The effect of clonidine, an alpha-2 adrenergic receptor agonist, on inflammatory response and postischemic endothelium function during early reperfusion in healthy volunteers

Journal of Cardiovascular Pharmacology

Volumn 60, Issue 6, 2012, Pages 553-560

  Gourdin, Maximilien ^a   Dubois, Philippe ^a   Mullier, Francois ^a   Chatelain, Bernard ^a   Dogné, Jean Michel ^b   Marchandise, Baudouin ^a   Jamart, Jacques ^a   De Kock, Marc ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF NAMUR   (Belgium)

Author keywords

alpha 2 adrenergic receptors; clonidine; endothelium; interleukin; ischemia reperfusion; neutrophils; platelets

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CLONIDINE; GLYCOPROTEIN IB ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; LEUKOCYTE ACTIVATION; MALE; NORMAL HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REPERFUSION; REPERFUSION INJURY; THROMBOCYTE ACTIVATION; VASCULAR ENDOTHELIUM;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADULT; ANTIGENS, CD11B; ANTIGENS, CD18; BELGIUM; BIOLOGICAL MARKERS; BRACHIAL ARTERY; CLONIDINE; CROSS-OVER STUDIES; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; FOREARM; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; REPERFUSION; REPERFUSION INJURY; TIME FACTORS; TOURNIQUETS; VASODILATION; YOUNG ADULT;

EID: 84871622094     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e31827303fa     Document Type: Article

References (53)

1. Garcia SC, Pomblum V, Gams E, et al. Independency of myocardial stunning of endothelial stunning? Basic Res Cardiol. 2007;102:359-367.
2. Lefer AM, Tsao PS, Lefer DJ, et al. Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia. Faseb J. 1991;5:2029-2034.
3. Qi XL, Nguyen TL, Andries L, et al. Vascular endothelial dysfunction contributes to myocardial depression in ischemia-reperfusion in the rat. Can J Physiol Pharmacol. 1998;76:35-45.
4. Besse S, Tanguy S, Boucher F, et al. Aortic vasoreactivity during prolonged hypoxia and hypoxia-reoxygenation in senescent rats. Mech Ageing Dev. 2002;123:275-285.
5. Seasholtz TM, Cai G, Wang HY, et al. Selected contribution: effects of ischemia-reperfusion on vascular contractility and alpha(1)-adrenergicreceptor signaling in the rat tail artery. J Appl Physiol. 2001;91: 1004-1010.
6. Dignan RJ, Dyke CM, Abd-Elfattah AS, et al. Coronary artery endothelial cell and smooth muscle dysfunction after global myocardial ischemia. Ann Thorac Surg. 1992;53:311-317.
7. Sun JZ, Li ZY, Zang YM, et al. Alterations of coronary vascular responses to noradrenaline, acetylcholine and isoprenaline during acute myocardial ischaemia in dogs. Br J Pharmacol. 1989;97:626-630.
8. Gourdin MJ, Ponchau O, Jamart J, et al. Prehypoxic clonidine administration improves vasomotricity of isolated rat aorta during reoxygenation. Eur J Anaesthesiol. 2010;27:965-972.
9. Dean JM, George S, Naylor AS, et al. Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep. Neuropharmacology. 2008;55:166-174.
10. Guo H, Takahashi S, Cho S, et al. The effects of dexmedetomidine on left ventricular function during hypoxia and reoxygenation in isolated rat hearts. Anesth Analg. 2005;100:629-635.
11. Laudenbach V, Mantz J, Lagercrantz H, et al. Effects of alpha(2)-adrenoceptor agonists on perinatal excitotoxic brain injury: comparison of clonidine and dexmedetomidine. Anesthesiology. 2002;96:134-141.
12. Okada H, Kurita T, Mochizuki T, et al. The cardioprotective effect of dexmedetomidine on global ischaemia in isolated rat hearths. Resuscitation. 2007;74:538-545.
13. Solez K, Ideura T, Silvia CB, et al. Clonidine after renal ischemia to lessen acute renal failure and microvascular damage. Kidney Int. 1980; 18:309-322.
14. Zhang Y. Clonidine preconditioning decreases infarct size and improves neurological outcome from transient forebrain ischemia in the rat. Neuroscience. 2004;125:625-631.
15. Gourdin MJ, Bree B, De Kock M. The impact of ischaemia-reperfusion on the blood vessel. Eur J Anaesthesiol. 2009;26:537-547.
16. Rodrigues SF, Granger DN. Role of blood cells in ischaemia-reperfusion induced endothelial barrier failure. Cardiovascular Res. 2010;87:291-299.
17. Pomerantz BJ, Reznikov LL, Harken AH, et al. Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta. Proc Natl Acad Sci USA. 2001;98:2871-2876.
18. Wanderer AA. Ischemic-reperfusion syndromes: biochemical and immunologic rationale for IL-1 targeted therapy. Clin Immunol. 2008;128: 127-132.
19. Zhang M, Chen L. Status of cytokines in ischemia reperfusion induced heart injury. Cardiovasc Hematol Disord Drug Targets. 2008;8: 161-172.
20. Watson R, Woodman R, Lockette W. Ephedra alkaloids inhibit platelet aggregation. Blood Coagul Fibrinolysis. 2010;21:266-271.
21. Lucchinetti E, Ambrosio S, Aguirre J, et al. Sevoflurane inhalation at sedative concentrations provides endothelial protection against ischemiareperfusion injury in humans. Anesthesiology. 2007;106:262-268.
22. Arndts D, Doevendans J, Kirsten R, et al. New aspects of the pharmacokinetics and pharmacodynamics of clonidine in man. Eur J Clin Pharmacol. 1983;24:21-30.
23. Kharbanda RK, Peters M, Walton B, et al. Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo. Circulation. 2001;103: 1624-1630.
24. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257-265.
25. Hughes S, Hendricks B, Edwards D, et al. Tourniquet-applied upper limb orthopaedic surgery results in increased inflammation and changes to leukocyte, coagulation and endothelial markers. PLoS One. 2010;5:e11846.
26. Krueger LA, Barnard MR, Frelinger AL III, et al. Immunophenotypic analysis of platelets. In Robinson JP, Darzynkiewicz Z, Dean PN, et al. (Eds.). Current protocols in cytometry. New York: John Wiley & Sons. Pp 6. 10. 1-6. 10. 17.
27. Liang KY, Zeger S. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73:13-22.
28. Molin JC, Bendhack LM. Clonidine induces rat aorta relaxation by nitric oxide-dependent and-independent mechanisms. Vascul Pharmacol. 2004;42:1-6.
29. Bruck H, Gossl M, Spitthover R, et al. The nitric oxide synthase inhibitor L-NMMA potentiates noradrenaline-induced vasoconstriction: effects of the alpha2-receptor antagonist yohimbine. J Hypertens. 2001;19:907-911.
30. Lembo G, Iaccarino G, Vecchione C, et al. Insulin modulation of an endothelial nitric oxide component present in the alpha2-and beta-adrenergic responses in human forearm. J Clin Invest. 1997;100:2007-2014.
31. Vinten-Johansen J, Shi W. Perconditioning and postconditioning: current knowledge, knowledge gaps, barriers to adoption, and future directions. J Cardiovasc Pharmacol Ther. 2011;16:260-266.
32. Han H, Wang Z, Zhang N, et al. Role of nitric oxide during the early phase myocardial ischemic preconditioning in rats. Chin Med J. 2008; 121:1210-1214.
33. Peltonen GL, Scalzo RL, Schweder MM, et al. Sympathetic inhibition attenuates hypoxia induced insulin resistance in healthy adult humans. J Physiol. 2012;590(Pt 11):2801-2809.
34. De Kock M, Laterre PF, Van Obbergh L, et al. The effects of intraoperative intravenous clonidine on fluid requirements, hemodynamic variables, and support during liver transplantation: a prospective, randomized study. Anesth Analg. 1998;86:468-476.
35. Pichot C, Geloen A, Ghignone M, et al. Alpha-2 agonists to reduce vasopressor requirements in septic shock? Med Hypotheses. 2010;75: 652-656.
36. Lorenz JJ, Furdon PJ, Taylor JD, et al. A cyclic adenosine 30, 50-monophosphate signal is required for the induction of IL-1 beta by TNF-alpha in human monocytes. J Immunol. 1995;155:836-844.
37. Vellenga E, van der Vinne B, De Wolf JT, et al. Simultaneous expression and regulation of G-CSF and IL-6 mRNA in adherent human monocytes and fibroblasts. Br J Haematol. 1991;78:14-18.
38. Schuett H, Luchtefeld M, Grothusen C, et al. How much is too much? Interleukin-6 and its signalling in atherosclerosis. Thromb Haemost. 2009;102:215-222.
39. Memis D, Hekimoglu S, Vatan I, et al. Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. Br J Anaesth. 2007;98:550-552.
40. Tasdogan M, Memis D, Sut N, et al. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth. 2009;21: 394-400.
41. Pate M, Damarla V, Chi DS, et al. Endothelial cell biology: role in the inflammatory response. Adv Clin Chem. 2010;52:109-130.
42. Altmann C, Andres-Hernando A, McMahan RH, et al. Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Am J Physiol Renal Physiol. 2012;302:F421-F432.
43. Ioannou A, Dalle Lucca J, Tsokos GC. Immunopathogenesis of ischemia/reperfusion-associated tissue damage. Clin Immunol. 2011; 141:3-14.
44. Motulsky HJ, Shattil SJ, Insel PA. Characterization of alpha 2-adrenergic receptors on human platelets using [3H]yohimbine. Biochem Biophys Res Commun. 1980;97:1562-1570.
45. Panosian JO, Marinetti GV. alpha 2-Adrenergic receptors in human polymorphonuclear leukocyte membranes. Biochem Pharmacol. 1983;32: 2243-2247.
46. Nishina K, Akamatsu H, Mikawa K, et al. The effects of clonidine and dexmedetomidine on human neutrophil functions. Anesth Analg. 1999; 88:452-458.
47. Alloatti G, Montrucchio G, Emanuelli G, et al. Platelet-activating factor (PAF) induces platelet/neutrophil co-operation during myocardial reperfusion. J Mol Cell Cardiol. 1992;24:163-171.
48. Heindl B, Zahler S, Welsch U, et al. Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts. Cardiovasc Res. 1998;38:383-394.
49. Montrucchio G, Alloatti G, Tetta C, et al. Release of platelet-activating factor from ischemic-reperfused rabbit heart. Am J Physiol. 1989;256 (4 Pt 2):H1236-H1246.
50. Akpek EA, Kahraman S, Yaman A, et al. The effect of pre-induction clonidine on platelet aggregation during minor surgery. Eur J Clin Pharmacol. 1998;54:459-462.
51. Ganter MT, Hofer CK, Spahn DR, et al. The effect of clonidine on perioperative blood coagulation. J Clin Anesth. 2005;17:456-462.
52. Petrusewicz J, Kalizsan R. Human blood platelet alpah adrenoceptor in view of the effects of various imidazol(in)e drugs on aggregation. Gen Pharmacol. 1991;22:819-823.
53. Tousoulis D, Antoniades C, Stefanadis C. Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques. Heart. 2005;91:553-558.