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Volumn 254, Issue 1-2, 2013, Pages 131-140

Immune response during interferon beta-1b treatment in patients with multiple sclerosis who experienced relapses and those who were relapse-free in the START study

Author keywords

Cytokines; Immune markers; Interferon beta 1b; Multiple sclerosis

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; GAMMA INTERFERON; INTERFERON BETA SERINE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4;

EID: 84871695430     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.08.012     Document Type: Article
Times cited : (22)

References (43)
  • 3
    • 67349201042 scopus 로고    scopus 로고
    • Interferon-beta therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism
    • Azoulay D., Mausner-Fainberg K., Urshansky N., Fahoum F., Karni A. Interferon-beta therapy up-regulates BDNF secretion from PBMCs of MS patients through a CD40-dependent mechanism. J. Neuroimmunol. 2009, 211:114-119.
    • (2009) J. Neuroimmunol. , vol.211 , pp. 114-119
    • Azoulay, D.1    Mausner-Fainberg, K.2    Urshansky, N.3    Fahoum, F.4    Karni, A.5
  • 4
    • 84862741487 scopus 로고    scopus 로고
    • Serum IL-17F does not predict poor response to IM IFNbeta-1a in relapsing-remitting MS
    • Bushnell S.E., Zhao Z., Stebbins C.C., Cadavid D., Buko A.M., Whalley E.T., et al. Serum IL-17F does not predict poor response to IM IFNbeta-1a in relapsing-remitting MS. Neurology 2012, 79:531-537.
    • (2012) Neurology , vol.79 , pp. 531-537
    • Bushnell, S.E.1    Zhao, Z.2    Stebbins, C.C.3    Cadavid, D.4    Buko, A.M.5    Whalley, E.T.6
  • 6
    • 59349113948 scopus 로고    scopus 로고
    • Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
    • Candelario-Jalil E., Yang Y., Rosenberg G.A. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience 2009, 158:983-994.
    • (2009) Neuroscience , vol.158 , pp. 983-994
    • Candelario-Jalil, E.1    Yang, Y.2    Rosenberg, G.A.3
  • 8
    • 79956116032 scopus 로고    scopus 로고
    • RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri L., Gyulveszi G., Tosevski V., Hesske L., Fontana A., Magnenat L., Suter T., Becher B. RORgammat drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 2011, 12:560-567.
    • (2011) Nat. Immunol. , vol.12 , pp. 560-567
    • Codarri, L.1    Gyulveszi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6    Suter, T.7    Becher, B.8
  • 10
    • 34249803582 scopus 로고    scopus 로고
    • Pathogenesis of myelin/oligodendrocyte damage in multiple sclerosis
    • Dhib-Jalbut S. Pathogenesis of myelin/oligodendrocyte damage in multiple sclerosis. Neurology 2007, 68:S13-S21.
    • (2007) Neurology , vol.68
    • Dhib-Jalbut, S.1
  • 11
    • 74249112995 scopus 로고    scopus 로고
    • Interferon-beta mechanisms of action in multiple sclerosis
    • Dhib-Jalbut S., Marks S. Interferon-beta mechanisms of action in multiple sclerosis. Neurology 2010, 74(Suppl. 1):S17-S24.
    • (2010) Neurology , vol.74 , Issue.SUPPL. 1
    • Dhib-Jalbut, S.1    Marks, S.2
  • 12
    • 77649104721 scopus 로고    scopus 로고
    • Neutralizing antibodies, MxA expression and MMP-9/TIMP-1 ratio as markers of bioavailability of interferon-beta treatment in multiple sclerosis patients: a two-year follow-up study
    • Garcia-Montojo M., Dominguez-Mozo M.I., De Las Heras V., Bartolome M., Garcia-Martinez A., Arroyo R., varez-Lafuente R. Neutralizing antibodies, MxA expression and MMP-9/TIMP-1 ratio as markers of bioavailability of interferon-beta treatment in multiple sclerosis patients: a two-year follow-up study. Eur. J. Neurol. 2010, 17:470-478.
    • (2010) Eur. J. Neurol. , vol.17 , pp. 470-478
    • Garcia-Montojo, M.1    Dominguez-Mozo, M.I.2    De Las Heras, V.3    Bartolome, M.4    Garcia-Martinez, A.5    Arroyo, R.6    varez-Lafuente, R.7
  • 13
    • 0037154192 scopus 로고    scopus 로고
    • Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines
    • Goodin D.S., Frohman E.M., Garmany G.P., Halper J., Likosky W.H., Lublin F.D., Silberberg D.H., Stuart W.H., van den Noort S. Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. Neurology 2002, 58:169-178.
    • (2002) Neurology , vol.58 , pp. 169-178
    • Goodin, D.S.1    Frohman, E.M.2    Garmany, G.P.3    Halper, J.4    Likosky, W.H.5    Lublin, F.D.6    Silberberg, D.H.7    Stuart, W.H.8    van den Noort, S.9
  • 14
    • 14844297366 scopus 로고    scopus 로고
    • Interferon-beta-1a induces increases in vascular cell adhesion molecule: implications for its mode of action in multiple sclerosis
    • Graber J., Zhan M., Ford D., Kursch F., Francis G., Bever C., Panitch H., Calabresi P.A., Dhib-Jalbut S. Interferon-beta-1a induces increases in vascular cell adhesion molecule: implications for its mode of action in multiple sclerosis. J. Neuroimmunol. 2005, 161:169-176.
    • (2005) J. Neuroimmunol. , vol.161 , pp. 169-176
    • Graber, J.1    Zhan, M.2    Ford, D.3    Kursch, F.4    Francis, G.5    Bever, C.6    Panitch, H.7    Calabresi, P.A.8    Dhib-Jalbut, S.9
  • 15
    • 33947681258 scopus 로고    scopus 로고
    • Cytokine changes during interferon-beta therapy in multiple sclerosis: correlations with interferon dose and MRI response
    • Graber J.J., Ford D., Zhan M., Francis G., Panitch H., Dhib-Jalbut S. Cytokine changes during interferon-beta therapy in multiple sclerosis: correlations with interferon dose and MRI response. J. Neuroimmunol. 2007, 185:168-174.
    • (2007) J. Neuroimmunol. , vol.185 , pp. 168-174
    • Graber, J.J.1    Ford, D.2    Zhan, M.3    Francis, G.4    Panitch, H.5    Dhib-Jalbut, S.6
  • 16
    • 37849004434 scopus 로고    scopus 로고
    • Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis?
    • Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: relevance for repair strategies in multiple sclerosis?. J. Neurol. Sci. 2008, 265:93-96.
    • (2008) J. Neurol. Sci. , vol.265 , pp. 93-96
    • Hohlfeld, R.1
  • 18
    • 0027503708 scopus 로고
    • Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis
    • Katz D., Taubenberger J.K., Cannella B., McFarlin D.E., Raine C.S., McFarland H.F. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann. Neurol. 1993, 34:661-669.
    • (1993) Ann. Neurol. , vol.34 , pp. 661-669
    • Katz, D.1    Taubenberger, J.K.2    Cannella, B.3    McFarlin, D.E.4    Raine, C.S.5    McFarland, H.F.6
  • 20
    • 79953803423 scopus 로고    scopus 로고
    • Determinants of interferon beta efficacy in patients with multiple sclerosis
    • Killestein J., Polman C.H. Determinants of interferon beta efficacy in patients with multiple sclerosis. Nat. Rev. Neurol. 2011, 7:221-228.
    • (2011) Nat. Rev. Neurol. , vol.7 , pp. 221-228
    • Killestein, J.1    Polman, C.H.2
  • 21
    • 33745868391 scopus 로고    scopus 로고
    • Dynamic T-lymphocyte chemokine receptor expression induced by interferon-beta therapy in multiple sclerosis
    • Krakauer M., Sorensen P.S., Khademi M., Olsson T., Sellebjerg F. Dynamic T-lymphocyte chemokine receptor expression induced by interferon-beta therapy in multiple sclerosis. Scand. J. Immunol. 2006, 64:155-163.
    • (2006) Scand. J. Immunol. , vol.64 , pp. 155-163
    • Krakauer, M.1    Sorensen, P.S.2    Khademi, M.3    Olsson, T.4    Sellebjerg, F.5
  • 22
    • 79961142202 scopus 로고    scopus 로고
    • Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration
    • Kurachi M., Kurachi J., Suenaga F., Tsukui T., Abe J., Ueha S., et al. Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration. J. Exp. Med. 2011, 208:1605-1620.
    • (2011) J. Exp. Med. , vol.208 , pp. 1605-1620
    • Kurachi, M.1    Kurachi, J.2    Suenaga, F.3    Tsukui, T.4    Abe, J.5    Ueha, S.6
  • 23
    • 0030483220 scopus 로고    scopus 로고
    • Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: a possible mechanism for treatment efficacy in multiple sclerosis
    • Leppert D., Waubant E., Burk M.R., Oksenberg J.R., Hauser S.L. Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: a possible mechanism for treatment efficacy in multiple sclerosis. Ann. Neurol. 1996, 40:846-852.
    • (1996) Ann. Neurol. , vol.40 , pp. 846-852
    • Leppert, D.1    Waubant, E.2    Burk, M.R.3    Oksenberg, J.R.4    Hauser, S.L.5
  • 24
    • 79959499097 scopus 로고    scopus 로고
    • The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment
    • Lindquist S., Hassinger S., Lindquist J.A., Sailer M. The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment. Mult. Scler. 2011, 17:851-866.
    • (2011) Mult. Scler. , vol.17 , pp. 851-866
    • Lindquist, S.1    Hassinger, S.2    Lindquist, J.A.3    Sailer, M.4
  • 25
    • 49449097216 scopus 로고    scopus 로고
    • Beta interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells
    • Martin-Saavedra F.M., Gonzalez-Garcia C., Bravo B., Ballester S. Beta interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells. Mol. Immunol. 2008, 45:4008-4019.
    • (2008) Mol. Immunol. , vol.45 , pp. 4008-4019
    • Martin-Saavedra, F.M.1    Gonzalez-Garcia, C.2    Bravo, B.3    Ballester, S.4
  • 26
    • 0028241924 scopus 로고
    • Defective production of anti-inflammatory cytokine, TGF-beta by T cell lines of patients with active multiple sclerosis
    • Mokhtarian F., Shi Y., Shirazian D., Morgante L., Miller A., Grob D. Defective production of anti-inflammatory cytokine, TGF-beta by T cell lines of patients with active multiple sclerosis. J. Immunol. 1994, 152:6003-6010.
    • (1994) J. Immunol. , vol.152 , pp. 6003-6010
    • Mokhtarian, F.1    Shi, Y.2    Shirazian, D.3    Morgante, L.4    Miller, A.5    Grob, D.6
  • 27
    • 0034333256 scopus 로고    scopus 로고
    • VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis
    • Muraro P.A., Leist T., Bielekova B., McFarland H.F. VLA-4/CD49d downregulated on primed T lymphocytes during interferon-beta therapy in multiple sclerosis. J. Neuroimmunol. 2000, 111:186-194.
    • (2000) J. Neuroimmunol. , vol.111 , pp. 186-194
    • Muraro, P.A.1    Leist, T.2    Bielekova, B.3    McFarland, H.F.4
  • 28
    • 0029762023 scopus 로고    scopus 로고
    • Review: cytokines and the pathogenesis of multiple sclerosis
    • Navikas V., Link H. Review: cytokines and the pathogenesis of multiple sclerosis. J. Neurosci. Res. 1996, 45:322-333.
    • (1996) J. Neurosci. Res. , vol.45 , pp. 322-333
    • Navikas, V.1    Link, H.2
  • 29
    • 0034256059 scopus 로고    scopus 로고
    • Multiple sclerosis: pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-beta
    • Ozenci V., Kouwenhoven M., Teleshova N., Pashenkov M., Fredrikson S., Link H. Multiple sclerosis: pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-beta. J. Neuroimmunol. 2000, 108:236-243.
    • (2000) J. Neuroimmunol. , vol.108 , pp. 236-243
    • Ozenci, V.1    Kouwenhoven, M.2    Teleshova, N.3    Pashenkov, M.4    Fredrikson, S.5    Link, H.6
  • 30
    • 70449380035 scopus 로고    scopus 로고
    • Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study
    • Pachner A.R., Cadavid D., Wolansky L., Skurnick J. Effect of anti-IFN{beta} antibodies on MRI lesions of MS patients in the BECOME study. Neurology 2009, 73:1485-1492.
    • (2009) Neurology , vol.73 , pp. 1485-1492
    • Pachner, A.R.1    Cadavid, D.2    Wolansky, L.3    Skurnick, J.4
  • 32
    • 44949152591 scopus 로고    scopus 로고
    • Bench to bedside: tempering antigen-presenting cells in multiple sclerosis
    • Prod'homme T., Zamvil S.S. Bench to bedside: tempering antigen-presenting cells in multiple sclerosis. Nat. Med. 2008, 14:614-615.
    • (2008) Nat. Med. , vol.14 , pp. 614-615
    • Prod'homme, T.1    Zamvil, S.S.2
  • 33
    • 0033998708 scopus 로고    scopus 로고
    • Cytokine secretion profile of myelin basic protein-specific T cells in multiple sclerosis
    • Rohowsky-Kochan C., Molinaro D., Cook S.D. Cytokine secretion profile of myelin basic protein-specific T cells in multiple sclerosis. Mult. Scler. 2000, 6:69-77.
    • (2000) Mult. Scler. , vol.6 , pp. 69-77
    • Rohowsky-Kochan, C.1    Molinaro, D.2    Cook, S.D.3
  • 35
    • 34248177331 scopus 로고    scopus 로고
    • Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-beta 1a, and high doses of immunoglobulins
    • Sarchielli P., Zaffaroni M., Floridi A., Greco L., Candeliere A., Mattioni A., Tenaglia S., Di Filippo M., Calabresi P. Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-beta 1a, and high doses of immunoglobulins. Mult. Scler. 2007, 13:313-331.
    • (2007) Mult. Scler. , vol.13 , pp. 313-331
    • Sarchielli, P.1    Zaffaroni, M.2    Floridi, A.3    Greco, L.4    Candeliere, A.5    Mattioni, A.6    Tenaglia, S.7    Di Filippo, M.8    Calabresi, P.9
  • 36
    • 0029011440 scopus 로고
    • Blood-brain barrier disruption on contrast-enhanced MRI in patients with mild relapsing-remitting multiple sclerosis: relationship to course, gender, and age
    • Stone L.A., Smith M.E., Albert P.S., Bash C.N., Maloni H., Frank J.A., McFarland H.F. Blood-brain barrier disruption on contrast-enhanced MRI in patients with mild relapsing-remitting multiple sclerosis: relationship to course, gender, and age. Neurology 1995, 45:1122-1126.
    • (1995) Neurology , vol.45 , pp. 1122-1126
    • Stone, L.A.1    Smith, M.E.2    Albert, P.S.3    Bash, C.N.4    Maloni, H.5    Frank, J.A.6    McFarland, H.F.7
  • 37
    • 0030498666 scopus 로고    scopus 로고
    • Interferon beta-1b decreases the migration of T lymphocytes in vitro: effects on matrix metalloproteinase-9
    • Stuve O., Dooley N.P., Uhm J.H., Antel J.P., Francis G.S., Williams G., Yong V.W. Interferon beta-1b decreases the migration of T lymphocytes in vitro: effects on matrix metalloproteinase-9. Ann. Neurol. 1996, 40:853-863.
    • (1996) Ann. Neurol. , vol.40 , pp. 853-863
    • Stuve, O.1    Dooley, N.P.2    Uhm, J.H.3    Antel, J.P.4    Francis, G.S.5    Williams, G.6    Yong, V.W.7
  • 38
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial
    • The IFNB Multiple Sclerosis Study Group*The University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 1995, 45:1277-1285.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 40
    • 49149116386 scopus 로고    scopus 로고
    • Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis
    • Wiesemann E., Deb M., Hemmer B., Radeke H.H., Windhagen A. Early identification of interferon-beta responders by ex vivo testing in patients with multiple sclerosis. Clin. Immunol. 2008, 128:306-313.
    • (2008) Clin. Immunol. , vol.128 , pp. 306-313
    • Wiesemann, E.1    Deb, M.2    Hemmer, B.3    Radeke, H.H.4    Windhagen, A.5
  • 41
    • 59249084979 scopus 로고    scopus 로고
    • Prospects of repair in multiple sclerosis
    • Yong V.W. Prospects of repair in multiple sclerosis. J. Neurol. Sci. 2009, 277(Suppl. 1):S16-S18.
    • (2009) J. Neurol. Sci. , vol.277 , Issue.SUPPL. 1
    • Yong, V.W.1
  • 42
    • 0034021267 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis
    • Zhang G.X., Baker C.M., Kolson D.L., Rostami A.M. Chemokines and chemokine receptors in the pathogenesis of multiple sclerosis. Mult. Scler. 2000, 6:3-13.
    • (2000) Mult. Scler. , vol.6 , pp. 3-13
    • Zhang, G.X.1    Baker, C.M.2    Kolson, D.L.3    Rostami, A.M.4
  • 43
    • 82755165048 scopus 로고    scopus 로고
    • Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation
    • Zhang L., Yuan S., Cheng G., Guo B. Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS One 2011, 6:e28432.
    • (2011) PLoS One , vol.6
    • Zhang, L.1    Yuan, S.2    Cheng, G.3    Guo, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.