-
1
-
-
80054872790
-
Alcoholic liver disease: Pathogenesis and new therapeutictargets
-
Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutictargets. Gastroenterology 2011; 141:1572-1585
-
(2011)
Gastroenterology
, vol.141
, pp. 1572-1585
-
-
Gao, B.1
Bataller, R.2
-
2
-
-
67649980707
-
Alcoholic liver disease and methionine metabolism
-
Kharbanda KK. Alcoholic liver disease and methionine metabolism. Sem LiverDis 2009; 29:155-165
-
(2009)
Sem LiverDis
, vol.29
, pp. 155-165
-
-
Kharbanda, K.K.1
-
3
-
-
84855281868
-
Mechanisms of alcohol-induced endoplasmic reticulum stress and organinjuries
-
Ji C. Mechanisms of alcohol-induced endoplasmic reticulum stress and organinjuries. Biochemy Res Int 2012; 2012:216450
-
(2012)
Biochemy Res Int
, vol.2012
, pp. 216450
-
-
Ji, C.1
-
4
-
-
84864376275
-
Aberrant hepatic methionine metabolism and genemethylation in the pathogenesis and treatment of alcoholic steatohepatitis
-
Halsted CH, Medici V. Aberrant hepatic methionine metabolism and genemethylation in the pathogenesis and treatment of alcoholic steatohepatitis.Int J Hepatol 2012; 2012:959746
-
(2012)
Int J Hepatol
, vol.2012
, pp. 959746
-
-
Halsted, C.H.1
Medici, V.2
-
5
-
-
33646231787
-
S-adenosylmethionine stabilizescystathionine beta-synthase and modulates redox capacity
-
Prudova A, Bauman Z, Braun A, et al. S-adenosylmethionine stabilizescystathionine beta-synthase and modulates redox capacity. Proc Natl AcadSci USA 2006; 103:6489-6494
-
(2006)
Proc Natl AcadSci USA
, vol.103
, pp. 6489-6494
-
-
Prudova, A.1
Bauman, Z.2
Braun, A.3
-
6
-
-
33845676630
-
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway
-
DOI 10.1016/j.jhep.2006.08.024, PII S0168827806005460
-
Kharbanda KK, Mailliard ME, Baldwin CR, et al. Betaine attenuates alcoholicsteatosis by restoring phosphatidylcholine generation via the phosphatidylethanolaminemethyltransferase pathway. J Hepatol 2007; 46:314-321 (Pubitemid 44959154)
-
(2007)
Journal of Hepatology
, vol.46
, Issue.2
, pp. 314-321
-
-
Kharbanda, K.K.1
Mailliard, M.E.2
Baldwin, C.R.3
Beckenhauer, H.C.4
Sorrell, M.F.5
Tuma, D.J.6
-
7
-
-
77950612408
-
Differences in betaine-homocysteinemethyltransferase expression, endoplasmic reticulum stress response, andliver injury between alcohol-fed mice and rats
-
Shinohara M, Ji C, Kaplowitz N. Differences in betaine- homocysteinemethyltransferase expression, endoplasmic reticulum stress response, andliver injury between alcohol-fed mice and rats. Hepatology 2010; 51:796-805
-
(2010)
Hepatology
, vol.51
, pp. 796-805
-
-
Shinohara, M.1
Ji, C.2
Kaplowitz, N.3
-
8
-
-
79952704984
-
Ethanol exposure modulates hepatic sadenosylmethionineand s-adenosylhomocysteine levels in the isolatedperfused rat liver through changes in the redox state of the NADHNAD(+)system
-
Watson WH, Song Z, Kirpich IA, et al. Ethanol exposure modulates hepatic Sadenosylmethionineand S-adenosylhomocysteine levels in the isolatedperfused rat liver through changes in the redox state of the NADH/NAD(\+)system. Biochim Biophys Acta 2011; 1812:613-618
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 613-618
-
-
Watson, W.H.1
Song, Z.2
Kirpich, I.A.3
-
9
-
-
0002705479
-
S-adenosylmethionine-dependent methyltransferases
-
Carmel R Jacobsen DW Editors. Cambridge: Cambridge University Press
-
Clarke S, Banfield K. S-adenosylmethionine-dependent methyltransferases. Homocysteine in health and disease. In: Carmel R, Jacobsen DW, editors.Cambridge: Cambridge University Press; 2001. pp. 63-78
-
(2001)
Homocysteine in Health and Disease
, pp. 63-78
-
-
Clarke, S.1
Banfield, K.2
-
10
-
-
78149347693
-
Involvement and mechanism of DGAT2 upregulationin the pathogenesis of alcoholic fatty liver disease
-
Wang Z, Yao T, Song Z. Involvement and mechanism of DGAT2 upregulationin the pathogenesis of alcoholic fatty liver disease. J Lipid Res 2010;51:3158-3165
-
(2010)
J Lipid Res
, vol.51
, pp. 3158-3165
-
-
Wang, Z.1
Yao, T.2
Song, Z.3
-
12
-
-
33845941642
-
Isoaspartyl post-translational modification triggers anti-tumor T and B lymphocyte immunity
-
DOI 10.1074/jbc.M604847200
-
Doyle HA, Zhou J, Wolff MJ, et al. Isoaspartyl posttranslational modificationtriggers antitumor T and B lymphocyte immunity. J Biol Chem 2006;281:32676-32683 (Pubitemid 46036823)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.43
, pp. 32676-32683
-
-
Doyle, H.A.1
Zhou, J.2
Wolff, M.J.3
Harvey, B.P.4
Roman, R.M.5
Gee, R.J.6
Koski, R.A.7
Mamula, M.J.8
-
13
-
-
33845945907
-
Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme
-
DOI 10.1074/jbc.M605421200
-
Vigneswara V, Lowenson JD, Powell CD, et al. Proteomic identification ofnovel substrates of a protein isoaspartyl methyltransferase repair enzyme.J Biol Chem 2006; 281:32619-32629 (Pubitemid 46036817)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.43
, pp. 32619-32629
-
-
Vigneswara, V.1
Lowenson, J.D.2
Powell, C.D.3
Thakur, M.4
Bailey, K.5
Clarke, S.6
Ray, D.E.7
Carter, W.G.8
-
15
-
-
27744528446
-
Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: Protection by betaine
-
DOI 10.1016/j.bcp.2005.09.021, PII S0006295205006271
-
Kharbanda KK, Rogers DD 2nd, Mailliard ME, et al. Role of elevatedS-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine.Biochem Pharmacol 2005; 70:1883-1890 (Pubitemid 41612019)
-
(2005)
Biochemical Pharmacology
, vol.70
, Issue.12
, pp. 1883-1890
-
-
Kharbanda, K.K.1
Rogers II, D.D.2
Mailliard, M.E.3
Siford, G.L.4
Barak, A.J.5
Beckenhauer, H.C.6
Sorrell, M.F.7
Tuma, D.J.8
-
16
-
-
27744540546
-
Tubercidin-inducedapoptosis via increased hepatocellular levels of S-adenosylhomocysteine isattenuated by betaine administration
-
Kharbanda KK, Rogers DD 2nd, Beckenhauer HC, et al. Tubercidin- inducedapoptosis via increased hepatocellular levels of S-adenosylhomocysteine isattenuated by betaine administration. Alcohol Clin Exp Res 2005; 29:182A
-
(2005)
Alcohol Clin Exp Res
, vol.29
-
-
Kharbanda, K.K.1
Rogers, I.I.D.D.2
Beckenhauer, H.C.3
-
17
-
-
34247558033
-
Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: Effects on protein-l-isoaspartyl methyltransferase activity
-
DOI 10.1016/j.jhep.2007.01.026, PII S0168827807000712
-
Kharbanda KK, Mailliard ME, Baldwin CR, et al. Accumulation of proteinsbearing atypical isoaspartyl residues in livers of alcohol-fed rats is preventedby betaine administration: effects on protein-L-isoaspartyl methyltransferaseactivity. J Hepatol 2007; 46:1119-1125 (Pubitemid 46669733)
-
(2007)
Journal of Hepatology
, vol.46
, Issue.6
, pp. 1119-1125
-
-
Kharbanda, K.K.1
Mailliard, M.E.2
Baldwin, C.R.3
Sorrell, M.F.4
Tuma, D.J.5
-
18
-
-
67649962630
-
Proteomic characterization of bothaltered protein level and isoaspartate carboxyl methylation in a model ofalcoholic liver disease
-
Carter WG, Vigneswara V, Atkins R, et al. Proteomic characterization of bothaltered protein level and isoaspartate carboxyl methylation in a model ofalcoholic liver disease. Alcohol Clin Exp Res 2008; 32:343A
-
(2008)
Alcohol Clin Exp Res
, vol.32
-
-
Carter, W.G.1
Vigneswara, V.2
Atkins, R.3
-
19
-
-
67649934683
-
Ethanol and hepatic C viral proteinsregulate interferon signaling in liver cells via impaired methylation of STAT1
-
Osna NA, Donohue TM, White RL, et al. Ethanol and hepatic C viral proteinsregulate interferon signaling in liver cells via impaired methylation of STAT1. Hepatology 2008; 48:327A
-
(2008)
Hepatology
, vol.48
-
-
Osna, N.A.1
Donohue, T.M.2
White, R.L.3
-
20
-
-
34848888039
-
Role of transmethylation reactions in alcoholic liver disease
-
Kharbanda KK. Role of transmethylation reactions in alcoholic liver disease.World J Gastroenterol 2007; 13:4947-4954 (Pubitemid 47496826)
-
(2007)
World Journal of Gastroenterology
, vol.13
, Issue.37
, pp. 4947-4954
-
-
Kharbanda, K.K.1
-
21
-
-
73449133690
-
Impaired methylation as a novelmechanism for proteasome suppression in liver cells
-
Osna NA, White RL, Donohue TM Jr, et al. Impaired methylation as a novelmechanism for proteasome suppression in liver cells. Biochem Biophys ResCommun 2010; 391:1291-1296
-
(2010)
Biochem Biophys ResCommun
, vol.391
, pp. 1291-1296
-
-
Osna, N.A.1
White, R.L.2
Donohue Jr., T.M.3
-
22
-
-
84871882435
-
Betaine treatment attenuateschronic ethanol-induced hepatic steatosis and alterations to the mitochondrialrespiratory chain proteome
-
Kharbanda KK, Todero SL, King AL, et al. Betaine treatment attenuateschronic ethanol-induced hepatic steatosis and alterations to the mitochondrialrespiratory chain proteome. Int J Hepatol 2012; 2012:962183
-
(2012)
Int J Hepatol
, vol.2012
, pp. 962183
-
-
Kharbanda, K.K.1
Todero, S.L.2
King, A.L.3
-
23
-
-
0028937163
-
Mice deficient in cystathionine betasynthase:animal models for mild and severe homocyst(e)inemia
-
Watanabe M, Osada J, Aratani Y, et al. Mice deficient in cystathionine betasynthase:animal models for mild and severe homocyst(e)inemia. Proc NatlAcad Sci USA 1995; 92:1585-1589
-
(1995)
Proc NatlAcad Sci USA
, vol.92
, pp. 1585-1589
-
-
Watanabe, M.1
Osada, J.2
Aratani, Y.3
-
24
-
-
0033365298
-
The molecular basis of cystathionine β-synthase deficiency in Dutch patients with homocystinuria: Effect of CBS genotype on biochemical and clinical phenotype and on response to treatment
-
DOI 10.1086/302439
-
Kluijtmans LA, Boers GH, Kraus JP, et al. The molecular basis of cystathioninebeta-synthase deficiency in Dutch patients with homocystinuria: effect of CBSgenotype on biochemical and clinical phenotype and on response to treatment.Am J Hum Genet 1999; 65:59-67 (Pubitemid 30470449)
-
(1999)
American Journal of Human Genetics
, vol.65
, Issue.1
, pp. 59-67
-
-
Kluijtmans, L.A.J.1
Boers, G.H.J.2
Kraus, J.P.3
Van Den Heuvel, L.P.W.J.4
Cruysberg, J.R.M.5
Trijbels, F.J.M.6
Blom, H.J.7
-
25
-
-
0037364454
-
Homocysteine-betaine interactions ina murine model of 5,10-methylenetetrahydrofolate reductase deficiency
-
Schwahn BC, Chen Z, Laryea MD, et al. Homocysteine-betaine interactions ina murine model of 5,10-methylenetetrahydrofolate reductase deficiency.FASEB J 2003; 17:512-514
-
(2003)
FASEB J
, vol.17
, pp. 512-514
-
-
Schwahn, B.C.1
Chen, Z.2
Laryea, M.D.3
-
26
-
-
17844385292
-
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C
-
DOI 10.1002/hep.20664
-
Adinolfi LE, Ingrosso D, Cesaro G, et al. Hyperhomocysteinemia and theMTHFR C677T polymorphism promote steatosis and fibrosis in chronichepatitis C patients. Hepatology 2005; 41:995-1003 (Pubitemid 40593907)
-
(2005)
Hepatology
, vol.41
, Issue.5
, pp. 995-1003
-
-
Adinolfi, L.E.1
Ingrosso, D.2
Cesaro, G.3
Cimmino, A.4
D'Anto, M.5
Capasso, R.6
Zappia, V.7
Ruggiero, G.8
-
27
-
-
77950622833
-
Epigenetic regulation of hepaticendoplasmic reticulum stress pathways in the ethanol-fed cystathionine betasynthase-deficient mouse
-
Esfandiari F, Medici V, Wong DH, et al. Epigenetic regulation of hepaticendoplasmic reticulum stress pathways in the ethanol-fed cystathionine betasynthase-deficient mouse. Hepatology 2010; 51:932-941
-
(2010)
Hepatology
, vol.51
, pp. 932-941
-
-
Esfandiari, F.1
Medici, V.2
Wong, D.H.3
-
28
-
-
84863516824
-
Interstrain differences in liver injury and onecarbonmetabolism in alcohol-fed mice
-
Tsuchiya M, Ji C, Kosyk O, et al. Interstrain differences in liver injury and onecarbonmetabolism in alcohol-fed mice. Hepatology 2012; 56:130-139
-
(2012)
Hepatology
, vol.56
, pp. 130-139
-
-
Tsuchiya, M.1
Ji, C.2
Kosyk, O.3
-
29
-
-
0036676924
-
Spontaneousoxidative stress and liver tumors in mice lacking methionine adenosyltransferase1A
-
Martinez-Chantar ML, Corrales FJ, Martinez-Cruz LA, et al. Spontaneousoxidative stress and liver tumors in mice lacking methionine adenosyltransferase1A. FASEB J 2002; 16:1292-1294
-
(2002)
FASEB J
, vol.16
, pp. 1292-1294
-
-
Martinez-Chantar, M.L.1
Corrales, F.J.2
Martinez-Cruz, L.A.3
-
30
-
-
42249100305
-
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
-
DOI 10.1002/hep.22159
-
Martinez-Chantar ML, Vazquez-Chantada M, Ariz U, et al. Loss of the glycineN-methyltransferase gene leads to steatosis and hepatocellular carcinoma inmice. Hepatology 2008; 47:1191-1199 (Pubitemid 351547905)
-
(2008)
Hepatology
, vol.47
, Issue.4
, pp. 1191-1199
-
-
Martinez-Chantar, M.L.1
Vazquez-Chantada, M.2
Ariz, U.3
Martinez, N.4
Varela, M.5
Luka, Z.6
Capdevila, A.7
Rodriguez, J.8
Aransay, A.M.9
Matthiesen, R.10
Yang, H.11
Calvisi, D.F.12
Esteller, M.13
Fraga, M.14
Lu, S.C.15
Wagner, C.16
Mato, J.M.17
-
31
-
-
80054691714
-
Deletion of betaine-homocysteineS-methyltransferase in mice perturbs choline and 1-carbon metabolism,resulting in fatty liver and hepatocellular carcinomas
-
Teng YW, Mehedint MG, Garrow TA, Zeisel SH. Deletion of betaine-homocysteineS-methyltransferase in mice perturbs choline and 1-carbon metabolism,resulting in fatty liver and hepatocellular carcinomas. J Biol Chem2011; 286:36258-36267
-
(2011)
J Biol Chem
, vol.286
, pp. 36258-36267
-
-
Teng, Y.W.1
Mehedint, M.G.2
Garrow, T.A.3
Zeisel, S.H.4
-
32
-
-
73349111259
-
Variant in PNPLA3 is associatedwith alcoholic liver disease
-
Tian C, Stokowski RP, Kershenobich D, et al. Variant in PNPLA3 is associatedwith alcoholic liver disease. Nat Genet 2010; 42:21-23
-
(2010)
Nat Genet
, vol.42
, pp. 21-23
-
-
Tian, C.1
Stokowski, R.P.2
Kershenobich, D.3
-
33
-
-
60749090926
-
S-adenosylmethionine regulatesapurinic/apyrimidinic endonuclease 1 stability: Implication in hepatocarcinogenesis
-
Tomasi ML, Iglesias-Ara A, Yang H, et al. S-adenosylmethionine regulatesapurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.Gastroenterology 2009; 136:1025-1036
-
(2009)
Gastroenterology
, vol.136
, pp. 1025-1036
-
-
Tomasi, M.L.1
Iglesias-Ara, A.2
Yang, H.3
-
34
-
-
77952707958
-
S-adenosylmethionine regulatesdual-specificity mitogen-activated protein kinase phosphatase expression inmouse and human hepatocytes
-
Tomasi ML, Ramani K, Lopitz-Otsoa F, et al. S-adenosylmethionine regulatesdual-specificity mitogen-activated protein kinase phosphatase expression inmouse and human hepatocytes. Hepatology 2010; 51:2152-2161
-
(2010)
Hepatology
, vol.51
, pp. 2152-2161
-
-
Tomasi, M.L.1
Ramani, K.2
Lopitz-Otsoa, F.3
-
35
-
-
84865502592
-
Hepatomacells from mice deficient in glycine N-methyltransferase have increasedRAS signaling and activation of liver kinase B1
-
Martinez-Lopez N, Garcia-Rodriguez JL, Varela-Rey M, et al. Hepatomacells from mice deficient in glycine N-methyltransferase have increasedRAS signaling and activation of liver kinase B1. Gastroenterology 2012;143:787-798
-
(2012)
Gastroenterology
, vol.143
, pp. 787-798
-
-
Martinez-Lopez, N.1
Garcia-Rodriguez, J.L.2
Varela-Rey, M.3
-
36
-
-
53849134138
-
S-adenosylmethionineand proliferation: New pathways, new targets
-
Martinez-Lopez N, Varela-Rey M, Ariz U, et al. S-adenosylmethionineand proliferation: new pathways, new targets. Biochem Soc Trans 2008;36:848-852
-
(2008)
Biochem Soc Trans
, vol.36
, pp. 848-852
-
-
Martinez-Lopez, N.1
Varela-Rey, M.2
Ariz, U.3
-
37
-
-
79953019668
-
GNMT expression increases hepatic folatecontents and folate-dependent methionine synthase-mediated homocysteineremethylation
-
Wang YC, Chen YM, Lin YJ, et al. GNMT expression increases hepatic folatecontents and folate-dependent methionine synthase-mediated homocysteineremethylation. Mol Med 2011; 17:486-494
-
(2011)
Mol Med
, vol.17
, pp. 486-494
-
-
Wang, Y.C.1
Chen, Y.M.2
Lin, Y.J.3
-
38
-
-
77955849533
-
Impaired homocysteine transsulfurationis an indicator of alcoholic liver disease
-
Medici V, Peerson JM, Stabler SP, et al. Impaired homocysteine transsulfurationis an indicator of alcoholic liver disease. J Hepatol 2010; 53:551-557
-
(2010)
J Hepatol
, vol.53
, pp. 551-557
-
-
Medici, V.1
Peerson, J.M.2
Stabler, S.P.3
-
40
-
-
80055103499
-
S-adenosyl-L-methionine treatment foralcoholic liver disease: A double-blinded, randomized, placebo-controlled trial
-
Medici V, Virata MC, Peerson JM, et al. S-adenosyl-L-methionine treatment foralcoholic liver disease: a double-blinded, randomized, placebo-controlled trial.Alcohol Clin Exp Res 2011; 35:1960-1965
-
(2011)
Alcohol Clin Exp Res
, vol.35
, pp. 1960-1965
-
-
Medici, V.1
Virata, M.C.2
Peerson, J.M.3
|