Effect of cholesterol, cholic acid and cholestyramine administration on the intestinal mRNA expressions related to cholesterol and bile acid metabolism in the rat

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 11, 2007, Pages 1832-1837

  Kamisako, Toshinori ^a   Ogawa, Hiroshi ^a   Yamamoto, Kazuo ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

ABCG5; ABCG8; Liver X receptor ; Multidrug resistance associated protein 2; Multidrug resistance associated protein 3; Small heterodimer partner

Indexed keywords

BILE ACID; BILE SALT; BREAST CANCER RESISTANCE PROTEIN; BREAST CANCER RESISTANCE PROTEIN 5; BREAST CANCER RESISTANCE PROTEIN 8; CHOLESTEROL; CHOLIC ACID; COLESTYRAMINE; HETERODIMER; LIPID; LIVER X RECEPTOR ALPHA; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; BLOOD; CALORIMETRY; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CONTROLLED STUDY; HOMEOSTASIS; LIPID BLOOD LEVEL; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE;

EID: 34948885729     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.04910.x     Document Type: Article

References (23)

1. Lammert F, Wang DQ. New insights into the genetic regulation of intestinal cholesterol absorption. Gastroenterology 2005 129 : 718 34.
2. Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol. Rev. 2003 83 : 633 71.
3. Ory DS. Nuclear receptor signaling in the control of cholesterol homeostasis: have the orphans found a home? Circ. Res. 2004 95 : 660 70.
4. Turley SD, Dietschy JM. Sterol absorption by the small intestine. Curr. Opin. Lipidol. 2003 14 : 233 40.
5. Altmann SW, Davis HR Jr., Zhu LJ fet al. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004 303 : 1201 4.
6. Mottino AD, Hoffman T, Jennes L, Vore M. Expression and localization of multidrug resistant protein mrp2 in rat small intestine. J. Pharmacol. Exp. Ther. 2000 293 : 717 23.
7. Rost D, Mahner S, Sugiyama Y, Stremmel W. Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 2002 282 : G720 26.
8. Love MW, Dawson PA. New insights into bile acid transport. Curr. Opin. Lipidol. 1998 9 : 225 9.
9. Shneider BL. Intestinal bile acid transport: biology, physiology, and pathophysiology. J. Pediatr. Gastroenterol. Nutr. 2001 32 : 407 17.
10. Kamisako T, Ogawa H. Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis. J. Gastroenterol. Hepatol. 2005 20 : 1429 34.
11. Shepherd J, Packard CJ, Bicker S, Lawrie TD, Morgan HG. Cholestyramine promotes receptor-mediated low-density-lipoprotein catabolism. N. Engl. J. Med. 1980 302 : 1219 22.
12. Ast M, Frishman WH. Bile acid sequestrants. J. Clin. Pharmacol. 1990 30 : 99 106.
13. Gustafsson BE, Angelin B, Einarsson K, Gustafsson JA. Influence of cholestyramine on synthesis of cholesterol and bile acids in germfree rats. J. Lipid Res. 1978 19 : 972 7.
14. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 1993 123 : 1939 51.
15. Hatch FT. Practical method for plasma lipoprotein analysis. In : Paletti R, Kritchevsky D, eds. Advance in Lipid Research, Vol. 1. New York and London : Academic Press, 1968 1 68.
16. Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J. Biol. Chem. 2002 277 : 18793 800.
17. Kaneko E, Matsuda M, Yamada Y, Tachibana Y, Shimomura I, Makishima M. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. J. Biol. Chem. 2003 278 : 36091 8.
18. Schultz JR, Tu H, Luk A fet al. Role of LXRs in control of lipogenesis. Genes Dev. 2000 14 : 2831 8.
19. Lu TT, Makishima M, Repa JJ fet al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell 2000 6 : 507 15.
20. Reynier MO, Montet JC, Gerolami A fet al. Comparative effects of cholic, chenodeoxycholic, and ursodeoxycholic acids on micellar solubilization and intestinal absorption of cholesterol. J. Lipid Res. 1981 22 : 467 73.
21. Duan LP, Wang HH, Wang DQ. Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice. J. Lipid Res. 2004 45 : 1312 23.
22. Felgines C, Mazur A, Rayssiguier Y. Effect of the interruption of enterohepatic circulation of bile acids by cholestyramine on apolipoprotein gene expression in the rat. Life Sci. 1994 55 : 1053 60.
23. Duan LP, Wang HH, Ohashi A, Wang DQ. Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects. Am. J. Physiol. Gastrointest. Liver Physiol. 2006 290 : G269 76.