunningham M., Faustman E., Foster P., Golub M., Henderson R., Hinberg I., Little R., Seed J., Shea K., Tabacova S., Tyl R., Williams P., Zacharewski T. NTP center for the evaluation of risks to human reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod. Toxicol. 2002, 16:529-653.
21. Lauf U., Giepmans B.N., Lopez P., Braconnot S., Chen S.C., Falk M.M. Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:10446-10451.
22. Leeder J.S., Kearns G.L. Pharmacogenetics in pediatrics. Implications for practice. Pediatr. Clin. North Am. 1997, 44:55-77.
23. Li J., Hampton T., Morgan J.P., Simons M. Stretch-induced VEGF expression in the heart. J. Clin. Invest. 1997, 100:18-24.
24. Loff S., Kabs F., Witt K., Sartoris J., Mandl B., Niessen K.H., Waag K.L. Polyvinylchloride infusion lines expose infants to large amounts of toxic plasticizers. J. Pediatr. Surg. 2000, 35:1775-1781.
25. Malek R.L., Irby R.B., Guo Q.M., Lee K., Wong S., He M., Tsai J., Frank B., Liu E.T., Quackenbush J., Jove R., Yeatman T.J., Lee N.H. Identification of Src transformation fingerprint in human colon cancer. Oncogene 2002, 21:7256-7265.
26. Malla N., Berg E., Uhlin-Hansen L., Winberg J.O. Interaction of pro-matrix metalloproteinase-9/proteoglycan heteromer with gelatin and collagen. J. Biol. Chem. 2008, 283:13652-13665.
27. Nabauer M., Callewaert G., Cleemann L., Morad M. Regulation of calcium release is gated by calcium current, not gating charge, in cardiac myocytes. Science 1989, 244:800-803.
28. Nakagomi M., Suzuki E., Usumi K., Saitoh Y., Yoshimura S., Nagao T., Ono H. Effects of endocrine disrupting chemicals on the microtubule network in Chinese hamster V79 cells in culture and in sertoli cells in rats. Teratogen. Carcinog. Mutagen. 2001, 21:453-462.
29. Park K., Kwak I.S. Calponin gene expression in Chironomus riparius exposed to di(2-ethylhexyl) phthalate. Environ. Toxicol. 2009, 24:555-562.
30. Peng H.J., Dai D.Z., Ji H., Dai Y. The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. Eur. J. Pharmacol. 2010, 634(1-3):101-106.
31. Petersen S.V., Lyman D.J., Roll D.B., Swinyard E.A. Toxicology of plastic devices having contact with blood. Final Report. Contract NIH-NHLI-73-2098-B 1975, National Technical Information Service. PB-250-102, Washington, DC.
32. Rock G., Labow R.S., Franklin C., Burnett R., Tocchi M. Hypotension and cardiac arrest in rats after infusion of mono(2-ethylhexyl) phthalate (MEHP), a contaminant of stored blood. N. Engl. J. Med. 1987, 316:1218-1219.
33. Shaw R.M., Fay A.J., Puthenveedu M.A., von Zastrow M., Jan Y.N., Jan L.Y. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell 2007, 128:547-560.
34. Shea K.M. Pediatric exposure and potential toxicity of phthalate plasticizers. Pediatrics 2003, 111:1467-1474.
35. Sjoberg P., Bondesson U. Determination of di(2-ethylhexyl) phthalate and four of its metabolites in blood plasma by gas chromatography-mass spectrometry. J. Chromatogr. 1985, 344:167-175.
36. Sjoberg P., Bondesson U., Sedin G., Gustafsson J. Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to exchange transfusions. Eur. J. Clin. Invest. 1985, 15:430-436.
37. Tamura K., Umemura S., Nyui N., Hibi K., Ishigami T., Kihara M., Toya Y., Ishii M. Activation of angiotensinogen gene in cardiac myocytes by angiotensin II and mechanical stretch. Am. J. Physiol. 1998, 275:R1-9.
38. Terentyev D., Cala S.E., Houle T.D., Viatchenko-Karpinski S., Gyorke I., Terentyeva R., Williams S.C., Gyorke S. Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes. Circ. Res. 2005, 96:651-658.
39. Villarreal F.J., Dillmann W.H. Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen. Am. J. Physiol. 1992, 262:H1861-H1866.
40. Wang N., Stamenovic D. Mechanics of vimentin intermediate filaments. J. Muscle Res. Cell. Motil. 2002, 23:535-540.
41. Yamazaki T., Komuro I., Kudoh S., Zou Y., Shiojima I., Hiroi Y., Mizuno T., Maemura K., Kurihara H., Aikawa R., Takano H., Yazaki Y. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J. Biol. Chem. 1996, 271:3221-3228.
42. Yao P.L., Lin Y.C., Richburg J.H. Mono-(2-ethylhexyl) phthalate-induced disruption of junctional complexes in the seminiferous epithelium of the rodent testis is mediated by MMP2. Biol. Reprod. 2010, 82:516-527.
43. Zhuang J., Yamada K.A., Saffitz J.E., Kleber A.G. Pulsatile stretch remodels cell-to-cell communication in cultured myocytes. Circ. Res. 2000, 87:316-322.