Evidence for coexistence of three β-adrenoceptor subtypes in human peripheral lymphocytes

Clinical Pharmacology and Therapeutics

Volumn 81, Issue 5, 2007, Pages 654-658

  Yu, Xi Yong ^a   Lin, Shu Guang ^a   Wang, Xiao Mei ^a   Liu, Yuan ^a   Zhang, Bin ^a   Lin, Qiu Xiong ^a   Yang, Min ^a   Zhou, Shu Feng ^b  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR 1; BETA ADRENERGIC RECEPTOR 2; BETA ADRENERGIC RECEPTOR 3; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; MESSENGER RNA; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR DENSITY;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADULT; BINDING, COMPETITIVE; BLOTTING, WESTERN; FEMALE; HUMANS; LYMPHOCYTES; MALE; PROPANOLAMINES; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 34247183712     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/sj.clpt.6100154     Document Type: Article

References (23)

1. Gauthier, C., Tavernier, G., Charpentier, F., Langin, D. & Le Marec, H. Functional beta3-adrenoceptor in the human heart. J. Clin. Invest. 98, 556-562 (1996).
2. Kaumann, A.J. Four beta-adrenoceptor subtypes in the mammalian heart. Trends Pharmacol. Sci. 18, 70-76 (1997).
3. Molenaar, P. & Kaumann, A.J. On criteria for functional beta 3-adrenoceptors. Trends Pharmacol. Sci. 18, 258 (1997).
4. Frielle, T., Collins, S., Daniel, K.W., Caron, M.G., Lefkowitz, R.J. & Kobilka, B.K. Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc. Natl. Acad. Sci. USA 84, 7920-7924 (1987).
5. Castellano, M. & Bohm, M. The cardiac beta-adrenoceptor-mediated signaling pathway and its alterations in hypertensive heart disease. Hypertension 29, 715-722 (1997).
6. Post, S.R., Hammond, H.K. & Insel, P.A. Beta-adrenergic receptors and receptor signaling in heart failure. Annu. Rev. Pharmacol. Toxicol. 39, 343-360 (1999).
7. Cohn, J.N. et al. Report of the national heart, lung, and blood institute special emphasis panel on heart failure research. Circulation 95, 766-770 (1997).
8. Ungerer, M., Bohm, M., Elce, J.S., Erdmann, E. & Lohse, M.J. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation 87, 454-463 (1993).
9. Brodde, O.E., Kretsch, R., Ikezono, K., Zerkowski, H.R. & Reidemeister, J.C. Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density. Science 231, 1584-1585 (1986).
10. Lohse, M.J. Molecular mechanisms of membrane receptor desensitization. Biochim. Biophys. Acta. 1179, 171-188 (1993).
11. Insel, P.A. Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors - evolving concepts and clinical implications. N. Engl. J. Med. 334, 580-585 (1996).
12. Muller, S., Hekman, M. & Lohse, M.J. Specific enhancement of beta-adrenergic receptor kinase activity by defined G-protein beta and gamma subunits. Proc. Natl. Acad. Sci. USA 90, 10439-10443 (1993).
13. Post, S.R., Aguila-Buhain, O. & Insel, P.A. A key role for protein kinase A in homologous desensitization of the beta 2-adrenergic receptor pathway in S49 lymphoma cells. J. Biol. Chem. 271, 895-900 (1996).
14. World Health Organization. International Statistical Classification of Diseases and Related Health Problems, World Health Organisation, Geneva (1992).
15. Singh, U. Study of beta adrenoceptors on subpopulations of thymocytes separated on ficoll-hypaque density gradients. Adv. Exp. Med. Biol. 149, 313-318 (1982).
16. Green, S.A., Holt, B.D. & Liggett, S.B. Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs. Mol. Pharmacol. 41, 889-893 (1992).
17. Yang-Feng, T.L. et al. Chromosomal organization of adrenergic receptor genes. Proc. Natl. Acad. Sci. USA 87, 1516-1520 (1990).
18. Emorine, L.J. et al. Molecular characterization of the human beta 3-adrenergic receptor. Science 245, 1118-1121 (1989).
19. Moniotte, S. et al. Real-time RT-PCR for the detection of beta-adrenoceptor messenger RNAs in small human endomyocardial biopsies. J. Mol. Cell. Cardiol. 33, 2121-2133 (2001).
20. Laemmli, U.K. Cleavage of structure proteins during the assembly of the head bacteriophage 14. Nature 227, 680-685 (1970).
21. Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).
22. Bylund, D.B. et al. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol. Rev. 46, 121-136 (1994).
23. Foord, S.M. et al. International Union of Pharmacology XLVI. G protein-coupled receptor list. Pharmacol. Rev. 57, 279-288 (2005).