Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation

Journal of Biological Chemistry

Volumn 287, Issue 53, 2012, Pages 44694-44702

  Nissinen, Liisa ^a   Koivunen, Jarkko ^b   Käpylä, Jarmo ^c   Salmela, Maria ^c   Nieminen, Jonna ^a   Jokinen, Johanna ^c   Sipilä, Kalle ^c   Pihlavisto, Marjo ^a   Pentikäinen, Olli T ^b   Marjamäki, Anne ^a   Heino, Jyrki ^c  

^a Biotie Therapies Corp   (Finland)

^b UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; CELL ADHESION; CHEMICAL ACTIVATION; COLLAGEN; CONFORMATIONS; METAL IONS; METALS; PLATELETS; SHEAR STRESS; SULFUR COMPOUNDS;

ACTIVATED CONFORMATION; DIFFERENTIAL SCANNING FLUORIMETRY; FUNCTIONAL STAGES; INTEGRIN CONFORMATION; INTEGRIN INHIBITORS; RECEPTOR ACTIVATION; SULFONAMIDE DERIVATIVES; THROMBUS FORMATION;

BINDING SITES;

BT 3033; BT 3034; COLLAGEN; PROTEIN INHIBITOR; RECOMBINANT PROTEIN; SULFONAMIDE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; BINDING SITE; CELL ADHESION; CHO CELL; CONTROLLED STUDY; FLUOROMETRY; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SHEAR STRESS; STRUCTURE ANALYSIS; THROMBOCYTE ADHESION;

EID: 84871813563     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309450     Document Type: Article

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