Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia

Journal of Biological Chemistry

Volumn 283, Issue 6, 2008, Pages 3559-3566

  Rossi, Franca ^a   Garavaglia, Silvia ^a   Montalbano, Valeria ^a   Walsh, Martin A ^b   Rizzi, Menico ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; BINDING SITES; BIOCHEMISTRY; BRAIN; PLANTS (BOTANY);

ACTIVE SITES; AMINOTRANSFERASE; ANOMALOUS DISPERSIONS; AROMATIC CAGES; ASPARTATE; CATALYTIC ACTIVITIES; COGNITIVE IMPAIRMENTS; DRUG TARGETS; FUNCTIONAL ROLES; HUMAN BRAINS; KYNURENIC ACIDS; LIGAND BINDINGS; NEUROLOGICAL DISEASES; RATIONAL DESIGNS; STRUCTURAL COMPARISONS; STRUCTURAL DIFFERENCES; TERMINAL REGIONS; UNIQUE FEATURES;

CRYSTAL STRUCTURE;

ASPARTATE AMINOTRANSFERASE; KYNURENINE AMINOTRANSFERASE; KYNURENINE AMINOTRANSFERASE 1; KYNURENINE AMINOTRANSFERASE 2; UNCLASSIFIED DRUG; AMINOTRANSFERASE; ENZYME INHIBITOR; KYNURENIC ACID; KYNURENINE OXOGLUTARATE TRANSAMINASE; KYNURENINE-OXOGLUTARATE TRANSAMINASE; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN TARGETING; SCHIZOPHRENIA; BRAIN; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; DIMERIZATION; DRUG DESIGN; METABOLISM; METHODOLOGY; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BRAIN; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; KYNURENIC ACID; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PROTEIN BINDING; RECOMBINANT PROTEINS; SCHIZOPHRENIA; TRANSAMINASES;

EID: 41249087474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707925200     Document Type: Article

References (55)

1. Stone, T. W. (2001) Toxicon 39, 61-73
2. Hilmas, C., Pereira, E. F., Alkondon, M., Rassoulpour, A., Schwarcz, R., and Albuquerque, E. X. (2001) J. Neurosci. 21, 7463-7473
3. Pereira, E. F., Hilmas, C., Santos, M. D., Alkondon, M., Maelicke, A., and Albuquerque, E. X. (2002) J. Neurobiol. 53, 479-500
4. Alkondon, M., Pereira, E. F., Yu, P., Arruda, E. Z., Almeida, L. E., Guidetti, P., Fawcett, W. P., Sapko, M. T., Randall, W. R., Schwarcz, R., Tagle, D. A., and Albuquerque, E. X. (2004) J. Neurosci. 24, 4635-4648
5. Perkins, M. N., and Stone, T. W. (1982) Brain Res. 247, 184-187
6. Schwarcz, R., and Pellicciari, R. (2002) J. Pharmacol. Exp. Ther. 303, 1-10
7. Sapko, M. T., Guidetti, P., Yu, P., Tagle, D. A., Pellicciari, R., and Schwarcz, R. (2006) Exp. Neurol. 197, 31-40
8. Andiné, P., Lehmann, A., Ellrén, K., Wennberg, E., Kjellmer, I., Nielsen, T., and Hagberg, H. (1988) Neurosci. Lett. 90, 208-212
9. Foster, A. C., Vezzani, A., French, E. D., and Schwarcz, R. (1984) Neurosci. Lett. 48, 273-278
10. Wu, H.-Q., Rassoulpour, A., and Schwarcz, R. (2007) J. Neural Transm. 114, 33-41
11. Rassoulpour, A., Wu, H. Q., Ferre, S., and Schwarcz, R. (2005) J. Neurochem. 93, 762-765
12. Poeggeler, B., Rassoulpour, A., Wu, H.-Q., Guidetti, P., Roberts, R. C., and Schwarcz, R. (2007) Neuroscience 148, 188-197
13. Erhardt, S., Blennow, K., Nordin, C., Skogh, E., Lindstrom, L. H., and Engberg, G. (2001) Neurosci. Lett. 313, 96-98
14. Schwarcz, R., Rassoulpour, A., Wu, H.-Q., Medoff, D., Tamminga, C. A., and Roberts, R. C. (2001) Biol. Psychiatry 50, 521-530
15. Baran, H., Cairns, N., Lubec, B., and Lubec, G. (1996) Life Sci. 58, 1891-1899
16. Chess, A. C., and Bucci, D. J. (2006) Behav. Brain Res. 170, 326-332
17. Moroni, F. (1999) Eur. J. Pharmacol. 375, 87-100
18. Okuno, E., Nakamura, M., and Schwarcz, R. (1991) Brain Res. 542, 307-312
19. Mosca, M., Cozzi, L., Breton, J., Avanzi, N., Toma, S., Okuno, E., Schwarcz, R., Speciale, C., Magagnin, S., Mostardini, M., and Benatti, L. (1996) Adv. Exp. Med. Biol. 398, 449-454
20. Buchli, R., Alberati-Giani, D., Malherbe, P., Kohler, C., Broger, C., and Cesura, A. M. (1995) J. Biol. Chem. 270, 29330-29335
21. Yu, P., Di Prospero, N. A., Sapko, M. T., Cai, T., Chen, A., Melendez-Ferro, M., Du, F., Whetsell, W. O., Jr., Guidetti, P., Schwarcz, R., and Tagle, D. A. (2004) Mol. Cell. Biol. 24, 6919-6930
22. Du, F., Schmidt, W., Okuno, E., Kido, R., Köler, C., and Schwarcz, R. (1992) J. Comp. Neurol. 321, 477-487
23. Guidetti, P., Hoffman, G. E., Melendez-Ferro, M., Albuquerque E. X., and Schwarcz, R. (2007) Glia 55, 78-92
24. Guidetti, P., Okuno, E., and Schwarcz, R. (1997) J. Neurosci. Res. 50, 457-465
25. Han, Q., Li, J., and Li, J. (2004) Eur. J. Biochem. 271, 4804-4814
26. Guidetti, P., Amori, L., Sapko, M. T., Okuno, E., and Schwarcz, R. (2007) J. Neurochem. 102, 103-111
27. Yu, P., Li, Z., Zhang, L., Tagle, D. A., and Cai, T. (2006) Gene 365, 111-118
28. Cooper, A. J. L. (2004) Neurochem. Int. 44, 557-577
29. Kiss, C., Ceresoli-Borroni, C. Guidetti, P., Zielke, C. L., Zielke, H. R., and Schwarcz, R. (2003) J. Neural Transm. 110, 1-14
30. Jansonius, J. N. (1998) Curr. Opin. Struct. Biol. 8, 759-769
31. Alexander, F. W., Sandmeier, E., Metha, P. K., and Christen, P. (1994) Eur. J. Biochem. 219, 953-960
32. Jensen, R. A., and Gu, W. (1996) J. Bacteriol. 178, 2161-2171
33. Schneider, G., Käck, H., and Lindqvist, Y. (2000) Structure 8, R1-R6
34. Rossi, F., Han, Q., Li, J., Li, J., and Rizzi, M. (2004) J. Biol. Chem. 279, 50214-50220
35. Chon, H., Matsumura, H., Koga, Y., Takano, K., and Kanaya, S. (2005) Proteins 61, 685-688
36. Han, Q., Gao, Y. G., Robinson, H., Ding, H., Wilson, S., and Li, J. (2005) FEBS J. 272, 2198-2206
37. Sambrook, J., Fritsh, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
38. Leslie, A. G. (1999) Acta Crystallogr. Sect. D 55, 1696-1702
39. Collaborative Computational Project, Number 4 (CCP4) (1994) Acta Crystallogr. Sect. D 50, 760-763
40. Schneider, T. R., and Sheldrick, G. M. (2002) Acta Crystallogr. Sect. D 58, 1772-1779
41. Bricogne, G., Vonrhein, C., Flensburg, C., Schiltz, M., and Paciorek, W. (2003) Acta Crystallogr. Sect. D 59, 2023-2030
42. Perrakis, A., Morris, R., and Lamzin, V. S. (1999) Nat. Struct. Biol. 6, 458-463
43. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
44. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D 53, 240-255
45. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
46. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
47. Esnouf, R. M. (1997) J. Mol. Graphics 15, 132-134
48. DeLano, W. L. (2002) The PyMOL Molecular Graphics System, DeLano Scientific, Palo Alto, CA
49. Christen, P., and Metha, P. K. (2001) Chem. Rec. 1, 436-447
50. Grishin, N. P., Phillips, M. A., and Goldsmith, E. J. (1995) Protein Sci. 4, 1291-1304
51. Holm, L., and Sander, C. (1993) J. Mol. Biol. 233, 123-138
52. Nakai, T., Okada, K., Akutsu, S., Miyahara, I., Kawaguchi S., Kato, R., Kuramitsu, S., and Hirotsu, K. (1999) Biochemistry 38, 2413-2424
53. Clausen, T., Huber, R., Laber, B., Pohlenz, H.-D., and Messerschmidt, A. (1996) J. Mol. Biol. 262, 202-224
54. Krupka, H. I., Huber, R., Holt, S. C., and Clausen, T. (2000) EMBO J. 19, 3168-3178
55. Denesyuk, A. I., Denessiouk, K. A., Korpela, T., and Johnson, M. S. (2002) J. Mol. Biol. 316, 155-172