Therapeutic gene silencing with siRNA for IL-23 but not for IL-17 suppresses the development of experimental autoimmune encephalomyelitis in rats

Journal of Neuroimmunology

Volumn 254, Issue 1-2, 2013, Pages 39-45

  Niimi, Naoko ^a   Kohyama, Kuniko ^a   Matsumoto, Yoh ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Experimental autoimmune encephalomyelitis; IL 12; IL 17; IL 23; SiRNA

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23P19; MESSENGER RNA; SMALL INTERFERING RNA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; FLOW CYTOMETRY; GENE SILENCING; IMMUNOTHERAPY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SPINAL CORD; TH1 CELL; TH17 CELL;

ANALYSIS OF VARIANCE; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FLOW CYTOMETRY; FREUND'S ADJUVANT; INTERLEUKIN-12; INTERLEUKIN-17; MYELIN BASIC PROTEIN; RATS; RATS, INBRED LEW; RNA, MESSENGER; RNA, SMALL INTERFERING; SEVERITY OF ILLNESS INDEX; SPINAL CORD; STATISTICS, NONPARAMETRIC; TH1 CELLS; TH17 CELLS; TIME FACTORS;

EID: 84871673478     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2012.08.015     Document Type: Article

References (29)

1. Ando D., Clayton J., Kono J., Urban J., Sercarz E.E. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 1989, 124:132.
2. Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., Parente E., Fili L., Ferri S., Frosali F., Giudici F., Romagnani P., Parronchi P., Tonelli F., Maggi E., Romagnani S. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007, 204:1849-1861.
3. Becher B., Durell B.G., Noelle R.J. IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J. Clin. Invest. 2003, 112:1186-1191.
4. Bettelli E., Korn T., Oukka M., Kuchroo V.K. Induction and effector functions of T(H)17 cells. Nature 2008, 453:1051-1057.
5. Chen Y., Langrish C.L., McKenzie B., Joyce-Shaikh B., Stumhofer J.S., McClanahan T., Blumenschein W., Churakovsa T., Low J., Presta L., Hunter C.A., Kastelein R.A., Cua D.J. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J. Clin. Invest. 2006, 116:1317-1326.
6. Collison L.W., Workman C.J., Kuo T.T., Boyd K., Wang Y., Vignali K.M., Cross R., Sehy D., Blumberg R.S., Vignali D.A. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007, 450:566-569.
7. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S.A., Gorman D., Kastelein R.A., Sedgwick J.D. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748.
8. Gocke A.R., Cravens P.D., Ben L.H., Hussain R.Z., Northrop S.C., Racke M.K., Lovett-Racke A.E. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J. Immunol. 2007, 178:1341-1348.
9. Gyulveszi G., Haak S., Becher B. IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo. Eur. J. Immunol. 2009, 39:1864-1869.
10. Haak S., Croxford A.L., Kreymborg K., Heppner F.L., Pouly S., Becher B., Waisman A. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 2009, 119:61-69.
11. Hofstetter H.H., Ibrahim S.M., Koczan D., Kruse N., Weishaupt A., Toyka K.V., Gold R. Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis. Cell. Immunol. 2005, 237:123-130.
12. Hu Y., Li D., Lu H. Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats. J. Gene Med. 2007, 9:217-229.
13. Klein R.S., Izikson L., Means T., Gibson H.D., Lin E., Sobel R.A., Weiner H.L., Luster A.D. IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. J. Immunol. 2004, 172:550-559.
14. Komiyama Y., Nakae S., Matsuki T., Nambu A., Ishigame H., Kakuta S., Sudo K., Iwakura Y. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 2006, 177:566-573.
15. Korn T., Bettelli E., Oukka M., Kuchroo V.K. IL-17 and Th17 cells. Annu. Rev. Immunol. 2009, 27:485-517.
16. Kotze M.J., de Villiers J.N., Rooney R.N., Grobbelaar J.J., Mansvelt E.P., Bouwens C.S., Carr J., Stander I., du Plessis L. Analysis of the NRAMP1 gene implicated in iron transport: association with multiple sclerosis and age effects. Blood Cells Mol. Dis. 2001, 27:44-53.
17. Kurschus F.C., Croxford A.L., Heinen A.P., Wortge S., Ielo D., Waisman A. Genetic proof for the transient nature of the Th17 phenotype. Eur. J. Immunol. 2010, 40:3336-3346.
18. Lee Y.K., Turner H., Maynard C.L., Oliver J.R., Chen D., Elson C.O., Weaver C.T. Late developmental plasticity in the T helper 17 lineage. Immunity 2009, 30:92-107.
19. Liu J.Q., Liu Z., Zhang X., Shi Y., Talebian F., Carl J.W., Yu C., Shi F.D., Whitacre C.C., Trgovcich J., Bai X.F. Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis. J. Immunol. 2012, 188:3099-3106.
20. Lovett-Racke A.E., Rocchini A.E., Choy J., Northrop S.C., Hussain R.Z., Ratts R.B., Sikder D., Racke M.K. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 2004, 21:719-731.
21. Luger D., Silver P.B., Tang J., Cua D., Chen Z., Iwakura Y., Bowman E.P., Sgambellone N.M., Chan C.C., Caspi R.R. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 2008, 205:799-810.
22. Matsumoto Y., Fujiwara M. The immunopathology of adoptively transferred experimental allergic encephalomyelitis (EAE) in Lewis rats. Part 1. Immunohistochemical examination of developing lesion of EAE. J. Neurol. Sci. 1987, 77:35-47.
23. McGeachy M.J., Cua D.J. Th17 cell differentiation: the long and winding road. Immunity 2008, 28:445-453.
24. McMahon E.J., Cook D.N., Suzuki K., Matsushima G.K. Absence of macrophage-inflammatory protein-1 alpha delays central nervous system demyelination in the presence of an intact blood-brain barrier. J. Immunol. 2001, 167:2964-2971.
25. Quinones M.P., Ahuja S.K., Jimenez F., Schaefer J., Garavito E., Rao A., Chenaux G., Reddick R.L., Kuziel W.A., Ahuja S.S. Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis. J. Clin. Invest. 2004, 113:856-866.
26. Shankar P., Manjunath N., Lieberman J. The prospect of silencing disease using RNA interference. JAMA 2005, 293:1367-1373.
27. Thakker P., Leach M.W., Kuang W., Benoit S.E., Leonard J.P., Marusic S. IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 2007, 178:2589-2598.
28. Wang X., Oka T., Chow F.L., Cooper S.B., Odenbach J., Lopaschuk G.D., Kassiri Z., Fernandez-Patron C. Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis. Hypertension 2009, 54:575-582.
29. Yang Y., Weiner J., Liu Y., Smith A.J., Huss D.J., Winger R., Peng H., Cravens P.D., Racke M.K., Lovett-Racke A.E. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 2009, 206:1549-1564.