Neural injury biomarkers of novel shellfish toxins, spirolides: A pilot study using immunochemical and transcriptional analysis

NeuroToxicology

Volumn 24, Issue 4-5, 2003, Pages 593-604

  Gill, Santokh ^a   Murphy, Meghan ^a   Clausen, Joann ^a   Richard, Don ^b   Quilliam, Michael ^c   MacKinnon, Shawna ^c   LaBlanc, Patricia ^c   Mueller, Rudi ^a   Pulido, Olga ^a  

^a HEALTH CANADA   (Canada)

^b CANADIAN FOOD INSPECTION AGENCY   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Biotoxins; Neural injury; Neuropathology; Neurotoxicology; Receptors; Spirolides

Indexed keywords

BIOLOGICAL MARKER; CHOLINERGIC RECEPTOR; HEAT SHOCK PROTEIN 72; NEUROTOXIN; PROTEIN C FOS; PROTEIN C JUN; SPIROLIDE; UNCLASSIFIED DRUG;

ALEXANDRIUM OSTENFELDII; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DINOFLAGELLATE; DISEASE MARKER; FEMALE; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHELLFISH; SPECIES DIFFERENCE;

ALEXANDRIUM; ALEXANDRIUM OSTENFELDII; BIVALVIA; DINOPHYCEAE; MOLLUSCA; RODENTIA;

EID: 0041736046     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(03)00014-7     Document Type: Conference Paper

References (36)

1. Amaral DG, Witter MP. Hippocampal formation. In: Paxinos G, editor. The rat nervous system. San Diego: Academic Publishers; 1995. p. 443-93.
2. Botana LM. Seafood and freshwater toxins. New York: Marcel Dekker; 2000. p. 1-798.
3. Broxup B. Neuropathology as a screen for neurotoxicity assessment. J Am Toxicol 1991;10:689-95.
4. Bywood PT, Johnson SM. Dendrite loss is a characteristic early indicator of toxin-induced neurodegeneration in rat midbrain slices. Exp Neurol 2000;161:306-16.
5. Cembella A, Lewis N, Quilliam M. The marine dinoflagellate Alexandrium ostenfeldii (Dinophyceae) as the causative organism of spirolide shellfish toxins. Phycologia 2000;39:67-74.
6. Clark RF, Williams SR, Nordt SP, Manoguerra AS. A review of selected seafood poisoning. Undersea Hyperb Med 1999;26:175-84.
7. Fix AS, Garman RH. Practical aspects of neuropathology: a technical guide for working with the nervous system. Toxicol Pathol 2000;28:122-31.
8. Garthwaite I. Keeping shellfish safe to eat: a brief review of shellfish toxins and methods for their detection. Trends Food Sci Technol 2001;11:235-44.
9. Gill S, Pulido O. Glutamate receptors in peripheral tissues: current knowledge. Toxicol Pathol 2001;29:208-23.
10. Gill S, Pulido O, Mueller R, McGuire P. Molecular and immunochemical characterization of the ionotropic glutamate receptors in the rat heart. Brain Res Bull 1998;46:429-34.
11. Gill S, Mueller R, McGuire P, Pulido O. Potential target sites in peripheral tissues for excitatory neurotransmission and excitotoxicity. Toxicol Pathol 2000;28:277-84.
12. Gulland F. Domoic acid toxicity in California sea lion (Zalophus californianus) stranded along the central California coast, May-October 1998. Report to the National Marine Fisheries Service Working Group on Unusual Marine Mammal Mortality Events. US Department of Commerce, MOAA Tech. Memo. NMFS-OPR-17, 2001. p. 1-45.
13. Hu T, Burton IW, Cembella AD, Curtis J, Quilliam M, Walter J, Wright JLC. Characterization of spirolides A, C and 13-desmethyl C, new marine toxins isolated from toxic plankton and contaminated shellfish. J Nat Prod 2001;64:308-12.
14. Ito E, Satake M, Ofuji K, Kurita N, McMahon T, James K et al.. Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon 2000;38:91-930.
15. Iverson F, Truelove J, Tryphonas L, Campbell J, Lok E. Domoic acid poisoning and mussel-associated intoxication: preliminary investigations into the response of mice and rats to toxic mussel extract. Food Toxic Toxic 1989;27:377-84.
16. Juranovic LR, Park DL. Foodborne toxins of marine origins. Rev Environ Contamin Toxicol 1991;117:51-94.
17. Leftley JW, Hannah H. Phycotoxins in seafood. In: Watson DH, editor. Natural toxicants in food. Culinary and Hospitality Industry Publications Services; 1998. p. 182-224.
18. Luna LG. Manual of histologic staining methods of the armed forces institute of pathology. 3rd ed. New York: McGraw-Hill; 1968.
19. Mos L. Domoic acid: a fascinating marine toxin. Environ Toxicol Pharmacol 2001;9:79-85.
20. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. New York: Academic Press; 1982.
21. Peng YG, Ramsdell JS. Brain fos induction is a sensitive biomarker for the lowest observed neurotoxicity effects of domoic acid. Fundam Appl Toxicol 1996;31:162-8.
22. Pentreath VW, Slamon ND. Astrocyte phenotype and prevention against oxidative damage in neurotoxicity. Human Exp Toxicol 2000;1:641-9.
23. Richard D, Arsenault E, Cembella A, Quilliam M. Investigations into the toxicology and pharmacology of spirolides, a novel group of shellfish toxins. In: Proceedings of the Ninth International Conference on Harmful Microalgae, IOC-UNESCO, 2001. p. 383-873.
24. Ross IA, Johnson W, Sapienza PP, Kim CS. Effects of the seafood toxin domoic acid on glutamate uptake by rat astrocytes. Food Chem Toxicol 2000;38:1005-11.
25. Scallet AC, Ye X, Ali SF. NOS and fos in rat and mouse brain regions. Ann N Y Acad Sci 1996;801:227-38.
26. Sharp FR, Saga SM. Alterations in gene expression as an early index of neuronal injury: heat shock and immediate early gene response. NeuroToxicology 1994;15:51-60.
27. Scholin CA, Gulland F, Doucette GJ, Benson S, Busman M, Chavez FP et al.. Mortality of sea lions along the central coast linked to a toxic diatom bloom. Nature 2000;403:80-4.
28. Son M, Shahed A, Werchan PM, Lee JC. C-fos an HSP 70 gene expression in rat brains in high gravitation-induced cerebral ischemia. Neurosci Lett 1995;200:81-4.
29. Takada N, Umemura N, Suenaga K, Chou T, Nagatsu A, Haino T et al.. Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawa bivalve Pinna muricata. Tet Lett 2001;42:3491-4.
30. Tischmeyer W, Grimm R. Activation of immediate early genes and memory formation. Cell Mol Sci 1999;55:564-74.
31. Todd E. Seafood-associated diseases and control in Canada. Rev Sci Tech 1997;16:661-72.
32. Uemura D, Chou T, Haino T, Nagatsu A, Fukuzawa S, Zheng S-z et al.. Pinnatoxin A: a toxic amphoteric macrocycle from the Okinawan Bivalve Pinna muricata. J Am Chem Soc 1995;117:1155-6.
33. Van Dolah FM. Marine algal toxins: origins, health effects and their increased occurrences. Environ Health Perspect 2000;108:133-41.
34. Whittle K, Galaher S. Marine toxins. Br Med Bull 2000;56:236-53.
35. Wright JLC, Boyd RK, de Freitas ASW, Falk M, Foxall RA, Jamieson WD et al.. Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern P.E.I. Can J Chem 1989;67:481-90.
36. Xu Z, Chang LW, Slikker W, Ali SF, Rountree RL, Scallet AC. A dose-response study of ibogaine-induced neuropathology in the rat cerebellum. Toxicol Sci 2000;57:95-101.