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Volumn 13, Issue 12, 2012, Pages 16241-16254

Alterations in glutathione redox metabolism, oxidative stress, and mitochondrial function in the left ventricle of elderly zucker diabetic fatty rat heart

Author keywords

Cardiomyocytes; Diabetes; Mitochondria; Obesity; Oxidative stress; Zucker rats

Indexed keywords

CYTOCHROME C OXIDASE; CYTOCHROME P450 2E1; GLUTATHIONE; GLUTATHIONE TRANSFERASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); STRESS ACTIVATED PROTEIN KINASE;

EID: 84871676679     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms131216241     Document Type: Article
Times cited : (44)

References (44)
  • 1
    • 34347352169 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy revisited
    • Boudina, S.; Abel, E.D. Diabetic cardiomyopathy revisited. Circulation 2007, 115, 3213-3223.
    • (2007) Circulation , vol.115 , pp. 3213-3223
    • Boudina, S.1    Abel, E.D.2
  • 2
  • 3
    • 79251551381 scopus 로고    scopus 로고
    • Regular physical exercise training assists in preventing type 2 diabetes development: Focus on its antioxidant and anti-inflammatory properties
    • Teixeira-lemos, E.; Nunes, S.; Teixeira, F.; Reis, F. Regular physical exercise training assists in preventing type 2 diabetes development: Focus on its antioxidant and anti-inflammatory properties. Cardiovasc. Diabetol. 2011, 10, 12-20.
    • (2011) Cardiovasc. Diabetol. , vol.10 , pp. 12-20
    • Teixeira-lemos, E.1    Nunes, S.2    Teixeira, F.3    Reis, F.4
  • 4
    • 78349297565 scopus 로고    scopus 로고
    • Oxidative stress and diabetic complications
    • Giacco, F.; Brownlee, M. Oxidative stress and diabetic complications. Circ. Res. 2010, 107, 1058-1070.
    • (2010) Circ. Res. , vol.107 , pp. 1058-1070
    • Giacco, F.1    Brownlee, M.2
  • 5
    • 77950915621 scopus 로고    scopus 로고
    • Oxidative stress and diabetic cardiovascular disorders: Roles of mitochondria and NADPH oxidase
    • Shen, G.X. Oxidative stress and diabetic cardiovascular disorders: Roles of mitochondria and NADPH oxidase. Can. J. Physiol. Pharmacol. 2010, 88, 241-248.
    • (2010) Can. J. Physiol. Pharmacol. , vol.88 , pp. 241-248
    • Shen, G.X.1
  • 6
    • 80053515769 scopus 로고    scopus 로고
    • The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro-and macrovascular complications: Avenues for a mechanistic-based therapeutic approach
    • Folli, F.; Corradi, D.; Fanti, P.; Davalli, A.; Paez, A.; Giaccari, A.; Perego, C.; Muscogiuri, G. The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro-and macrovascular complications: Avenues for a mechanistic-based therapeutic approach. Curr. Diabetes Rev. 2011, 7, 313-324.
    • (2011) Curr. Diabetes Rev. , vol.7 , pp. 313-324
    • Folli, F.1    Corradi, D.2    Fanti, P.3    Davalli, A.4    Paez, A.5    Giaccari, A.6    Perego, C.7    Muscogiuri, G.8
  • 8
    • 80054820905 scopus 로고    scopus 로고
    • Sex-dependent hepatic transcript and metabolites in the development of glucose intolerance and insulin resistance in Zucker diabetic fatty rats
    • Gustavsson, C.; Soga, T.; Wahlstrom, E.; Vesterlund, M.; Azimi, A.; Norstedt, G.; Tollet-Egnell, P. Sex-dependent hepatic transcript and metabolites in the development of glucose intolerance and insulin resistance in Zucker diabetic fatty rats. J. Mol. Endocrinol. 2011, 47, 129-143.
    • (2011) J. Mol. Endocrinol. , vol.47 , pp. 129-143
    • Gustavsson, C.1    Soga, T.2    Wahlstrom, E.3    Vesterlund, M.4    Azimi, A.5    Norstedt, G.6    Tollet-Egnell, P.7
  • 9
    • 84858225542 scopus 로고    scopus 로고
    • Novel phramcological approaches to the treatment of type 2 diabtes
    • Verspohl, E.J. Novel phramcological approaches to the treatment of type 2 diabtes. Pharmacol. Rev. 2012, 64, 188-237.
    • (2012) Pharmacol. Rev. , vol.64 , pp. 188-237
    • Verspohl, E.J.1
  • 10
  • 11
    • 39149094573 scopus 로고    scopus 로고
    • Long-term effects of type 2 diabetes mellitus on heart rhythm in the Goto-Kakizaki rat
    • Howarth, F.C.; Jacobson, M.; Shafiullah, M.; Adeghate, E. Long-term effects of type 2 diabetes mellitus on heart rhythm in the Goto-Kakizaki rat. Exp. Physiol. 2008, 362-369.
    • (2008) Exp. Physiol. , pp. 362-369
    • Howarth, F.C.1    Jacobson, M.2    Shafiullah, M.3    Adeghate, E.4
  • 12
    • 79960697907 scopus 로고    scopus 로고
    • Structural lesions and changing pattern of expression of genes encoding cardiac muscle proteins are associated with ventricular myocyte dysfunction in type 2 diabetic Goto-Kakizaki rats fed a high-fat diet
    • Howarth, F.C.; Qureshi, M.A.; Sobhy, Z.H.; Parekh, K.; Yammahi, S.R.; Adrian, T.E.; Adeghate, E. Structural lesions and changing pattern of expression of genes encoding cardiac muscle proteins are associated with ventricular myocyte dysfunction in type 2 diabetic Goto-Kakizaki rats fed a high-fat diet. Exp. Physiol. 2011, 96, 765-777.
    • (2011) Exp. Physiol. , vol.96 , pp. 765-777
    • Howarth, F.C.1    Qureshi, M.A.2    Sobhy, Z.H.3    Parekh, K.4    Yammahi, S.R.5    Adrian, T.E.6    Adeghate, E.7
  • 13
    • 79951482601 scopus 로고    scopus 로고
    • Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart
    • Howarth, F.C.; Qureshi, M.A.; Hassan, Z.; Al Kury, L.T.; Isaev, D.; Parekh, K.; Yammahi, S.R.; Adrian, T.E.; Adeghate, E. Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+ signalling in young type 2 Zucker diabetic fatty rat heart. Exp. Physiol. 2011, 96, 325-337.
    • (2011) Exp. Physiol. , vol.96 , pp. 325-337
    • Howarth, F.C.1    Qureshi, M.A.2    Hassan, Z.3    Al Kury, L.T.4    Isaev, D.5    Parekh, K.6    Yammahi, S.R.7    Adrian, T.E.8    Adeghate, E.9
  • 14
    • 85027923791 scopus 로고    scopus 로고
    • Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in elderly type 2 Zucker diabetic fatty rat heart
    • Howarth, F.C.; Qureshi, M.A.; Hassan, Z.; Isaev, D.; Parekh, K.; John, A.; Oz, M.; Raza, H.; Adeghate, E.; Adrian, T.E. Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in elderly type 2 Zucker diabetic fatty rat heart. Mol. Cell. Biochem. 2012, 361, 267-280.
    • (2012) Mol. Cell. Biochem. , vol.361 , pp. 267-280
    • Howarth, F.C.1    Qureshi, M.A.2    Hassan, Z.3    Isaev, D.4    Parekh, K.5    John, A.6    Oz, M.7    Raza, H.8    Adeghate, E.9    Adrian, T.E.10
  • 15
    • 1042268842 scopus 로고    scopus 로고
    • Glutathione metabolism and oxidative stress in neonatal rat tissues from streptozotocin-induced diabetic mothers
    • Raza, H.; John, A. Glutathione metabolism and oxidative stress in neonatal rat tissues from streptozotocin-induced diabetic mothers. Diabetes Metab. Res. Rev. 2004, 20, 72-78.
    • (2004) Diabetes Metab. Res. Rev. , vol.20 , pp. 72-78
    • Raza, H.1    John, A.2
  • 16
    • 0347360363 scopus 로고    scopus 로고
    • Elevated mitochondrial cytochrome P4502E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats. Tissue specific variations and roles in oxidative stress
    • Raza, H.; Prabu, S.K.; Robin, M.-A.; Avadhani, N.G. Elevated mitochondrial cytochrome P4502E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats. Tissue specific variations and roles in oxidative stress. Diabetes 2004, 53, 185-194.
    • (2004) Diabetes , vol.53 , pp. 185-194
    • Raza, H.1    Prabu, S.K.2    Robin, M.-A.3    Avadhani, N.G.4
  • 17
    • 0346654087 scopus 로고    scopus 로고
    • Tissue specific expression and immunohistochemical localization of glutathione S-transferase in streptozotocin induced diabetic rats: Modulation by Momordica charantia (karela) extract
    • Raza, H.; Ahmed, I.; John, A. Tissue specific expression and immunohistochemical localization of glutathione S-transferase in streptozotocin induced diabetic rats: Modulation by Momordica charantia (karela) extract. Life Sci. 2004, 74, 1503-1511.
    • (2004) Life Sci. , vol.74 , pp. 1503-1511
    • Raza, H.1    Ahmed, I.2    John, A.3
  • 18
    • 79957845530 scopus 로고    scopus 로고
    • Impaired mitochondrial respiratory functions and oxidative stress in streptozotocin-induced diabetic rats
    • Raza, H.; Prabu, S.K.; John, A.; Avadhani, N.G. Impaired mitochondrial respiratory functions and oxidative stress in streptozotocin-induced diabetic rats. Int. J. Mol. Sci. 2011, 12, 3133-3147.
    • (2011) Int. J. Mol. Sci. , vol.12 , pp. 3133-3147
    • Raza, H.1    Prabu, S.K.2    John, A.3    Avadhani, N.G.4
  • 19
    • 41049100518 scopus 로고
    • A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase
    • Beers, R.F.; Sizer, I.W. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J. Biol. Chem. 1952, 195, 133-140.
    • (1952) J. Biol. Chem. , vol.195 , pp. 133-140
    • Beers, R.F.1    Sizer, I.W.2
  • 20
    • 0033631571 scopus 로고    scopus 로고
    • Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract
    • Raza, H.; Ahmed, I.; John, A.; Sharma, A.K. Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract. J. Biochem. Mol. Toxicol. 2000, 14, 131-139.
    • (2000) J. Biochem. Mol. Toxicol. , vol.14 , pp. 131-139
    • Raza, H.1    Ahmed, I.2    John, A.3    Sharma, A.K.4
  • 21
    • 0033573975 scopus 로고    scopus 로고
    • Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats
    • Enriquez, A.; Leclercq, I.; Farrell, G.C.; Robertson, G. Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem. Biophys. Res. Commun. 1999, 255, 300-306.
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , pp. 300-306
    • Enriquez, A.1    Leclercq, I.2    Farrell, G.C.3    Robertson, G.4
  • 22
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 23
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin, H.; Staehelin, T.; Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 1979, 76, 4350-4354.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 26
    • 27844452535 scopus 로고    scopus 로고
    • Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats
    • Howarth, F.C.; Jacobson, M.; Shafiullah, M.; Adeghate, E. Long-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats. Exp. Physiol. 2005, 90, 827-835.
    • (2005) Exp. Physiol. , vol.90 , pp. 827-835
    • Howarth, F.C.1    Jacobson, M.2    Shafiullah, M.3    Adeghate, E.4
  • 27
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
    • Shimabukuro, M.; Zhou, Y.T.; Levi, M.; Unger, R.H. Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes. Proc. Natl. Acad. Sci. USA 1998, 95, 2498-2502.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 29
    • 1942422613 scopus 로고    scopus 로고
    • Onset of diabetes in Zucker diabetic fatty (ZDF) rats leads to improved recovery of function after ischemia in the isolated perfused heart
    • Wang, P.; Chatham, J.C. Onset of diabetes in Zucker diabetic fatty (ZDF) rats leads to improved recovery of function after ischemia in the isolated perfused heart. Am. J. Physiol. Endocrinol. MeTable 2004, 286, E725-E736.
    • (2004) Am. J. Physiol. Endocrinol. MeTable , vol.286
    • Wang, P.1    Chatham, J.C.2
  • 30
    • 67650095384 scopus 로고    scopus 로고
    • Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH
    • Serpillon, S.; Floyd, B.C.; Gupte, R.S.; George, S.; Kozicky, M.; Neito, V.; Recchia, F.; Stanley, W.; Wolin, M.S.; Gupte, S.A. Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH. Am. J. Physiol. Heart Circ. Physiol. 2009, 297, H153-H162.
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.297
    • Serpillon, S.1    Floyd, B.C.2    Gupte, R.S.3    George, S.4    Kozicky, M.5    Neito, V.6    Recchia, F.7    Stanley, W.8    Wolin, M.S.9    Gupte, S.A.10
  • 31
    • 33644552417 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
    • Tianzheng, Y.; James, L.R.; Yisang, Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc. Natl. Acad. Sci. USA 2006, 103, 2653-2658.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 2653-2658
    • Tianzheng, Y.1    James, L.R.2    Yisang, Y.3
  • 33
    • 77952951283 scopus 로고    scopus 로고
    • Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperinsulinemia: A study in Zucker diabetic fatty rats
    • Lenaers, E.; de Feyter, H.M.; Hoeks, J.; Schrauwen, P.; Schaart, G.; Nabben, M.; Nicolay, K.; Prompers, J.J.; Hesselink, M.K. Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperinsulinemia: A study in Zucker diabetic fatty rats. Obesity 2010, 18, 1100-1107.
    • (2010) Obesity , vol.18 , pp. 1100-1107
    • Lenaers, E.1    de Feyter, H.M.2    Hoeks, J.3    Schrauwen, P.4    Schaart, G.5    Nabben, M.6    Nicolay, K.7    Prompers, J.J.8    Hesselink, M.K.9
  • 34
    • 2942667688 scopus 로고    scopus 로고
    • Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
    • McClung, J.P.; Roneker, C.A.; Mu, W.; Lisk, D.J.; Langlais, P.; Liu, F.; Lei, X.G. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc. Natl. Acad. Sci. USA 2004, 101, 8852-8857.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8852-8857
    • McClung, J.P.1    Roneker, C.A.2    Mu, W.3    Lisk, D.J.4    Langlais, P.5    Liu, F.6    Lei, X.G.7
  • 36
    • 79955060097 scopus 로고    scopus 로고
    • Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice
    • Zhang, W.; Lu, D.; Dong, W.; Zhang, L.; Zhang, X.; Quan, X.; Ma, C.; Lain, H.; Zhang, L. Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice. FEBS J. 2011, 278, 1484-1492.
    • (2011) FEBS J. , vol.278 , pp. 1484-1492
    • Zhang, W.1    Lu, D.2    Dong, W.3    Zhang, L.4    Zhang, X.5    Quan, X.6    Ma, C.7    Lain, H.8    Zhang, L.9
  • 38
    • 84856098506 scopus 로고    scopus 로고
    • Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats
    • Lakshmanan, A.P.; Harima, M.; Sukumaran, V.; Soetikno, V.; Thandavarayan, R.A.; Suzuki, K.; Kodama, M.; Nagata, M.; Takagi, R.; Watanabe, K. Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Biochem. Pharm. 2012, 83, 653-660.
    • (2012) Biochem. Pharm. , vol.83 , pp. 653-660
    • Lakshmanan, A.P.1    Harima, M.2    Sukumaran, V.3    Soetikno, V.4    Thandavarayan, R.A.5    Suzuki, K.6    Kodama, M.7    Nagata, M.8    Takagi, R.9    Watanabe, K.10
  • 39
    • 84862930802 scopus 로고    scopus 로고
    • NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-κB in cardiomyocytes exposed to high glucose
    • Tsai, K.H.; Wang, W.J.; Lin, C.W.; Pai, P.; Lai, T.Y.; Tsai, C.Y.; Kuo, W.W. NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-κB in cardiomyocytes exposed to high glucose. J. Cell. Physiol. 2012, 227, 1347-1357.
    • (2012) J. Cell. Physiol. , vol.227 , pp. 1347-1357
    • Tsai, K.H.1    Wang, W.J.2    Lin, C.W.3    Pai, P.4    Lai, T.Y.5    Tsai, C.Y.6    Kuo, W.W.7
  • 40
    • 0037230304 scopus 로고    scopus 로고
    • Activation of the JNK signaling pathway: Breaking the brake on apoptosis
    • Anning, L. Activation of the JNK signaling pathway: Breaking the brake on apoptosis. BioEssays 2002, 25, 17-24.
    • (2002) BioEssays , vol.25 , pp. 17-24
    • Anning, L.1
  • 41
    • 80755184724 scopus 로고    scopus 로고
    • Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: Role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet
    • Syed, I.; Kyathanahalli, C.N.; Jayaram, B.; Govind, S.; Rhodes, C.J.; Kowluru, R.A.; Kowluru, A. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: Role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Diabetes 2011, 60, 2843-2852.
    • (2011) Diabetes , vol.60 , pp. 2843-2852
    • Syed, I.1    Kyathanahalli, C.N.2    Jayaram, B.3    Govind, S.4    Rhodes, C.J.5    Kowluru, R.A.6    Kowluru, A.7
  • 42
    • 2142827887 scopus 로고    scopus 로고
    • Increase in intranuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: Evidence for a proinflammatory effect
    • Aljada, A.; Mohanty, P.; Ghanim, H.; Abdo, T.; Tripathy, D.; Chaudhuri, A.; Dandona, P. increase in intranuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: Evidence for a proinflammatory effect. Am. J. Clin. Nutr. 2004, 79, 682-690.
    • (2004) Am. J. Clin. Nutr. , vol.79 , pp. 682-690
    • Aljada, A.1    Mohanty, P.2    Ghanim, H.3    Abdo, T.4    Tripathy, D.5    Chaudhuri, A.6    Dandona, P.7
  • 44
    • 33751504623 scopus 로고    scopus 로고
    • Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes
    • Aragno, M.; Mastrocola, R.; Medana, C.; Catalano, M.G.; Vercellinatto, I.; Danni, O.; Bocuzzi, G. Oxidative stress-dependent impairment of cardiac-specific transcription factors in experimental diabetes. Endocrinology 2006, 147, 5967-5974.
    • (2006) Endocrinology , vol.147 , pp. 5967-5974
    • Aragno, M.1    Mastrocola, R.2    Medana, C.3    Catalano, M.G.4    Vercellinatto, I.5    Danni, O.6    Bocuzzi, G.7


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