메뉴 건너뛰기




Volumn 17, Issue 3, 2010, Pages 470-478

Neutralizing antibodies, MxA expression and MMP-9/TIMP-1 ratio as markers of bioavailability of interferon-beta treatment in multiple sclerosis patients: A two-year follow-up study

Author keywords

CPE; Interferon beta; MMP 9; Multiple sclerosis; MxA; Neutralizing antibodies; TIMP 1

Indexed keywords

BETA INTERFERON; BIOLOGICAL MARKER; GELATINASE B; MYXOVIRUS RESISTANCE PROTEIN A; NEUTRALIZING ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

EID: 77649104721     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02890.x     Document Type: Article
Times cited : (16)

References (33)
  • 1
    • 0035954361 scopus 로고    scopus 로고
    • PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS
    • PRISMS Study Group
    • PRISMS Study Group. PRISMS-4: long-term efficacy of interferon-beta-1a in relapsing MS. Neurology 2001 56 : 1628.
    • (2001) Neurology , vol.56 , pp. 1628
  • 2
    • 1542346260 scopus 로고    scopus 로고
    • Interferon-beta-1b slows progression of atrophy in RRMS: Three-year follow-up in NAb- and NAb+ patients
    • Frank JA, Richert N, Bash C, et al. Interferon-beta-1b slows progression of atrophy in RRMS: three-year follow-up in NAb- and NAb+ patients. Neurology 2004 62 : 719 725.
    • (2004) Neurology , vol.62 , pp. 719-725
    • Frank, J.A.1    Richert, N.2    Bash, C.3
  • 3
    • 0033763507 scopus 로고    scopus 로고
    • Immunogenicity of interferon-beta in multiple sclerosis patients: Influence of preparation, dosage, dose frequency, and route of administration. Danish Multiple Sclerosis Study Group
    • Ross C, Clemmesen KM, Svenson M, et al. Immunogenicity of interferon-beta in multiple sclerosis patients: influence of preparation, dosage, dose frequency, and route of administration. Danish Multiple Sclerosis Study Group. Ann Neurol 2000 48 : 706 712.
    • (2000) Ann Neurol , vol.48 , pp. 706-712
    • Ross, C.1    Clemmesen, K.M.2    Svenson, M.3
  • 4
    • 0037180479 scopus 로고    scopus 로고
    • Randomized, comparative study of interferon beta-1a treatment regimens in MS: The EVIDENCE Trial
    • Panitch H, Goodin DS, Francis G, et al. Randomized, comparative study of interferon beta-1a treatment regimens in MS: the EVIDENCE Trial. Neurology 2002 59 : 1496 1506.
    • (2002) Neurology , vol.59 , pp. 1496-1506
    • Panitch, H.1    Goodin, D.S.2    Francis, G.3
  • 5
    • 0031841745 scopus 로고    scopus 로고
    • Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Rudick RA, Simonian NA, Alam JA, et al. Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Multiple Sclerosis Collaborative Research Group (MSCRG). Neurology 1998 50 : 1266 1272.
    • (1998) Neurology , vol.50 , pp. 1266-1272
    • Rudick, R.A.1    Simonian, N.A.2    Alam, J.A.3
  • 6
    • 22044436956 scopus 로고    scopus 로고
    • Interferon beta-1a in MS: Results following development of neutralizing antibodies in PRISMS
    • Francis GS, Rice GP, Alsop JC. Interferon beta-1a in MS: results following development of neutralizing antibodies in PRISMS. Neurology 2005 65 : 48 55.
    • (2005) Neurology , vol.65 , pp. 48-55
    • Francis, G.S.1    Rice, G.P.2    Alsop, J.C.3
  • 7
    • 34547661898 scopus 로고    scopus 로고
    • Neutralising antibodies to interferon beta in multiple sclerosis : EExpert panel report
    • Hartung HP, Polman C, Bertolotto A, et al. Neutralising antibodies to interferon beta in multiple sclerosis : expert panel report. J Neurol 2007 254 : 827 837.
    • (2007) J Neurol , vol.254 , pp. 827-837
    • Hartung, H.P.1    Polman, C.2    Bertolotto, A.3
  • 8
    • 0033551546 scopus 로고    scopus 로고
    • Matrix metalloproteinases in inflammatory demyelination: Targets for treatment
    • Kieseier BC, Seifert T, Giovannoni G, Hartung HP. Matrix metalloproteinases in inflammatory demyelination: targets for treatment. Neurology 1999 53 : 20 25.
    • (1999) Neurology , vol.53 , pp. 20-25
    • Kieseier, B.C.1    Seifert, T.2    Giovannoni, G.3    Hartung, H.P.4
  • 9
    • 0032693982 scopus 로고    scopus 로고
    • Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis
    • Waubant E, Goodkin DE, Gee L, et al. Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis. Neurology 1999 53 : 1397 1401.
    • (1999) Neurology , vol.53 , pp. 1397-1401
    • Waubant, E.1    Goodkin, D.E.2    Gee, L.3
  • 10
    • 10744229980 scopus 로고    scopus 로고
    • Neutralizing antibodies against IFN-beta in multiple sclerosis: Antagonization of IFN-beta mediated suppression of MMPs
    • Gilli F, Bertolotto A, Sala A, et al. Neutralizing antibodies against IFN-beta in multiple sclerosis: antagonization of IFN-beta mediated suppression of MMPs. Brain 2004 127 : 259 268.
    • (2004) Brain , vol.127 , pp. 259-268
    • Gilli, F.1    Bertolotto, A.2    Sala, A.3
  • 11
    • 0142092636 scopus 로고    scopus 로고
    • Optimization of RNA yield, purity and mRNA copy number by treatment of urine cell pellets with RNAlater
    • Medeiros M, Sharma VK, Ding R, et al. Optimization of RNA yield, purity and mRNA copy number by treatment of urine cell pellets with RNAlater. J Immunol Methods 2003 279 : 135 142.
    • (2003) J Immunol Methods , vol.279 , pp. 135-142
    • Medeiros, M.1    Sharma, V.K.2    Ding, R.3
  • 12
    • 5144235025 scopus 로고    scopus 로고
    • Overexpression of matrix metalloproteinase-1 and -9 mRNA is associated with progression of oral dysplasia to cancer
    • Jordan RC, Abeo-Ong M, Shiboski CH, et al. Overexpression of matrix metalloproteinase-1 and -9 mRNA is associated with progression of oral dysplasia to cancer. Clin Cancer Res 2004 10 : 6460 6465.
    • (2004) Clin Cancer Res , vol.10 , pp. 6460-6465
    • Jordan, R.C.1    Abeo-Ong, M.2    Shiboski, C.H.3
  • 13
    • 0242404144 scopus 로고    scopus 로고
    • Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: Detection of antibody-mediated decreased bioactivity (ADB)
    • Pachner AR, Bertolotto A, Deisenhammer F. Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: detection of antibody-mediated decreased bioactivity (ADB). Neurology 2003 61 : S24 S26.
    • (2003) Neurology , vol.61
    • Pachner, A.R.1    Bertolotto, A.2    Deisenhammer, F.3
  • 14
    • 4344660973 scopus 로고    scopus 로고
    • Biological activity of interferon betas in patients with multiple sclerosis is affected by treatment regimen and neutralising antibodies
    • Bertolotto A, Sala A, Malucchi S, et al. Biological activity of interferon betas in patients with multiple sclerosis is affected by treatment regimen and neutralising antibodies. J Neurol Neurosurg Psychiatry 2004 75 : 1294 1299.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 1294-1299
    • Bertolotto, A.1    Sala, A.2    Malucchi, S.3
  • 15
    • 0022555790 scopus 로고
    • Quantitation of neutralization of interferon by antibody
    • Kawade Y. Quantitation of neutralization of interferon by antibody. Methods Enzymol 1986 119 : 558 573.
    • (1986) Methods Enzymol , vol.119 , pp. 558-573
    • Kawade, Y.1
  • 16
    • 3242892400 scopus 로고    scopus 로고
    • Immunogenicity of recombinant human proteins: Causes and consequences
    • Schellekens H, Casadevall N. Immunogenicity of recombinant human proteins: causes and consequences. J Neurol 2004 251 (Suppl. 2 II4 II9.
    • (2004) J Neurol , vol.251 , Issue.SUPPL.. 2
    • Schellekens, H.1    Casadevall, N.2
  • 17
    • 34250223447 scopus 로고    scopus 로고
    • Neutralizing antibodies to interferon
    • Noronha A. Neutralizing antibodies to interferon. Neurology 2007 68 : S16 S22.
    • (2007) Neurology , vol.68
    • Noronha, A.1
  • 18
    • 0022318418 scopus 로고
    • WHO Expert Committee on Biological Standardization. Thirty-fifth report
    • WHO Expert Committee on Biological Standardization. Thirty-fifth report. World Health Organ Tech Rep Ser 1985 725 : 1 140.
    • (1985) World Health Organ Tech Rep ser , vol.725 , pp. 1-140
  • 19
    • 0005489101 scopus 로고    scopus 로고
    • Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: Experience during the first three years
    • The IFNB Multiple Sclerosis Study Group, University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group, University of British Columbia MS/MRI Analysis Group. Neutralizing antibodies during treatment of multiple sclerosis with interferon beta-1b: experience during the first three years. Neurology 1996 47 : 889 894.
    • (1996) Neurology , vol.47 , pp. 889-894
  • 20
    • 0242571617 scopus 로고    scopus 로고
    • Strategies to treat and prevent the development of neutralizing anti-interferon-beta antibodies
    • Giovannoni G. Strategies to treat and prevent the development of neutralizing anti-interferon-beta antibodies. Neurology 2003 61 : S13 S17.
    • (2003) Neurology , vol.61
    • Giovannoni, G.1
  • 21
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993 43 : 655 661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 22
    • 0037181634 scopus 로고    scopus 로고
    • Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: Results of a 2-year prospective randomised multicentre study (INCOMIN)
    • Durelli L, Verdun E, Barbero P, et al. Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet 2002 359 : 1453 1460.
    • (2002) Lancet , vol.359 , pp. 1453-1460
    • Durelli, L.1    Verdun, E.2    Barbero, P.3
  • 23
    • 0041850097 scopus 로고    scopus 로고
    • Neutralising antibodies to interferon beta during the treatment of multiple sclerosis
    • Polman CH, Kappos L, Petkau J, Thompson A. Neutralising antibodies to interferon beta during the treatment of multiple sclerosis. J Neurol Neurosurg Psychiatry 2003 74 : 1162 1163.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 1162-1163
    • Polman, C.H.1    Kappos, L.2    Petkau, J.3    Thompson, A.4
  • 24
    • 22044450811 scopus 로고    scopus 로고
    • Neutralizing antibodies and efficacy of interferon beta-1a: A 4-year controlled study
    • Kappos L, Clanet M, Sandberg-Wollheim M, et al. Neutralizing antibodies and efficacy of interferon beta-1a: a 4-year controlled study. Neurology 2005 65 : 40 47.
    • (2005) Neurology , vol.65 , pp. 40-47
    • Kappos, L.1    Clanet, M.2    Sandberg-Wollheim, M.3
  • 25
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. the Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol 1996 39 : 285 294.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 26
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group on interferon beta-1b in secondary progressive MS
    • European Study Group on interferon beta-1b in secondary progressive MS. Placebo-controlled multicentre randomised trial of interferon beta-1b in treatment of secondary progressive multiple sclerosis. Lancet 1998 352 : 1491 1497.
    • (1998) Lancet , vol.352 , pp. 1491-1497
  • 27
    • 8844222623 scopus 로고    scopus 로고
    • Interferon beta-1b in secondary progressive MS: Results from a 3-year controlled study
    • Panitch H, Miller A, Paty D, Weinshenker B. Interferon beta-1b in secondary progressive MS: results from a 3-year controlled study. Neurology 2004 63 : 1788 1795. (Pubitemid 39532370)
    • (2004) Neurology , vol.63 , Issue.10 , pp. 1788-1795
    • Panitch, H.1
  • 28
    • 0034749944 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis
    • Leppert D, Lindberg RL, Kappos L, Leib SL. Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis. Brain Res Brain Res Rev 2001 36 : 249 257.
    • (2001) Brain Res Brain Res Rev , vol.36 , pp. 249-257
    • Leppert, D.1    Lindberg, R.L.2    Kappos, L.3    Leib, S.L.4
  • 29
    • 0027944171 scopus 로고
    • Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases
    • Gijbels K, Galardy RE, Steinman L. Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. J Clin Invest 1994 94 : 2177 2182.
    • (1994) J Clin Invest , vol.94 , pp. 2177-2182
    • Gijbels, K.1    Galardy, R.E.2    Steinman, L.3
  • 30
    • 0030483220 scopus 로고    scopus 로고
    • Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis
    • Leppert D, Waubant E, Burk MR, Oksenberg JR, Hauser SL. Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: a possible mechanism for treatment efficacy in multiple sclerosis. Ann Neurol 1996 40 : 846 852.
    • (1996) Ann Neurol , vol.40 , pp. 846-852
    • Leppert, D.1    Waubant, E.2    Burk, M.R.3    Oksenberg, J.R.4    Hauser, S.L.5
  • 31
    • 0027169231 scopus 로고
    • Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein
    • Proost P, Van DJ, Opdenakker G. Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein. Biochem Biophys Res Commun 1993 192 : 1175 1181.
    • (1993) Biochem Biophys Res Commun , vol.192 , pp. 1175-1181
    • Proost, P.1    Van, D.J.2    Opdenakker, G.3
  • 32
    • 0031798063 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis
    • Leppert D, Ford J, Stabler G, et al. Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis. Brain 1998 121 (Pt 12 2327 2334.
    • (1998) Brain , vol.121 , Issue.PART 12 , pp. 2327-2334
    • Leppert, D.1    Ford, J.2    Stabler, G.3
  • 33
    • 0037435501 scopus 로고    scopus 로고
    • IFNbeta lowers MMP-9/TIMP-1 ratio, which predicts new enhancing lesions in patients with SPMS
    • Waubant E, Goodkin D, Bostrom A, et al. IFNbeta lowers MMP-9/TIMP-1 ratio, which predicts new enhancing lesions in patients with SPMS. Neurology 2003 60 : 52 57.
    • (2003) Neurology , vol.60 , pp. 52-57
    • Waubant, E.1    Goodkin, D.2    Bostrom, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.