Tackling Obstacles for Gene Therapy Targeting Neurons: Disrupting Perineural Nets with Hyaluronidase Improves Transduction

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Wanisch, Klaus ^a   Kovac, Stjepana ^a,b   Schorge, Stephanie ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYALURONIDASE; LENTIVIRUS VECTOR; PROPIDIUM IODIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CELL CULTURE; CELL MATURATION; CELL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGRADATION KINETICS; DRUG DETERMINATION; EXTRACELLULAR MATRIX; GENETIC TRANSDUCTION; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NERVE CELL; NONHUMAN; RAT; SIGNAL TRANSDUCTION; TOXICITY TESTING; VIRAL GENE THERAPY;

ANIMALS; BRAIN; GENETIC THERAPY; GENETIC VECTORS; HEK293 CELLS; HUMANS; HYALURONOGLUCOSAMINIDASE; IMAGE PROCESSING, COMPUTER-ASSISTED; LENTIVIRUS; MALE; NERVE NET; NEUROGENESIS; NEURONS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; TRANSDUCTION, GENETIC;

RATTUS;

EID: 84871882527     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053269     Document Type: Article

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