Beta 1-adrenergic receptor-directed autoimmunity as a cause of dilated cardiomyopathy in rats

International Journal of Cardiology

Volumn 112, Issue 1, 2006, Pages 7-14

  Jahns, Roland ^a   Boivin, Valérie ^a   Lohse, Martin J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

1 adrenergic receptor; Autoimmunity; Dilated cardiomyopathy; Rat; Receptor antibodies

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; GUANOSINE TRIPHOSPHATE; HLA ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANTIGEN STRUCTURE; ANTIGENICITY; ARTICLE; AUTOIMMUNITY; CHAGAS DISEASE; CONFORMATIONAL TRANSITION; CONGESTIVE CARDIOMYOPATHY; EXTRACELLULAR MATRIX; GRAVES DISEASE; HEART LEFT VENTRICLE HYPERTROPHY; IMMUNOADSORPTION; IMMUNOPRECIPITATION; IMMUNOSTIMULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MYASTHENIA GRAVIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FAMILY;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CARDIOMYOPATHY, DILATED; HUMANS; MYOCARDIAL CONTRACTION; RATS; RECEPTORS, ADRENERGIC, BETA-1;

EID: 33747366438     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2006.05.008     Document Type: Article

References (63)

1. Richardson P., McKenna W., Bristow M., et al. Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies. Circulation 93 (1996) 841-842
2. American Heart Association, Dallas; Heart Disease and Stroke Statistics - 2005 Update.
3. Morita H., Seidman J., and Seidman C.E. Genetic causes of human heart failure. J Clin Invest 115 (2005) 518-526
4. 1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation 99 (1999) 649-654
5. Liao L., Sindhwani R., Rojkind M., Factor S., Leinwand L., and Diamond B. Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity. J Exp Med 181 (1995) 1123-1131
6. Luppi P., Rudert W.A., Zanone M.M., et al. Idiopathic dilated cardiomyopathy. A superantigen-driven autoimmune disease. Circulation 98 (1998) 777-785
7. Noutsias M., Seeberg B., Schultheiss H.P., and Kühl U. Expression of cell adhesion molecules in dilated cardiomyopathy: evidence for endothelial activation in inflammatory cardiomyopathy. Circulation 99 (1999) 2124-2131
8. Elies R., Ferrari I., Wallukat G., et al. Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease. J Immunol 157 (1996) 4203-4211
9. Caforio A.L., Mahon N.J., Tona F., and McKenna W.J. Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance. Eur J Heart Fail 4 (2002) 411-417
10. Rose N.R. Infection, mimics, and autoimmune disease. J Clin Invest 107 (2001) 943-944
11. Fu M.L.X., Magnusson Y., Bergh C.H., Waagstein F., Hjalmarson Å., and Hoebeke J. Localization of a functional autoimmune epitope on the second extracellular loop of the human muscarinic receptor in patients with idiopathic DCM. J Clin Invest 91 (1993) 1964-1968
12. 1-adrenoceptor with positive chronotropic effect. Circulation 89 (1994) 2760-2767
13. Schulze K., Becker B.F., Schauer R., and Schultheiss H.P. Antibodies to ADP-ATP carrier - an autoantigen in myocarditis and dilated cardiomyopathy-impair cardiac function. Circulation 81 (1990) 959-969
14. Eriksson U., Ricci R., Hunziker L., et al. Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med 9 12 (2003) 1484-1490
15. Okazaki T., Tanaka Y., Nishio R., et al. Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat Med 9 12 (2003) 1477-1483
16. Jahns R., Boivin V., and Lohse M.J. Beta1-adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy. Trends Cardiovasc Med 16 (2006) 20-24
17. 1-adrenergic receptor antibodies and heart failure: causation, not just correlation. J Clin Invest 113 (2004) 1379-1382
18. Engelhardt S., Hein L., Dyachenkow V., Kranias E.G., Isenberg G., and Lohse M.J. Altered calcium handling is critically involved in the cardiotoxic effects of chronic β-adrenergic stimulation. Circulation 109 (2004) 1154-1160
19. 1-adrenergic receptor. Proc Natl Acad Sci U S A 84 (1987) 7920-7924
20. Hein L., and Kobilka B.K. Adrenergic receptor signal transduction and regulation. Neuropharmacology 34 4 (1995) 357-366
21. Bywater R.P. Location and nature of the residues important for ligand recognition in G-protein coupled receptors. J Mol Recognit 18 (2005) 60-72
22. Hoffmann C., Leitz M.R., Oberdorf-Maass S., Lohse M.J., and Klotz K.N. Comparative pharmacology of human β-adrenergic receptor subtypes: characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch Pharmacol 362 (2004) 151-159
23. Lohse M.J., Engelhardt S., and Eschenhagen T. What is the role of β-adrenergic signaling in heart failure?. Circ Res 93 (2003) 896-906
24. 2-adrenergic receptors involves Asn-293. Proc Natl Acad Sci U S A 93 (1996) 9276-9281
25. 2-adrenoceptor. EMBO J 16 (1997) 6737-6747
26. 2-adrenergic receptor. Biochemistry 29 (1990) 2335-2342
27. 2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines. J Biol Chem 269 (1994) 6743-6752
28. 2-adrenergic receptor: effect of DTT on receptor conformation monitored by circular dichroism and fluorescence spectroscopy. Biochemistry 35 (1996) 14445-14451
29. 1-adrenergic receptors of turkey erythrocyte membranes. J Biol Chem 254 (1978) 4462-4469
30. 1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies. J Am Coll Cardiol 36 (2000) 1280-1287
31. Hoebeke J. Structural basis of autoimmunity against G protein-coupled membrane receptors. Int J Cardiol 54 (1996) 103-111
32. 1-adrenoceptor. J Autoimmun 13 2 (1999) 179-186
33. Rose N.R. Viral damage or molecular mimicry-placing the blame in myocarditis. Nat Med 6 (2000) 631-632
34. Brown J.H., Jardetzky T.S., Gorga J.C., et al. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (Lond) 364 (1993) 33-39
35. Guillet J.G., Hoebeke J., Lengagne R., Borras-Herrera F., Strosberg A.D., and Borras-Cuesta F. Haplotype specific homology scanning algorithm to predict T cell epitopes from protein sequences. J Mol Recognit 4 (1991) 17-25
36. Magnusson Y., Hoyer S., Lengagne R., et al. Antigenic analysis of the second extracellular loop of the human β-adrenergic receptors. Clin Exp Immunol 78 (1989) 42-48
37. Tate K., Magnusson Y., Viguier M., et al. Epitope-analysis of T- and B-cell response against the human beta 1-adrenoceptor. Biochimie 76 (1994) 159-164
38. 2-adrenoceptors with domain-specific fusion protein antibodies. Eur J Pharmacol 316 (1996) 111-121
39. Matsui S., Fu M., Katsuda S., et al. Peptides derived from cardiovascular G-protein-coupled receptors induce morphological cardiomyopathic changes in immunized rabbits. J Mol Cell Cardiol 29 (1997) 641-655
40. 1-adrenergic receptors induces β-adrenergic receptor desensitization and myocardial hypertrophy in vivo. Circ Res 88 (2001) 578-586
41. 1-adrenergic receptor directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 113 (2004) 1419-1429
42. 1-AR. Circulation 110 Suppl. III (2004) 598 2779
43. 1-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits. J Am Coll Cardiol 43 (2004) 1090-1100
44. 1-adrenoceptor autoimmunity in cardiomyopathy. Int J Cardiol 54 (1996) 137-141
45. 1-adrenoceptor as antigen: functional aspects. Eur Heart J 16 Suppl. 0 (1995) 85-88
46. 2-adrenergic receptor. FEBS Lett 399 (1996) 188-191
47. Milligan G., and Bond A. Inverse agonism and the regulation of receptor number. TIPS 18 (1997 (Dec.)) 468-474
48. Witebsky E., Rose N.R., Terplan K., Paine J.R., and Egan R.W. Chronic thyreoiditis and autoimmunization. J Am Med Assoc 164 (1957) 1439-1447
49. Rose N.R., and Bona C. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 14 (1993) 426-430
50. Matsui S., Fu M., Katsuda S., et al. Transfer of rabbit autoimmune cardiomyopathy into severe combined immunodeficiency mice. J Cardiovasc Pharmacol 42 Suppl. 1 (2003) S99-S103
51. Omerovic E., Bollano E., Andersson B., et al. Induction of cardiomyopathy in severe combined immunodeficiency mice by transfer of lymphocytes from patients with idiopathic dilated cardiomyopathy. Autoimmunity 32 (2000) 271-280
52. D'Ambrosio A., Patti G., Manzoli A., et al. The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy. Heart 85 (2001) 499-504
53. Hershko A.Y., and Naparstek Y. Removal of pathogenic autoantibodies by immunoadsorption. Ann N Y Acad Sci 1051 (2005) 635-646
54. 1-adrenoceptor antibodies are not associated with cardiomyopathies secondary to valvular or hypertensive heart disease. J Am Coll Cardiol 34 (1999) 1545-1551
55. 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: mapping of epitopes in the first and second extracellular loops. J Mol Cell Cardiol 27 (1995) 397-406
56. 1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 37 (2001) 418-424
57. Chiale P.A., Ferrari I., Mahler E., et al. Differential profile and biochemical effects of antiautonomic membrane receptor antibodies in ventricular arrhythmias and sinus node dysfunction. Circulation 103 (2001) 1765-1771
58. 1-adrenoceptor predict increased mortality in dilated cardiomyopathy. Circulation 110 Abst. Suppl. III (2004) 555 2583
59. Ogawa S., and Yoshikawa T. Autoantibodies: emerging upstream targets of arrhythmias and sudden cardiac death in patients with dilated cardiomyopathy. J Mol Cell Cardiol 33 (2001) 1761-1763
60. Matsui S., and Fu M.L. Prevention of experimental autoimmune cardiomyopathy in rabbits by receptor blockers. Autoimmunity 43 (2001) 217-220
61. 1-adrenergic antibodies directed against cardiac proteins from patients with idiopathic DCM. N Engl J Med 347 (2002) 1806
62. Anderton S.M. Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes, and possibilities. Immunology 104 (2001) 367-376
63. 1-adrenergic receptors. Circulation 102 Abst. Suppl. II (2005) 5 120