Trauma profile in Egyptian adolescents with first-episode schizophrenia: Relation to psychopathology and plasma brain-derived neurotrophic factor

Journal of Nervous and Mental Disease

Volumn 201, Issue 1, 2013, Pages 23-29

  Fawzi, Mounir H ^a   Kira, Ibrahim A ^b   Fawzi, Mohab M ^a   Mohamed, Hanan E ^c   Fawzi, Maggie M ^c  

^a ZAGAZIG UNIVERSITY   (Egypt)

^b Center for Cumulative Trauma Studies   (United States)

^c Zagazig University   (Egypt)

Author keywords

BDNF; brain derived neurotrophic factor; cumulative trauma; Egypt; schizophrenia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADOLESCENT; ARTICLE; EGYPT; FAMILY HISTORY; FEMALE; HOSTILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PHYSICAL ABUSE; POSITIVE AND NEGATIVE SYNDROME SCALE; POSITIVE SYNDROME; PROTEIN BLOOD LEVEL; PSYCHOTRAUMA; SCHIZOPHRENIA; SEXUAL ABUSE; SOCIAL CLASS;

EID: 84871907889     PISSN: 00223018     EISSN: 1539736X     Source Type: Journal    
DOI: 10.1097/NMD.0b013e31827ab268     Document Type: Article

References (70)

1. Alvarez MJ, Roura P, Osés A, Foguet Q, Solà J, Arrufat FX (2011) Prevalence and clinical impact of childhood trauma in patients with severe mental disorders. J Nerv Ment Dis. 199:156-161.
2. Angelucci F, Gelfo F, De Bartolo P, Caltagirone C, Petrosini L (2011) BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration. Neurochem Int. 59:1-4.
3. Baron RM, Kenny DA (1986) The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 51:1173-1182.
4. Bebbington P, Jonas S, Kuipers E, King M, Cooper C, Brugha T, Meltzer H, McManus S, Jenkins R (2011) Childhood sexual abuse and psychosis: Data from a cross-sectional national psychiatric survey in England. Br J Psychiatry. 199:29-37.
5. Bremner JD, Bolus R, Mayer EA (2007) Psychometric properties of the Early Trauma Inventory-Self Report. J Nerv Ment Dis. 195:211-218.
6. Buckley PF, Pillai A, Howell KR (2011) Brain-derived neurotrophic factor: Findings in schizophrenia. Curr Opin Psychiatry. 24:122-127.
7. Bus BA, Tendolkar I, Franke B, de Graaf J, Heijer MD, Buitelaar JK, Oude Voshaar RC (2012) Serum brain-derived neurotrophic factor: Determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people. World J Biol Psychiatry. 13:39-47.
8. Chen CC, Huang TL (2011) Effects of antipsychotics on the serum BDNF levels in schizophrenia. Psychiatry Res. 189:327-330.
9. Chen da C, Wang J, Wang B, Yang SC, Zhang CX, Zheng YL, Li YL, Wang N, Yang KB, Xiu MH, Kosten TR, Zhang XY (2009) Decreased levels of serum brain-derived neurotrophic factor in drug-naBve first-episode schizophrenia: Relationship to clinical phenotypes. Psychopharmacology (Berl). 207: 375-380.
10. Cutajar MC, Mullen PE, Ogloff JR, Thomas SD, Wells DL, Spataro J (2010) Schizophrenia and other psychotic disorders in a cohort of sexually abused children. Arch Gen Psychiatry. 67:1114-1119.
11. Dell'osso L, Carmassi C, Del Debbio A, Dell'osso MC, Bianchi C, da Pozzo E, Origlia N, Domenici L, Massimetti G, Marazziti D, Piccinni A (2009) Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder. Prog Neuropsychopharmacol Biol Psychiatry. 33:899-902.
12. Durany N, Michel T, Zo?chling R, Boissl KW, Cruz-Sánchez FF, Riederer P, Thome J (2001) Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr Res. 52:79-86.
13. Fahmy SI, El-Sherbini AF (1983) Determining simple parameters for social classification for health research. Bull High Inst Publ Health. 8:95-99.
14. Fawzi MM, El-Amin HM, Fawzi MH (2011a) Duration of untreated psychosis in two Arab samples from Egypt and Saudi Arabia: Clinical and sociocultural correlates. Middle East Curr Psychiatry. 18:217-225.
15. Fawzi MH, Fawzi MM (2012) Disordered eating attitudes in Egyptian antipsychotic naive patients with schizophrenia. Compr Psychiatry. 53:259-268.
16. Fawzi MH, Fawzi MM, Fawzi MM, Said NS (2011b) C-reactive protein serum level in drug-free male Egyptian patients with schizophrenia. Psychiatry Res. 190:91-97.
17. Fawzi MH, Fawzi MM, Khedr HH, Fawzi MM (2007) Tobacco smoking in Egyptian schizophrenia patients with and without obsessive-compulsive symptoms. Schizophr Res. 95:236-246.
18. First MB, Gibbon M, Spitzer RL, Williams GBW (1996) User's guide for the Structured Interview for DSMYIV Axis I DisordersVResearch version (SCID-I, version 2.0). New York: Biometrics Research.
19. Fisher HL, Jones PB, Fearon P, Craig TK, Dazzan P, Morgan K, Hutchinson G, Doody GA, McGuffin P, Leff J, Murray RM, Morgan C (2010) The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder. Psychol Med. 40:1967-1978.
20. Galletly C, Van Hooff M, McFarlane A (2011) Psychotic symptoms in young adults exposed to childhood traumaVA 20 year follow-up study. Schizophr Res. 127:76-82.
21. Gama CS, Andreazza AC, Kunz M, Berk M, Belmonte-de-Abreu PS, Kapczinski F (2007) Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder. Neurosci Lett. 420:45-48.
22. Gearon JS, Kaltman SI, Brown C, Bellack AS (2003) Traumatic life events and PTSD among women with substance use disorders and schizophrenia. Psychiatr Serv. 54:523-528.
23. Green MJ, Matheson SL, Shepherd A, Weickert CS, Carr VJ (2011) Brain-derived neurotrophic factor levels in schizophrenia: A systematic review with metaanalysis. Mol Psychiatry. 16:960-972.
24. Grillo RW, Ottoni GL, Leke R, Souza DO, Portela LV, Lara DR (2007) Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics. J Psychiatr Res. 41:31-35.
25. Hoy K, Barrett S, Shannon C, Campbell C, Watson D, Rushe T, Shevlin M, Bai F, Cooper S, Mulholland C (2012) Childhood trauma and hippocampal and amygdalar volumes in first-episode psychosis. Schizophr Bull.38:1162-1169.
26. Huang TL, Lee CT (2006) Associations between serum brain-derived neurotrophic factor levels and clinical phenotypes in schizophrenia patients. J Psychiatr Res. 40:664-668.
27. Jindal RD, Pillai AK, Mahadik SP, Eklund K, Montrose DM, Keshavan MS (2010) Decreased BDNF in patients with antipsychotic naBve first episode schizophrenia. Schizophr Res. 119:47-51.
28. Karege F, Schwald M, Cisse M (2002) Postnatal developmental profile of brainderived neurotrophic factor in rat brain and platelets. Neurosci Lett. 328: 261-264.
29. Kauer-Sant'Anna M, Tramontina J, Andreazza AC, Cereser K, da Costa S, Santin A, Yatham LN, Kapczinski F (2007) Traumatic life events in bipolar disorder: Impact on BDNF levels and psychopathology. Bipolar Disord. 9:128-135.
30. Kay SR, Fiszbein A, Opler LA (1987) The Positive and Negative Syndrome Scale (PANSS) or schizophrenia. Schizophr Bull. 13:261-276.
31. Kay SR, Fiszbein A, Opler LA (1992) Positive and Negative Syndrome Scale (PANSS) manual. Toronto, ON, Canada: Multi-Health Systems.
32. Kilcommons AM, Morrison AP (2005) Relationships between trauma and psychosis: An exploration of cognitive and dissociative factors. Acta Psychiatr Scand. 112:351-359.
33. Kim D, Kaspar V, Noh S, Nam JH (2006) Sexual and physical abuse among Korean female inpatients with schizophrenia. J Trauma Stress. 19:279-289.
34. Kira IA, Lewandowski L, Templin T, Ramaswamy V, Ozkan B, Mohanesh J (2008) Measuring cumulative trauma dose, types, and profiles using a developmentbased taxonomy of traumas. Traumatology. 14:62-87.
35. Kira IA, Templin T, Lewandowski L, Ramaswamy V, Ozkan B, Abou-Mediane S, Mohanesh J, Abdulkhaleq H, Nasser A (2011) Cumulative tertiary appraisals of traumatic events across cultures: Two studies. J Loss Trauma. 16:43-66.
36. Larkin W, Read J (2008) Childhood trauma and psychosis: Evidence, pathways, and implications. J Postgrad Med. 54:287-293.
37. Lommen MJ, Restifo K (2009) Trauma and posttraumatic stress disorder (PTSD) in patients with schizophrenia or schizoaffective disorder. Community Ment Health J. 45:485-496.
38. Lysaker PH, Beattie NL, Strasburger AM, Davis LW (2005) Reported history of child sexual abuse in schizophrenia: Associations with heightened symptom levels and poorer participation over four months in vocational rehabilitation. J Nerv Ment Dis. 193:790-795.
39. Marder SR, Davis JM, Chouinard G (1997) The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: Combined results of the North American trials. J Clin Psychiatr. 58:538-546.
40. Mass R, Schoemig T, Hitschfeld K, Wall E, Haasen C (2000) Psychopathological syndromes of schizophrenia: Evaluation of the dimensional structure of the positive and negative syndrome scale. Schizophr Bull. 26:167-177.
41. McCarthy-Jones S (2011) Voices from the storm: A critical review of quantitative studies of auditory verbal hallucinations and childhood sexual abuse. Clin Psychol Rev. 31:983-992.
42. Morgan C, Fisher H (2007) Environment and schizophrenia: Environmental factors in schizophrenia: Childhood traumaVA critical review. Schizophr Bull. 33:3-10.
43. Mueser KT, Goodman LB, Trumbetta SL, Rosenberg SD, Osher C, Vidaver R, Auciello P, Foy DW (1998) Trauma and posttraumatic stress disorder in severe mental illness. J Consult Clin Psychol. 66:493-499.
44. Newman JM, Turnbull A, Berman BA, Rodrigues S, Serper MR (2010) Impact of traumatic and violent victimization experiences in individuals with schizophrenia and schizoaffective disorder. J Nerv Ment Dis. 198:708-714.
45. O'Brien RM (2007) A caution regarding rules of thumb for variance inflation factors. Qual Quantity. 41:673-690.
46. Ognibene E, Adriani W, Caprioli A, Ghirardi O, Ali SF, Aloe L, Laviola G (2008) The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice. Prog Neuropsychopharmacol Biol Psychiatry. 32:1269-1276.
47. Okasha A, Kamel M, Hassan AH (1968) Preliminary psychiatric observations in Egypt. Br J Psychiatry. 114:949-955.
48. Palmer BW, Dunn LB, Appelbaum PS, Mudaliar S, Thal L, Henry R, Golshan S, Jeste DV (2005) Assessment of capacity to consent to research among older persons with schizophrenia, Alzheimer disease, or diabetes mellitus: Comparison of a 3-item questionnaire with a comprehensive standardized capacity instrument. Arch Gen Psychiatry. 62:726-733.
49. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 37: 1553-1561.
50. Pardridge WM (2002) Neurotrophins, neuroprotection and the blood-brain barrier. Curr Opin Investig Drugs. 3:1753-1757.
51. Park SW, Lee JG, Ha EK, Choi SM, Cho HY, Seo MK, Kim YH (2009) Differential effects of aripiprazole and haloperidol on BDNF-mediated signal changes in SH-S-5Y cells. Eur Neuropsychopharmacol. 19:356-362.
52. Pedrini M, Chendo I, Grande I, Lobato MI, Belmonte-de-Abreu PS, Lersch C (2011) Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: A positive correlation. Neurosci Lett. 491:207-210.
53. Pillai A, Kale A, Joshi S, Naphade N, Raju MS, Nasrallah H, Mahadik SP (2010) Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: Correlation with plasma BDNF and psychopathology. Int J Neuropsychopharmacol. 13:535-539.
54. Pirildar S, Go?nu?l AS, Taneli F, Akdeniz F (2004) Low serum levels of brain-derived neurotrophic factor in patients with schizophrenia do not elevate after antipsychotic treatment. Prog Neuropsychopharmacol Biol Psychiatry. 28:709-713.
55. Read J, Agar K, Argyle N, Aderhold V (2003) Sexual and physical abuse during childhood and adulthood as predictors of hallucinations, delusions and thought disorder. Psychol Psychother. 76:1-22.
56. Read J, van Os J, Morrison AP, Ross CA (2005) Childhood trauma, psychosis and schizophrenia: A literature review with theoretical and clinical implications. Acta Psychiatr Scand. 112:330-350.
57. Reis HJ, Nicolato R, Barbosa IG, Teixeira do Prado PH, Romano-Silva MA, Teixeira AL (2008) Increased serum levels of brain-derived neurotrophic factor in chronic institutionalized patients with schizophrenia. Neurosci Lett. 439:157-159.
58. Ross CA, Anderson G, Clark P (1994) Childhood abuse and the positive symptoms of schizophrenia. Hosp Community Psychiatry. 45:489-491.
59. Roy CA, Perry JC (2004) Instruments for the assessment of childhood trauma in adults. J Nerv Ment Dis. 192:343-351.
60. Scott J, Chant D, Andrews G, Martin G, McGrath J (2007) Association between trauma exposure and delusional experiences in a large community-based sample. Br J Psychiatry. 190:339-343.
61. Shevlin M, Dorahy MJ, Adamson G (2007) Trauma and psychosis: An analysis of the National Comorbidity Survey. Am J Psychiatry. 164:166-169.
62. Shimizu E, Hashimoto K, Watanabe H, Komatsu N, Okamura N, Koike K, Shinoda N, Nakazato M, Kumakiri C, Okada S, Iyo M (2003) Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls. Neurosci Lett. 351:111-114.
63. Sobel M (1982) Asymptotic confidence intervals for indirect effects in structural equations models. In Leinhart S (Ed), Sociological methodology (pp. 290-312).
64. San Francisco: Jossey-Bass. Spataro J, Mullen PE, Burgess PM, Wells DL, Moss SA (2004) Impact of child sexual abuse on mental health: Prospective study in males and females. Br J Psychiatry. 184:416-421.
65. Srinivasan TN, Thara R (2002) Smoking in schizophreniaVAll is not biological. Schizophr Res. 56:67-74.
66. Tan YL, Zhou DF, Cao LY, Zou YZ, Zhang XY (2005) Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics. Neurosci Lett. 382:27-32.
67. van Os J, Krabbendam L, Myin-Germeys I, Delespaul P (2005) The schizophrenia environment. Curr Opin Psychiatry. 18:141-145.
68. van Winkel R, Stefanis NC, Myin-Germeys I (2008) Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull. 34:1095-1105.
69. Xiu MH, Hui L, Dang YF, Hou TD, Zhang CX, Zheng YL, Chen da C, Kosten TR, Zhang XY (2009) Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry. 33:1508-1512.
70. Yoshimura R, Hori H, Sugita A, Ueda N, Kakihara S, Umene W, Nakano Y, Shinkai K, Mitoma M, Ohta M, Shinkai T, Nakamura J (2007) Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 31:1072-1077.