Increased gait variability in mice with small cerebellar cortex lesions and normal rotarod performance

Behavioural Brain Research

Volumn 241, Issue 1, 2013, Pages 32-37

  Stroobants, Stijn ^a   Gantois, Ilse ^a   Pooters, Tine ^a   D'Hooge, Rudi ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Ataxia; Behavioural testing; Cerebellar lesioned mice; Rotarod; Treadmill gait analysis

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CEREBELLUM CORTEX; CEREBELLUM INJURY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FUNCTIONAL ASSESSMENT; GAIT; LATENT PERIOD; LOCOMOTION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ROTAROD TEST; TASK PERFORMANCE; WALKING SPEED;

ANIMALS; CEREBELLAR CORTEX; FEMALE; GAIT; MICE; MOTOR ACTIVITY; ROTAROD PERFORMANCE TEST;

EID: 84871827714     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.11.034     Document Type: Article

References (56)

1. Bailey K.R., Rustay N.R., Crawley J.N. Behavioral phenotyping of transgenic and knockout mice: practical concerns and potential pitfalls. ILAR Journal 2006, 47:124-131.
2. Dunham N.W., Miya T.S. A note on a simple apparatus for detecting neurological deficit in rats and mice. Journal of the American Pharmaceutical Association (Baltimore) 1957, 46:208-209.
3. Gunn R.K., Keenan M.E., Brown R.E. Analysis of sensory, motor and cognitive functions of the coloboma (C3Sn.Cg-Cm/J) mutant mouse. Genes, Brain and Behavior 2011, 10:579-588.
4. Truong D.T., Venna V.R., McCullough L.D., Fitch R.H. Deficits in auditory, cognitive, and motor processing following reversible middle cerebral artery occlusion in mice. Experimental Neurology 2012, 238:114-121.
5. Yokoi F., Dang M.T., Yang G., Li J., Doroodchi A., Zhou T., et al. Abnormal nuclear envelope in the cerebellar Purkinje cells and impaired motor learning in DYT11 myoclonus-dystonia mouse models. Behavioural Brain Research 2012, 227:12-20.
6. Chang M., Cooper J.D., Sleat D.E., Cheng S.H., Dodge J.C., Passini M.A., et al. Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis. Molecular Therapy 2008, 16:649-656.
7. Stroobants S., Leroy T., Eckhardt M., Aerts J.M., Berckmans D., D'Hooge R. Early signs of neurolipidosis-related behavioural alterations in a murine model of metachromatic leukodystrophy. Behavioural Brain Research 2008, 189:306-316.
8. Varejao A.S., Meek M.F., Ferreira A.J., Patricio J.A., Cabrita A.M. Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis. Journal of Neuroscience Methods 2001, 108:1-9.
9. Rushton R., Steinberg H., Tinson C. Effects of a single experience on subsequent reactions to drugs. British Journal of Pharmacology and Chemotherapy 1963, 20:99-105.
10. Schallert T., Whishaw I.Q., Ramirez V.D., Teitelbaum P. Compulsive abnormal walking caused by anticholinergics in akinetic, 6-hydroxydopamine-treated rats. Science 1978, 199:1461-1463.
11. Jolicoeur F.B., Rondeau D.B., Hamel E., Butterworth R.F., Barbeau A. Measurement of ataxia and related neurological signs in the laboratory rat. Canadian Journal of Neurological Sciences 1979, 6:209-215.
12. Knippenberg S., Thau N., Dengler R., Petri S. Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS). Behavioural Brain Research 2010, 213:82-87.
13. Filali M., Lalonde R., Rivest S. Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis. Behavioural Brain Research 2011, 225:215-221.
14. Baldo G., Mayer F.Q., Martinelli B., Dilda A., Meyer F., Ponder K.P., et al. Evidence of a progressive motor dysfunction in Mucopolysaccharidosis type I mice. Behavioural Brain Research 2012, 233:169-175.
15. Gerlai R. Phenomics: fiction or the future. Trends in Neurosciences 2002, 25:506-509.
16. Hamers F.P., Lankhorst A.J., van Laar T.J., Veldhuis W.B., Gispen W.H. Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries. Journal of Neurotrauma 2001, 18:187-201.
17. Hampton T.G., Stasko M.R., Kale A., Amende I., Costa A.C. Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiology and Behavior 2004, 82:381-389.
18. Wooley C.M., Sher R.B., Kale A., Frankel W.N., Cox G.A., Seburn K.L. Gait analysis detects early changes in transgenic SOD1(G93A) mice. Muscle and Nerve 2005, 32:43-50.
19. Guillot T.S., Asress S.A., Richardson J.R., Glass J.D., Miller G.W. Treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease or amyotrophic lateral sclerosis. Journal of Motor Behavior 2008, 40:568-577.
20. Koopmans G.C., Deumens R., Brook G., Gerver J., Honig W.M., Hamers F.P., et al. Strain and locomotor speed affect over-ground locomotion in intact rats. Physiology and Behavior 2007, 92:993-1001.
21. Cendelin J., Voller J., Vozeh F. Ataxic gait analysis in a mouse model of the olivocerebellar degeneration. Behavioural Brain Research 2010, 210:8-15.
22. Brooks S.P., Dunnett S.B. Tests to assess motor phenotype in mice: a user's guide. Nature Reviews Neuroscience 2009, 10:519-529.
23. Vandeputte C., Taymans J.M., Casteels C., Coun F., Ni Y., Van Laere K., et al. Automated quantitative gait analysis in animal models of movement disorders. BMC Neuroscience 2010, 11:92.
24. Mancuso R., Olivan S., Osta R., Navarro X. Evolution of gait abnormalities in SOD1(G93A) transgenic mice. Brain Research 2011, 1406:65-73.
25. Sherrard R.M. Cerebellar control of fine motor function. Animal models of movement disorders Vol. II 2011, 263-279. Humana Press, New York. E.L. Lane, S.B. Dunnett (Eds.).
26. Goddyn H., Leo S., Meert T., D'Hooge R. Differences in behavioural test battery performance between mice with hippocampal and cerebellar lesions. Behavioural Brain Research 2006, 173:138-147.
27. Meng H., Larson S.K., Gao R., Qiao X. BDNF transgene improves ataxic and motor behaviors in stargazer mice. Brain Research 2007, 1160:47-57.
28. Ferdinandusse S., Zomer A.W., Komen J.C., van den Brink C.E., Thanos M., Hamers F.P., et al. Ataxia with loss of Purkinje cells in a mouse model for Refsum disease. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:17712-17717.
29. Plomp J.J., van den Maagdenberg A.M., Kaja S. The ataxic Cacna1a-mutant mouse rolling nagoya: an overview of neuromorphological and electrophysiological findings. Cerebellum 2009, 8:222-230.
30. Ranade S.C., Sarfaraz Nawaz M., Kumar Rambtla P., Rose A.J., Gressens P., Mani S. Early protein malnutrition disrupts cerebellar development and impairs motor coordination. British Journal of Nutrition 2012, 107:1167-1175.
31. Paxinos G., Franklin K.B.J. The mouse brain in stereotaxic coordinates 2001, Academic Press, San Diego. 2nd ed.
32. Leroy T., Silva M., D'Hooge R., Aerts J.M., Berckmans D. Automated gait analysis in the open-field test for laboratory mice. Behavior Research Methods 2009, 41:148-153.
33. Leroy T., Stroobants S., Aerts J.M., D'Hooge R., Berckmans D. Automatic analysis of altered gait in arylsulphatase A-deficient mice in the open field. Behavior Research Methods 2009, 41:787-794.
34. Berntson G.G., Schumacher K.M. Effects of cerebellar lesions on activity, social interactions, and other motivated behaviors in the rat. Journal of Comparative and Physiological Psychology 1980, 94:706-717.
35. Joyal C.C., Meyer C., Jacquart G., Mahler P., Caston J., Lalonde R. Effects of midline and lateral cerebellar lesions on motor coordination and spatial orientation. Brain Research 1996, 739:1-11.
36. Oliver P.L., Keays D.A., Davies K.E. Behavioural characterisation of the robotic mouse mutant. Behavioural Brain Research 2007, 181:239-247.
37. Auvray N., Caston J., Reber A., Stelz T. Role of the cerebellum in the ontogenesis of the equilibrium behavior in the young rat: a behavioral study. Brain Research 1989, 505:291-301.
38. Caston J., Jones N., Stelz T. Role of preoperative and postoperative sensorimotor training on restoration of the equilibrium behavior in adult mice following cerebellectomy. Neurobiology of Learning and Memory 1995, 64:195-202.
39. Zion C., Auvray N., Caston J., Reber A., Stelz T. Effects of cerebellectomy at day 15 on the ontogenesis of the equilibrium behavior in the rat. Brain Research 1990, 515:104-110.
40. Lin C.H., Tallaksen-Greene S., Chien W.M., Cearley J.A., Jackson W.S., Crouse A.B., et al. Neurological abnormalities in a knock-in mouse model of Huntington's disease. Human Molecular Genetics 2001, 10:137-144.
41. Kale A., Amende I., Meyer G.P., Crabbe J.C., Hampton T.G. Ethanol's effects on gait dynamics in mice investigated by ventral plane videography. Alcoholism, Clinical and Experimental Research 2004, 28:1839-1848.
42. Amende I., Kale A., McCue S., Glazier S., Morgan J.P., Hampton T.G. Gait dynamics in mouse models of Parkinson's disease and Huntington's disease. Journal of NeuroEngineering and Rehabilitation 2005, 2:20.
43. Gomez-Sintes R., Lucas J.J. NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. Journal of Clinical Investigation 2010, 120:2432-2445.
44. Stroobants S., Gerlach D., Matthes F., Hartmann D., Fogh J., Gieselmann V., et al. Intracerebroventricular enzyme infusion corrects central nervous system pathology and dysfunction in a mouse model of metachromatic leukodystrophy. Human Molecular Genetics 2011, 20:2760-2769.
45. Damme M., Stroobants S., Walkley S.U., Lullmann-Rauch R., D'Hooge R., Fogh J., et al. Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in alpha-mannosidosis. Journal of Neuropathology and Experimental Neurology 2011, 70:83-94.
46. Serrao M., Pierelli F., Ranavolo A., Draicchio F., Conte C., Don R., et al. Gait pattern in inherited cerebellar ataxias. Cerebellum 2012, 11:194-211.
47. Callisaya M.L., Blizzard L., Schmidt M.D., Martin K.L., McGinley J.L., Sanders L.M., et al. Gait, gait variability and the risk of multiple incident falls in older people: a population-based study. Age and Ageing 2011, 40:481-487.
48. Reelick M.F., Kessels R.P., Faes M.C., Weerdesteyn V., Esselink R.A. Olde Rikkert MG. Increased intra-individual variability in stride length and reaction time in recurrent older fallers. Aging Clinical and Experimental Research 2011, 23:393-399.
49. Wuehr M, Schniepp R, Ilmberger J, Brandt T, Jahn K. Speed-dependent temporospatial gait variability and long-range correlations in cerebellar ataxia. Gait Posture; doi:10.1016/j.gaitpost.2012.07.003.
50. Morton S.M., Bastian A.J. Mechanisms of cerebellar gait ataxia. Cerebellum 2007, 6:79-86.
51. Pereira J.E., Cabrita A.M., Filipe V.M., Bulas-Cruz J., Couto P.A., Melo-Pinto P., et al. A comparison analysis of hindlimb kinematics during overground and treadmill locomotion in rats. Behavioural Brain Research 2006, 172:212-218.
52. Herbin M., Hackert R., Gasc J.P., Renous S. Gait parameters of treadmill versus overground locomotion in mouse. Behavioural Brain Research 2007, 181:173-179.
53. Shiotsuki H., Yoshimi K., Shimo Y., Funayama M., Takamatsu Y., Ikeda K., et al. A rotarod test for evaluation of motor skill learning. Journal of Neuroscience Methods 2010, 189:180-185.
54. D'Hooge R., Lullmann-Rauch R., Beckers T., Balschun D., Schwake M., Reiss K., et al. Neurocognitive and psychotiform behavioral alterations and enhanced hippocampal long-term potentiation in transgenic mice displaying neuropathological features of human alpha-mannosidosis. Journal of Neuroscience 2005, 25:6539-6549.
55. Monville C., Torres E.M., Dunnett S.B. Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model. Journal of Neuroscience Methods 2006, 158:219-223.
56. Pallier P.N., Drew C.J., Morton A.J. The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function. Brain Research Bulletin 2009, 78:347-355.