Alpha-2 agonists to reduce vasopressor requirements in septic shock?

Medical Hypotheses

Volumn 75, Issue 6, 2010, Pages 652-656

  Pichot, C ^a   Geloen A ^b   Ghignone, M ^c   Quintin, L ^b  

^a Memorial Hospital   (France)

^b UNIVERSITÉ DE LYON   (France)

^c Critical Care Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CATECHOLAMINE; CLONIDINE; DEXMEDETOMIDINE; GLYCERYL TRINITRATE; HYPERTENSIVE FACTOR; PHENYLEPHRINE; PLACEBO;

ARTICLE; BLOOD VESSEL REACTIVITY; CATECHOLAMINE BLOOD LEVEL; DENERVATION; DOWN REGULATION; HUMAN; NONHUMAN; PERIPHERAL CIRCULATION; SENSITIZATION; SEPTIC SHOCK; UPREGULATION; VASOCONSTRICTION;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; BLOOD PRESSURE; CATECHOLAMINES; GENE EXPRESSION REGULATION; HUMANS; RATS; SHOCK, SEPTIC; VASOCONSTRICTOR AGENTS;

EID: 77958492655     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2010.08.010     Document Type: Article

References (47)

1. Deans K.J., Haley M., Natanson C., Eichacker P.Q., Minneci P.C. Novel therapies for sepsis: a review. J Trauma 2005, 58:867-874.
2. Dellinger R.P., Levy M.M., Carlet J.M., Bion J., Parker M.M., Jaeschke R., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Int Care Med 2008, 34:17-60.
3. Sprung C.L., Annane D., Keh D., Moreno R., Singer M., Freivogel K., et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008, 358:111-124.
4. Thomas V.L., Nielsen M.S. Administration of angiotensin II in refractory septic shock. Crit Care Med 1991, 19:1084-1086.
5. Benedict C.R., Rose J.A. Arterial norepinephrine changes in patients with septic shock. Circ Shock 1992, 38:165-172.
6. Collin S., Levy B. Pathophysiological mechanisms of vascular hyporesponsiveness in shock states. Reanimation 2008, 17:101-110.
7. Petros A., Bennett D., Vallance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 1991, 338:1557-1558.
8. Schneider F., Lutun P., Hasselmann M., Stoclet J.C., Tempe J.D. Methylene blue increases systemic vascular resistance in human septic shock. Preliminary observations. Intensive Care Med 1992, 18:309-311.
9. Bellissant E., Annane D. Effect of hydrocortisone on phenylephrine - mean arterial pressure dose-response relationship in septic shock. Clin Pharmacol Ther 2000, 68:293-303.
10. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., et al. Early goal directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377.
11. Parker M.M., Shelhamer J.H., Bacharach S.L., Green M.V., Natanson C., Frederick T.M., et al. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984, 100:483-490.
12. Putensen C., Zech S., Wrigge H., Zinserling J., Stuber F., von S.T., et al. Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. Am J Respir Crit Care Med 2001, 164:43-49.
13. Mangano D.T., Layug E.L., Wallace A.W., Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. N Engl J Med 1996, 335:1713-1720.
14. Wallace A.W., Galindez D., Salalieh A., Layug E.L., Lazo E.A., Haratonik K.A., et al. Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery. Anesthesiology 2004, 101:284-293.
15. Schmittinger C.A., Wurzinger B., Deutinger M., Wohlmuth C., Knotzer H., Torgersen C., et al. How to protect the heart in septic shock: a hypothesis on the pathophysiology and treatment of septic heart failure. Med Hypotheses 2010, 74:460-465.
16. Bucher M., Kees F., Taeger K., Kurtz A. Cytokines down-regulate alpha1-adrenergic receptor expression during endotoxemia. Crit Care Med 2003, 31:566-571.
17. Butler J., Kelly J.G., O'Malley O., Pidgeon F. Beta-adrenoceptor adaptation to acute exercise. J Physiol (Lond) 1983, 344:113-117.
18. Ohman E.M., Butler J., Kelly J., Horgan J., O'Malley K. Beta-adrenoceptor adaptation to endurance training. J Cardiovasc Pharmacol 1987, 10:728-731.
19. Schultz K.D., Fritschka E., Kribben A., Rothschild M., Thiede H.M., Distler A., et al. Alpha 2- and beta 2-adrenoceptor downregulation in marathon runners. J Hypertens Suppl 1989, 7:S48-S49.
20. Silverman H.J., Penaranda R., Orens J.B., Lee N.H. Impaired beta-adrenergic receptor stimulation of cyclic adenosine monophosphate in human septic shock: association with myocardial hyporesponsiveness to catecholamines. Crit Care Med 1993, 21:31-39.
21. Saito T., Takanashi M., Gallagher E., Fuse A., Suzaki S., Inagaki O., et al. Corticosteroid effect on early beta-adrenergic down-regulation during circulatory shock: hemodynamic study and beta-adrenergic receptor assay. Intens Care Med 1995, 21:204-210.
22. Mathias C.J., Reid J.L., Wing L.M.H., Frankel H.L., Christensen N.J. Antihypertensive effects of clonidine in tetraplegic subjects devoid of central sympathetic control. Clin Sci 1979, 57:425S-428S.
23. Robertson D., Goldberg M.R., Hollister A.S., Wade D., Robertson R.M. Clonidine raises blood pressure in severe idiopathic orthostatic hypotension. Am J Med 1983, 74:193-200.
24. Bannister R., Boylston A.W., Davies I.B., Mathias C.J., Sever P.S., Sudera D. Beta-receptor numbers and thermodynamics in denervation supersensitivity. J Physiol 1981, 319:369-377.
25. Dollery C.T., Harington M., Hodge J.V. Haemodynamic studies with methyldopa: effect on cardiac output and response to pressor amines. Br Heart J 1963, 25:670-676.
26. Burn J.H., Rand M.J. The action of sympathomimetic amines in animals treated with reserpine. J Physiol 1958, 144:314-336.
27. Grimm L.J., Blendy J.A., Kellar K.J., Perry D.C. Chronic reserpine administration selectively up-regulates beta 1- and alpha 1b-adrenergic receptors in rat brain: an autoradiographic study. Neuroscience 1992, 47:77-86.
28. Freed C.R., Wang C.H., U'Prichard D.C. Changes in brain alpha-adrenergic receptors after alphamethyldopa administration to spontaneously hypertensive rats. Hypertension 1984, 6:II34-II39.
29. Kobinger W., Pichler L. The central modulatory effect of clonidine on the cardiodepressor reflex after suppression of synthesis and storage of noradrenaline. Eur J Pharmacol 1975, 30:56-62.
30. Zoukos Y., Thomaides T., Pavitt D.V., Leonard J.P., Cuzner M.L., Mathias C.J. Upregulation of beta adrenoceptors on circulating mononuclear cells after reduction of central sympathetic outflow by clonidine in normal subjects. Clin Auton Res 1992, 2:165-170.
31. Quintin L., Bouilloc X., Butin E., Bayon M.C., Brudon J.R., Levron J.C., et al. Clonidine for aortic surgery in hypertensive patients: a double blind controlled randomized study. Anesth Analg 1996, 83:687-695.
32. Nishikawa T., Kimura T., Taguchi N., Dohi S. Oral clonidine preanesthetic medication augments the pressor responses to intravenous ephedrine in awake or anesthetized patients. Anesthesiology 1991, 74:705-710.
33. Inomata S., Nishikawa T., Kihara S., Akiyoshi Y. Enhancement of pressor response to intravenous phenylephrine following oral clonidine medication in awake and anaesthetized patients. Can J Anaesth 1995, 42:119-125.
34. Parlow J., Sagnard P., Begou G., Viale J.P., Quintin L. The effects of clonidine on sensitivity to phenylephrine and nitroprusside in patients with essential hypertension recovering from surgery. Anesth Analg 1999, 88:1239-1243.
35. De Kock M., Laterre P.F., Van Obbergh L., Carlier M., Lerut J. The effects of intraoperative intravenous clonidine on fluid requirements, hemodynamic variables, and support during liver transplantation: a prospective, randomized study. Anesth Analg 1998, 86:468-476.
36. Morris G.M., Hadcock J.R., Malbon C.C. Cross-regulation between G-protein-coupled receptors. Activation of beta 2-adrenergic receptors increases alpha 1-adrenergic receptor mRNA levels. J Biol Chem 1991, 266:2233-2238.
37. Copik A.J., Ma C., Kosaka A., Sahdeo S., Trane A., Ho H., et al. Facilitatory interplay in alpha 1a and beta 2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction. Mol Pharmacol 2009, 75:713-728.
38. Wing L.M., Reid J.L., Davies D.S., Dargie H.J., Dollery C.T. Apparent resistance to hypotensive effect of clonidine. Br Med J 1977, 1:136-138.
39. Ellis C.G., Bateman R.M., Sharpe M.D., Sibbald W.J., Gill R. Effect of a maldistribution of microvascular blood flow on capillary O2 extraction in sepsis. Am J Physiol 2002, 282:H156-H164.
40. Spronk P.E., Ince C., Gardien M.J., Mathura K.R., Oudemans-van Straaten H.M., Zandstra D.F. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002, 360:1395-1396.
41. Prys-Roberts C. Regulation of the circulation. The circulation in anaesthesia: applied physiology and pharmacology 1980, 179-207. Blackwell, Oxford. C. Prys-Roberts (Ed.).
42. Myburgh J.A. An appraisal of selection and use of catecholamines in septic shock: old becomes new again. Crit Care Resuscitation 2006, 8:353-360.
43. Taniguchi T., Kidani Y., Kanakura H., Takemoto Y., Yamamoto K. Effects of dexmedetomidine on mortality rate and inflammatory response to endotoxin-induced shock in rats. Crit Care Med 2004, 32:1322-1326.
44. Taniguchi T., Kurita A., Kobayashi K., Yamamoto K., Inaba H. Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats. J Anesth 2008, 22:221-228.
45. Hofer S., Steppan J., Wagner T., Funke B., Lichtenstern C., Martin E., et al. Central sympatholytics prolong survival in experimental sepsis. Crit Care 2009, 13:R11.
46. Dodd-o J.M., Breslow M.J., Dorman T., Rosenfeld B.A. Preserved sympathetic response to hypotension despite perioperative alpha-2 agonist administration. Anesth Analg 1997, 84:1208-1210.
47. Sauder P., Andreoletti M., Cambonie G., Capellier G., Feissel M., Gall O., et al. Sedation and analgesia in intensive care. French Crit Care Soc. Ann Fr Anesth Reanim 2008, 27:541-551.