Tourniquet-applied upper limb orthopaedic surgery results in increased inflammation and changes to leukocyte, coagulation and endothelial markers

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Hughes, Stephen F ^a,d   Hendricks, Beverly D ^b   Edwards, David R ^c   Middleton, Jim F ^d  

^a UNIVERSITY OF CHESTER   (United Kingdom)

^b GLAN CLWYD HOSPITAL   (United Kingdom)

^c YSBYTY GWYNEDD   (United Kingdom)

^d KEELE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CD11B ANTIGEN; HYDROGEN PEROXIDE; L SELECTIN; PROTEIN C; VON WILLEBRAND FACTOR;

ADULT; AGED; ANALYZER; ARM; ARTICLE; BLOOD SAMPLING; CELL ISOLATION; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; ELECTIVE SURGERY; ENZYME LINKED FLUORESCENT ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE; LEUKOCYTE ACTIVATION; MALE; MONOCYTE; NEUTROPHIL; ORTHOPEDIC SURGERY; PATIENT MONITORING; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REPERFUSION; TOURNIQUET; TOURNIQUET APPLIED UPPER LIMB ORTHOPEDIC SURGERY; VENOUS BLOOD; CYTOLOGY; METABOLISM; METHODOLOGY; MIDDLE AGED;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD11B; C-REACTIVE PROTEIN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; HYDROGEN PEROXIDE; L-SELECTIN; LEUKOCYTES; MALE; MIDDLE AGED; ORTHOPEDIC PROCEDURES; PROTEIN C; TOURNIQUETS; UPPER EXTREMITY; VON WILLEBRAND FACTOR;

EID: 77955608829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011846     Document Type: Article

References (27)

1. Babior BM (1992) Neutrophil function as related to neutrophil-endothelial cell interactions. Nonv Rev Fr Hematol 34: S29-S35.
2. Hughes SF, Cotter MJ, Evans S-A, Jones KP, Adams RA (2006) The role of leukocytes in damage to the vascular endothelium during ischaemia-reperfusion injury. Br J Biomed Sci 63(4): 166-170.
3. Bradbury AW, Murie JA, Ruckley CV (1993) Role of the leukocyte in the pathogenesis of vascular disease. Br J Surg 12: 1503-1512.
4. Jang Y, Lincoff AM, Plow EF, Topol EJ (1994) Cell adhesion molecules in coronary artery disease. J Am Coll Cardiol 24: 1591-1601.
5. Tedder TF, Steeber DA, Chen A, Engel P (1995) The selectins: Vascular adhesion molecules. FASEB J 9: 866-873.
6. Lan W, Harmon D, Wang JH, Ghori K, Shorten G, et al. (2004) The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion. Eur J Anaesthesiol 11: 892-897.
7. Kirkipatrick UJ, Blann A, Adams R, McCollum CN (2000) Soluble adhesion molecules in clinical ischaemic injury. Int J Surg Investig 2: 151-158.
8. Engler RL (1989) Free radical and granulocyte-mediated injury during myocardial ischemia and reperfusion. Am J Cardiol 63: 19E-23E.
9. Schmid-Schonbein GW, Engler RL (1990) Perspectives of leukocyte activation in the microcirculation. Biorheology 27: 859-869.
10. ten Raa S, van den Tol MP, Sluiter W, Hofland LJ, van Eijck CH, et al. (2006) The role of neutrophils and oxygen free radicals in post-operative adhesions. J Surg Res 1: 45-52.
11. Kisiel W (1979) Human plasma protein C: isolation, characterisation and mechanism of activation by a thrombin. Journal Clin Invest 64: 761-769.
12. Marlar RA, Adcock DM (1989) Clinical evaluation of protein C: a comparative review if antigenic and functional assays. Hum Pathol 20: 1040-1047.
13. Blann AD, McCollum CN (1994) Von Willebrand factor, endothelial cell damage and atherosclerosis. Eur J Vasc Surg 8: 10-15.
14. Foster W, Shantsila E, Carruthers D, Lip GY, Blann AD (2009) Circulating endothelial cells and rheumatoid arthritis: relationship with plasma markers of endothelial damage/dysfunction. Rheumatology (Oxford) 3: 285-288.
15. Blann AD, Seigneur M, Adams RA, McCollum CN (1996) Neutrophil elastase, von Willebrand factor, soluble thrombomodulin and percutaneous oxygen in peripheral atherosclerosis. Eur J Vasc Endovasc Surg 12: 218-222.
16. Leff JA, Rapine JE (1990) Blood cells and ischemia-reperfusion injury. Blood Cells 16: 183-191.
17. Sekamp A, Ward PA (1993) Ischemia-reperfusion injury. Agents Actions Suppl 41: 137-152.
18. Norwood M, Bown M, Sayers R (2005) Ischaemia-Reperfusion Injury and Regional Inflammatory Responses in Abdominal Aortic Aneurysm Repair. Eur J Vasc Endovas Surg 28: 234-245.
19. Pahl MV, Vaziri ND, Connall T, Morrison D, Kim C, et al. (2005) Systemic upregulation of leukocyte integrins in response to lower body ischemiareperfusion during abdominal aortic aneurysm repair. J NATL Med Assoc 97: 172-179.
20. Parslew R, Braithwaite I (1997) An investigation into the effect of ischaemia and pressure on irritant inflammation. Br J Dermatol 136: 734-736.
21. Hughes SF, Hendricks BD, Edwards DR, Bastawrous SS, Roberts G, et al. (2007) Mild episodes of tourniquet-induced forearm ischaemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. Journal of Inflammation [Lond] 4(1): 12.
22. Lennie SE, Lowe GDO, Barbenel JC (1987) Filterability of white blood cell subpopulations, separated by an improved method. Clin Hemorheol 7: 811-816.
23. Bass DA, Parce JW, Dechatelet LR, Szedja P, Seeds MC, et al. (1983) Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 130: 1910-1917.
24. Price CP, Trull AK, Berr D, Gorman EG (1987) Development and Validation of a Particle-Enhanced Turbidimetric Immunoassay for C-reactive protein. J Immunol Methods 99: 205-211.
25. Seekamp A, van Griensven M, Hildebrandt F, Brauer N, Jochum M, et al. (2001) The effect of trauma on neutrophil L-selectin expression and sL-selectin serum levels. Shock 4: 254-60.
26. Sutter PM, Spagnoli GC, Marx A, Gurke L, Troeger H, et al. (1997) Increased surface expression of CD18 and CD11b in leukocytes after tourniquet ischemia during elective hand surgery. World Journal of Surgery. pp 179-84. discussion 185.
27. Orrego LM, Pérez CM, Pérez YM, Cheyre EJ, Mardones PR (2005) Plasma C reactive protein in elective orthopedic surgery. Rev Med Chil 11: 1341-1348.