Ginsenoside Rh2 induces human hepatoma cell apoptosis via bax/bak triggered cytochrome C release and caspase-9/caspase-8 activation

International Journal of Molecular Sciences

Volumn 13, Issue 12, 2012, Pages 15523-15535

  Guo, Xiao Xi ^a   Guo, Qiao ^a   Li, Yang ^a   Lee, Seung Ki ^b   Wei, Xue Ning ^a   Jin, Ying Hua ^a  

^a JILIN UNIVERSITY   (China)

^b Seoul National University   (South Korea)

Author keywords

Apoptosis; Bax Bak translocation; Caspase activation cascade; Caspase 8 Bid pathway; Ginsenoside Rh2

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; GINSENOSIDE RH 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; BAK1 PROTEIN, HUMAN; BAX PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; GINSENOSIDE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME RELEASE; GENE INACTIVATION; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; RNA INTERFERENCE; DRUG EFFECTS; LIVER CELL CARCINOMA; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; ENZYME ACTIVATION; GINSENOSIDES; HUMANS; LIVER NEOPLASMS;

EID: 84871708479     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131215523     Document Type: Article

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