Inhibitory effect of estrogen on Rac1-expression in monocytes

Biochemical and Biophysical Research Communications

Volumn 386, Issue 1, 2009, Pages 45-49

  Adam, Oliver ^a   Hagel, Marion ^a   Theobald, Katharina ^a   Böhm, Michael ^a   Laufs, Ulrich ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Estrogen; Monocytes; Oxidative stress; Rac1 GTPase

Indexed keywords

ANGIOTENSIN II; ESTRADIOL; FREE RADICAL; GUANOSINE TRIPHOSPHATASE; MUTANT PROTEIN; OXYGEN RADICAL; RAC PROTEIN; RAC1 PROTEIN; RACL61 PROTEIN; RACN17 PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED OVARIAN HYPERSTIMULATION; CONTROLLED STUDY; DOWN REGULATION; ESTROGEN ACTIVITY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFERTILITY THERAPY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIME;

ANGIOTENSIN II; DOWN-REGULATION; ESTRADIOL; ESTROGENS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MONOCYTES; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 67649365440     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.05.126     Document Type: Article

References (36)

1. Glass C.K., and Witztum J.L. Atherosclerosis: the road ahead. Cell 104 (2001) 503-516
2. Ross R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340 (1999) 115-126
3. Cathcart M.K., Morel D.W., and Chisolm III G.M. Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. J. Leukoc. Biol. 38 (1985) 341-350
4. Cathcart M.K. Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages: contributions to atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 23-28
5. Libby P., Ridker P.M., and Maseri A. Inflammation and atherosclerosis. Circulation 105 (2002) 1135-1143
6. Griendling K.K., and Harrison D.G. Out, damned dot: studies of the NADPH oxidase in atherosclerosis. J. Clin. Invest. 108 (2001) 1423-1424
7. Heitzer T., Schlinzig T., Krohn K., Meinertz T., and Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104 (2001) 2673-2678
8. Sorescu D., Szocs K., and Griendling K.K. NAD(P)H oxidases and their relevance to atherosclerosis. Trends Cardiovasc. Med. 11 (2001) 124-131
9. Vignais P.V. The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell. Mol. Life Sci. 59 (2002) 1428-1459
10. Aktories K. Bacterial toxins that target Rho proteins. J. Clin. Invest. 99 (1997) 827-829
11. Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
12. Diekmann D., Abo A., Johnston C., Segal A.W., and Hall A. Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. Science 265 (1994) 531-533
13. Wagner A.H., Schroeter M.R., and Hecker M. 17Beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J. 15 (2001) 2121-2130
14. Wassmann S., Laufs U., Baumer A.T., Muller K., Konkol C., Sauer H., Böhm M., and Nickenig G. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Mol. Pharmacol. 59 (2001) 646-654
15. Gorzalczany Y., Sigal N., Itan M., Lotan O., and Pick E. Targeting of Rac1 to the phagocyte membrane is sufficient for the induction of NADPH oxidase assembly. J. Biol. Chem. 275 (2000) 40073-40081
16. Pracyk J.B., Tanaka K., Hegland D.D., Kim K.S., Sethi R., Rovira I.I., Blazina D.R., Lee L., Bruder J.T., Kovesdi I., Goldshmidt-Clermont P.J., Irani K., and Finkel T. A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. J. Clin. Invest. 102 (1998) 929-937
17. Adam O., Frost G., Custodis F., Sussman M.A., Schäfers H.J., Böhm M., and Laufs U. Role of Rac1 GTPase activation in atrial fibrillation. J. Am. Coll. Cardiol. 50 (2007) 359-367
18. Laufs U., Adam O., Strehlow K., Wassmann S., Konkol C., Laufs K., Schmidt W., Böhm M., and Nickenig G. Down-regulation of Rac-1 GTPase by estrogen. J. Biol. Chem. 278 (2003) 5956-5962
19. Barbacanne M.A., Rami J., Michel J.B., Souchard J.P., Philippe M., Besombes J.P., Bayard F., and Arnal J.F. Estradiol increases rat aorta endothelium-derived relaxing factor (EDRF) activity without changes in endothelial NO synthase gene expression: possible role of decreased endothelium-derived superoxide anion production. Cardiovasc. Res. 41 (1999) 672-681
20. Grodstein F., Stampfer M.J., Manson J.E., Colditz G.A., Willett W.C., Rosner B., Speizer F.E., and Hennekens C.H. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N. Engl. J. Med. 335 (1996) 453-461
21. Mendelsohn M.E., and Karas R.H. The protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 340 (1999) 1801-1811
22. Nickenig G., Baumer A.T., Grohe C., Kahlert S., Strehlow K., Rosenkranz S., Stablein A., Beckers F., Smits J.F., Daemen M.J., Vetter H., and Böhm M. Estrogen modulates AT1 receptor gene expression in vitro and in vivo. Circulation 97 (1998) 2197-2201
23. van Eickels M., Grohe C., Cleutjens J.P., Janssen B.J., Wellens H.J., and Doevendans P.A. 17beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation 104 (2001) 1419-1423
24. Laufs U., and Liao J.K. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 273 (1998) 24266-24271
25. Daiber A., August M., Baldus S., Wendt M., Oelze M., Sydow K., Kleschyov A.L., and Munzel T. Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012. Free Radic. Biol. Med.. 36 (2004) 101-111
26. Keidar S., Kaplan M., and Aviram M. Angiotensin II-modified LDL is taken up by macrophages via the scavenger receptor, leading to cellular cholesterol accumulation. Arterioscler. Thromb. Vasc. Biol. 16 (1996) 97-105
27. Sulistiyani, and St. Clair R.W. Effect of 17 beta-estradiol on metabolism of acetylated low-density lipoprotein by THP-1 macrophages in culture. Arterioscler. Thromb. Vasc. Biol. 17 (1997) 1691-1700
28. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., and Witztum J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320 (1989) 915-924
29. Witztum J.L., and Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88 (1991) 1785-1792
30. Griendling K.K., and Alexander R.W. Oxidative stress and cardiovascular disease. Circulation 96 (1997) 3264-3265
31. Zhao X., Carnevale K.A., and Cathcart M.K. Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex. J. Biol. Chem. 278 (2003) 40788-40792
32. Alloul N., Gorzalczany Y., Itan M., Sigal N., and Pick E. Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1. Biochemistry 40 (2001) 14557-14566
33. Harokopakis E., Albzreh M.H., Martin M.H., and Hajishengallis G. TLR2 transmodulates monocyte adhesion and transmigration via Rac1- and PI3K-mediated inside-out signaling in response to Porphyromonas gingivalis fimbriae. J. Immunol. 176 (2006) 7645-7656
34. Friedrich E.B., Clever Y.P., Wassmann S., Hess C., and Nickenig G. 17Beta-estradiol inhibits monocyte adhesion via down-regulation of Rac1 GTPase. J. Mol. Cell. Cardiol. 40 (2006) 87-95
35. Su L.F., Knoblauch R., and Garabedian M.J. Rho GTPases as modulators of the estrogen receptor transcriptional response. J. Biol. Chem. 276 (2001) 3231-3237
36. Kim K.S., Takeda K., Sethi R., Pracyk J.B., Tanaka K., Zhou Y.F., Yu Z.X., Ferrans V.J., Bruder J.T., Kovesdi I., Irani K., Goldschmidt-Clermont P., and Finkel T. Protection from reoxygenation injury by inhibition of rac1. J. Clin. Invest. 101 (1998) 1821-1826