Effects of α2-adrenoceptor agonists on perinatal excitotoxic brain injury: Comparison of clonidine and dexmedetomidine

Anesthesiology

Volumn 96, Issue 1, 2002, Pages 134-141

  Laudenbach, Vincent ^a   Mantz, Jean ^b   Lagercrantz, Hugo ^c   Desmonts, Jean Marie ^b   Evrard, Philippe ^a   Gressens, Pierre ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b INSERM   (France)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; DEXMEDETOMIDINE; IBOTENIC ACID; N METHYL DEXTRO ASPARTIC ACID; YOHIMBINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; MALE; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; TOXICITY;

EID: 0036137630     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200201000-00026     Document Type: Article

References (53)

1. Preterm singleton births-United States 1989-1996
2. The changing panorama of cerebral palsy-bilateral spastic forms in particular
3. Excitatory amino acids in the cerebrospinal fluid of asphyxiated infants: Relationship to hypoxic-ischemic encephalopathy
4. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development
5. Calcium: Still center-stage in hypoxic-ischemic neuronal death
6. Excitotoxicity, free radicals, and cell membrane changes
7. Glutamate neurotoxicity and diseases of the nervous system
8. Effect of ibotenate on brain development: An excitotoxic mouse model of microgyria and posthypoxic-like lesions
9. Environmental and genetic determinants of neural migration and postmigratory survival
10. Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium
11. Regulation of neuroprotective action of vasoactive intestinal peptide in the murine developing brain by protein kinase C and mitogen-activated protein kinase cascades: In vivo and in vitro studies
12. Vasoactive intestinal peptide prevents excitotoxic cell death in the murine developing brain
13. Glycine antagonist and NO synthase inhibitor protect the developing mouse brain against neonatal excitotoxic lesions
14. Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain
15. 2-adrenergic agonists
16. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins: A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system
17. Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia
18. Neuroprotective effects of dexmedetomidine in the gerbil hippocampus after transient global ischemia
19. Clonidine decreases plasma catecholamines and improves outcome from incomplete ischemia in the rat
20. Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acidinduced convulsions and neuronal damage
21. Formation, maturation, and disorders of brain neocortex
22. Central role of microglia in neonatal excitotoxic lesions of the murine periventricular white matter
23. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist
24. Neuritic differentiation and synaptogenesis in serum-free neuronal cultures of the rat cerebral cortex
25. Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity
26. Reproductive physiology
27. Gender-linked brain injury in experimental stroke
28. Do women fare worse: A metaanalysis of gender differences in traumatic brain injury outcome
29. Female TBI patients recover better than males
30. Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies
31. Predictors of low and very low birth weight and the relation of these to cerebral palsy
32. Periventricular leukomalacia: Risk factors revisited
33. 2-adrenergic antagonist atipamezole
34. Hypoxic-ischaemic brain damage in immature rats: Effects of adrenoceptor modulation
35. NMDA and kainate-evoked release of nitric oxide and classical transmitters in the rat striatum: In vivo evidence that nitric oxide may play a neuroprotective role
36. The locus coeruleus noradrenergic system in the rat brain studied by dual-probe microdialysis
37. Postnatal development of brain alpha 1-adrenergic receptors: In vitro autoradiography with [125I]HEAT in normal rats and rats treated with alpha-difluoromethylomithine, a specific, irreversible inhibitor of ornithine decarboxylase
38. Developmental changes of cerebral cortical [3H] clonidine binding in rats: Influences of guanine nucleotide and cations
39. 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat
40. A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents
41. 2-Adrenoceptor agonists decrease cyclic guanosine 3′,5′-monophosphate in the mouse brain
42. Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells: Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation
43. Presynaptic alpha2-adrenoceptors control excitatory, but not inhibitory, transmission at rat hippocampal synapses
44. Presynaptic inhibition of excitatory synaptic transmission mediated by alpha adrenergic receptors in area CA3 of the rat hippocampus in vitro
45. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices
46. Dexmedetomidine does not attenuate increases in excitatory amino acids after transient global ischemia in the rabbit
47. Alpha2A- but not alpha2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: Voltammetric data
48. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
49. Dexmedetomidine-induced stimulation of glutamine oxidation in astrocytes: A possible mechanism for its neuroprotective activity
50. Control of glutamate clearance and synaptic efficacy by glial coverage of neurons
51. Mechanisms of dexmedetomidine-induced cerebrovascular effects in canine in vivo experiments
52. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
53. Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation