Influence of acylation on the adsorption of insulin to hydrophobic surfaces

Pharmaceutical Research

Volumn 28, Issue 5, 2011, Pages 1031-1040

  Pinholt, Charlotte ^a   Hostrup, Susanne ^b   Bukrinsky, Jens Thostrup ^c   Frokjaer, Sven ^a   Jorgensen, Lene ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c Novozymes Biopharma DK A S   (United Kingdom)

Author keywords

acylated insulin; CD; insulin; ITC; protein adsorption

Indexed keywords

POLYSTYRENE; RECOMBINANT HUMAN INSULIN;

ACYLATION; ARTICLE; BINDING AFFINITY; CHEMICAL COMPOSITION; CIRCULAR DICHROISM; DRUG ADSORPTION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG STRUCTURE; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL; SURFACE PROPERTY;

ADSORPTION; AMINO ACID SEQUENCE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INSULIN; MOLECULAR SEQUENCE DATA; SURFACE PROPERTIES;

EID: 79955577684     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0349-6     Document Type: Article

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