Reversible lipidization prolongs the pharmacological effect, plasma duration, and liver retention of octreotide

Pharmaceutical Research

Volumn 22, Issue 2, 2005, Pages 220-227

  Yuan, Liyun ^a   Wang, Jeff ^b   Shen, Wei Chiang ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Growth hormone; Liver cancers; Liver retention; Octreotide; Reversible lipidization

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; OCTREOTIDE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENTIATION; DRUG RETENTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE BLOOD LEVEL; INHIBITION KINETICS; LIVER CLEARANCE; LIVER METABOLISM; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSIBLE AQUEOUS LIPIDIZATION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; GROWTH HORMONE; HUMANS; LIPIDS; LIVER; MALE; MICE; OCTREOTIDE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 16844369137     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-004-1189-z     Document Type: Article

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