β1-Adrenoceptor Autoantibodies from DCM Patients Enhance the Proliferation of T Lymphocytes through the β1-AR/cAMP/PKA and p38 MAPK Pathways

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Du, Yunhui ^a,b   Yan, Li ^c   Wang, Jin ^d   Zhan, Wenzhang ^e   Song, Kai ^f   Han, Xue ^a   Li, Xiao ^a   Cao, Jimin ^c   Liu, Huirong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^d SHANXI MEDICAL UNIVERSITY   (China)

^e Department of Internal Medicine   (China)

^f CHANGZHI MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYTOKINE; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GAMMA INTERFERON; INTERLEUKIN 4; METOPROLOL; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NITRATE; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; ASSAY; BLOOD SAMPLING; CD3+ T LYMPHOCYTE; CELL SURFACE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WESTERN BLOTTING;

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-AGONISTS; AGED; ANIMALS; AUTOANTIBODIES; CARDIOMYOPATHY, DILATED; CELL PROLIFERATION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; HUMANS; IMIDAZOLES; INTERFERON-GAMMA; ISOPROTERENOL; ISOQUINOLINES; MALE; METOPROLOL; MIDDLE AGED; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-1; SIGNAL TRANSDUCTION; SULFONAMIDES; T-LYMPHOCYTES;

EID: 84871783214     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052911     Document Type: Article

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