Partial neuroprotection with low-dose infusion of the α2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep

Neuropharmacology

Volumn 55, Issue 2, 2008, Pages 166-174

  Dean, Justin M ^a,b   George, Sherly ^a   Naylor, Andrew S ^a   Mallard, Carina ^b   Gunn, Alistair J ^a   Bennet, Laura ^a  

^a THE UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Alpha adrenergic receptors; Fetal sheep; Hypoxic ischemic brain injury; Neuroprotection

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CASPASE 3; CELL MARKER; CLONIDINE; NEURON SPECIFIC NUCLEAR PROTEIN;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; CELL SURVIVAL; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE CALCULATION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG MEGADOSE; ELECTROENCEPHALOGRAM; FETUS; FETUS DISEASE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; SEIZURE; SHEEP; UMBILICAL CORD BLOOD FLOW;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANOXIA; BRAIN; CLONIDINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; FEMALE; PHOSPHOPYRUVATE HYDRATASE; PREGNANCY; PREMATURE BIRTH; SHEEP; TIME FACTORS; UMBILICAL CORD;

EID: 47149104656     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.05.009     Document Type: Article

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