Myocardial insulin resistance, metabolic stress and autophagy in diabetes

Clinical and Experimental Pharmacology and Physiology

Volumn 40, Issue 1, 2013, Pages 56-61

  Mellor, Kimberley M ^a   Bell, James R ^a   Ritchie, Rebecca H ^a   Delbridge, Lea Md ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Autophagy; Cardiac; Diabetes; Excitation contraction coupling; Insulin resistance; Metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; FRUCTOSE; GLUCOSE TRANSPORTER 4;

ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; DIABETIC CARDIOMYOPATHY; DISEASE COURSE; ENERGY RESOURCE; EXCITATION CONTRACTION COUPLING; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOLYSIS; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; METABOLIC STRESS; MYOCARDIAL INSULIN RESISTANCE; MYOFILAMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; SARCOLEMMA; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM; CARDIOMEGALY; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FRUCTOSE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HEART; INSULIN RESISTANCE; MICE; MICE, INBRED C57BL; MYOCARDIUM; MYOCYTES, CARDIAC; MYOFIBRILS; SARCOPLASMIC RETICULUM; STRESS, PHYSIOLOGICAL;

EID: 84871696119     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2012.05738.x     Document Type: Article

References (56)

1. De Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai N. Prevalence of the metabolic syndrome in American adolescents. Findings from the Third National Health and Nutrition Examination Survey. Circulation 2004; 110: 2494-7.
2. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am. J. Clin. Nutr. 2002; 76: 911-22.
3. Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: The Framingham Study. J. Am. Coll. Cardiol. 1993; 22: 6A-13A.
4. Kamalesh M. Heart failure in diabetes and related conditions. J. Cardiac Fail. 2007; 13: 861-73.
5. Boyer JK, Thanigaraj S, Schechtman KB, Perez JE. Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus. Am. J. Cardiol. 2004; 93: 870-5.
6. Fukuta H, Little WC. Contribution of systolic and diastolic abnormalities to heart failure with a normal and a reduced ejection fraction. Prog. Cardiovasc. Dis. 2007; 49: 229-40.
7. Stanley WC, Lopaschuk GD, McCormack JG. Regulation of energy substrate metabolism in the diabetic heart. Cardiovasc. Res. 1997; 34: 25-33.
8. Feuvray D, Darmellah A. Diabetes-related metabolic perturbations in cardiac myocyte. Diabetes Metab. 2008; 34(Suppl. 1): S3-9.
9. 2+ transport. Circ. Res. 1995; 77: 88-97.
10. 2+ release by glycolysis in cat atrial myocytes. J. Physiol. 2005; 564: 697-714.
11. How OJ, Aasum E, Severson DL, Chan WY, Essop MF, Larsen TS. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 2006; 55: 466-73.
12. An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am. J. Physiol. Heart Circ. Physiol. 2006; 291: H1489-506.
13. Goldhaber J. Metabolism in normal and ischemic myocardium. In: Langer GA (ed). The Myocardium, 2nd edn. Academic Press, London. 1997; Ch. 7.
14. Schwenk RW, Luiken JJ, Bonen A, Glatz JF. Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease. Cardiovasc. Res. 2008; 79: 249-58.
15. Abel ED. Glucose transport in the heart. Front. Biosci. 2004; 9: 201-15.
16. Steinbusch LK, Schwenk RW, Ouwens DM, Diamant M, Glatz JF, Luiken JJ. Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes. Cell. Mol. Life Sci. 2011; 68: 2525-38.
17. Ouwens DM, Diamant M, Fodor M et al. Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification. Diabetologia 2007; 50: 1938-48.
18. Van den Brom CE, Huisman MC, Vlasblom R et al. Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: Studies using positron emission tomography. Cardiovasc. Diabetol. 2009; 8: 39.
19. Depre C, Young ME, Ying J et al. Streptozotocin-induced changes in cardiac gene expression in the absence of severe contractile dysfunction. J. Mol. Cell. Cardiol. 2000; 32: 985-96.
20. Kainulainen H, Breiner M, Schurmann A, Marttinen A, Virjo A, Joost HG. In vivo glucose uptake and glucose transporter proteins GLUT1 and GLUT4 in heart and various types of skeletal muscle from streptozotocin-diabetic rats. Biochim. Biophys. Acta 1994; 1225: 275-82.
21. Sokolovska J, Isajevs S, Sugoka O et al. Correction of glycaemia and GLUT1 level by mildronate in rat streptozotocin diabetes mellitus model. Cell Biochem. Funct. 2011; 29: 55-63.
22. Mellor KM, Ritchie RH, Delbridge LM. Reactive oxygen species and insulin-resistant cardiomyopathy. Clin. Exp. Pharmacol. Physiol. 2010; 37: 222-8.
23. Bugger H, Abel ED. Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin. Sci. 2008; 114: 195-210.
24. Dabkowski ER, Baseler WA, Williamson CL et al. Mitochondrial dysfunction in the type 2 diabetic heart is associated with alterations in spatially distinct mitochondrial proteomes. Am. J. Physiol. Heart Circ. Physiol. 2010; 299: H529-40.
25. 2+ handling in vitro. PLoS ONE 2011; 6: e25204.
26. Kawasaki T, Akanuma H, Yamanouchi T. Increased fructose concentrations in blood and urine in patients with diabetes. Diabetes Care 2002; 25: 353-7.
27. Levi B, Werman MJ. Long-term fructose consumption accelerates glycation and several age-related variables in male rats. J. Nutr. 1998; 128: 1442-9.
28. 2+ handling and myofilament responsiveness. Am. J. Physiol. Heart Circ. Physiol. 2012; 302: H964-72.
29. Mellor KM, Ritchie RH, Davidoff AJ, Delbridge LMD. Elevated dietary sugar and the heart: Experimental models and myocardial remodeling. Can. J. Physiol. Pharmacol. 2010; 88: 525-40.
30. Huser J, Wang YG, Sheehan KA, Cifuentes F, Lipsius SL, Blatter LA. Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J. Physiol. 2000; 524: 795-806.
31. Pierce GN, Philipson KD. Binding of glycolytic enzymes to cardiac sarcolemmal and sarcoplasmic reticular membranes. J. Biol. Chem. 1985; 260: 6862-70.
32. + regulation in normal and failing hearts. J. Pharmacol. Sci. 2006; 100: 315-22.
33. + channels. Cardiovasc. Drugs Ther. 1993; 7(Suppl. 3): 499-505.
34. +-ATPase reactivation is delayed in the absence of glycolytic ATP in isolated rat hearts. Am. J. Physiol. Heart Circ. Physiol. 2001; 280: H2189-95.
35. Gibbs CL, Chapman JB. Cardiac heat production. Annu. Rev. Physiol. 1979; 41: 507-19.
36. Kaczmarczyk SJ, Andrikopoulos S, Favaloro J et al. Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy. J. Mol. Endocrinol. 2003; 31: 449-59.
37. Ritchie RH, Quinn JM, Cao AH et al. The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo. J. Mol. Cell. Cardiol. 2007; 42: 1119-28.
38. 2+ and proton flux dysregulation. J. Mol. Cell. Cardiol. 2010; 48: 663-72.
39. Huggins CE, Domenighetti AA, Ritchie ME et al. Functional and metabolic remodelling in GLUT4-deficient hearts confers hyper-responsiveness to substrate intervention. J. Mol. Cell. Cardiol. 2008; 44: 270-80.
40. Mellor K, Ritchie RH, Meredith G, Woodman OL, Morris MJ, Delbridge LM. High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy. Nutrition 2009; 26: 842-8.
41. Mellor KM, Bell JR, Young MJ, Ritchie RH, Delbridge LM. Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J. Mol. Cell. Cardiol. 2011; 50: 1035-43.
42. Briat A, Slimani L, Perret P et al. In vivo assessment of cardiac insulin resistance by nuclear probes using an iodinated tracer of glucose transport. Eur. J. Nucl. Med. Mol. imaging 2007; 34: 1756-64.
43. Qin B, Polansky MM, Harry D, Anderson RA. Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. Mol. Nutr. Food Res. 2010; 54(Suppl. 1): S14-23.
44. Cao J, Xu D, Wang D et al. ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. Free Radic. Biol. Med. 2009; 47: 536-47.
45. Chang KC, Liang JT, Tseng CD et al. Aminoguanidine prevents fructose-induced deterioration in left ventricular-arterial coupling in Wistar rats. Br. J. Pharmacol. 2007; 151: 341-6.
46. Chess DJ, Xu W, Khairallah R et al. The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high fructose diet. Am. J. Physiol. Heart Circ. Physiol. 2008; 295: H2223-30.
47. Mellor KM, Reichelt ME, Delbridge LM. Autophagy anomalies in the diabetic myocardium. Autophagy 2011; 7: 1263-7.
48. Nishida K, Kyoi S, Yamaguchi O, Sadoshima J, Otsu K. The role of autophagy in the heart. Cell Death Differ. 2009; 16: 31-8.
49. Gustafsson AB, Gottlieb RA. Autophagy in ischemic heart disease. Circ. Res. 2009; 104: 150-8.
50. Dorn 2nd GW. Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling. Cardiovasc. Res. 2009; 81: 465-73.
51. Matsui Y, Takagi H, Qu X et al. Distinct roles of autophagy in the heart during ischemia and reperfusion. Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 2007; 100: 914-22.
52. Takagi H, Matsui Y, Hirotani S, Sakoda H, Asano T, Sadoshima J. AMPK mediates autophagy during myocardial ischemia in vivo. Autophagy 2007; 3: 405-7.
53. Xie Z, Lau K, Eby B et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes 2011; 60: 1770-8.
54. Iribarren C, Karter AJ, Go AS et al. Glycemic control and heart failure among adult patients with diabetes. Circulation 2001; 103: 2668-73.
55. Witteles RM, Tang WH, Jamali AH, Chu JW, Reaven GM, Fowler MB. Insulin resistance in idiopathic dilated cardiomyopathy: A possible etiologic link. J. Am. Coll. Cardiol. 2004; 44: 78-81.
56. Witteles RM, Fowler MB. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. J. Am. Coll. Cardiol. 2008; 51: 93-102.