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Volumn 58, Issue 1-2, 2013, Pages 21-30

Recent development in the effects of statins on cardiovascular disease through Rac1 and NADPH oxidase

Author keywords

Cardiovascular disease; NADPH oxidases; Pleiotropic; Rac1; Statin

Indexed keywords

ALPHA CATENIN; ATORVASTATIN; BETA CATENIN; COLESTILAN; CONNECTIVE TISSUE GROWTH FACTOR; CONNEXIN 43; FLUINDOSTATIN; GERANYLGERANYL PYROPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; OXIDOREDUCTASE; PRAVASTATIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5; SUPEROXIDE; UNCLASSIFIED DRUG;

EID: 84871711868     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.10.003     Document Type: Review
Times cited : (20)

References (87)
  • 4
    • 77951281040 scopus 로고    scopus 로고
    • Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes
    • Ago T., Kuroda J., Pain J., Fu C., Li H., Sadoshima J. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ. Res. 2010, 106(7):1253-1264.
    • (2010) Circ. Res. , vol.106 , Issue.7 , pp. 1253-1264
    • Ago, T.1    Kuroda, J.2    Pain, J.3    Fu, C.4    Li, H.5    Sadoshima, J.6
  • 5
    • 77649291952 scopus 로고    scopus 로고
    • Pravastatin counteracts angiotensin II-induced upregulation and activation of NADPH oxidase at plasma membrane of human endothelial cells
    • Alvarez E., Rodino-Janeiro B.K., Ucieda-Somoza R., Gonzalez-Juanatey J.R. Pravastatin counteracts angiotensin II-induced upregulation and activation of NADPH oxidase at plasma membrane of human endothelial cells. J. Cardiovasc. Pharmacol. 2010, 55(2):203-212.
    • (2010) J. Cardiovasc. Pharmacol. , vol.55 , Issue.2 , pp. 203-212
    • Alvarez, E.1    Rodino-Janeiro, B.K.2    Ucieda-Somoza, R.3    Gonzalez-Juanatey, J.R.4
  • 6
    • 77957221105 scopus 로고    scopus 로고
    • Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity
    • Antoniades C., Bakogiannis C., Tousoulis D., Reilly S., Zhang M.H., Paschalis A., et al. Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation 2010, 122(11 Suppl.):S66-S73.
    • (2010) Circulation , vol.122 , Issue.11 SUPPL.
    • Antoniades, C.1    Bakogiannis, C.2    Tousoulis, D.3    Reilly, S.4    Zhang, M.H.5    Paschalis, A.6
  • 7
    • 84055182538 scopus 로고    scopus 로고
    • Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment
    • Antoniades C., Demosthenous M., Reilly S., Margaritis M., Zhang M.H., Antonopulos A., Marinou K., Nahar K., et al. Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. J. Am. Coll. Cardiol. 2012, 59(1):60-70.
    • (2012) J. Am. Coll. Cardiol. , vol.59 , Issue.1 , pp. 60-70
    • Antoniades, C.1    Demosthenous, M.2    Reilly, S.3    Margaritis, M.4    Zhang, M.H.5    Antonopulos, A.6    Marinou, K.7    Nahar, K.8
  • 8
    • 57249115882 scopus 로고    scopus 로고
    • Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway
    • Baba T.T., Nemoto T.K., Miyazaki T., Oida S. Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway. J. Muscle Res. Cell Motil. 2008, 29(2-5):127-134.
    • (2008) J. Muscle Res. Cell Motil. , vol.29 , Issue.2-5 , pp. 127-134
    • Baba, T.T.1    Nemoto, T.K.2    Miyazaki, T.3    Oida, S.4
  • 9
    • 65249103435 scopus 로고    scopus 로고
    • Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells
    • Basuroy S., Bhattacharya S., Leffler C.W., Parfenova H. Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells. Am. J. Physiol. Cell Physiol. 2009, 296(3):C422-C432.
    • (2009) Am. J. Physiol. Cell Physiol. , vol.296 , Issue.3
    • Basuroy, S.1    Bhattacharya, S.2    Leffler, C.W.3    Parfenova, H.4
  • 10
    • 79251589339 scopus 로고    scopus 로고
    • Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-alpha-induced apoptosis
    • Basuroy S., Tcheranova D., Bhattacharya S., Leffler C.W., Parfenova H.K. Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-alpha-induced apoptosis. Am. J. Physiol. 2011, 300(2):C256-C265.
    • (2011) Am. J. Physiol. , vol.300 , Issue.2
    • Basuroy, S.1    Tcheranova, D.2    Bhattacharya, S.3    Leffler, C.W.4    Parfenova, H.K.5
  • 12
    • 0030071631 scopus 로고    scopus 로고
    • Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets
    • Chen L.Y., Mehta J.L. Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets. J. Cardiovasc. Pharmacol. 1996, 27(1):154-158.
    • (1996) J. Cardiovasc. Pharmacol. , vol.27 , Issue.1 , pp. 154-158
    • Chen, L.Y.1    Mehta, J.L.2
  • 13
    • 77955485289 scopus 로고    scopus 로고
    • Effect of statins on atrial fibrillation after cardiac surgery: a duration- and dose-response meta-analysis
    • Chen W.T., Krishnan G.M., Sood N., Kluger J., Coleman C.I. Effect of statins on atrial fibrillation after cardiac surgery: a duration- and dose-response meta-analysis. J. Thorac. Cardiovasc. Surg. 2010, 140(2):364-372.
    • (2010) J. Thorac. Cardiovasc. Surg. , vol.140 , Issue.2 , pp. 364-372
    • Chen, W.T.1    Krishnan, G.M.2    Sood, N.3    Kluger, J.4    Coleman, C.I.5
  • 14
    • 84867161527 scopus 로고    scopus 로고
    • Distribution and risk profile of paroxysmal, persistent, and permanent atrial fibrillation in routine clinical practice: insight from the real-life global survey evaluating patients with atrial fibrillation international registry
    • Chiang C.E., Naditch-Brule L., Murin J., Goethals M., Inoue H., O'Neill J., Silva-Cardoso J., Zharinov O., et al. Distribution and risk profile of paroxysmal, persistent, and permanent atrial fibrillation in routine clinical practice: insight from the real-life global survey evaluating patients with atrial fibrillation international registry. Circ. Arrhythm. Electrophysiol. 2012, 5(4):632-639.
    • (2012) Circ. Arrhythm. Electrophysiol. , vol.5 , Issue.4 , pp. 632-639
    • Chiang, C.E.1    Naditch-Brule, L.2    Murin, J.3    Goethals, M.4    Inoue, H.5    O'Neill, J.6    Silva-Cardoso, J.7    Zharinov, O.8
  • 15
    • 84857412317 scopus 로고    scopus 로고
    • Effect of perioperative statins on death, myocardial infarction, and atrial fibrillation, and length of stay: a systematic review and meta-analysis
    • Chopra V., Wesorick D.H., Sussman J.B., Greene T., Rogers M., Froehlich J.B., Eagle K.A., Sain S. Effect of perioperative statins on death, myocardial infarction, and atrial fibrillation, and length of stay: a systematic review and meta-analysis. Arch. Surg. 2012, 147(2):181-189.
    • (2012) Arch. Surg. , vol.147 , Issue.2 , pp. 181-189
    • Chopra, V.1    Wesorick, D.H.2    Sussman, J.B.3    Greene, T.4    Rogers, M.5    Froehlich, J.B.6    Eagle, K.A.7    Sain, S.8
  • 18
    • 84871713202 scopus 로고    scopus 로고
    • Endothelial cell to cell junctions and the control of vascular permeability
    • Dejana E. Endothelial cell to cell junctions and the control of vascular permeability. Vascul. Pharmacol. 2012, 56(5-6):307.
    • (2012) Vascul. Pharmacol. , vol.56 , Issue.5-6 , pp. 307
    • Dejana, E.1
  • 19
    • 3142654859 scopus 로고    scopus 로고
    • Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species
    • Diebold B.A., Fwolder B., Lu J., Dinauer M.C., Bokoch G.M. Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species. J. Biol. Chem. 2004, 279(27):28136-28142.
    • (2004) J. Biol. Chem. , vol.279 , Issue.27 , pp. 28136-28142
    • Diebold, B.A.1    Fwolder, B.2    Lu, J.3    Dinauer, M.C.4    Bokoch, G.M.5
  • 20
    • 27444447834 scopus 로고    scopus 로고
    • Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice
    • Dikalova A., Clempus R., Lassegue B., Cheng G., McCoy J., Dikalov S., et al. Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation 2005, 112:2668-2676.
    • (2005) Circulation , vol.112 , pp. 2668-2676
    • Dikalova, A.1    Clempus, R.2    Lassegue, B.3    Cheng, G.4    McCoy, J.5    Dikalov, S.6
  • 22
    • 11444263199 scopus 로고    scopus 로고
    • The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle
    • Ellmark S.H., Dusting G.J., Fui M.N., Guzzo-Pernell N., Drummond G.R. The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Cardiovasc. Res. 2005, 65(2):495-504.
    • (2005) Cardiovasc. Res. , vol.65 , Issue.2 , pp. 495-504
    • Ellmark, S.H.1    Dusting, G.J.2    Fui, M.N.3    Guzzo-Pernell, N.4    Drummond, G.R.5
  • 23
    • 33645732870 scopus 로고    scopus 로고
    • Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production
    • Erdos B., Snipes J.A., Tulbert C.D., Katakam P., Miller A.W., Busija D.W. Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production. Am. J. Physiol. Heart Circ. Physiol. 2006, 290(3):H1264-H1270.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290 , Issue.3
    • Erdos, B.1    Snipes, J.A.2    Tulbert, C.D.3    Katakam, P.4    Miller, A.W.5    Busija, D.W.6
  • 24
    • 16344370063 scopus 로고    scopus 로고
    • Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases
    • Ghittoni R., Patrussi L., Pirozzi K., Pellegrini M., Lazzerini P.E., Capecchi P.L., et al. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J. 2005, 19(6):605-607.
    • (2005) FASEB J. , vol.19 , Issue.6 , pp. 605-607
    • Ghittoni, R.1    Patrussi, L.2    Pirozzi, K.3    Pellegrini, M.4    Lazzerini, P.E.5    Capecchi, P.L.6
  • 26
    • 55949095391 scopus 로고    scopus 로고
    • Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease
    • Guzik T.J., Chen W., Gongora M.C., Guzik B., Lob H.E., Mangalat D., et al. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. J. Am. Coll. Cardiol. 2008, 52(22):1803-1809.
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.22 , pp. 1803-1809
    • Guzik, T.J.1    Chen, W.2    Gongora, M.C.3    Guzik, B.4    Lob, H.E.5    Mangalat, D.6
  • 27
    • 34249804809 scopus 로고    scopus 로고
    • Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats
    • Habibi J., Whaley-Connell A., Qazi M.A., Hayden M.R., Cooper S.A., Tramontano A., et al. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats. Endocrinology 2007, 148(5):2181-2188.
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2181-2188
    • Habibi, J.1    Whaley-Connell, A.2    Qazi, M.A.3    Hayden, M.R.4    Cooper, S.A.5    Tramontano, A.6
  • 28
    • 71449105935 scopus 로고    scopus 로고
    • Statins have beneficial effects on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia
    • Hamilton P.K., Hughes S.M., Plumb R.D., Devine A., Leahey W., Lyons K.S., et al. Statins have beneficial effects on platelet free radical activity and intracellular distribution of GTPases in hyperlipidaemia. Clin. Sci. (Lond.) 2010, 118(5):359-366.
    • (2010) Clin. Sci. (Lond.) , vol.118 , Issue.5 , pp. 359-366
    • Hamilton, P.K.1    Hughes, S.M.2    Plumb, R.D.3    Devine, A.4    Leahey, W.5    Lyons, K.S.6
  • 29
    • 34249293701 scopus 로고    scopus 로고
    • Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase
    • (Jun)
    • Haramaki N., Ikeda H., Takenaka K., Katoh A., Sugano R., Yamagishi S., et al. Fluvastatin alters platelet aggregability in patients with hypercholesterolemia: possible improvement of intraplatelet redox imbalance via HMG-CoA reductase. Arterioscler. Thromb. Vasc. Biol. 2007, 27(6):1471-1477. (Jun).
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , Issue.6 , pp. 1471-1477
    • Haramaki, N.1    Ikeda, H.2    Takenaka, K.3    Katoh, A.4    Sugano, R.5    Yamagishi, S.6
  • 30
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: new insights into their function from in vivo studies
    • Heasman S.J., Ridley A.J. Mammalian Rho GTPases: new insights into their function from in vivo studies. Nat. Rev. Mol. Cell Biol. 2008, 9(9):690-701.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , Issue.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 31
    • 79551652731 scopus 로고    scopus 로고
    • Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1
    • Hoang V.M., Nagy J.A., Senger D.R. Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood 2011, 117(5):1751-1760.
    • (2011) Blood , vol.117 , Issue.5 , pp. 1751-1760
    • Hoang, V.M.1    Nagy, J.A.2    Senger, D.R.3
  • 32
    • 33751182650 scopus 로고    scopus 로고
    • Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke
    • Hong H., Zeng J.S., Kreulen D.L., Kaufman D.I., Chen A.F. Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke. Am. J. Physiol. Heart Circ. Physiol. 2006, 291(5):H2210-H2215.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , Issue.5
    • Hong, H.1    Zeng, J.S.2    Kreulen, D.L.3    Kaufman, D.I.4    Chen, A.F.5
  • 33
    • 64249168985 scopus 로고    scopus 로고
    • NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-[U+FE5B]beta[U+FE5C]1 and insulin-like growth factor binding protein-3
    • Ismail S., Sturrock A., Wu P., Cahill B., Norman K., Huecksteadt T., et al. NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-[U+FE5B]beta[U+FE5C]1 and insulin-like growth factor binding protein-3. Am. J. Physiol. Lung Cell. Mol. Physiol. 2009, 296(3):L489-L499.
    • (2009) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.296 , Issue.3
    • Ismail, S.1    Sturrock, A.2    Wu, P.3    Cahill, B.4    Norman, K.5    Huecksteadt, T.6
  • 34
    • 67849088501 scopus 로고    scopus 로고
    • Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke
    • Jackman K.A., Miller A.A., Drummond G.R., Sobey C.G. Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Res. 2009, 1286:215-220.
    • (2009) Brain Res. , vol.1286 , pp. 215-220
    • Jackman, K.A.1    Miller, A.A.2    Drummond, G.R.3    Sobey, C.G.4
  • 35
    • 67651156448 scopus 로고    scopus 로고
    • Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets
    • Jaquet V., Scapozza L., Clark R.A., Krause K.H., Lambeth J.D. Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid. Redox Signal. 2009, 11(10):2535-2552.
    • (2009) Antioxid. Redox Signal. , vol.11 , Issue.10 , pp. 2535-2552
    • Jaquet, V.1    Scapozza, L.2    Clark, R.A.3    Krause, K.H.4    Lambeth, J.D.5
  • 36
    • 73549096170 scopus 로고    scopus 로고
    • Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/-mice
    • Judkins C.P., Diep H., Broughton B.R., Mast A.E., Hooker E.U., Miller A.A., et al. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/-mice. Am. J. Physiol. Heart Circ. Physiol. 2010, 298(1):H24-H32.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298 , Issue.1
    • Judkins, C.P.1    Diep, H.2    Broughton, B.R.3    Mast, A.E.4    Hooker, E.U.5    Miller, A.A.6
  • 37
    • 35649015344 scopus 로고    scopus 로고
    • NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    • Kahles T., Luedike P., Endres M., Galla H.J., Steinmetz H., Busse R., et al. NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke 2007, 38(11):3000-3006.
    • (2007) Stroke , vol.38 , Issue.11 , pp. 3000-3006
    • Kahles, T.1    Luedike, P.2    Endres, M.3    Galla, H.J.4    Steinmetz, H.5    Busse, R.6
  • 38
    • 77955844394 scopus 로고    scopus 로고
    • NADPH oxidase Nox1 contributes to ischemic injury in experimental stoke in mice
    • Kahles T., Kohnen A., Heumueller S., Rappert A., Bechmann I., Liebner S., et al. NADPH oxidase Nox1 contributes to ischemic injury in experimental stoke in mice. Neurobiol. Dis. 2010, 40(1):185-192.
    • (2010) Neurobiol. Dis. , vol.40 , Issue.1 , pp. 185-192
    • Kahles, T.1    Kohnen, A.2    Heumueller, S.3    Rappert, A.4    Bechmann, I.5    Liebner, S.6
  • 40
    • 70349566487 scopus 로고    scopus 로고
    • The WASP and WAVE family proteins
    • Kurisu S., Takenawa T. The WASP and WAVE family proteins. Genome Biol. 2009, 10(6):226.
    • (2009) Genome Biol. , vol.10 , Issue.6 , pp. 226
    • Kurisu, S.1    Takenawa, T.2
  • 42
    • 77950896739 scopus 로고    scopus 로고
    • NADPH oxidases: functions and pathologies in the vasculature
    • Lassegue B., Griendling K.K. NADPH oxidases: functions and pathologies in the vasculature. Arterioscler. Thromb. Vasc. Biol. 2010, 30(4):653-661.
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , Issue.4 , pp. 653-661
    • Lassegue, B.1    Griendling, K.K.2
  • 47
    • 33745320293 scopus 로고    scopus 로고
    • Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway
    • Liang S.L., Liu H., Zhou A. Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway. J. Immunol. 2006, 177(1):651-656.
    • (2006) J. Immunol. , vol.177 , Issue.1 , pp. 651-656
    • Liang, S.L.1    Liu, H.2    Zhou, A.3
  • 48
    • 80052327048 scopus 로고    scopus 로고
    • Recent development in pleiotropic effects of statins on cardiovascular disease through regulation of transforming growth factor-beta superfamily
    • Ma S., Ma C.C. Recent development in pleiotropic effects of statins on cardiovascular disease through regulation of transforming growth factor-beta superfamily. Cytokine Growth Factor Rev. 2011, 22(3):167-175.
    • (2011) Cytokine Growth Factor Rev. , vol.22 , Issue.3 , pp. 167-175
    • Ma, S.1    Ma, C.C.2
  • 49
    • 0141841614 scopus 로고    scopus 로고
    • Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    • Maack C., Kartes T., Kilter H., Schafers H.J., Nickenig G., Bohm M., Laufs U. Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment. Circulation 2003, 108(13):1567-1574.
    • (2003) Circulation , vol.108 , Issue.13 , pp. 1567-1574
    • Maack, C.1    Kartes, T.2    Kilter, H.3    Schafers, H.J.4    Nickenig, G.5    Bohm, M.6    Laufs, U.7
  • 50
    • 0029257415 scopus 로고
    • Identification of constitutive and inducible forms of nitric oxide synthase in human platelets
    • Mehta J.L., Chen L.Y., Kone B.C., Mehta P., Turner P. Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J. Lab. Clin. Med. 1995, 125(3):370-377.
    • (1995) J. Lab. Clin. Med. , vol.125 , Issue.3 , pp. 370-377
    • Mehta, J.L.1    Chen, L.Y.2    Kone, B.C.3    Mehta, P.4    Turner, P.5
  • 51
    • 0142026447 scopus 로고    scopus 로고
    • Regulation of actin dynamics by WASP family proteins
    • Miki H., Takenawa T. Regulation of actin dynamics by WASP family proteins. J. Biochem. 2003, 134(3):309-313.
    • (2003) J. Biochem. , vol.134 , Issue.3 , pp. 309-313
    • Miki, H.1    Takenawa, T.2
  • 52
    • 0032403083 scopus 로고    scopus 로고
    • WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac
    • Miki H., Suetsugu S., Takenawa T. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J. 1998, 17(23):6923-6941.
    • (1998) EMBO J. , vol.17 , Issue.23 , pp. 6923-6941
    • Miki, H.1    Suetsugu, S.2    Takenawa, T.3
  • 53
    • 77955283973 scopus 로고    scopus 로고
    • Rac1-mediated mitochondrial H202 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1
    • Murthy S., Ryan A., He C., Mallampalli R.K., Carter A.B. Rac1-mediated mitochondrial H202 generation regulates MMP-9 gene expression in macrophages via inhibition of SP-1 and AP-1. J. Biol. Chem. 2010, 285(32):25062-25073.
    • (2010) J. Biol. Chem. , vol.285 , Issue.32 , pp. 25062-25073
    • Murthy, S.1    Ryan, A.2    He, C.3    Mallampalli, R.K.4    Carter, A.B.5
  • 54
    • 0034994490 scopus 로고    scopus 로고
    • Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites
    • Nakagawa M., Fukata M., Yamaga M., Itoh N., Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J. Cell Sci. 2001, 114(Pt 10):1829-1838.
    • (2001) J. Cell Sci. , vol.114 , Issue.PART 10 , pp. 1829-1838
    • Nakagawa, M.1    Fukata, M.2    Yamaga, M.3    Itoh, N.4    Kaibuchi, K.5
  • 56
    • 0032167411 scopus 로고    scopus 로고
    • A requirement for the Rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy
    • Pracyk J.B., Tanaka K., Hegland D.D., Kim K.S., Sethi R., Rovira I.I., et al. A requirement for the Rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. J. Clin. Invest. 1998, 102(5):929-937.
    • (1998) J. Clin. Invest. , vol.102 , Issue.5 , pp. 929-937
    • Pracyk, J.B.1    Tanaka, K.2    Hegland, D.D.3    Kim, K.S.4    Sethi, R.5    Rovira, I.I.6
  • 57
    • 79953216728 scopus 로고    scopus 로고
    • Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomized controlled trials
    • Raihimi K., Emberson J., McGale P., Majoni W., Merhi A., Asselbergs F.W., Krane V., Macfarlane P.W. Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomized controlled trials. BMJ 2011, 342:d1250.
    • (2011) BMJ , vol.342
    • Raihimi, K.1    Emberson, J.2    McGale, P.3    Majoni, W.4    Merhi, A.5    Asselbergs, F.W.6    Krane, V.7    Macfarlane, P.W.8
  • 59
    • 80052602720 scopus 로고    scopus 로고
    • Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins
    • Reilly S.N., Jayaraam R., Nahar K., Antoniades C., Verheule S., Channon K.M., Alp N.J., Schotten U., Casadei B. Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins. Circulation 2011, 124(10):1107-1117.
    • (2011) Circulation , vol.124 , Issue.10 , pp. 1107-1117
    • Reilly, S.N.1    Jayaraam, R.2    Nahar, K.3    Antoniades, C.4    Verheule, S.5    Channon, K.M.6    Alp, N.J.7    Schotten, U.8    Casadei, B.9
  • 60
    • 84864800398 scopus 로고    scopus 로고
    • Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases
    • Roe N.D., Ren J. Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases. Vascul. Pharmacol. 2012, 57(5-6):168-172.
    • (2012) Vascul. Pharmacol. , vol.57 , Issue.5-6 , pp. 168-172
    • Roe, N.D.1    Ren, J.2
  • 61
    • 78049375431 scopus 로고    scopus 로고
    • RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor α and stimulation of vascular smooth muscle cell migration
    • Rolli-Derkinderen M., Toumaniantz G., Pacaud P., Loirand G. RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor α and stimulation of vascular smooth muscle cell migration. Mol. Cell. Biol. 2010, 30(20):4786-4796.
    • (2010) Mol. Cell. Biol. , vol.30 , Issue.20 , pp. 4786-4796
    • Rolli-Derkinderen, M.1    Toumaniantz, G.2    Pacaud, P.3    Loirand, G.4
  • 62
    • 0033605738 scopus 로고    scopus 로고
    • Inhibition of myosin light chain kinase by p21-activated kinase
    • Sanders L.C., Matsumura F., Bokoch G.M., de Lancrolle P. Inhibition of myosin light chain kinase by p21-activated kinase. Science 1999, 283(5410):2083-2085.
    • (1999) Science , vol.283 , Issue.5410 , pp. 2083-2085
    • Sanders, L.C.1    Matsumura, F.2    Bokoch, G.M.3    de Lancrolle, P.4
  • 63
    • 70349305709 scopus 로고    scopus 로고
    • Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection
    • Sawada N., Liao J.K. Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection. Expert Rev. Neurother. 2009, 9(8):1171-1186.
    • (2009) Expert Rev. Neurother. , vol.9 , Issue.8 , pp. 1171-1186
    • Sawada, N.1    Liao, J.K.2
  • 64
  • 66
    • 0043166521 scopus 로고    scopus 로고
    • Statins promote potent systemic antioxidant effects through specific inflammatory pathways
    • Shishehbor M.H., Brennan M.L., Aviles R.J., Fu X., Penn M.S., Sprecher D.L., et al. Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation 2003, 108(4):426-431.
    • (2003) Circulation , vol.108 , Issue.4 , pp. 426-431
    • Shishehbor, M.H.1    Brennan, M.L.2    Aviles, R.J.3    Fu, X.4    Penn, M.S.5    Sprecher, D.L.6
  • 67
    • 59349103744 scopus 로고    scopus 로고
    • Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase
    • Sugawara T., Ayer R., Jadhav V., Chen W., Tsubokawa T., Zhang J.H. Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase. J. Neurosci. Res. 2008, 86(16):3635-3643.
    • (2008) J. Neurosci. Res. , vol.86 , Issue.16 , pp. 3635-3643
    • Sugawara, T.1    Ayer, R.2    Jadhav, V.3    Chen, W.4    Tsubokawa, T.5    Zhang, J.H.6
  • 68
    • 44949106317 scopus 로고    scopus 로고
    • Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
    • Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J. 2008, 275(13):3249-3277.
    • (2008) FEBS J. , vol.275 , Issue.13 , pp. 3249-3277
    • Sumimoto, H.1
  • 69
    • 0035186999 scopus 로고    scopus 로고
    • Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy
    • Takemoto M., Node K., Nakagami H., Liao Y., Grimm M., Takemoto Y., et al. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J. Clin. Invest. 2001, 108(10):1429-1437.
    • (2001) J. Clin. Invest. , vol.108 , Issue.10 , pp. 1429-1437
    • Takemoto, M.1    Node, K.2    Nakagami, H.3    Liao, Y.4    Grimm, M.5    Takemoto, Y.6
  • 70
    • 33845729059 scopus 로고    scopus 로고
    • The WASP-WAVE protein network: connecting the membrane to the cytoskeleton
    • Takenawa T., Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat. Rev. Mol. Cell Biol. 2007, 8(1):37-48.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , Issue.1 , pp. 37-48
    • Takenawa, T.1    Suetsugu, S.2
  • 71
    • 38349138319 scopus 로고    scopus 로고
    • Angiotensin II activates signal tranducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodelling
    • Tsai C.T., Lai L.P., Kuo K.T., Hwang J.J., Hsieh C.S., Hsu K.L., Tseng C.D., Tseng Y.Z., Chiang F.T., Lin J.L. Angiotensin II activates signal tranducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodelling. Circulation 2008, 117(3):344-355.
    • (2008) Circulation , vol.117 , Issue.3 , pp. 344-355
    • Tsai, C.T.1    Lai, L.P.2    Kuo, K.T.3    Hwang, J.J.4    Hsieh, C.S.5    Hsu, K.L.6    Tseng, C.D.7    Tseng, Y.Z.8    Chiang, F.T.9    Lin, J.L.10
  • 72
    • 75749118290 scopus 로고    scopus 로고
    • Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization
    • von Lohneysen K., Noack D., Wood M.R., Friedman J.S., Knaus U.G. Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization. Mol. Cell. Biol. 2010, 30(4):961-975.
    • (2010) Mol. Cell. Biol. , vol.30 , Issue.4 , pp. 961-975
    • von Lohneysen, K.1    Noack, D.2    Wood, M.R.3    Friedman, J.S.4    Knaus, U.G.5
  • 73
    • 0036569874 scopus 로고    scopus 로고
    • Increased atrial fibrillation mortality: United States, 1980-1998
    • Wattigney W.A., Mensah G.A., Croft J.B. Increased atrial fibrillation mortality: United States, 1980-1998. Am. J. Epidemiol. 2002, 155(9):819-826.
    • (2002) Am. J. Epidemiol. , vol.155 , Issue.9 , pp. 819-826
    • Wattigney, W.A.1    Mensah, G.A.2    Croft, J.B.3
  • 74
    • 2342418629 scopus 로고    scopus 로고
    • Rho-family GTPases: it's not only Rac and Rho (and I like it)
    • Wennerberg K., Der C.J. Rho-family GTPases: it's not only Rac and Rho (and I like it). J. Cell Sci. 2004, 117(Pt 8):1301-1312.
    • (2004) J. Cell Sci. , vol.117 , Issue.PART 8 , pp. 1301-1312
    • Wennerberg, K.1    Der, C.J.2
  • 75
    • 16844387479 scopus 로고    scopus 로고
    • The Ras superfamily at a glance
    • Wennerberg K., Rossman K.L., Der C.J. The Ras superfamily at a glance. J. Cell Sci. 2005, 118(Pt 5):843-846.
    • (2005) J. Cell Sci. , vol.118 , Issue.PART 5 , pp. 843-846
    • Wennerberg, K.1    Rossman, K.L.2    Der, C.J.3
  • 76
    • 0037157824 scopus 로고    scopus 로고
    • Intergrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
    • Werner E., Werb Z. Intergrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J. Cell Biol. 2002, 158(2):357-368.
    • (2002) J. Cell Biol. , vol.158 , Issue.2 , pp. 357-368
    • Werner, E.1    Werb, Z.2
  • 77
    • 38549135458 scopus 로고    scopus 로고
    • Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment
    • Whaley-Connell A., Habibi J., Nistala R., Cooper S.A., Karuparthi P.R., Hayden M.R., et al. Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment. Hypertension 2008, 51(2):474-480.
    • (2008) Hypertension , vol.51 , Issue.2 , pp. 474-480
    • Whaley-Connell, A.1    Habibi, J.2    Nistala, R.3    Cooper, S.A.4    Karuparthi, P.R.5    Hayden, M.R.6
  • 78
    • 77955980491 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition
    • Wind S., Beuerlein K., Armitage M.E., Taye A., Kumar A.H., Janowitz D., et al. Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition. Hypertension 2010, 56(3):490-497.
    • (2010) Hypertension , vol.56 , Issue.3 , pp. 490-497
    • Wind, S.1    Beuerlein, K.2    Armitage, M.E.3    Taye, A.4    Kumar, A.H.5    Janowitz, D.6
  • 81
    • 80051724623 scopus 로고    scopus 로고
    • The effects of statin on atrial fibrillation: a meta-analysis of published data from randomized controlled trials
    • Xu Q., Guan Y.Q., Zhang D., Su G.H. The effects of statin on atrial fibrillation: a meta-analysis of published data from randomized controlled trials. Curr. Med. Res. Opin. 2011, 27(9):1771-1779.
    • (2011) Curr. Med. Res. Opin. , vol.27 , Issue.9 , pp. 1771-1779
    • Xu, Q.1    Guan, Y.Q.2    Zhang, D.3    Su, G.H.4
  • 82
    • 0032565769 scopus 로고    scopus 로고
    • Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
    • Yang N., Higuchi O., Ohashi K., Nagata K., Wada A., Kangawa K., Nishida E., Mizuno K. Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 1998, 393(6687):809-812.
    • (1998) Nature , vol.393 , Issue.6687 , pp. 809-812
    • Yang, N.1    Higuchi, O.2    Ohashi, K.3    Nagata, K.4    Wada, A.5    Kangawa, K.6    Nishida, E.7    Mizuno, K.8
  • 83
    • 34247251313 scopus 로고    scopus 로고
    • 2-elevated by oxidized LDL enhances human aortic smooth muscle cell proliferation
    • 2-elevated by oxidized LDL enhances human aortic smooth muscle cell proliferation. J. Biomed. Sci. 2007, 14(2):245-254.
    • (2007) J. Biomed. Sci. , vol.14 , Issue.2 , pp. 245-254
    • Yin, C.C.1    Huang, K.T.2
  • 84
    • 0032493445 scopus 로고    scopus 로고
    • Gp91 (phox) is the heme binding subunit of the superoxide-generating NADPH oxidase
    • Yu L., Quinn M.T., Cross A.R., Dinauer M.C. Gp91 (phox) is the heme binding subunit of the superoxide-generating NADPH oxidase. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(14):7993-7998.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , Issue.14 , pp. 7993-7998
    • Yu, L.1    Quinn, M.T.2    Cross, A.R.3    Dinauer, M.C.4
  • 85
    • 70350337947 scopus 로고    scopus 로고
    • The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes
    • Yuzawa S., Miyano K., Honbou K., Inagaki F., Sumimoto H. The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes. J. Innate Immun. 2009, 1(6):543-555.
    • (2009) J. Innate Immun. , vol.1 , Issue.6 , pp. 543-555
    • Yuzawa, S.1    Miyano, K.2    Honbou, K.3    Inagaki, F.4    Sumimoto, H.5
  • 86
    • 78149239505 scopus 로고    scopus 로고
    • NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis
    • Zhang M., Brewer A.C., Schroder K., Santos C.X., Grieve D.J., Wang M., et al. NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107(42):18121-18126.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.42 , pp. 18121-18126
    • Zhang, M.1    Brewer, A.C.2    Schroder, K.3    Santos, C.X.4    Grieve, D.J.5    Wang, M.6
  • 87
    • 84866325854 scopus 로고    scopus 로고
    • NOX-4 dependent hydrogen peroxide overproduction in human atrial fibrillation and HL-1 atrial cells: relationship to hypertension
    • Zhang J., Youn J.Y., Kim A.Y., Ramirez R.J., Gao L., Ngo D., Cheng P., Scovotti J., Mahajan A., Cai H. NOX-4 dependent hydrogen peroxide overproduction in human atrial fibrillation and HL-1 atrial cells: relationship to hypertension. Front. Physiol. 2012, 3(140).
    • (2012) Front. Physiol. , vol.3 , Issue.140
    • Zhang, J.1    Youn, J.Y.2    Kim, A.Y.3    Ramirez, R.J.4    Gao, L.5    Ngo, D.6    Cheng, P.7    Scovotti, J.8    Mahajan, A.9    Cai, H.10


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