Influence of acylation on the adsorption of GLP-2 to hydrophobic surfaces

International Journal of Pharmaceutics

Volumn 440, Issue 1, 2013, Pages 63-71

  Pinholt, Charlotte ^a   Kapp, Sebastian J ^a   Bukrinsky, Jens T ^b   Hostrup, Susanne ^c   Frokjaer, Sven ^a   Norde, Willem ^d,e   Jorgensen, Lene ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Novozymes Biopharma DK A S   (United Kingdom)

^c NOVO NORDISK A S   (Denmark)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Acylation; GLP 2; ITC; Protein adsorption; Reflectometry; TIRF

Indexed keywords

ARGININE; BETA ALANINE; FATTY ACID; GLUCAGON LIKE PEPTIDE 2; LEUCINE; LYSINE; NANOPARTICLE; POLYSTYRENE;

ACYLATION; ADSORPTION KINETICS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AQUEOUS SOLUTION; ARTICLE; CHEMICAL PHENOMENA; CIRCULAR DICHROISM; COMPARATIVE STUDY; COVALENT BOND; DRUG ADSORPTION; ENTHALPY; FLUORESCENCE; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MATHEMATICAL MODEL; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN SECRETION; PROTEIN STRUCTURE; REFLECTOMETRY;

ACYLATION; ADSORPTION; GLUCAGON-LIKE PEPTIDE 2; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NANOPARTICLES; POLYSTYRENES;

EID: 84871616760     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.01.040     Document Type: Article

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