Feasibility and effects of patient-cooperative robot-aided gait training applied in a 4-week pilot trial

Journal of NeuroEngineering and Rehabilitation

Volumn 9, Issue 1, 2012, Pages

  Schück, Alex ^b,d   Labruyère, Rob ^b,c   Vallery, Heike ^a,b,f   Riener, Robert ^a,b   Duschau Wicke, Alexander ^a,b,e  

^a Institute of Robotics and Intelligent Systems   (Switzerland)

^b BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d University College Physiotherapy Thim Van der Laan   (Switzerland)

^e HOCOMA AG   (Switzerland)

^f KHALIFA UNIVERSITY   (United Arab Emirates)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE BEHAVIOR; ADOLESCENT; ADULT; AGED; ARTICLE; BODY WEIGHT; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COMPUTER INTERFACE; EXERCISE; FEASIBILITY STUDY; FEMALE; GAIT; HUMAN; MALE; MIDDLE AGED; NEUROLOGIC GAIT DISORDER; PARESIS; PATIENT COMPLIANCE; PHYSICAL EDUCATION; PHYSIOLOGY; PILOT STUDY; ROBOTICS; SPINAL CORD INJURY; STATISTICAL MODEL; TREATMENT OUTCOME; WALKING;

ADOLESCENT; ADULT; AGED; BODY WEIGHT; FEASIBILITY STUDIES; FEEDBACK, PSYCHOLOGICAL; FEMALE; GAIT; GAIT DISORDERS, NEUROLOGIC; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; PARESIS; PATIENT COMPLIANCE; PHYSICAL EDUCATION AND TRAINING; PHYSICAL EXERTION; PILOT PROJECTS; ROBOTICS; SPINAL CORD INJURIES; STROKE; TREATMENT OUTCOME; USER-COMPUTER INTERFACE; WALKING; YOUNG ADULT;

MLCS; MLOWN;

EID: 84871818473     PISSN: None     EISSN: 17430003     Source Type: Journal    
DOI: 10.1186/1743-0003-9-31     Document Type: Article

References (78)

1. The Bobath concept: a critical review of the theoretical assumptions that guide physiotherapy practice in stroke rehabilitation. Lennon S, Phys Therapy Rev 1996 35 45
2. Seligman MEP, Helplessness: On Depression, Development, and Death San Francisco: WH Freeman 1975
3. Technique to improve chronic motor deficit after stroke. Taub E, Miller NE, Novack TA, Cook EW, Fleming WC, Nepomuceno CS, Connell JS, Crago JE, Arch Phys Med Rehabilitation 1993 74 4 347 354
4. Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial. Wolf SL, Winstein CJ, Miller JP, Taub E, Uswatte G, Morris D, Giuliani C, Light KE, Nichols-Larsen D, for the EXCITE Investigators, JAMA 2006 296 17 2095 2104 10.1001/jama.296.17.2095 17077374
5. Retention of upper limb function in stroke survivors who have received constraint-induced movement therapy: the EXCITE randomised trial. Wolf SL, Winstein CJ, Miller JP, Thompson PA, Taub E, Uswatte G, Morris D, Blanton S, Nichols-Larsen D, Clark PC, Lancet Neurol 2008 7 1 33 40 10.1016/S1474-4422(07) 70294-6 18077218
6. Constraint-induced therapy versus dose-matched control intervention to improve motor ability, basic/extended daily functions, and quality of life in stroke. Lin K-C, Wu C-Y, Liu J-S, Chen Y-T, Hsu C-J, Neurorehabil Neural Repair 2009 23 2 160 165 18981188
7. Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury. Maier IC, Baumann K, Thallmair M, Weinmann O, Scholl J, Schwab ME, J Neurosci 2008 28 38 9386 9403 10.1523/JNEUROSCI.1697-08.2008 18799672
8. Description and application of a system for locomotor rehabilitation. Barbeau H, Wainberg M, Finch L, Med Biol Eng Comput 1987 25 3 341 344 10.1007/BF02447435 3449731
9. Optimal outcomes obtained with body-Weight support combined with treadmill training in stroke subjects. Barbeau H, Visintin M, Arch Phys Med Rehabilitation 2003 84 10 1458 1465 10.1016/S0003-9993(03)00361-7
10. Physical determinants, emerging concepts, and training approaches in gait of individuals with spinal cord injury. Barbeau H, Nadeau S, Garneau C, J Neurotrauma 2006 23 3-4 571 585 10.1089/neu.2006.23.571 16629638
11. Implications of assist-as-needed robotic step training after a complete spinal cord injury on intrinsic strategies of motor learning. Cai LL, Fong AJ, Otoshi CK, Liang Y, Burdick JW, Roy RR, Edgerton VR, J Neurosci 2006 26 41 10564 10568 10.1523/JNEUROSCI.2266-06.2006 17035542
12. Activity-based therapies. Dromerick A, Lum P, Hidler J, NeuroRX 2006 3 4 428 438 10.1016/j.nurx.2006.07.004 17012056
13. A treadmill apparatus and harness support for evaluation and rehabilitation of gait. Norman K, Pepin A, Ladouceur M, Barbeau H, Arch Phys Med Rehabilitation 1995 76 8 772 778 10.1016/S0003-9993(95)80533-8
14. A new approach to retrain gait in stroke patients through body weight support and treadmill stimulation. Visintin M, Barbeau H, Korner-Bitensky N, Mayo NE, Stroke; J Cerebral Circulation 1998 29 6 1122 1128 10.1161/01.STR.29.6. 1122 23269862
15. Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI. Dobkin B, Apple D, Barbeau H, Basso M, Behrman A, Deforge D, Ditunno J, Dudley G, Elashoff R, Fugate L, Harkema S, Saulino M, Scott M, Neurology 2006 66 4 484 493 10.1212/01.wnl.0000202600.72018.39 16505299
16. Weight-supported treadmill versus over-ground training after spinal cord injury: from a physical therapist's point of view. van Hedel Hubertus JA, PHYS THER 2006 86 10 1444 1447 10.2522/ptj.2006.86.10.1444 17012649
17. Effects of task-specific locomotor and strength training in adults who were ambulatory after stroke: results of the STEPS randomized clinical trial. Sullivan KJ, Brown DA, Klassen T, Mulroy S, Ge T, Azen SP, Winstein CJ, Phys Therapy 2007 87 12 1580 1602 10.2522/ptj.20060310
18. Treadmill training of paraplegic patients using a robotic orthosis. Colombo G, Joerg M, Schreier R, Dietz V, J Rehabil Res Dev 2000 37 6 693 700 11321005
19. Locomotor training in subjects with sensori-motor deficits: an overview of the robotic gait orthosis Lokomat. Riener R, Lünenburger L, Maier I, Colombo G, Dietz V, J Healthcare Eng 2010 1 2 216
20. A mechanized gait trainer for restoration of gait. Hesse S, Uhlenbrock D, J Rehabilitation Res Dev 2000 37 6 701 708
21. Robotic gait-assisted therapy in patients with neurological injury. Sayers SP, Krug J, Missouri Med 2008 105 2 153 158 18453195
22. Gait rehabilitation machines based on programmable footplates. Schmidt H, Werner C, Bernhardt R, Hesse S, Krüger Jörg, J Neuroengineering Rehabilitation 2007 4 2+ 10.1186/1743-0003-4-2
23. Design and evaluation of the LOPES exoskeleton robot for interactive gait rehabilitation. Veneman JF, Kruidhof R, Hekman EEG, Ekkelenkamp R, Van Asseldonk EHF, van der Kooij H, IEEE Trans Neural Syst Rehabil Eng 2007 15 3 379 386 17894270
24. Active Leg Exoskeleton (ALEX) for gait rehabilitation of motor-impaired patients. Banala SK, Agrawal SK, Scholz JP, Proc IEEE 10th Int Conf Rehabil Robot Noordwijk 2007 401 407
25. A robot and control algorithm that can synchronously assist in naturalistic motion during body-weight-supported gait training following neurologic injury. Aoyagi D, Ichinose WE, Harkema SJ, Reinkensmeyer DJ, Bobrow JE, IEEE Trans Neural Syst Rehabil Eng 2007 15 3 387 400 17894271
26. Lower extremity exoskeletons and active orthoses: challenges and state-of-the-art. Dollar AM, Herr H, Robotics IEEE Trans on 2008 24 1 144 158
27. Electromechanical-assisted training for walking after stroke. Mehrholz J, Werner C, Kugler J, Pohl M, Cochrane Database of Systematic Rev (Online) 2007 4
28. Locomotor training for walking after spinal cord injury. Mehrholz J, Kugler J, Pohl M, Cochrane Database of Systematic Rev (Online) 2008 2
29. Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study. Husemann B, Müller F, Krewer C, Heller S, Koenig E, Stroke; J Cerebral Circulation 2007 38 2 349 354 10.1161/01.STR.0000254607.48765.cb 23269862
30. Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the lokomat gait orthosis. Mayr A, Kofler M, Quirbach E, Matzak H, Frohlich K, Saltuari L, Neurorehabil Neural Repair 2007 21 4 307 314 10.1177/1545968307300697 17476001
31. The effectiveness of locomotor therapy using robotic-assisted gait training in subacute stroke patients: a randomized controlled trial. Schwartz I, Sajin A, Fisher I, Neeb M, Shochina M, Katz-Leurer M, Meiner Z, PM R: J Injury, Funct, Rehabilitation 2009 1 6 516 523 10.1016/j.pmrj.2009.03.009
32. Pilot study of Lokomat versus manual-assisted treadmill training for locomotor recovery post-stroke. Westlake Kelly, Patten C, J NeuroEngineering Rehabilitation 2009 6 1 18+ 10.1186/1743-0003-6-18
33. Multicenter randomized clinical trial evaluating the effectiveness of the Lokomat in subacute stroke. Hidler J, Nichols D, Pelliccio M, Brady K, Campbell DD, Kahn JH, Hornby GT, Neurorehabil Neural Repair 2009 23 1 5 13 19109447
34. Enhanced gait-related improvements after therapist- versus robotic-assisted locomotor training in subjects with chronic stroke: a randomized controlled study. Hornby GT, Campbell DD, Kahn JH, Demott T, Moore JL, Roth HR, Stroke 2008 39 6 1786 1792 10.1161/STROKEAHA.107.504779 18467648
35. Synaptic weight noise during MLP learning enhances fault-tolerance, generalisation and learning trajectory. Murray AF, Edwards PJ, IEEE Trans on Neural Networks 1993 5 5 792 802
36. Bernstein NA, The Co-ordination and regulation of movements First English edition. Pergamon Press Ltd. 1967
37. Impedance control-an approach to manipulation. I-Theory. II-Implementation. III-Applications. Hogan N, ASME Trans J Dynamic Syst Meas Control B 1985 107 1 24 10.1115/1.3140702
38. Patient-cooperative strategies for robot-aided treadmill training: first experimental results. Riener R, Lünenburger L, Jezernik S, Anderschitz M, Colombo G, Dietz V, IEEE Trans Neural Syst Rehabil Eng 2005 13 3 380 394 10.1109/TNSRE.2005.848628 16200761
39. Robotic movement training as an optimization problem: designing a controller that assists only as needed. Emken JL, Bobrow JE, Reinkensmeyer DJ, IEEE Int. Conf. on Rehabilitation Robotics (ICORR) Chicago 2005 307 312
40. Robotics, motor learning, and neurologic recovery. Reinkensmeyer DJ, Emken JL, Cramer SC, Ann Rev Biomed Eng 2004 6 497 525 10.1146/annurev.bioeng.6. 040803.140223
41. Patient-driven control of FES-supported standing up: a simulation study. Riener R, Fuhr T, Rehabilitation Eng, IEEE Trans on 1998 6 2 113 124 10.1109/86.681177
42. Automatic gait-pattern adaptation algorithms for rehabilitation with a 4-DOF robotic orthosis. Jezernik S, Colombo G, Morari M, IEEE Trans Robot Autom 2004 20 3 574 582 10.1109/TRA.2004.825515
43. Human-centered rehabilitation robotics. Riener R, Frey M, Bernhardt M, Nef T, Colombo G, Rehabilitation Robotics, 2005. ICORR 2005. 9th International Conference on. 2005 319 322
44. Tools for understanding and optimizing robotic gait training. Reinkensmeyer DJ, Aoyagi D, Emken JL, Galvez JA, Ichinose W, Kerdanyan G, Maneekobkunwong S, Minakata K, Nessler JA, Weber R, Roy RR, de Leon R, Bobrow JE, Harkema SJ, Edgerton VR, J Rehabil Res Dev 2006 43 5 657 670 10.1682/JRRD.2005.04.0073 17123206
45. The effects on kinematics and muscle activity of walking in a robotic gait trainer during zero-force control. van Asseldonk EHF, Veneman JF, Ekkelenkamp R, Buurke JH, van der Helm FCT, van der Kooij H, IEEE Trans Neural Syst Rehabil Eng 2008 16 4 360 370 18713676
46. Patient-cooperative control: providing safe support without restricting movement. Vallery H, Guidali M, Duschau-Wicke A, Riener R, World Congress on Medical Physics and Biomedical Engineering, September 7-12, 2009, Munich, Germany Berlin, Heidelberg: Springer Berlin Heidelberg, Dössel Olaf, Schlegel WolfgangC., 2009 166 169
47. Feasibility of manual teach-and-replay and continuous impedance shaping for robotic locomotor training following spinal cord injury. Emken JL, Harkema SJ, Beres-Jones JA, Ferreira CK, Reinkensmeyer DJ, IEEE Trans Biomed Eng 2008 55 1 322 334 18232376
48. Review of control strategies for robotic movement training after neurologic injury. Marchal Crespo L, Reinkensmeyer D, J Neuroengineering rehabilitation 2009 6 1 20+ 10.1186/1743-0003-6-20
49. Effects of consistency vs. variability in robotically controlled training of stepping in adult spinal mice. Cai LL, Fong AJ, Otoshi CK, Liang YQ, Cham JG, Zhong H, Roy RR, Edgerton VR, Burdick JW, Chicago 2005
50. Path control: a method for patient-cooperative robot-aided gait rehabilitation. Duschau-Wicke A, von Zitzewitz J, Caprez A, Lünenburger L, Riener R, IEEE Trans Neural Syst Rehabilitation Eng 2010 18 1 38 48
51. Patient-cooperative control increases active participation of individuals with SCI during robot-aided gait training. Duschau-Wicke A, Caprez A, Riener R, J NeuroEngineering Rehabilitation 2010 7 1 43+ 10.1186/1743-0003-7-43
52. A novel mechatronic body weight support system. Frey M, Colombo G, Vaglio M, Bucher R, Jörg M, Riener R, IEEE Trans Neural Syst Rehabil Eng 2006 14 3 311 321 10.1109/TNSRE.2006.881556 17009491
53. Generalized elasticities improve patient-cooperative control of rehabilitation robots. Vallery H, Duschau-Wicke A, Riener R, IEEE Int Conf on Rehabilitation Robotics (ICORR). 2009 535 541
54. Optimized passive dynamics improve transparency of haptic devices. Vallery H, Duschau-Wicke A, Riener R, IEEE Int Conf Robot Aut (ICRA). 2009 301 306
55. A Novel method for automatic treadmill speed adaptation. von Zitzewitz J, Bernhardt M, Riener R, IEEE Trans Neural Syst Rehabil Eng 2007 15 3 401 409 17894272
56. International standards for neurological and functional classification of spinal cord injury. Maynard FM, Bracken MB, Creasey G, Ditunno JF, Donovan WH, Ducker TB, Garber SL, Marino RJ, Stover SL, Tator CH, Others, Spinal Cord 1997 35 266 274 10.1038/sj.sc.3100432 9160449
57. The Spinal Cord Independence Measure (SCIM) version III: reliability and validity in a multi-center international study. Itzkovich M, Gelernter I, Biering-Sorensen F, Weeks C, Laramee MT, Craven BC, Tonack M, Hitzig SL, Glaser E, Zeilig G, Aito S, Scivoletto G, Mecci M, Chadwick RJ, Masry WS, Osman A, Glass CA, Silva P, Soni BM, Gardner BP, Savic G, Bergström EM, Bluvshtein V, Ronen J, Catz A, Disabil Rehabil 2007 29 24 1926 1933 10.1080/ 09638280601046302 17852230
58. On the reliability and validity of manual muscle testing: a literature review. Cuthbert SC, Goodheart GJ, Chiropractic Osteopathy 2007 15 4+ 10.1186/1746-1340-15-4 17341308
59. Common errors and clinical guidelines for manual muscle testing: the arm test and other inaccurate procedures. Schmitt WH, Cuthbert SC, Chiropractic Osteopathy 2008 16 16+ 10.1186/1746-1340-16-16 19099575
60. Mini-mental state examination. Cockrell JR, Folstein MF, Principles Pract Geriatric Psychiatry 1988 140 141
61. Walking index for spinal cord injury (WISCI II): scale revision. Dittuno PL, Dittuno JF, Spinal Cord 2001 39 654 656 10.1038/sj.sc.3101223 11781863
62. Walking during daily life can be validly and responsively assessed in subjects with a spinal cord injury. van Hedel HJ, Dietz V, European multicenter study on human spinal cord injury EM-SCI study group, Neurorehabilitation Neural Repair 2009 23 2 117 124 18997156
63. Virtual reality and gait rehabilitation Augmented feedback for the Lokomat. Zimmerli L, Duschau-Wicke A, Mayr A, Riener R, Lünenburger L, Virtual Rehabilitation International Conference. 2009 150 153
64. Perceived exertion as an indicator of somatic stress. Borg G, Scand J Rehabilitation Med 1970 2 2 92 98
65. The relationship between perceived exertion and physiologic indicators of stress during graded arm exercise in persons with spinal cord injuries. Lewis JE, Nash MS, Hamm LF, Martins SC, Groah SL, Arch Phys Med Rehabilitation 2007 88 9 1205 1211 10.1016/j.apmr.2007.05.016
66. Hermens HJ, Freriks B, Merletti R, Stegeman D, Blok J, Rau G, Disselhorst-Klug C, Haegg G, European Recommendations for Surface Electromyography 1999
67. International standards for neurological classification of spinal cord injury. Marino RJ, Barros T, Biering-Sorensen F, Burns SP, Donovan WH, Graves DE, Haak M, Hudson LM, Priebe MM, ASIA Neurological Standards Committee 2002, J Spinal Cord Med 2003 26 Suppl 1
68. Outcome measures in spinal cord injury: recent assessments and recommendations for future directions. Alexander MS, Anderson KD, Biering-Sorensen F, Blight AR, Brannon R, Bryce TN, Creasey G, Catz A, Curt A, Donovan W, Ditunno J, Ellaway P, Finnerup NB, Graves DE, Haynes BA, Heinemann AW, Jackson AB, Johnston MV, Kalpakjian CZ, Kleitman N, Krassioukov A, Krogh K, Lammertse D, Magasi S, Mulcahey MJ, Schurch B, Sherwood A, Steeves JD, Stiens S, Tulsky DS, van Hedel HJA, Whiteneck G, Spinal Cord 2009 47 8 582 591 10.1038/sc.2009.18 19381157
69. Quantification of the dynamic properties of EMG patterns during gait. Ricamato AL, Hidler JM, J Electromyography Kinesiology 2005 15 4 384 392 10.1016/j.jelekin.2004.10.003
70. Gibbons JD, Nonparametric Statistical Inference. Marcel Dekker Ltd 1985
71. Hochberg Yosef, Tamhane AjitC, Multiple Comparison Procedures (Wiley Series in Probability and Statistics). Wiley 1987
72. Regulating intensity using perceived exertion in spinal cord-injured participants. Goosey-Tolfrey V, Lenton J, Goddard J, Oldfield V, Tolfrey K, Eston R, Med Sci Sports Exercise 2010 42 3 608 613 10.1249/MSS.0b013e3181b72cbc
73. Alterations in muscle activation patterns during robotic-assisted walking. Hidler JM, Wall AE, Clin Biomech 2005 20 2 184 193 10.1016/j. clinbiomech.2004.09.016
74. Metabolic costs and muscle activity patterns during robotic- and therapist-assisted treadmill walking in individuals with incomplete spinal cord injury. Israel JF, Campbell DD, Kahn JH, Hornby GT, Phys Therapy 2006 86 11 1466 1478 10.2522/ptj.20050266
75. Do robotic and non-robotic arm movement training drive motor recovery after stroke by a common neural mechanism? Experimental evidence and a computational model. Reinkensmeyer DJ, Maier MA, Guigon E, Chan V, Akoner O, Wolbrecht ET, Cramer SC, Bobrow JE, Conf. IEEE Engineering in Medicine and Biology Society (EMBS). 2009 2439 2441
76. Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial. Wirz M, Zemon DH, Rupp R, Scheel A, Colombo G, Dietz V, Hornby TG, Arch Phys Med Rehabil 2005 86 4 672 680 10.1016/j.apmr.2004.08.004 15827916
77. A functional threshold for long-term use of hand and arm function can be determined: predictions from a computational model and supporting data from the Extremity Constraint-Induced Therapy Evaluation (EXCITE) Trial. Schweighofer N, Han CE, Wolf SL, Arbib MA, Winstein CJ, Phys therapy 2009 89 12 1327 1336 10.2522/ptj.20080402
78. Stroke rehabilitation reaches a threshold. Han CE, Arbib MA, Schweighofer N, PLoS Computat Biol 2008 4 8