Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats

Journal of Gene Medicine

Volumn 9, Issue 3, 2007, Pages 217-229

  Hu, Ying Bin ^a   Li, Ding Guo ^a   Lu, Han Ming ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Gene therapy; Hepatic stellate cell; Liver fibrosis; Matrix metalloproteinase; Small interfering RNA; Tissue inhibitor of metalloproteinase 2

Indexed keywords

MATRIX METALLOPROTEINASE; SMALL INTERFERING RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE SILENCING; GENE TARGETING; GENE THERAPY; HISTOPATHOLOGY; LIVER BIOPSY; LIVER FIBROSIS; LIVER REGENERATION; MALE; NONHUMAN; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; SPRAGUE DAWLEY RAT; STELLATE CELL; TRANSMISSION ELECTRON MICROSCOPY;

ACTINS; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE III; EXTRACELLULAR MATRIX; GENE THERAPY; HYDROXYPROLINE; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

RATTUS;

EID: 34047187004     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1009     Document Type: Article

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