Effects of Environmentally Relevant Mixtures of Persistent Organic Pollutants on the Developmental Neurobiology in Rats

Toxicologic Pathology

Volumn 41, Issue 1, 2013, Pages 38-47

  Gill, Santokh ^a   Bowers, Wayne J ^b   Nakai, Jamie S ^b   Yagminas, al ^b   Mueller, Rudi ^a   Pulido, Olga ^a  

^a TOXICOLOGY RESEARCH DIVISION   (Canada)

^b Environmental Health Center   (Canada)

Author keywords

biomarkers; chemical mixtures; environmental toxicology; neuropathology; toxicologic pathology

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; 2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; ACETYLCHOLINESTERASE; ALDRIN; AROCLOR 1254; CYCLOOXYGENASE 2; DICHLORODIPHENYTTRICHLOROETHANE; DIELDRIN; ETHANE; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN 72; HEPTACHLOR EPOXIDE; HEXACHLOROBENZENE; HEXANE; MICROTUBULE ASSOCIATED PROTEIN 2; MIREX; MUSCARINIC M1 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; NEUROFILAMENT PROTEIN; NEURON SPECIFIC ENOLASE; NONACHLOR; ORGANOCHLORINE DERIVATIVE; OXYCHLORDANE; PROTEIN C FOS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL PROLIFERATION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; MALE; MITOSIS; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; POSTNATAL DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; SUBVENTRICULAR ZONE; TRANSCRIPTION REGULATION;

ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL MARKERS; BRAIN; BRAIN CHEMISTRY; COMPLEX MIXTURES; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; HYDROCARBONS, CHLORINATED; MALE; MATERNAL EXPOSURE; MITOSIS; NERVE TISSUE PROTEINS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

ANIMALIA; RATTUS;

EID: 84871651523     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312451370     Document Type: Article

References (49)

1. Abelsohn A. Brian L. Gibson B. L. Margaret D. Sanborn M. D. Weir E. (2002). Identifying and managing adverse environmental health effects: 5. Persistent organic pollutants. CMAJ 166, 1549–54.
2. Amaral D. G. Winter M. P. (1995). Hippocampal formation. In The Rat Nervous System (Paxinos G., ed.), pp. 443–93. Academic Publishers, San Diego, CA.
3. Bondy S. C. Campbell A. (2005). Developmental neurotoxicology. J. Neurosci Res 81, 605–612.
4. Bowers W. J. Nakai J. S. Chu I. Wade M. G. Moir D. Yagminas A. Gill S. Pulido O. Mueller R. (2004). Early developmental neurotoxicity of a PCB/organochlorine mixture in rodents after gestational and lactational exposure. Toxicol Sci 771, 51–62.
5. Campbell C. Seidler F. Slotkin T. (1997). Chlorpyrifos interferes with cell development in rat brain regions. Brain Research Bulletin 43, 179–89.
6. Carpenter D. O. Arcaro K. F. Bush B. Niemi W. D. Pang S. Vakharia D. D. (1998). Human health and chemical mixtures: An overview. Environ Health Perspect 106, 1263–70.
7. Carpenter D. O. Arcaro K. Spink D. C. (2002). Understanding the human health effects of chemical mixtures. Environ Health Perspect 110, 25–42.
8. Chanda S. Pope C. (1996). Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. Pharmacol Biochem Behav 53, 771–76.
9. Chu I. Bowers W. Caldwell D. Nakai J. Pulido O. Yagminas A. Wade M. Moir D. Gill S. Mueller R. (2005). Toxicological effects of gestational and lactational exposure to a mixture of persistent organochlorine in rats: Systemic effects. Toxicol Sci 88, 645–55.
10. Cory-Slechta D. A. (2005). Studying toxicants as single chemicals: Does this strategy adequately identify neurotoxic risk? Neurotoxicology 26, 491–510.
11. Davis J. M. Svendsgaard D. J. (1989). U-shaped dose-response curves: Their occurrence and implication for risk assessment. J Toxicol Environ Health 30, 71–83.
12. Debes F. Budtz-Jorgensen E. Weihe P. White R. F. Grandjean P. (2006). Impact of prenatal methylmercury exposure on neurobehavioral function at age 14 years. Neurotoxicol Teratol 28, 536–47.
13. Duffell S. J. Soames A. R. Gunby S. (2000). Morphometric analysis of the developing rat brain. Toxicol Pathol 28, 157–63.
14. Erickson P. Talts H. (2000). Neonatal exposure to neurotoxic pesticides increase adult susceptibility. NeuroToxicology 21, 37–48.
15. Evangelista de Duffard A. M. Duffard R. (1996). Behavioral toxicology, risk assessment, and chlorinated hydrocarbons. Environ Health Perspect 104, 353–60.
16. Forcelli P. A. Gale K. Kondratyev A. (2011). Early postnatal exposure of rats to lamotrigine, but not phenytoin, reduces seizure threshold in adulthood. Epilepsia 52, 20–22.
17. Garman R. H. Fix A. S. Jortner B. S. Jensen K. F. Hardisty J. F. Claudio L. Ferenc S. (2001). Methods to identify and characterize developmental neurotoxicity for human health risk assessment. II: Neuropathology. Environ Health Perspect 109, 93–100.
18. Gilbert S. G. Grant-Webster K. S. (1995). Neurobehavioral effects of developmental methylmercury exposure. Environ Health Perspect 103, 135–42.
19. Gill S. Mueller R. Murphy M. Clausen J. Richards D. Quilliam M. MacKinnon S. LaBlanc P. Pulido O. (2003). Neural injury biomarkers of novel shellfish toxins, spirolides: A pilot study using immunochemical and transcriptional analysis. Neurotoxicology 24, 593–604.
20. Health Canada. (1998). Persistent environmental contaminants and the Great Lakes Basin population: An exposure assessment. (Minister of Public Works and Government Services Canada, Cat No H46–2/98–218E).
21. Hites R. A. Foran J. A. Carpenter D. O. Hamilton M. C. Knuth B. A. Schwager S. J. (2004). Global assessment of organic contaminants in farmed salmon. Science 303, 226–9.
22. IIwaniuk A. N. Koperski D. T. Cheng K. M. Elliott J. E. Smith L. K. Wilson L. K. Wylie D. R. (2006). The effects of environmental exposure to DDT on the brain of a songbird: Changes in structures associated with mating and song. Behav Brain Res 173, 1–10.
23. Jacobson J. L. Jacobson S. W. (1997). Evidence for PCBs as neurodevelopmental toxicants in humans. Neurotoxicology 18, 415–24.
24. Kodavanti P. R. (2005). Neurotoxicity of persistent organic pollutants: Possible modes of action and further considerations. Dose-Response 3, 273–305.
25. Luna L. G. (1968). Manual of Histological Staining Methods of the Armed Forces Institute of Pathology, 3rd ed. McGraw-Hill, New York, NY.
26. Marone M. Mozzetti S. De Ritis D. Pierlli L. Scambia G. (2001). Semi-quantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same samples. Biol Proced Online 3, 19–25.
27. Marotta D. Marini A. Banaudha K. Maharaj S. V. Ives J. Morrissette C. R. Jonas W. B. (2002). Non-linear effects of cycloheximide in glutamate treated cultured rat cerebellar neurons. Neurotoxicology 23, 307–12.
28. Marotta D. Marini A. Banaudha K. Maharaj S. V. Jonas W. B. (2003). Nonlinear effects of glutamate and KCl on glutamate toxicity in cultured rat cerebellar neurons. Int J Neurosci. 113, 491–502.
29. Moser V. C. Casey M. Hamm A. Carter W. H. Simmons J. E. Gennings C. (2005). Neurotoxicological and statistical analyses of a mixture of five organophosphorus pesticides using a ray design. Toxicol Sci 86, 101–15.
30. Newland M. Rassmussen E. (2002). Aging unmasks adverse effects of gestational exposure to methylmercury in rats. Neurotoxicol Teratol 22, 819–28.
31. Paxinos G. Watson C. (1986). The Rat Brain in Stereotaxic Coordinates, 2nd ed. Academic Press, Inc., San Diego, CA.
32. Powers B. E. Lin T. M. Vanka A. Peterson R. E. Juraska J. M. Schantz S. L. (2005). Tetrachlorodibenzo-p-dioxin exposure alters radial arm maze performance and hippocampal morphology in female AhR mice. Genes Brain Behav 4, 51–59.
33. Qing Q. L. Loganath A. Chong Y. S. Tan J. Obbard J. P. (2005). Persistent organic pollutants and adverse health effect in humans. J Toxicol Environ Health 69, 1987–2005.
34. Rice D. C. (1995). Neurotoxicity of lead, methylmercury, and PCBs in relation to the Great Lakes. Environ Health Perspect 103, 71–87.
35. Rodier P. M. (1976). Critical periods for behavioral anomalies in mice. Environ Health Perspect 18, 79–83.
36. Rodier P. M. Gramann W. J. (1979). Morphologic effects of interference with cell proliferation in the early fetal period. Neurobehavioral Toxicology 1, 129–35.
37. Rodier P. M. Reynolds S. S. Roberts W. N. (1979). Behavioral consequences of interference with CNS development in the early fetal period. Teratology 19, 327–65.
38. Romanko M. J. Zhu C. Bahr B. A. Blomgren K. Levison S. W. (2007). Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia. J Neurochem 103, 1121–31.
39. Rutten B. Schmitz C. Gerlach O. Oyen H. de Mesquita E. Steinbusch H. Korr H. (2007). The aging brain: Accumulation of DNA damage or neuron loss? Neurobiol Aging 28, 91–98.
40. Schantz S. L. Widholm J. J. (2001). Cognitive effects of endocrine-disrupting chemicals in animals. Environ Health Perspect 109, 1197–206.
41. Seegal R. F. (2000). The neurotoxicological consequences of developmental exposure to PCBs. Toxicol Sci 57, 1–3.
42. Seegal R. F. Pappas B. A. Park G. A. (1998). Neurochemical effects of consumption of Great Lakes salmon by rats. Regul Toxicol Pharmacol 27, S68–75.
43. Slikker W. Bowyer J. F. (2005). Biomarkers of adult and developmental neurotoxicology. Toxicol Appl Pharmacol 206, 255–260.
44. Stein J. Schettler T. Wakkinga D. Valenti M. (2002). In harms way: Toxic threats to child development. Dev Behav Pediatr 22, S13–22.
45. Stellman S. D. Djordjevic M. V. Britton J. A. Muscat J. E. Citron M. L. Kemeny M. Busch E. Gong L. (1998). Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York. Cancer Epidemiol Biomarkers Prev 9, 1241–9.
46. Tilson H. A. (2000). Neurotoxicology risk assessment guidelines: Developmental neurotoxicology. Neurotoxicology 21, 189–94.
47. Truelove J. Mueller R. Pulido O. Iverson F. (1996). Subchronic toxicity study of domoic acid in the rat. Food Chem Toxicol 34, 525–9.
48. Weiss B. (2000). Vulnerability to pesticide neurotoxicity is a lifetime issue. Neurotoxicology 21, 67–73.
49. Wigle D. Arbuckle T. E. Turner M. C. Bérubé A. Yang Q. Liu S. Krewski D. (2008). Epidemiological evidence of relationhsip between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health, Part B 11, 373–517.