Structural Requirements for Cub Domain Containing Protein 1 (CDCP1) and Src Dependent Cell Transformation

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Kollmorgen, Gwendlyn ^a   Bossenmaier, Birgit ^a   Niederfellner, Gerhard ^a   Häring, Hans Ulrich ^b   Lammers, Reiner ^b  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CUB DOMAIN CONTAINING PROTEIN 1; DIMER; MEMBRANE PROTEIN; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; RETROVIRUS VECTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN 3T3; CELL SURFACE; CELL TRANSFORMATION; CONTROLLED STUDY; FIBROBLAST; MYRISTYLATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION;

ANIMALS; ANTIGENS, CD; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; LIPOYLATION; MICE; MUTATION; NEOPLASM PROTEINS; NIH 3T3 CELLS; PHOSPHORYLATION; SRC-FAMILY KINASES;

EID: 84871750920     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053050     Document Type: Article

References (43)

1. Talamonti MS, Roh MS, Curley SA, Gallick GE, (1993) Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest 91: 53-60.
2. Irby RB, Yeatman TJ, (2000) Role of Src expression and activation in human cancer. Oncogene 19: 5636-5642.
3. Brunton VG, Ozanne BW, Paraskeva C, Frame MC, (1997) A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. Oncogene 14: 283-293.
4. Yeatman TJ, (2004) A renaissance for SRC. Nat Rev Cancer 4: 470-480.
5. Ingley E, (2008) Src family kinases: regulation of their activities, levels and identification of new pathways. Biochim Biophys Acta 1784: 56-65.
6. Irby RB, Mao W, Coppola D, Kang J, Loubeau JM, et al. (1999) Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet 21: 187-190.
7. Salmond RJ, Filby A, Qureshi I, Caserta S, Zamoyska R, (2009) T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol Rev 228: 9-22.
8. Falahati R, Leitenberg D, (2007) Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development. J Immunol 178: 2056-2064.
9. Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, et al. (2003) Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem 278: 20716-20723.
10. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, et al. (2006) Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 116: 1346-1359.
11. Brown TA, Yang TM, Zaitsevskaia T, Xia Y, Dunn CA, et al. (2004) Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. J Biol Chem 279: 14772-14783.
12. Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, et al. (2005) The C2 domain of PKCδ is a phosphotyrosine binding domain. Cell 121: 271-280.
13. Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, et al. (2001) Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 20: 4402-4408.
14. Hooper JD, Zijlstra A, Aimes RT, Liang H, Claassen GF, et al. (2003) Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene 22: 1783-1794.
15. Yang L, Nyalwidhe JO, Guo S, Drake RR, Semmes OJ, (2011) Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. Mol Cell Proteomics 10: M110.007294.
16. Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM, (2005) Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 24: 5333-5343.
17. Ikeda J, Oda T, Inoue M, Uekita T, Sakai R, et al. (2009) Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung. Cancer Sci 100: 429-433.
18. Awakura Y, Nakamura E, Takahashi T, Kotani H, Mikami Y, et al. (2008) Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma. J Cancer Res Clin Oncol 134: 1363-1369.
19. Gioia R, Leroy C, Drullion C, Lagarde V, Etienne G, et al. (2011) Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells. Blood 118: 2211-2221.
20. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, et al. (2011) VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKCδ-driven migration. Proc Natl Acad Sci U S A 108: 1931-1936.
21. Uekita T, Jia L, Narisawa-Saito M, Yokota J, Kiyono T, et al. (2007) CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol 27: 7649-7660.
22. Roussel MF, Dull TJ, Rettenmier CW, Ralph P, Ullrich A, et al. (1987) Transforming potential of the c-fms proto-oncogene (CSF-1 receptor). Nature325: 549-52.
23. Bork P, Beckmann G, (1993) The CUB domain. A widespread module in developmentally regulated proteins. J Mol Biol 231: 539-545.
24. Wong CH, Baehner FL, Spassov DS, Ahuja D, Wang D, et al. (2009) Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers. Clin Cancer Res 15: 2311-2322.
25. Valdez-Taubas J, Pelham H, (2005) Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. EMBO J 24: 2524-25232.
26. Perry SE, Robinson P, Melcher A, Quirke P, Bühring HJ, et al. (2007) Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. FEBS Lett 581: 1137-1142.
27. Kim LC, Song L, Haura EB, (2009) Src kinases as therapeutic targets for cancer. Nat Rev Clin Oncol 6: 587-595.
28. Cooper JA, Qian H, (2008) A mechanism for SRC kinase-dependent signaling by noncatalytic receptors. Biochemistry 47: 5681-5688.
29. Veillette A, Bookman MA, Horak EM, Samelson LE, Bolen JB, (1989) Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature 338: 257-259.
30. Liu H, Ong SE, Badu-Nkansah K, Schindler J, White FM, et al. (2011) CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc Natl Acad Sci U S A 108: 1379-1384.
31. Spassov DS, Wong CH, Sergina N, Ahuja D, Fried M, et al. (2011) Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Mol Cell Biol 31: 766-782.
32. Spassov DS, Ahuja D, Wong CH, Moasser MM, (2011) The structural features of Trask that mediate its anti-adhesive functions. PLoS One 6: e19154.
33. He Y, Wortmann A, Burke LJ, Reid JC, Adams MN, et al. (2010) Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCδ. J Biol Chem. 285: 26162-26173.
34. Casar B, He Y, Iconomou M, Hooper JD, Quigley JP, et al. (2011) Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene. doi: 10.1038/onc.2011.555.
35. Benes CH, Poulogiannis G, Cantley LC, Soltoff SP, (2012) The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Oncogene 31: 653-663.
36. Law ME, Corsino PE, Jahn SC, Davis BJ, Chen S, et al. (2012) Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. Oncogene. doi: 10.1038/onc.2012.138.
37. Orsulic S, Kemler R. Expression of Eph receptors and ephrins is differentially regulated by E-cadherin. J Cell Sci 113: 1793-1802.
38. Alvares SM, Dunn CA, Brown TA, Wayner EE, Carter WG, (2008) The role of membrane microdomains in transmembrane signaling through the epithelial glycoprotein Gp140/CDCP1. Biochim Biophys Acta 1780: 486-496.
39. Abrami L, Leppla SH, van der Goot FG, (2006) Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. J Cell Biol 172: 309-320.
40. Patwardhan P, Resh MD, (2010) Myristoylation and membrane binding regulate c-Src stability and kinase activity. Mol Cell Biol 30: 4094-4107.
41. Deryugina EI, Conn EM, Wortmann A, Partridge JJ, Kupriyanova TA, et al. (2009) Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination. Mol Cancer Res 7: 1197-1211.
42. Bühring HJ, Kuçi S, Conze T, Rathke G, Bartolović K, et al. (2004) CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin. Stem Cells 22: 334-343.
43. Chen C, Okayama H, (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745-2752.