IFN-Inducible Protein 10/CXC Chemokine Ligand 10-Independent Induction of Experimental Autoimmune Encephalomyelitis

Journal of Immunology

Volumn 172, Issue 1, 2004, Pages 550-559

  Klein, Robyn S ^a   Izikson, Leonid ^b   Means, Terry ^a   Gibson, Hilary D ^a   Lin, Eugene ^a   Sobel, Raymond A ^c   Weiner, Howard L ^b   Luster, Andrew D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MONOKINE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ACTIVE IMMUNIZATION; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; HISTOPATHOLOGY; LYMPHOCYTIC INFILTRATION; LYMPHOID TISSUE; MOUSE; MULTIPLE SCLEROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL;

EID: 0346734180     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.1.550     Document Type: Article

References (64)

1. Martin, R., and H. F. McFarland. 1995. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. CRC Crit. Rev. Clin. Lab. Sci. 32:121.
2. Steinman, L. 1996. Multiple, sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85:299.
3. Raine, C. S., B. Cannella, A. M. Duijvestijn, and A. H. Cross. 1990. Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab. Invest. 63:476.
4. Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28:254.
5. + T cell cytokine profile in experimental allergic encephalomyelitis. Eur. J. Immunol. 27:2840.
6. Miller, D. H., O. A. Khan, W. A. Sheremata, L. D. Blumhardt, G. P. Rice, M. A. Libonati, A. J. Willmer-Hulme, C. M. Dalton, K. A. Miszkiel, and P. W. O'Connor. 2003. A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 348:15.
7. Brennan, F. R., J. K. O'Neill, S. J. Allen, C. Butter, G. Nuki, and D. Baker. 1999. CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease. Immunology 98:427.
8. Baron, J. L., J. A. Madri, N. H. Ruddle, G. Hashim, and C. A. Janeway, Jr. 1993. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:57.
9. 1 integrin. Nature 356:63.
10. 4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc. Natl. Acad. Sci. USA 96:6896.
11. Luster, A. D. 1998. Chemokines: chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338:436.
12. Fife, B. T., G. B. Huffnagle, W. A. Kuziel, and W. J. Karpus. 2000. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 192:899.
13. Izikson, L., R. S. Klein, I. F. Charo, H. L. Weiner, and A. D. Luster. 2000. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J. Exp. Med. 192:1075.
14. Huang, D. R., J. Wang, P. Kivisakk, B. J. Rollins, and R. M. Ransohoff. 2001. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193:713.
15. Sorensen, T. L., M. Tani, J. Jensen, V. Pierce, C. Lucchinetti, V. A. Folcik, S. Qin, J. Rottman, F. Sellebjerg, R. M. Strieter, et al. 1999. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J. Clin. Invest. 103:807.
16. Sindern, E., T. Patzold, L. M. Ossege, A. Gisevius, and J. P. Malin. 2002. Expression of chemokine receptor CXCR3 on cerebrospinal fluid T-cells is related to active MRI lesion appearance in patients with relapsing-remitting multiple sclerosis. J. Neuroimmunol. 131:186.
17. + T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. USA 96:6873.
18. Sorensen, T. L., F. Sellebjerg, C. V. Jensen, R. M. Strieter, and R. M. Ransohoff. 2001. Chemokines CXCL10 and CCL2: differential involvement in intrathecal inflammation in multiple sclerosis. Eur. J. Neurol. 8:665.
19. Ransohoff, R. M., T. A. Hamilton, M. Tani, M. H. Stoler, H. E. Shick, J. A. Major, M. L. Estes, D. M. Thomas, and V. K. Tuohy. 1993. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB J. 7:592.
20. Fischer, F. R., L. Santambrogio, Y. Luo, M. A. Berman, W. W. Hancock, and M. E. Dorf. 2000. Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression. J Neuroimmunol. 110:195.
21. Huang, D., Y. Han, M. R. Rani, A. Glabinski, C. Trebst, T. Sorensen, M. Tani, J. Wang, P. Chien, S. O'Bryan, et al. 2000. Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquiste regulation. Immunol. Rev. 177:52.
22. Hamilton, N. H., J. L. Banyer, A. J. Hapel, S. Mahalingam, A. J. Ramsay, I. A. Ramshaw, and S. A. Thomson. 2002. IFN-γ regulates murine interferon-inducible T cell α chemokine (I-TAC) expression in dendritic cell lines and during experimental autoimmune encephalomyelitis (EAE). Scand. J. Immunol. 55:171.
23. Sorensen, T. L., C. Trebst, P. Kivisakk, K. L. Klaege, A. Majmudar, R. Ravid, H. Lassmann, D. B. Olsen, R. M. Strieter, R. M. Ransohoff, and F. Sellebjerg. 2002. Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. J. Neuroimmunol. 127:59.
24. Teleshova, N., M. Pashenkov, Y. M. Huang, M. Soderstrom, P. Kivisakk, V. Kostulas, M. Haglund, and H. Link. 2002. Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid. J. Neurol. 249:723.
25. Eikelenboom, M. J., J. Killestein, T. Izeboud, N. F. Kalkers, R. A. Van Lier, F. Barkhof, B. M. Uitdehaag, and C. H. Polman. 2002. Chemokine receptor expression on T cells is related to new lesion development in multiple sclerosis. J. Neuroimmunol. 133:225.
26. Lahrtz, F., L. Piali, D. Nadal, H. W. Pfister, K. S. Spanaus, M. Baggiolini, and A. Fontana. 1997. Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon-γ inducible protein-10 and monocyte chemotactic protein-1. Eur. J. Immunol. 27:2484.
27. Khan, I. A., J. A. MacLean, F. S. Lee, L. Casciotti, E. DeHaan, J. D. Schwartzman, and A. D. Luster. 2000. IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection. Immunity 12:483.
28. Liu, M. T., B. P. Chen, P. Oertel, M. J. Buchmeier, D. Armstrong, T. A. Hamilton, and T. E. Lane. 2000. The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease. J. Immunol. 165:2327.
29. + T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 166:7617.
30. Hancock, W. W., W. Gao, V. Csizmadia, K. L. Faia, N. Shemmeri, and A. D. Luster. 2001. Donor-derived IP-10 initiates development of acute allograft rejection. J. Exp. Med. 193:975.
31. Zhang, Z., L. Kaptanoglu, W. Haddad, D. Ivancic, Z. Alnadjim, S. Hurst, D. Tishler, A. D. Luster, T. A. Barrett, and J. Fryer. 2002. Donor T cell activation initiates small bowel allograft rejection through an IFN-γ-inducible protein-10-dependent mechanism. J. Immunol. 168:3205.
32. Dufour, J. H., M. Dziejman, M. T. Liu, J. H. Leung, T. E. Lane, and A. D. Luster. 2002. IFN-γ-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J. Immunol. 168:3195.
33. Liu, M. T., H. S. Keirstead, and T. E. Lane. 2001. Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis. J. Immunol. 167:4091.
34. Wildbaum, G., N. Netzer, and N. Karin. 2002. Plasmid DNA encoding IFN-γ-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. J. Immunol. 168:5885.
35. Narumi, S., T. Kaburaki, H. Yoneyama, H. Iwamura, Y. Kobayashi, and K. Matsushima. 2002. Neutralization of IFN-inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis. Eur. J. Immunol. 32:1784.
36. Braun, M. C., E. Lahey, and B. L. Kelsall. 2000. Selective suppression of IL-12 production by chemoattractants. J. Immunol. 164:3009.
37. Khoury, S. J., W. W. Hancock, and H. L. Weiner. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, 4, and prostaglandin E expression in the brain. J. Exp. Med. 176:1355.
38. Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
39. Issazadeh, S., M. Mustafa, A. Ljungdahl, B. Hojeberg, A. Dagerlind, R. Elde, and T. Olsson. 1995. Interferon γ, interleukin 4 and transforming growth factor β in experimental autoimmune encephalomyelitis in Lewis rats: dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J. Neurosci. Res. 40:579.
40. Bettelli, E., M. P. Das, E. D. Howard, H. L. Weiner, R. A. Sobel, and V. K. Kuchroo. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 161:3299.
41. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995.
42. Cautain, B., J. Damoiseaux, I. Bernard, H. van Straaten, P. van Breda Vriesman, B. Boneu, P. Druet, and A. Saoudi. 2001. Essential role of TGF-β in the natural resistance to experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 31:1132.
43. Kolb, S. A., B. Sporer, F. Lahrtz, U. Koedel, H. W. Pfister, and A. Fontana. 1999. Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-γ inducible protein 10. J. Neuroimmunol. 93:172.
44. Wang, H. Y., M. Matsui, S. Araya, N. Onai, K. Matsushima, and T. Saida. 2002. Chemokine receptors associated with immunity within and outside the central nervous system in early relapsing-remitting multiple sclerosis. J. Neuroimmunol. 133:184.
45. Glabinski, A. R., M. Tani, V. K. Tuohy, R. J. Tuthill, and R. M. Ransohoff. 1995. Central nervous system chemokine mRNA accumulation follows initial leukocyte entry at the onset of acute murine experimental autoimmune encephalomyelitis. Brain Behav. Immun. 9:315.
46. Miyagishi, R., S. Kikuchi, C. Takayama, Y. Inoue, and K. Tashiro. 1997. Identification of cell types producing RANTES, MIP-1α and MIP-1β in rat experimental autoimmune encephalomyelitis by in situ hybridization. J. Neuroimmunol. 77:17.
47. Gangur, V., F. E. Simons, and K. T. Hayglass. 1998. Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-γ over IL-4 responses. FASEB J. 12:705.
48. Yoneyama, H., S. Narumi, Y. Zhang, M. Murai, M. Baggiolini, A. Lanzavecchia, T. Ichida, H. Asakura, and K. Matsushima. 2002. Pivotal role of dendritic cell-derived CXCL10 in the retention of T helper cell I lymphocytes in secondary lymph nodes. J. Exp. Med. 195:1257.
49. Duong, T. T., J. St Louis, J. J. Gilbert, F. D. Finkelman, and G. H. Strejan. 1992. Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse. J. Neuroimmunol. 36:105.
50. Ferber, I. A., S. Brocke, C. Taylor-Edwards, W. Ridgway, C. Dinisco, L. Steinman, D. Dalton, and C. G. Fathman. 1996. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156:5.
51. Willenborg, D. O., S. Fordham, C. C. Bernard, W. B. Cowden, and 1. A. Ramshaw. 1996. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 157:3223.
52. Glabinski, A. R., M. Krakowski, Y. Han, T. Owens, and R. M. Ransohoff. 1999. Chemokine expression in GKO mice (lacking interferon-γ) with experimental autoimmune encephalomyelitis. J. Neurovirol. 5:95.
53. Blom, T., A. Franzen, D. Heinegard, and R. Holmdahl. 2003. Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease" [Author reply appears in 2003 Science 299:1845]. Science 299:1845.
54. Blom, T., A. Franzen, D. Heinegard, and R. Holmdahl. 2003. Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease" [Author reply appears in 2003 Science 299:1845]. Science 299:1845.
55. Racke, M. K., S. Dhib-Jalbut, B. Cannella, P. S. Albert, C. S. Raine, and D. E. McFarlin. 1991. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1. J. Immunol. 146:3012.
56. Mathisen, P. M., M. Yu, J. M. Johnson, J. A. Drazba, and V. K. Tuohy. 1997. Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells. J. Exp. Med. 186:159.
57. Chen, L. Z., G. M. Hochwald, C. Huang, G. Dakin, H. Tao, C. Cheng, W. J. Simmons, G. Dranoff, and G. J. Thorbecke. 1998. Gene therapy in allergic encephalomyelitis using myelin basic protein-specific T cells engineered to express latent transforming growth factor-β1. Proc. Natl. Acad. Sci. USA 95:12516.
58. Cua, D. J., H. Groux, D. R. Hinton, S. A. Stohlman, and R. L. Coffman. 1999. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 189:1005.
59. + TCR-specific T cells involves IL-4, IL-10 and IFN-γ. Autoimmunity 31:237.
60. Rott, O., B. Fleischer, and E. Cash. 1994. Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur. J. Immunol. 24:1434.
61. Cannella, B., Y. L. Gao, C. Brosnan, and C. S. Raine. 1996. IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45:735.
62. Xiao, B. G., X. F. Bai, G. X. Zhang, and H. Link. 1998. Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats. J. Neuroimmunol. 84:230.
63. Croxford, J. L., K. Triantaphyllopoulos, O. L. Podhajcer, M. Feldmann, D. Baker, and Y. Chernajovsky. 1998. Cytokine gene therapy in experimental allergic encephalomyelitis by injection of plasmid DNA-cationic liposome complex into the central nervous system. J. Immunol. 160:5181.
64. + regulatory T cells. J. Exp. Med. 194:847.