Toxicological effects of gestational and lactational exposure to a mixture of persistent organochlorines in rats: Systemic effects

Toxicological Sciences

Volumn 88, Issue 2, 2005, Pages 645-655

  Chu, Ih ^a,c   Bowers, Wayne J ^a   Caldwell, Don ^b   Nakai, Jamie ^a   Pulido, Olga ^b   Yagminas, Al ^a   Wade, Michael G ^a   Moir, David ^a   Gill, Santokh ^b   Mueller, Rudi ^b  

^a Environmental Health Center   (Canada)

^b TOXICOLOGY RESEARCH DIVISION   (Canada)

^c Environmental Health Centre Ottawa   (Canada)

Author keywords

Aroclor 1254; Great Lakes St. Lawrence region; Organochlorine mixtures; PCBs; Systemic toxicity

Indexed keywords

AROCLOR; CHOLESTEROL; CORN OIL; ORGANOCHLORINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CANADA; CELL DENSITY; CELL VACUOLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENDOCRINE SYSTEM; ENZYME ACTIVITY; FATALITY; FEMALE; GROWTH INHIBITION; HEPATOMEGALY; IMMUNOPATHOLOGY; LACTATION; LIVER; LIVER HYPERTROPHY; LIVER MICROSOME; LYMPHOCYTE; LYMPHOID CELL; MALE; MOLECULAR DYNAMICS; MORTALITY; NERVE CELL DIFFERENTIATION; NEUROCHEMISTRY; NONHUMAN; PERINATAL PERIOD; POLLUTANT; PREGNANCY; PROGENY; RAT; SPLEEN; THYMUS; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; CANADA; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD CONTAMINATION; HEPATOMEGALY; HYDROCARBONS, CHLORINATED; LACTATION; LONGEVITY; MALE; MATERNAL EXPOSURE; MICROSOMES, LIVER; ORGAN SIZE; ORGANOGENESIS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; THYMUS GLAND; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; ZEA MAYS;

EID: 27944496524     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi335     Document Type: Article

References (31)

1. Arnold, D. L., Bryce, F., Miller, D., Stapley, R., Malcom, S., and Hayward, S. (1998). The toxicological effects following the ingestion of Chinook salmon from the Great Lakes by Sprague-Dawley rats during a two-generation feeding-reproduction study. Reg. Toxicol. Pharmacol. 27, S18-S27.
2. Bowers, W. J., Nakai, J. S., Chu, I., Wade, G. M., Moir, D., Yagminas, A., Gill, S., Olga, P., and Mueller, R. (2004). Early developmental neurotoxicity of a PCB/organochlorine mixture in rodents after gestational and lactational exposure. Toxicol. Sci. 77, 51-62.
3. Chandra, M., and Frith, C. H. (1993). Non-neoplastic renal lesions in Sprague-Dawley and Fischer-344 rats, Exp. Toxicol. Pathol. 45, 4339-4447.
4. Chu, I., Villeneuve, D. C., Valli, V. E., Ritter, L., Norstrom, R. J., Ryan, J. J., and Becking, G. C. (1984). Toxicological response and its reversibility in rats fed Lake Ontario or Pacific Coho salmon for 13 weeks. J. Environ. Health Sci. B19, 713-731.
5. Chu, I., Villeneuve, D. C., Yagminas, A., Lecavalier, P., Håkansson, H., Ahlborg, U. G., Valli, V. E., Kennedy, S. W., Bergman, A., Seegal, R. F., et al. (1995). Toxicity of PCB 77 (3,3′,4,4′-tetrachlorobiphenyl) and PCB 118 (2,3,4,4′,5-pentachlorobiphenyl) in the rat following subchronic dietary exposure. Fundam. Appl. Toxicol. 26, 282-292.
6. Chu, I., Lecavalier, P., Håkansson, H., Yagminas, A., Valli, V. E., Poon, P. and Feeley, M. (2001). Mixture effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyl congeners in rats. Chemosphere 43, 807-814.
7. Daly, H. B., Stewart, P. W., Lunkenheimer, L., and Sargent, D. (1998). Maternal consumption of Lake Ontario salmon in rats produces behavioral changes in the offspring. Toxicol. Ind. Health 14, 25-39.
8. Germolec, D. R., Kashon, M., Nyska, A., Kuper, C. F., Portier, C., Kommineni, C., Johnson, K. A., and Luster, M. I. (2004). The accuracy of extended histopathology to detect immunotoxic chemicals. Toxicol. Sci. 82, 504-514.
9. Hany, J., Lilienthal, H., Sarasin, A., Roth-Härer, A., Fastabend, A., Dunemann, L., Lichtensteiger, W., and Winneke, G. (1999a). Developmental exposure of rats to a reconstituted PCB mixture or Aroclor 1254: Effects on organ weights, aromatase activity, sex hormone levels and sweet preference behaviour. Toxicol. Appl. Pharmacol. 158, 231-243.
10. Hany, J., Lilienthal, H., Roth-Härer, A., and Winneke, G. (1999b). Behavioral effects following single and combined maternal exposure to PCB 77 (3,4,3′,4′-tetrachlorobiphenyl) and PCB 47 (2,4,2′,4′-tetrachlorobiphenyl) in rats. Neurotoxicol. Teratol. 21, 147-156.
11. Health Canada. (1998). Persistent environmental contaminants and the Great Lakes Basin population: An exposure assessment, Public Works and Government Services Canada, Cat. No. H46-2/98-218E.
12. ICICIS Group (International Collaborative Immunotoxicity Study Group). (1998). Report of validation study of assessment of direct immunotoxicity in the rat. Toxicology 125, 183-20.
13. Iverson, F., Mehta, R., Hierlihy, L., Gurofsky, S., Lok, E., Mueller, R., Bourbonnais, D. H., and Spear, P. A. (1998). Microsomal enzyme activity, glutathione S-transferase-placental form expression, cell proliferation, and vitamin A stores of rats consuming Great Lakes salmon. Reg. Toxicol. Pharmacol. 27, S76-S89.
14. Jacobson, J. L., Jacobson, S. W., and Humphrey, H. E. (1990). Effects of exposure to PCBs and related compounds on growth and activity in children. Neurotoxicol. Teratol. 12, 319-326.
15. Jacobson, J. L., and Jacobson, S. W. (1997). Evidence for PCBs as neurodevelopmental toxicants in humans. Neurotoxicology 18, 415-424.
16. Kearney, J. P., Cole, D. C., Ferron, L. A., and Weber, J. P. (1999). Blood PCB, p,p′-DDE, and mirex levels in Great Lakes fish and waterfowl consumers in two Ontario communities, Environ. Res. 80, S138-S149.
17. Kosatsky, T., Przybysz, R., Shatenstein, B., Weber, J. P., and Armstrong, B. (1999a). Fish consumption and contaminant exposure among Montreal-area sport fishers: A pilot study, Environ. Res. 80, S150-S158.
18. Kosatsky, T., Przybysz, R., Shatenstein, B., Weber, J. P., and Armstrong, B. (1999b), Contaminant exposure in Montrealers of Asian origin fishing the St. Lawrence River: Exploratory assessment, Environ. Res. 80, S159-S165.
19. Lubet, R. A., Nims, R. W., Mayer, R. T., Cameron, J. W., and Schechtman, L. M. (1985). Measurement of cytochrome P-450 dependent de-alkylation of alkoxyphenoxazones in hepatic S9 and hepatocyte homogenates: Effects of dicumarol. Mutat. Res. 142, 127-131.
20. Meany, J. E., and Pocker, Y. (1979). The in vitro inactivation of lactate dehydrogenase by organochlorine insecticides. Pestic. Biochem. Physiol. 11, 232-242.
21. Nakai, J. S., Elwin, J., Chu, I., and Marro, L. (2005). Effects of anaesthetics/terminal procedures on neurotransmitters from non-dosed and Aroclor1254-dosed rats. J. Appl. Toxicol. 25, 224-233.
22. Pappas, B. A., Murtha, S. J., Park, G. A., Hewitt, K., Seegal, R. F., and Jordan, S. A. (1998). Neurobehavioral effects of chronic ingestion of Great Lakes Chinook salmon. Reg. Toxicol. Pharmacol. 27, S55-S67.
23. Roegge, C. S., Widholm, J. J., Engeseth, N. J., Wang, X., Brosch, K. O., Seegal, R. F., and Schantz, S. (2005). Delayed spatial alternation impairments in adult rats following dietary n-6 deficiency during development. Neurotoxicol. Teratol. 27, 485-495.
24. Rogan, W. J., and Gladden, B. C. (1991) PCBs and DDE and child development at 18 and 24 months. Ann. Epidemiol. 1, 407-413.
25. Seegal, R. F., Pappas, B. A., and Park, G. A. (1998). Neurochemical effects of consumption of Great Lakes salmon by rats. Regul. Toxicol. Pharmacol. S68-S75.
26. Stern, N., Öberg, M., Casabonna, H., Trossvik, C., Manzoor, E., Johansson, N., Lind, M., Öberg, J., Feinstein, R., Johansson, A., et al. (2002). Subchronic toxicity of Baltic Herring oil and its fractions in the rat II: Clinical observations and toxicological parameters. Pharmacol. Toxicol. 91, 232-244.
27. Stewart, P. W., Reihman, J., Lonky, E. I., Darvill, T. J., and Pagano, J. (2003). Cognitive development in preschool children prenatally exposed to PCBs and MeHg. Neurotoxicol. Teratol. 25, 11-22.
28. Tatematsu, M., Kaku, T., Medline, A., and Farber, E. (1985). Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene. Lab. Invest. 52, 354-362.
29. Tryphonas, H., McGuire, P., Fernie, S., Miller, D., Stapley, R., Bryce, F., Arnold, D. L., and Fournier, M. (1998). Effects of Great Lakes fish consumption on the immune system of Sprague-Dawley rats investigated during a two-generation reproductive study. Regul. Toxicol. Pharmacol. 27, S28-S39.
30. Villeneuve, D. C., Valli, V. E., Norstrom, R. J., Freeman, H., Sanglang, G. B., Ritter, L., and Becking, G. C. (1981). Toxicological response of rats fed Lake Ontario or Pacific Coho salmon for 28 days. J. Environ. Health B16, 649-689.
31. Wade, M., Foster, W., Younglai, E. V., McMahon, A., Leingartner, K., Yagminas, A., Blakey, D., Fournier, M., Desaulniers, D., and Hughes, C. L. (2002). Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: Systemic, immune and reproductive effects. Toxicol. Sci. 67, 131-143.