Transcriptional Regulation of 15-Lipoxygenase Expression by Histone H3 Lysine 4 Methylation/Demethylation

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Liu, Cheng ^a,b   Xu, Dawei ^a   Han, Hongya ^a   Fan, Yidong ^b   Schain, Frida ^a   Xu, Zhonghua ^b   Claesson, Hans Erik ^a   Björkholm, Magnus ^a   Sjöberg, Jan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE 1; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE SMCX; HISTONE H3; HISTONE H3 LYSINE 4; HISTONE METHYLTRANSFERASE; HISTONE METHYLTRANSFERASE SMYD3; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE SILENCING; HISTONE ACETYLATION; HISTONE DEMETHYLATION; HISTONE METHYLATION; HISTONE TRIMETHYLATION; HODGKIN DISEASE; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; UPREGULATION;

ARACHIDONATE 15-LIPOXYGENASE; CELL LINE; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE EXPRESSION REGULATION; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; LYSINE; METHYLATION; MODELS, BIOLOGICAL; OXIDOREDUCTASES, N-DEMETHYLATING; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; STAT6 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84871692844     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052703     Document Type: Article

References (41)

1. Schewe T, (2002) 15-lipoxygenase-1: a prooxidant enzyme. Biol Chem 383: 365-374.
2. Kuhn H, O'Donnell VB, (2006) Inflammation and immune regulation by 12/15-lipoxygenases. Prog Lipid Res 45: 334-356.
3. Dobrian AD, Lieb DC, Cole BK, Taylor-Fishwick DA, Chakrabarti SK, et al. (2011) Functional and pathological roles of the 12- and 15-lipoxygenases. Prog Lipid Res 50: 115-131.
4. Zuo X, Peng Z, Wu Y, Moussalli MJ, Yang XL, et al. (2012) Effects of Gut-Targeted 15-LOX-1 Transgene Expression on Colonic Tumorigenesis in Mice. J Natl Cancer Inst 104: 709-716.
5. Kelavkar UP, Hutzley J, McHugh K, Allen KG, Parwani A, (2009) Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes. Neoplasia 11: 692-699.
6. Claesson HE, (2009) On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. Prostaglandins Other Lipid Mediat 89: 120-125.
7. Zhao J, O'Donnell VB, Balzar S, St Croix CM, Trudeau JB, et al. (2011) 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. Proc Natl Acad Sci U S A 108: 14246-14251.
8. Rong S, Cao Q, Liu M, Seo J, Jia L, et al. (2012) Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis. J Lipid Res 53: 686-695.
9. Chen B, Tsui S, Boeglin WE, Douglas RS, Brash AR, et al. (2006) Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines. J Biol Chem 281: 18296-18306.
10. Wu SH, Liao PY, Yin PL, Zhang YM, Dong L, (2009) Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acute poststreptococcal glomerulonephritis. Am J Pathol 174: 115-122.
11. van Leyen K, Duvoisin RM, Engelhardt H, Wiedmann M, (1998) A function for lipoxygenase in programmed organelle degradation. Nature 395: 392-395.
12. Ezaki J, Kominami E, Ueno T, (2011) Peroxisome degradation in mammals. IUBMB Life 63: 1001-1008.
13. Zuo X, Morris JS, Shureiqi I, (2008) Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells. J Biol Chem 283: 31341-31347.
14. Das S, Roth CP, Wasson LM, Vishwanatha JK, (2007) Signal transducer and activator of transcription-6 (STAT6) is a constitutively expressed survival factor in human prostate cancer. Prostate 67: 1550-1564.
15. Conrad DJ, Lu M, (2000) Regulation of human 12/15-lipoxygenase by Stat6-dependent transcription. Am J Respir Cell Mol Biol 22: 226-234.
16. Liu C, Xu D, Sjoberg J, Forsell P, Bjorkholm M, et al. (2004) Transcriptional regulation of 15-lipoxygenase expression by promoter methylation. Exp Cell Res 297: 61-67.
17. Liu C, Schain F, Han H, Xu D, Andersson-Sand H, et al. (2012) Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line. Exp Cell Res 318: 169-176.
18. Shankaranarayanan P, Chaitidis P, Kuhn H, Nigam S, (2001) Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. J Biol Chem 276: 42753-42760.
19. Kamitani H, Taniura S, Ikawa H, Watanabe T, Kelavkar UP, et al. (2001) Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. Carcinogenesis 22: 187-191.
20. Kelavkar UP, Harya NS, Hutzley J, Bacich DJ, Monzon FA, et al. (2007) DNA methylation paradigm shift: 15-lipoxygenase-1 upregulation in prostatic intraepithelial neoplasia and prostate cancer by atypical promoter hypermethylation. Prostaglandins Other Lipid Mediat 82: 185-197.
21. Zuo X, Shen L, Issa JP, Moy O, Morris JS, et al. (2008) 15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation. Faseb J.
22. Berger SL, (2007) The complex language of chromatin regulation during transcription. Nature 447: 407-412.
23. Ordovas JM, Smith CE, (2010) Epigenetics and cardiovascular disease. Nat Rev Cardiol 7: 510-519.
24. Hamamoto R, Furukawa Y, Morita M, Iimura Y, Silva FP, et al. (2004) SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat Cell Biol 6: 731-740.
25. Cock-Rada AM, Medjkane S, Janski N, Yousfi N, Perichon M, et al. (2012) SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9. Cancer Res 72: 810-820.
26. Niu X, Zhang T, Liao L, Zhou L, Lindner DJ, et al. (2012) The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene 31: 776-786.
27. Marafioti T, Hummel M, Foss HD, Laumen H, Korbjuhn P, et al. (2000) Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 95: 1443-1450.
28. Xu D, Gruber A, Peterson C, Pisa P, (1998) Telomerase activity and the expression of telomerase components in acute myelogenous leukaemia. Br J Haematol 102: 1367-1375.
29. Andersson E, Schain F, Svedling M, Claesson HE, Forsell PK, (2006) Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity. Biochim Biophys Acta 1761: 1498-1505.
30. Wittwer J, Marti-Jaun J, Hersberger M, (2006) Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1. Hum Mutat 27: 78-87.
31. Ge Z, Liu C, Bjorkholm M, Gruber A, Xu D, (2006) Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telomerase reverse transcriptase expression/telomerase activation induced by proliferation. Mol Cell Biol 26: 230-237.
32. Eissenberg JC, Shilatifard A, (2010) Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol 339: 240-249.
33. Liu C, Fang X, Ge Z, Jalink M, Kyo S, et al. (2007) The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3. Cancer Res 67: 2626-2631.
34. Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, et al. (2007) The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature 447: 601-605.
35. Kelavkar U, Wang S, Montero A, Murtagh J, Shah K, et al. (1998) Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes. Mol Biol Rep 25: 173-182.
36. Quina AS, Buschbeck M, Di Croce L, (2006) Chromatin structure and epigenetics. Biochem Pharmacol 72: 1563-1569.
37. Kim H, Heo K, Kim JH, Kim K, Choi J, et al. (2009) Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription. J Biol Chem 284: 19867-19877.
38. Pray-Grant MG, Daniel JA, Schieltz D, Yates JR 3rd, Grant PA (2005) Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation. Nature 433: 434-438.
39. Silva FP, Hamamoto R, Kunizaki M, Tsuge M, Nakamura Y, et al. (2007) Enhanced methyltransferase activity of SMYD3 by the cleavage of its N-terminal region in human cancer cells. Oncogene.
40. Kelavkar U, Lin Y, Landsittel D, Chandran U, Dhir R, (2006) The yin and yang of 15-lipoxygenase-1 and delta-desaturases: dietary omega-6 linoleic acid metabolic pathway in prostate. J Carcinog 5: 9.
41. Jensen LR, Amende M, Gurok U, Moser B, Gimmel V, et al. (2005) Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. Am J Hum Genet 76: 227-236.