Transcriptome changes initiated by carbon starvation in Aspergillus nidulans

Microbiology (United Kingdom)

Volumn 159, Issue 1, 2013, Pages 176-190

  Szilágyi, Melinda ^a   Miskei, Márton ^a   Karányi, Zsolt ^b   Lenkey, Béla ^a   Pócsi, István ^a   Emri, Tamás ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CARBON; HYDROLASE; LIPID; TRANSCRIPTOME;

ARTICLE; ASPERGILLUS NIDULANS; BACTERIAL CELL WALL; BIOSYNTHESIS; CELL DEATH; ENZYME DEGRADATION; FUNGAL REPRODUCTION; GENETIC ANALYSIS; MACROAUTOPHAGY; NITROGEN METABOLISM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REGULATORY MECHANISM; STARVATION; STRESS; UPREGULATION;

ASPERGILLUS NIDULANS; CARBON; CELL WALL; GENE EXPRESSION REGULATION, FUNGAL; METABOLIC NETWORKS AND PATHWAYS; MICROARRAY ANALYSIS; MICROBIAL VIABILITY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRESS, PHYSIOLOGICAL; TRANSCRIPTOME;

BACTERIA (MICROORGANISMS); EMERICELLA NIDULANS; FUNGI;

EID: 84871681352     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.062935-0     Document Type: Article

References (110)

1. Adams, T. H., Boylan, M. T. & Timberlake, W. E. (1988). brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 54, 353-362.
2. Adams, T. H., Wieser, J. K. & Yu, J. H. (1998). Asexual sporulation in Aspergillus nidulans. Microbiol Mol Biol Rev 62, 35-54.
3. Alfonso, C., Nuero, O. M., Santamaría, F. & Reyes, F. (1995). Purification of a heat-stable chitin deacetylase from Aspergillus nidulans and its role in cell wall degradation. Curr Microbiol 30, 49-54.
4. Barratt, R. W., Johnson, G. B. & Ogata, W. N. (1965). Wild-type and mutant stocks of Aspergillus nidulans. Genetics 52, 233-246.
5. Basten, D. E., Moers, A. P., Ooyen, A. J. & Schaap, P. J. (2005). Characterisation of Aspergillus niger prolyl aminopeptidase. Mol Genet Genomics 272, 673-679.
6. Bauer, S., Vasu, P., Persson, S., Mort, A. J. & Somerville, C. R. (2006). Development and application of a suite of polysaccharide-degrading enzymes for analyzing plant cell walls. Proc Natl Acad Sci U S A 103, 11417-11422.
7. Bendtsen, J. D., Nielsen, H., von Heijne, G. & Brunak, S. (2004). Improved prediction of signal peptides: SignalP 3.0. J Mol Biol 340, 783-795.
8. Bernardo, S. M., Gray, K. A., Todd, R. B., Cheetham, B. F. & Katz, M. E. (2007). Characterization of regulatory non-catalytic hexokinases in Aspergillus nidulans. Mol Genet Genomics 277, 519-532.
9. Birse, C. E. & Clutterbuck, A. J. (1990). N-Acetyl-6-hydroxytryptophan oxidase, a developmentally controlled phenol oxidase from Aspergillus nidulans. J Gen Microbiol 136, 1725-1730.
10. Borgia, P. T., Iartchouk, N., Riggle, P. J., Winter, K. R., Koltin, Y. & Bulawa, C. E. (1996). The chsB gene of Aspergillus nidulans is necessary for normal hyphal growth and development. Fungal Genet Biol 20, 193-203.
11. Brown, D. W., Adams, T. H. & Keller, N. P. (1996). Aspergillus has distinct fatty acid synthases for primary and secondary metabolism. Proc Natl Acad Sci U S A 93, 14873-14877.
12. Bussink, H. J. & Osmani, S. A. (1999). A mitogen-activated protein kinase (MPKA) is involved in polarized growth in the filamentous fungus, Aspergillus nidulans. FEMS Microbiol Lett 173, 117-125.
13. Cebollero, E. & Gonzalez, R. (2006). Induction of autophagy by second-fermentation yeasts during elaboration of sparkling wines. Appl Environ Microbiol 72, 4121-4127.
14. Cheng, J., Park, T. S., Chio, L. C., Fischl, A. S. & Ye, X. S. (2003). Induction of apoptosis by sphingoid long-chain bases in Aspergillus nidulans. Mol Cell Biol 23, 163-177.
15. Choi, C. J., Ju, H. J., Park, B. H., Qin, R., Jahng, K. Y., Han, D. M. & Chae, K. S. (2005). Isolation and characterization of the Aspergillus nidulans eglC gene encoding a putative b-1,3-endoglucanase. Fungal Genet Biol 42, 590-600.
16. Chomczynski, P. (1993). A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15, 532-534, 536-537.
17. Colabardini, A. C., De Castro, P. A., De Gouvê a, P. F., Savoldi, M., Malavazi, I., Goldman, M. H. & Goldman, G. H. (2010). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response. Mol Microbiol 78, 1259-1279.
18. d'Enfert, C. & Fontaine, T. (1997). Molecular characterization of the Aspergillus nidulans treA gene encoding an acid trehalase required for growth on trehalose. Mol Microbiol 24, 203-216.
19. da Silva Ferreira, M. E., Savoldi, M., Sueli Bonato, P., Goldman, M. H. & Goldman, G. H. (2006). Fungal metabolic model for tyrosinemia type 3: molecular characterization of a gene encoding a 4-hydroxyphenyl pyruvate dioxygenase from Aspergillus nidulans. Eukaryot Cell 5, 1441-1445.
20. de Groot, P. W., Brandt, B. W., Horiuchi, H., Ram, A. F., de Koster, C. G. & Klis, F. M. (2009). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans. Fungal Genet Biol 46 (Suppl. 1), S72-S81.
21. De Marco, J. L. & Felix, C. R. (2002). Characterization of a protease produced by a Trichoderma harzianum isolate which controls cocoa plant witches' broom disease. BMC Biochem 3, 3.
22. Dinamarco, T. M., Figueiredo Pimentel, B. C., Savoldi, M., Malavazi, I., Soriani, F. M., Uyemura, S. A., Ludovico, P., Goldman, M. H. S. & Goldman, G. H. (2010). The roles played by Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase (AifA) and NADH-ubiquinone oxidoreductases (NdeA-B and NdiA) in farnesol resistance. Fungal Genet Biol 47, 1055-1069.
23. Dixon, D. M., Szaniszlo, P. J. & Polak, A. (1991). Dihydroxynaphthalene (DHN) melanin and its relationship with virulence in the early stages of phaeohyphomycosis. In The Fungal Spore and Disease Initiation in Plants and Animals, pp. 297-318. Edited by G. T. Cole & H. C. Hoch. New York: Plenum Press.
24. Eades, C. J. & Hintz, W. E. (2000). Characterization of the class I amannosidase gene family in the filamentous fungus Aspergillus nidulans. Gene 255, 25-34.
25. Edlayne, G., Simone, A. & Felicio, J. D. (2009). Chemical and biological approaches for mycotoxin control: a review. Recent Pat Food Nutr Agric 1, 155-161.
26. Eigentler, A., Pócsi, I. & Marx, F. (2012). The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans. Arch Microbiol 194, 427-437.
27. Elad, Y. (2000). Biological control of foliar pathogens by means of Trichoderma harzianum and potential modes of action. Crop Prot 19, 709-714.
28. Emri, T., Pócsi, I. & Szentirmai, A. (1999). Analysis of the oxidative stress response of Penicillium chrysogenum to menadione. Free Radic Res 30, 125-132.
29. Emri, T., Molnár, Zs., Pusztahelyi, T. & Pócsi, I. (2004). Physiological and morphological changes in autolyzing Aspergillus nidulans cultures. Folia Microbiol (Praha) 49, 277-284.
30. Emri, T., Molnár, Z. & Pócsi, I. (2005). The appearances of autolytic and apoptotic markers are concomitant but differently regulated in carbon-starving Aspergillus nidulans cultures. FEMS Microbiol Lett 251, 297-303.
31. Emri, T., Molnár, Zs., Szilágyi, M. & Pócsi, I. (2008). Regulation of autolysis in Aspergillus nidulans. Appl Biochem Biotechnol 151, 211-220.
32. Emri, T., Szilágyi, M., László, K., M-Hamvas, M. & Pócsi, I. (2009). PepJ is a new extracellular proteinase of Aspergillus nidulans. Folia Microbiol (Praha) 54, 105-109.
33. Erdei, E., Pusztahelyi, T., Miskei, M., Barna, T. & Pócsi, I. (2008). Characterization and heterologous expression of an age-dependent fungal/bacterial type chitinase of Aspergillus nidulans. Acta Microbiol Immunol Hung 55, 351-361.
34. Fillinger, S., Chaveroche, M. K., van Dijck, P., de Vries, R., Ruijter, G., Thevelein, J. & d'Enfert, C. (2001). Trehalose is required for the acquisition of tolerance to a variety of stresses in the filamentous fungus Aspergillus nidulans. Microbiology 147, 1851-1862.
35. Fischer, R. & Kües, U. (2006). Asexual sporulation in mycelial fungi. In The Mycota, Growth, Differentiation and Sexuality, vol. 1, pp. 263-292. Edited by R. Fischer & U. Kües. Berlin: Springer-Verlag.
36. Fitzgibbon, G. J., Morozov, I. Y., Jones, M. G. & Caddick, M. X. (2005). Genetic analysis of the TOR pathway in Aspergillus nidulans. Eukaryot Cell 4, 1595-1598.
37. Flipphi, M., Sun, J., Robellet, X., Karaffa, L., Fekete, E., Zeng, A.-P. & Kubiecek, C. P. (2009). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp. Fungal Genet Biol 46 (Suppl. 1), S19-S44.
38. Forment, J. V., Flipphi, M., Ramón, D., Ventura, L. & Maccabe, A. P. (2006). Identification of the mstE gene encoding a glucose-inducible, low affinity glucose transporter in Aspergillus nidulans. J Biol Chem 281, 8339-8346.
39. Fridovich, I. (1998). Oxygen toxicity: a radical explanation. J Exp Biol 201, 1203-1209.
40. Fujioka, T., Mizutani, O., Furukawa, K., Sato, N., Yoshimi, A., Yamagata, Y., Nakajima, T. & Abe, K. (2007). MpkA-dependent and-independent cell wall integrity signaling in Aspergillus nidulans. Eukaryot Cell 6, 1497-1510.
41. García-Lepe, R., Nuero, O. M., Reyes, F. & Santamaría, F. (1997). Lipases in autolysed cultures of filamentous fungi. Lett Appl Microbiol 25, 127-130.
42. Girardin, H., Paris, S., Rault, J., Bellon-Fontaine, M. N. & Latgé, J. P. (1999). The role of the rodlet structure on the physicochemical properties of Aspergillus conidia. Lett Appl Microbiol 29, 364-369.
43. Han, K. H., Seo, J. A. & Yu, J. H. (2004). Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (Ga) signalling. Mol Microbiol 53, 529-540.
44. Hansberg, W., de Groot, H. & Sies, H. (1993). Reactive oxygen species associated with cell differentiation in Neurospora crassa. Free Radic Biol Med 14, 287-293.
45. Hegedüs, N., Leiter, E., Kovács, B., Tomori, V., Kwon, N. J., Emri, T., Marx, F., Batta, G., Csernoch, L. & other authors (2011). The small molecular mass antifungal protein of Penicillium chrysogenum-a mechanism of action oriented review. J Basic Microbiol 51, 561-571.
46. Horiuchi, H. (2009). Functional diversity of chitin synthases of Aspergillus nidulans in hyphal growth, conidiophore development and septum formation. Med Mycol 47 (Suppl. 1), S47-S52.
47. Hortschansky, P., Eisendle, M., Al-Abdallah, Q., Schmidt, A. D., Bergmann, S., Thön, M., Kniemeyer, O., Abt, B., Seeber, B. & other authors (2007). Interaction of HapX with the CCAAT-binding complex-a novel mechanism of gene regulation by iron. EMBO J 26, 3157-3168.
48. Jakubowski, W., Biliński, T. & Bartosz, G. (2000). Oxidative stress during aging of stationary cultures of the yeast Saccharomyces cerevisiae. Free Radic Biol Med 28, 659-664.
49. Jayashree, T. & Subramanyam, C. (2000). Oxidative stress as a prerequisite for aflatoxin production by Aspergillus parasiticus. Free Radic Biol Med 29, 981-985.
50. Johnstone, I. L., McCabe, P. C., Greaves, P., Gurr, S. J., Cole, G. E., Brow, M. A., Unkles, S. E., Clutterbuck, A. J., Kinghorn, J. R. & Innis, M. A. (1990). Isolation and characterisation of the crnA-niiA-niaD gene cluster for nitrate assimilation in Aspergillus nidulans. Gene 90, 181-192.
51. Jorge, J. A., Polizeli, M. L., Thevelein, J. M. & Terenzi, H. F. (1997). Trehalases and trehalose hydrolysis in fungi. FEMS Microbiol Lett 154, 165-171.
52. Katz, M. E., Gray, K. A. & Cheetham, B. F. (2006). The Aspergillus nidulans xprG (phoG) gene encodes a putative transcriptional activator involved in the response to nutrient limitation. Fungal Genet Biol 43, 190-199.
53. Katz, M. E., Bernardo, S. M. & Cheetham, B. F. (2008). The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation. Curr Genet 54, 47-55.
54. Kawasaki, L. & Aguirre, J. (2001). Multiple catalase genes are differentially regulated in Aspergillus nidulans. J Bacteriol 183, 1434-1440.
55. Kawasaki, L., Wysong, D., Diamond, R. & Aguirre, J. (1997). Two divergent catalase genes are differentially regulated during Aspergillus nidulans development and oxidative stress. J Bacteriol 179, 3284-3292.
56. Keller, N. P., Turner, G. & Bennett, J. W. (2005). Fungal secondary metabolism-from biochemistry to genomics. Nat Rev Microbiol 3, 937-947.
57. Kelly, R., Register, E., Hsu, M. J., Kurtz, M. & Nielsen, J. (1996). Isolation of a gene involved in 1,3-b-glucan synthesis in Aspergillus nidulans and purification of the corresponding protein. J Bacteriol 178, 4381-4391.
58. Kiel, J. A. & van der Klei, I. J. (2009). Proteins involved in microbody biogenesis and degradation in Aspergillus nidulans. Fungal Genet Biol 46 (Suppl. 1), S62-S71.
59. Kim, S., Matsuo, I., Ajisaka, K., Nakajima, H. & Kitamoto, K. (2002). Cloning and characterization of the nagA gene that encodes b-Nacetylglucosaminidase from Aspergillus nidulans and its expression in Aspergillus oryzae. Biosci Biotechnol Biochem 66, 2168-2175.
60. Kim, Y., Islam, N., Moss, B. J., Nandakumar, M. P. & Marten, M. R. (2011). Autophagy induced by rapamycin and carbon-starvation have distinct proteome profiles in Aspergillus nidulans. Biotechnol Bioeng 108, 2705-2715.
61. Klich, M., Mendoza, C., Mullaney, E., Keller, N. & Bennett, J. W. (2001). A new sterigmatocystin-producing Emericella variant from agricultural desert soils. Syst Appl Microbiol 24, 131-138.
62. Koibuchi, K., Nagasaki, H., Yuasa, A., Kataoka, J. & Kitamoto, K. (2000). Molecular cloning and characterization of a gene encoding glutaminase fromAspergillus oryzae. ApplMicrobiol Biotechnol 54, 59-68.
63. Kuo, M. J. & Alexander, M. (1967). Inhibition of the lysis of fungi by melanins. J Bacteriol 94, 624-629.
64. Lara-Ortíz, T., Riveros-Rosas, H. & Aguirre, J. (2003). Reactive oxygen species generated by microbial NADPH oxidase NoxA regulate sexual development in Aspergillus nidulans. Mol Microbiol 50, 1241-1255.
65. Madeo, F., Herker, E., Wissing, S., Jungwirth, H., Eisenberg, T. & Fröhlich, K. U. (2004). Apoptosis in yeast. Curr Opin Microbiol 7, 655-660.
66. Molnár, Zs., Mészáros, E., Szilágyi, Zs., Rosén, S., Emri, T. & Pócsi, I. (2004). Influence of fadAG203R and DflbA mutations on morphology and physiology of submerged Aspergillus nidulans cultures. Appl Biochem Biotechnol 118, 349-360.
67. Molnár, Zs., Emri, T., Zavaczki, E., Pusztahelyi, T. & Pócsi, I. (2006). Effects of mutations in the GanB/RgsA G protein mediated signalling on the autolysis of Aspergillus nidulans. J Basic Microbiol 46, 495-503.
68. Mori, K., Kawahara, T., Yoshida, H., Yanagi, H. & Yura, T. (1996). Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathway. Genes Cells 1, 803-817.
69. Nahlik, K. (2007). The COP9 signalosome of Aspergillus nidulans: regulation of protein degradation and transcriptional pathways in sexual development. PhD thesis, Georg August University Göttingen.
70. Nakamura, T., Maeda, Y., Tanoue, N., Makita, T., Kato, M. & Kobayashi, T. (2006). Expression profile of amylolytic genes in Aspergillus nidulans. Biosci Biotechnol Biochem 70, 2363-2370.
71. Navarro, R. E., Stringer, M. A., Hansberg, W., Timberlake, W. E. & Aguirre, J. (1996). catA, a new Aspergillus nidulans gene encoding a developmentally regulated catalase. Curr Genet 29, 352-359.
72. Nitsche, B. M., Jørgensen, T. R., Akeroyd, M., Meyer, V. & Ram, A. F. (2012). The carbon starvation response of Aspergillus niger during submerged cultivation: insights from the transcriptome and secretome. BMC Genomics 13, 380.
73. Oberegger, H., Zadra, I., Schoeser, M. & Haas, H. (2000). Iron starvation leads to increased expression of Cu/Zn-superoxide dismutase in Aspergillus. FEBS Lett 485, 113-116.
74. Park, B. W., Han, K. H., Lee, C. Y., Lee, C. H. & Maeng, P. J. (1997). Cloning and characterization of the citA gene encoding the mitochondrial citrate synthase of Aspergillus nidulans. Mol Cells 7, 290-295.
75. Pateman, J. A., Doy, C. H., Olsen, J. E., Norris, U., Creaser, E. H. & Hynes, M. (1983). Regulation of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (AldDH) in Aspergillus nidulans. Proc R Soc Lond B Biol Sci 217, 243-264.
76. Peña-Montes, C., González, A., Castro-Ochoa, D. & Farrés, A. (2008). Purification and biochemical characterization of a broad substrate specificity thermostable alkaline protease from Aspergillus nidulans. Appl Microbiol Biotechnol 78, 603-612.
77. Pócsi, I., Pusztahelyi, T., Sámi, L. & Emri, T. (2003). Autolysis of Penicillium chrysogenum-a holistic approach. Indian J Biotechnol 2, 293-301.
78. Pócsi, I., Prade, R. A. & Penninckx, M. J. (2004). Glutathione, altruistic metabolite in fungi. Adv Microb Physiol 49, 1-76.
79. Pócsi, I., Leiter, É., Kwon, N. J., Shin, K. S., Pusztahelyi, T., Emri, T., Abuknesha, R., Price, R. & Yu, J. H. (2009). Asexual sporulation signalling regulates autolysis of Aspergillus nidulans via modulating the chitinase ChiB production. J Appl Microbiol 107, 514-523.
80. Pollack, J. K., Harris, S. D. & Marten, M. R. (2009). Autophagy in filamentous fungi. Fungal Genet Biol 46, 1-8.
81. Punt, P. J., Dingemanse, M. A., Jacobs-Meijsing, B. J., Pouwels, P. H. & van den Hondel, C. A. (1988). Isolation and characterization of the glyceraldehyde-3-phosphate dehydrogenase gene of Aspergillus nidulans. Gene 69, 49-57.
82. Pusztahelyi, T., Klement, E., Szajli, E., Klem, J., Miskei, M., Karányi, Z., Emri, T., Kovács, S., Orosz, G. & other authors (2011). Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans. Fungal Genet Biol 48, 92-103.
83. Read, N. D. (2011). Exocytosis and growth do not occur only at hyphal tips. Mol Microbiol 81, 4-7.
84. Reino, J. L., Guerrero, R. F., Hernández-Galán, R. & Collado, I. G. (2008). Secondary metabolites from species of the biocontrol agent Trichoderma. Phytochem Rev 7, 89-123.
85. Reyes, F., Villanueva, P. & Alfonso, C. (1990). Nucleases in the autolysis of filamentous fungi. FEMS Microbiol Lett 69, 67-72.
86. Richie, D. L., Hartl, L., Aimanianda, V., Winters, M. S., Fuller, K. K., Miley, M. D., White, S., McCarthy, J. W., Latgé, J. P. & other authors (2009). A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus. PLoS Pathog 5, e1000258.
87. Robson, G. D. (2006). Programmed cell death in the aspergilli and other filamentous fungi. Med Mycol 44 (s1), 109-114.
88. Saloheimo, M., Valkonen, M. & Penttilä, M. (2003). Activation mechanisms of the HAC1-mediated unfolded protein response in filamentous fungi. Mol Microbiol 47, 1149-1161.
89. Sámi, L., Emri, T. & Pócsi, I. (2001). Autolysis and aging of Penicillium chrysogenum cultures under carbon starvation: glutathione metabolism and formation of reactive oxygen species. Mycol Res 105, 1246-1250.
90. Savoldi, M., Malavazi, I., Soriani, F. M., Capellaro, J. L., Kitamoto, K., da Silva Ferreira, M. E., Goldman, M. H. & Goldman, G. H. (2008). Farnesol induces the transcriptional accumulation of the Aspergillus nidulans apoptosis-inducing factor (AIF)-like mitochondrial oxidoreductase. Mol Microbiol 70, 44-59.
91. Schneider, T., Gerrits, B., Gassmann, R., Schmid, E., Gessner, M. O., Richter, A., Battin, T., Eberl, L. & Riedel, K. (2010). Proteome analysis of fungal and bacterial involvement in leaf litter decomposition. Proteomics 10, 1819-1830.
92. Semighini, C. P., Savoldi, M., Goldman, G. H. & Harris, S. D. (2006). Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA. Genetics 173, 87-98.
93. Sharon, A., Finkelstein, A., Shlezinger, N. & Hatam, I. (2009). Fungal apoptosis: function, genes and gene function. FEMS Microbiol Rev 33, 833-854.
94. Skromne, I., Sánchez, O. & Aguirre, J. (1995). Starvation stress modulates the expression of the Aspergillus nidulans brlA regulatory gene. Microbiology 141, 21-28.
95. Stinnett, S. M., Espeso, E. A., Cobeño, L., Araújo-Bazán, L. & Calvo, A. M. (2007). Aspergillus nidulans VeA subcellular localization is dependent on the importin a carrier and on light. Mol Microbiol 63, 242-255.
96. Stringer, M. A., Dean, R. A., Sewall, T. C. & Timberlake, W. E. (1991). Rodletless, a new Aspergillus developmental mutant induced by directed gene inactivation. Genes Dev 5, 1161-1171.
97. Suzuki, Y., Murray, S. L., Wong, K. H., Davis, M. A. & Hynes, M. J. (2012). Reprogramming of carbon metabolism by the transcriptional activators AcuK and AcuM in Aspergillus nidulans. Mol Microbiol 84, 942-964.
98. Szilágyi, M., Kwon, N. J., Dorogi, C., Pócsi, I., Yu, J. H. & Emri, T. (2010). The extracellular b-1,3-endoglucanase EngA is involved in autolysis of Aspergillus nidulans. J Appl Microbiol 109, 1498-1508.
99. Szilágyi, M., Kwon, N. J., Bakti, F., M-Hamvas, M., Jámbrik, K., Park, H., Pócsi, I., Yu, J. H. & Emri, T. (2011). Extracellular proteinase formation in carbon starving Aspergillus nidulans cultures-physiological function and regulation. J Basic Microbiol 51, 625-634.
100. Szilágyi, M., Anton, F., Forgács, K., Yu, J. H., Pócsi, I. & Emri, T. (2012). Antifungal activity of extracellular hydrolases produced by autolysing Aspergillus nidulans cultures. J Microbiol 50, 849-854.
101. Terabayashi, Y., Shimizu, M., Kitazume, T., Masuo, S., Fujii, T. & Takaya, N. (2012). Conserved and specific responses to hypoxia in Aspergillus oryzae and Aspergillus nidulans determined by comparative transcriptomics. Appl Microbiol Biotechnol 93, 305-317.
102. von Döhren, H. (2009). A survey of nonribosomal peptide synthetase (NRPS) genes in Aspergillus nidulans. Fungal Genet Biol 46 (Suppl. 1), S45-S52.
103. Wang, Y., Song, J. Z., Yang, Q., Liu, Z. H., Huang, X. M. & Chen, Y. (2010). Cloning of a heat-stable chitin deacetylase gene from Aspergillus nidulans and its functional expression in Escherichia coli. Appl Biochem Biotechnol 162, 843-854.
104. Wei, H., Scherer, M., Singh, A., Liese, R. & Fischer, R. (2001). Aspergillus nidulans a-1,3 glucanase (mutanase), mutA, is expressed during sexual development and mobilizes mutan. Fungal Genet Biol 34, 217-227.
105. Wei, H., Vienken, K., Weber, R., Bunting, S., Requena, N. & Fischer, R. (2004). A putative high affinity hexose transporter, hxtA, of Aspergillus nidulans is induced in vegetative hyphae upon starvation and in ascogenous hyphae during cleistothecium formation. Fungal Genet Biol 41, 148-156.
106. White, S., McIntyre, M., Berry, D. R. & McNeil, B. (2002). The autolysis of industrial filamentous fungi. Crit Rev Biotechnol 22, 1-14.
107. Winderickx, J., Holsbeeks, I., Lagatie, O., Giots, F., Thevelein, J. & de Winde, H. (2003). From feast to famine; adaptation to nutrient availability in yeast. Top Curr Genet 1, 305-386.
108. Yamazaki, H., Tanaka, A., Kaneko, J., Ohta, A. & Horiuchi, H. (2008). Aspergillus nidulans ChiA is a glycosylphosphatidylinositol (GPI)-anchored chitinase specifically localized at polarized growth sites. Fungal Genet Biol 45, 963-972.
109. Yang, Z., Huang, J., Geng, J., Nair, U. & Klionsky, D. J. (2006). Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell 17, 5094-5104.
110. Yu, J. H., Butchko, R. A., Fernandes, M., Keller, N. P., Leonard, T. J. & Adams, T. H. (1996). Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Curr Genet 29, 549-555.