Serum levels of brain-derived neurotrophic factor in patients with schizophrenia and bipolar disorder

Neuroscience Letters

Volumn 420, Issue 1, 2007, Pages 45-48

  Gama, Clarissa Severino ^a,b   Andreazza, Ana Cristina ^a   Kunz, Maurício ^a,b   Berk, Michael ^c,d,e   Belmonte de Abreu, Paulo Silva ^a,b   Kapczinski, Flavio ^a,b  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d ORYGEN RESEARCH CENTRE   (Australia)

^e FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

Antipsychotics; Bipolar disorder; Brain derived neurotrophic factor; Schizophrenia

Indexed keywords

ATYPICAL ANTIPSYCHOTIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CLOZAPINE; LITHIUM; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; VALPROIC ACID;

ADULT; ARTICLE; BIPOLAR DISORDER; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHIZOPHRENIA; VEIN PUNCTURE;

ADULT; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 34248663802     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.04.001     Document Type: Article

References (33)

1. Azevedo M.H., Soares M.J., Coelho I., Dourado A., Valente J., Macedo A., Pato M., and Pato C. Using consensus OPCRIT diagnoses - an efficient procedure for best-estimate lifetime diagnoses. Br. J. Psychiatry 175 (1999) 154-157
2. Bai O., Chlan-Fourney J., Bowen R., Keegan D., and Li X.M. Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J. Neurosci. Res. 71 1 (2003) 127-131
3. Belmaker R.H. Bipolar disorder. N. Engl. J. Med. 351 5 (2004) 476-486
4. Castren E. Is mood chemistry?. Nat. Rev. Neurosci. 6 3 (2005) 241-246
5. Chen Q.Y., Chen Q., Feng G.Y., Wan C.L., Lindpaintner K., Wang L.J., Chen Z.X., Gao Z.S., Tang J.S., Li X.W., and He L. Association between the brain-derived neurotrophic factor (BDNF) gene and schizophrenia in the Chinese population. Neurosci. Lett. 397 3 (2006) 285-290
6. Coyle J.T., and Duman R.S. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron. 38 2 (2003) 157-160
7. Craddock M., Asherson P., Owen M.J., Williams J., McGuffin P., and Farmer A.E. Concurrent validity of the OPCRIT diagnostic system - comparison of OPCRIT diagnoses with consensus best-estimate lifetime diagnoses. Br. J. Psychiatry 169 1 (1996) 58-63
8. Cunha A.B., Frey B.N., Andreazza A.C., Goi J.D., Rosa A.R., Goncalves C.A., Santin A., and Kapczinski F. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neurosci. Lett. 398 3 (2006) 215-219
9. Frey B.N., Andreazza A.C., Cereser K.M., Martins M.R., Valvassori S.S., Reus G.Z., Quevedo J., and Kapczinski F. Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. Life Sci. 79 3 (2006) 281-286
10. Fukumoto T., Morinobu S., Okamoto Y., Kagaya A., and Yamawaki S. Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain. Psychopharmacology (Berl) 158 1 (2001) 100-106
11. Gama C.S., Salvador M., Andreazza A.C., Kapczinski F., and Silva Belmonte-de-Abreu P. Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine. Prog. Neuropsychopharmacol. Biol. Psychiatry 30 3 (2006) 512-515
12. Gratacos M., Gonzalez J.R., Mercader J.M., Cid R.D., Urretavizcaya M., and Estivill X. Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol. Psychiatry 61 7 (2007) 911-922
13. Grillo R.W., Ottoni G.L., Leke R., Souza D.O., Portela L.V., and Lara D.R. Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics. J. Psychiatr. Res. 41 1-2 (2007) 31-35
14. Guy W. ECDEU assessment manual for psychopharmacology US Department of Health, Education, and Welfare publication (ADM) 76-338 (1976), National Institute of Mental Health, Rockville, MD 218-222
15. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23 (1960) 56-62
16. Jockers-Scherubl M.C., Danker-Hopfe H., Mahlberg R., Selig F., Rentzsch J., Schurer F., Lang U.E., and Hellweg R. Brain-derived neurotrophic factor serum concentrations are increased in drug-naive schizophrenic patients with chronic cannabis abuse and multiple substance abuse. Neurosci. Lett. 371 1 (2004) 79-83
17. Jonsson E.G., Edman-Ahlbom B., Sillen A., Gunnar A., Kulle B., Frigessi A., Vares M., Ekholm B., Wode-Helgodt B., Schumacher J., Cichon S., Agartz I., Sedvall G.C., Hall H., and Terenius L. Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study. Prog. Neuropsychopharmacol. Biol. Psychiatry 30 5 (2006) 924-933
18. Lieberman J.A. Pathophysiologic mechanisms in the pathogenesis and clinical course of schizophrenia. J. Clin. Psychiatry 60 Suppl. 12 (1999) 9-12
19. Lohoff F.W., Sander T., Ferraro T.N., Dahl J.P., Gallinat J., and Berrettini W.H. Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 139 1 (2005) 51-53
20. Machado-Vieira R., Dietrich M.O., Leke R., Cereser V.H., Zanatto V., Kapczinski F., Souza D.O., Portela L.V., and Gentil V. Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode. Biol. Psychiatry 61 2 (2007) 142-144
21. Mahadik S.P., Pillai A., Joshi S., and Foster A. Prevention of oxidative stress-mediated neuropathology and improved clinical outcome by adjunctive use of a combination of antioxidants and omega-3 fatty acids in schizophrenia. Int. Rev. Psychiatry 18 2 (2006) 119-131
22. McGuffin P., Farmer A., and Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness - development and reliability of the OPCRIT system. Arch. Gen. Psychiatry 48 8 (1991) 764-770
23. Neves-Pereira M., Mundo E., Muglia P., King N., Macciardi F., and Kennedy J.L. The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am. J. Hum. Genet. 71 3 (2002) 651-655
24. Park S.W., Lee S.K., Kim J.M., Yoon J.S., and Kim Y.H. Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats. Neurosci. Lett. 402 1-2 (2006) 25-29
25. Palomino A., Vallejo-Illarramendi A., Gonzalez-Pinto A., Aldama A., Gonzalez-Gomez C., Mosquera F., Gonzalez-Garcia G., and Matute C. Decreased levels of plasma BDNF in first-episode schizophrenia and bipolar disorder patients. Schizophr. Res. 86 1-3 (2006) 321-322
26. Qian L., Zhao J., Shi Y., Zhao X., Feng G., Xu F., Zhu S., and He L. Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis. Biochem. Biophys. Res. Commun. 353 3 (2007) 738-743
27. Rybakowski J.K., Borkowska A., Czerski P.M., Skibinska M., and Hauser J. Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord. 5 6 (2003) 468-472
28. Rybakowski J.K., Borkowska A., Skibinska M., Szczepankiewicz A., Kapelski P., Leszczynska-Rodziewicz A., Czerski P.M., and Hauser J. Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene. Psychiatry Clin. Neurosci. 60 1 (2006) 70-76
29. Soares J.C., and Mann J.J. The functional neuroanatomy of mood disorders. J. Psychiatr. Res. 31 4 (1997) 393-432
30. Strakowski S.M., Adler C.M., Holland S.K., Mills N.P., DelBello M.P., and Eliassen J.C. Abnormal FMRI brain activation in euthymic bipolar disorder patients during a counting Stroop interference task. Am. J. Psychiatry 162 9 (2005) 1697-1705
31. Tan Y.L., Zhou D.F., Cao L.Y., Zou Y.Z., and Zhang X.Y. Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics. Neurosci. Lett. 382 1-2 (2005) 27-32
32. Tan Y.L., Zhou D.F., and Zhang X.Y. Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements. Schizophr. Res. 74 2-3 (2005) 263-270
33. Young R.C., Biggs J.T., Ziegler V.E., and Meyer D.A. A rating scale mania: reliability, validity and sensitivity. Br. J. Psychiatry 133 (1978) 429-435