Macrophages regulate smooth muscle differentiation of mesenchymal stem cells via a prostaglandin F2α-mediated paracrine mechanism

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 11, 2012, Pages 2733-2740

  Lee, Mi Jeong ^a   Kim, Min Young ^a   Heo, Soon Chul ^a   Kwon, Yang Woo ^a   Kim, Young Mi ^a   Do, Eun Kyoung ^a   Park, Ji Hye ^a   Lee, Jung Sub ^b   Han, Jin ^c   Kim, Jae Ho ^a,d  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Inje University   (South Korea)

^d Pusan National University Yangsan Hospital   (South Korea)

Author keywords

Differentiation; Inflammation; Interleukin 1 ; Mesenchymal stem cells; Smooth muscle cells

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CARBACHOL; INTERLEUKIN 1BETA; POTASSIUM CHLORIDE; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN F2 ALPHA RECEPTOR; PROSTAGLANDIN RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ACTA2 PROTEIN, HUMAN; ACTIN; AUTACOID; BIOLOGICAL MARKER; PROSTAGLANDIN F2ALPHA RECEPTOR;

ADIPOSE TISSUE CELL; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL TRANSPLANTATION; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; LIMB ISCHEMIA; MACROPHAGE; MACROPHAGE ACTIVATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; PROTEIN SECRETION; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; TISSUE REGENERATION; ADIPOSE TISSUE; ANIMAL; BLOOD FLOW; CELL LINE; COCULTURE; CULTURE MEDIUM; CYTOLOGY; DISEASE MODEL; GENETIC TRANSFECTION; GENETICS; HINDLIMB; IMMUNOLOGY; ISCHEMIA; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; NUDE MOUSE; PATHOPHYSIOLOGY; RNA INTERFERENCE; SKELETAL MUSCLE; TIME; TRANSPLANTATION; VASCULARIZATION;

ACTINS; ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL LINE; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DINOPROST; DISEASE MODELS, ANIMAL; HINDLIMB; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; ISCHEMIA; MACROPHAGE ACTIVATION; MACROPHAGES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MICE, NUDE; MUSCLE, SKELETAL; MYOCYTES, SMOOTH MUSCLE; NEOVASCULARIZATION, PHYSIOLOGIC; PARACRINE COMMUNICATION; RECEPTORS, PROSTAGLANDIN; REGIONAL BLOOD FLOW; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION;

EID: 84871902265     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.112.300230     Document Type: Article

References (42)

1. Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 2004;36:568-584.
2. Prockop DJ, Kota DJ, Bazhanov N, Reger RL. Evolving paradigms for repair of tissues by adult stem/progenitor cells (MSCs). J Cell Mol Med. 2010;14:2190-2199.
3. Salem HK, Thiemermann C. Mesenchymal stromal cells: current understanding and clinical status. Stem Cells. 2010;28:585-596.
4. Chamberlain G, Fox J, Ashton B, Middleton J. Concise review: mesen-chymal stem cells: their phenotype, differentiation capacity, immunolog-ical features, and potential for homing. Stem Cells. 2007;25:2739-2749.
5. Schäffer A, Büchler C. Concise review: adipose tissue-derived stromal cells-basic and clinical implications for novel cell-based therapies. Stem Cells. 2007;25:818-827.
6. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767-801.
7. Liu C, Nath KA, Katusic ZS, Caplice NM. Smooth muscle progenitor cells in vascular disease. Trends Cardiovasc Med. 2004;14:288-293.
8. Abedin M, Tintut Y, Demer LL. Mesenchymal stem cells and the artery wall. Circ Res. 2004;95:671-676.
9. Corselli M, Chen CW, Crisan M, Lazzari L, Péault B. Perivascular ancestors of adult multipotent stem cells. Arterioscler Thromb Vasc Biol. 2010;30:1104-1109.
10. Davani S, Marandin A, Mersin N, Royer B, Kantelip B, Herve P, Etievent JP, Kantelip JP. Mesenchymal progenitor cells differentiate into an endo-thelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation. 2003;108(1 Suppl): II253-II258.
11. Yoon YS, Wecker A, Heyd L, Park JS, Tkebuchava T, Kusano K, Hanley A, Scadova H, Qin G, Cha DH, Johnson KL, Aikawa R, Asahara T, Losordo DW. Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest. 2005;115:326-338.
12. Gojo S, Gojo N, Takeda Y, Mori T, Abe H, Kyo S, Hata J, Umezawa A. In vivo cardiovasculogenesis by direct injection of isolated adult mesen-chymal stem cells. Exp Cell Res. 2003;288:51-59.
13. Kinner B, Zaleskas JM, Spector M. Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells. Exp Cell Res. 2002;278:72-83.
14. Wang D, Park JS, Chu JS, Krakowski A, Luo K, Chen DJ, Li S. Proteomic profling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation. J Biol Chem. 2004; 279:43725-43734.
15. Kobayashi N, Yasu T, Ueba H, Sata M, Hashimoto S, Kuroki M, Saito M, Kawakami M. Mechanical stress promotes the expression of smooth muscle-like properties in marrow stromal cells. Exp Hematol. 2004;32:1238-1245.
16. Ball SG, Shuttleworth AC, Kielty CM. Direct cell contact infuences bone marrow mesenchymal stem cell fate. Int J Biochem Cell Biol. 2004;36:714-727.
17. Jeon ES, Park WS, Lee MJ, Kim YM, Han J, Kim JH. A Rho kinase/myo-cardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells. Circ Res. 2008;103:635-642.
18. Kim MR, Jeon ES, Kim YM, Lee JS, Kim JH. Thromboxane a(2) induces differentiation of human mesenchymal stem cells to smooth muscle-like cells. Stem Cells. 2009;27:191-199.
19. Kim YM, Jeon ES, Kim MR, Lee JS, Kim JH. Bradykinin-induced expression of alpha-smooth muscle actin in human mesenchymal stem cells. Cell Signal. 2008;20:1882-1889.
20. Kim YM, Jeon ES, Kim MR, Jho SK, Ryu SW, Kim JH. Angiotensin II-induced differentiation of adipose tissue-derived mesenchymal stem cells to smooth muscle-like cells. Int J Biochem Cell Biol. 2008;40:2482-2491.
21. Leibovich SJ, Wiseman DM. Macrophages, wound repair and angiogen-esis. Prog Clin Biol Res. 1988;266:131-145.
22. Ono M. Molecular links between tumor angiogenesis and infamma-tion: infammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci. 2008;99:1501-1506.
23. Ricciotti E, FitzGerald GA. Prostaglandins and infammation. Arterioscler Thromb Vasc Biol. 2011;31:986-1000.
24. Bos CL, Richel DJ, Ritsema T, Peppelenbosch MP, Versteeg HH. Prostanoids and prostanoid receptors in signal transduction. Int J Biochem Cell Biol. 2004;36:1187-1205.
25. Yuhki K, Kashiwagi H, Kojima F, Kawabe J, Ushikubi F. Roles of prostanoids in the pathogenesis of cardiovascular diseases. Int Angiol. 2010;29(2 Suppl):19-27.
26. Smyth EM, Grosser T, Wang M, Yu Y, FitzGerald GA. Prostanoids in health and disease. J Lipid Res. 2009;50:S423-S428.
27. Fetalvero KM, Shyu M, Nomikos AP, Chiu YF, Wagner RJ, Powell RJ, Hwa J, Martin KA. The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathway. Am J Physiol Heart Circ Physiol. 2006;290:H1337-H1346.
28. Apte RN, Voronov E. Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy? Immunol Rev. 2008;222:222-241.
29. Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci. 2008;13:453-461.
30. Aikawa M, Sivam PN, Kuro-o M, Kimura K, Nakahara K, Takewaki S, Ueda M, Yamaguchi H, Yazaki Y, Periasamy M. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ Res. 1993;73:1000-1012.
31. Gabbiani G. The myofbroblast in wound healing and fbrocontractive diseases. J Pathol. 2003;200:500-503.
32. Jeon ES, Moon HJ, Lee MJ, Song HY, Kim YM, Bae YC, Jung JS, Kim JH. Sphingosylphosphorylcholine induces differentiation of human mes-enchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism. J Cell Sci. 2006;119(Pt 23):4994-5005.
33. Jeon ES, Moon HJ, Lee MJ, Song HY, Kim YM, Cho M, Suh DS, Yoon MS, Chang CL, Jung JS, Kim JH. Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myof-broblast-like cells. Stem Cells. 2008;26:789-797.
34. Liu L, Clipstone NA. Prostaglandin F2alpha induces the normoxic activation of the hypoxia-inducible factor-1 transcription factor in differentiating 3T3-L1 preadipocytes: Potential role in the regulation of adipogenesis. J Cell Biochem. 2008;105:89-98.
35. Rodriguez AM, Elabd C, Delteil F, Astier J, Vernochet C, Saint-Marc P, Guesnet J, Guezennec A, Amri EZ, Dani C, Ailhaud G. Adipocyte differentiation of multipotent cells established from human adipose tissue. Biochem Biophys Res Commun. 2004;315:255-263.
36. Serrero G, Lepak NM, Goodrich SP. Prostaglandin F2 alpha inhibits the differentiation of adipocyte precursors in primary culture. Biochem Biophys Res Commun. 1992;183:438-442.
37. Fujimori K, Ueno T, Amano F. Prostaglandin F(2alpha) suppresses early phase of adipogenesis, but is not associated with osteoblastogenesis in mouse mesenchymal stem cells. Prostaglandins Other Lipid Mediat. 2010;93:52-59.
38. 2 receptors 3 due to the emerging expression of adenylyl cyclase 8. J Cell Physiol. 2006;208:495-505.
39. Woodward DF, Jones RL, Narumiya S. International Union of Basic and Clinical Pharmacology. LXXXIII: classifcation of prostanoid receptors, updating 15 years of progress. Pharmacol Rev. 2011;63:471-538.
40. Feng J, Mantesso A, Sharpe PT. Perivascular cells as mesenchymal stem cells. Expert Opin Biol Ther. 2010;10:1441-1451.
41. Covas DT, Panepucci RA, Fontes AM, Silva WA Jr, Orellana MD, Freitas MC, Neder L, Santos AR, Peres LC, Jamur MC, Zago MA. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profle with CD146+ perivas-cular cells and fbroblasts. Exp Hematol. 2008;36:642-654.
42. Chen CW, Montelatici E, Crisan M, Corselli M, Huard J, Lazzari L, Péault B. Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both? Cytokine Growth Factor Rev. 2009;20:429-434.